Toxicity of valproic acid in isolated rat liver mitochondria

Toxicology Mechanisms and Methods

Volumn 23, Issue 8, 2013, Pages 617-623

  Jafarian, Iman ^a   Eskandari, Mohammad Reza ^a   Mashayekhi, Vida ^a,b   Ahadpour, Morteza ^a   Hosseini, Mir Jamal ^a,b  

^a ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytochrome c; Isolated mitochondria; Mitochondrial membrane potential collapse ( m); Oxidative stress; Valproic acid (VPA)

Indexed keywords

BUTYLCRESOL; CYCLOSPORIN A; CYTOCHROME C; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; VALPROIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; ULTRACENTRIFUGATION;

ANIMALS; ANTICONVULSANTS; CYTOCHROMES C; GLUTATHIONE; MALE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VALPROIC ACID;

EID: 84886446333     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2013.821567     Document Type: Article

References (32)

1. Baracca A, Sgarbi G, Solaini G, Lenaz G. (2003). Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis. Biochim Biophys Acta 1606: 137-46.
2. 2 generation in isolated mitochondria. J Bioenerg Biomembr 34:227-33.
3. Blaheta RA, Michaelis M, Driever PH, Cinatl Jr J. (2005). Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies. Med Res Rev 25:383-97.
4. Boelsterli UA. (2003). Idiosyncratic drug hepatotoxicity revisited: new insights from mechanistic toxicology. Toxicol Mech Methods 13: 3-20.
5. Bohan TP, Helton E, McDonald I, et al. (2001). Effect of L-carnitine treatment for valproate-induced hepatotoxicity. Neurology 56:1405-9.
6. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-54.
7. Chang TK, Abbott FS. (2006). Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity. Drug Metab Rev 38:627-39.
8. Duan S, Hajek P, Lin C, et al. (2003). Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis. J Biol Chem 278:1346-53.
9. Ghazi-Khansari M, Mohammadi-Bardbori A, Hosseini MJ. (2006). Using Janus green B to study paraquat toxicity in rat liver mitochondria: role of ACE inhibitors (thiol and nonthiol ACEi). Ann N Y Acad Sci 1090:98-107.
10. Hosseini MJ, Shaki F, Ghazi-Khansari M, Pourahmad J. (2013). Toxicity of vanadium on isolated rat liver mitochondria: a new mechanistic approach. Metallomics 5:152-66.
11. Johannessen SI, Landmark CJ. (2010). Antiepileptic drug interactions-principles and clinical implications. Curr Neuropharmacol 8:254-67.
12. Junior HV, de Franca Fonteles MM, Mendes de Freitas R. (2009). Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum. Oxid Med Cell Longev 2:130-7.
13. Kiang TK, Teng XW, Karagiozov S, et al. (2010). Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis and oxidative stress in sandwich-cultured rat hepatocytes. Toxicol Sci 118:501-9.
14. Lambowitz AM. (1979). Preparation and analysis of mitochondrial ribosomes. Methods Enzymol 59:421-33.
15. Lash LH. (2006). Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact 163: 54-67.
16. Lenaz G. (2001). The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 52:159-64.
17. McLaughlin DB, Eadie MJ, Parker-Scott SL, et al. (2000). Valproate metabolism during valproate-associated hepatotoxicity in a surviving adult patient. Epilepsy Res 41:259-68.
18. Mohammadi-Bardbori A, Nejati M, Esmaeili J, et al. (2008). Comparative measurement of in vitro paraquat and aflatoxin B1 cytotoxicity using three different cytotoxicity assays in pheochromocytoma cells (PC-12). Toxicol Mech Methods 18: 685-9.
19. Nutt LK, Gogvadze V, Uthaisang W, et al. (2005). Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis. Cancer Biol Ther 4:459-67.
20. Paradies G, Petrosillo G, Pistolese M, Ruggiero FM. (2001). Reactive oxygen species generated by the mitochondrial respiratory chain affect the complex III activity via cardiolipin peroxidation in beef-heart submitochondrial particles. Mitochondrion 1:151-9.
21. Perucca E. (2002). Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 16:695-714.
22. Pourahmad J, Eskandari MR, Kaghazi A, et al. (2012). A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis. Toxicol In Vitro 26: 545-51.
23. Russmann S, Kullak-Ublick GA, Grattagliano I. (2009). Current concepts of mechanisms in drug-induced hepatotoxicity. Curr Med Chem 16:3041-53.
24. Sadegh C, Schreck RP. (2003). The spectroscopic determination of aqueous sulfite using Ellman's reagent. MURJ 8:39-43.
25. Shaki F, Hosseini MJ, Ghazi-Khansari M, Pourahmad J. (2012). Toxicity of depleted uranium on isolated rat kidney mitochondria. Biochim Biophys Acta 1820:1940-50.
26. Shao L, Cui J, Young LT, Wang JF. (2008). The effect of mood stabilizer lithium on expression and activity of glutathione S-transferase isoenzymes. Neuroscience 151:518-24.
27. Silva MF, Aires CC, Luis PB, et al. (2008). Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review. J Inherit Metab Dis 31:205-16.
28. Tong V, Chang TK, Chen J, Abbott FS. (2003). The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. Free Radic Biol Med 34:1435-46.
29. Tong V, Teng XW, Chang TK, Abbott FS. (2005a). Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci 86:427-35.
30. Tong V, Teng XW, Chang TK, Abbott FS. (2005b). Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicol Sci 86: 436-43.
31. Zhang F, Xu Z, Gao J, et al. (2008). In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain. Environ Toxicol Pharmacol 26:232-6.
32. Zhao Y, Ye L, Liu H, et al. (2010). Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress. J Inorg Biochem 104:371-8.