Fully convergent chemical synthesis of ester insulin: Determination of the high resolution X-ray structure by racemic protein crystallography

Journal of the American Chemical Society

Volumn 135, Issue 8, 2013, Pages 3173-3185

  Avital Shmilovici, Michal ^a   Mandal, Kalyaneswar ^a   Gates, Zachary P ^a   Phillips, Nelson B ^b   Weiss, Michael A ^b   Kent, Stephen B H ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOSYNTHESIS; CRYSTAL ATOMIC STRUCTURE; CRYSTALS; ENANTIOMERS; ESTERS; MOLECULES; PEPTIDES; PH; RATS; X RAY CRYSTALLOGRAPHY; X RAYS;

BIOLOGICAL ASSAYS; INSULIN MOLECULES; INSULIN RECEPTORS; MEDICINAL CHEMISTRY; POLYPEPTIDE CHAIN; PROTEIN CRYSTALLOGRAPHY; PROTEIN MOLECULES; PROTEIN X-RAY CRYSTALLOGRAPHY;

INSULIN;

ASPARTIC ACID; ESTER INSULIN; GLUCOSE; INSULIN DERIVATIVE; INSULIN RECEPTOR; LYSINE; MONOMER; PROINSULIN; PROLINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HORMONE RECEPTOR INTERACTION; INSULIN SYNTHESIS; INSULIN TREATMENT; NONHUMAN; PARTICLE SIZE; PEPTIDE SYNTHESIS; PH; PROTEIN FOLDING; RAT; SAPONIFICATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 84874621257     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja311408y     Document Type: Article

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