메뉴 건너뛰기




Volumn 41, Issue 3, 2000, Pages 259-268

Valproate metabolism during valproate-associated hepatotoxicity in a surviving adult patient

Author keywords

Oxidation; Anticonvulsants; Hepatotoxicity; Metabolism; Valproate

Indexed keywords

VALPROIC ACID;

EID: 0034308080     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(00)00151-0     Document Type: Article
Times cited : (22)

References (27)
  • 1
    • 0023694528 scopus 로고
    • Metabolic activation of valproic acid and drug-mediated hepatotoxicity: Role of the terminal olefin, 2-n-propyl-4-pentenoic acid
    • Baillie T.A. Metabolic activation of valproic acid and drug-mediated hepatotoxicity: role of the terminal olefin, 2-n-propyl-4-pentenoic acid. Chem. Res. Toxicol. 1:1988;195-199.
    • (1988) Chem. Res. Toxicol. , vol.1 , pp. 195-199
    • Baillie, T.A.1
  • 2
    • 0025734152 scopus 로고
    • Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations
    • Bjorge S.M., Baillie T.A. Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations. Drug Metab. Dispos. 19:1991;823-829.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 823-829
    • Bjorge, S.M.1    Baillie, T.A.2
  • 3
    • 0029925182 scopus 로고    scopus 로고
    • Valproic acid hepatic fatalities: III: US experience since 1986
    • Bryant A.E., Dreifuss F.E. Valproic acid hepatic fatalities: III: US experience since 1986. Neurology. 46:1996;465-469.
    • (1996) Neurology , vol.46 , pp. 465-469
    • Bryant, A.E.1    Dreifuss, F.E.2
  • 4
    • 0015220460 scopus 로고
    • A 'new' disorder of isoleucine catabolism
    • Daum R.S., Mamer O.A., Lamm P.H., Scriver P.R. A 'new' disorder of isoleucine catabolism. Lancet. ii:1971;1289-1290.
    • (1971) Lancet , vol.2 , pp. 1289-1290
    • Daum, R.S.1    Mamer, O.A.2    Lamm, P.H.3    Scriver, P.R.4
  • 5
    • 0028045747 scopus 로고
    • Valproic acid: A reappraisal of its pharmacological properties and clinical efficacy in epilepsy
    • Davis R., Peters D.H., McTavish D. Valproic acid: a reappraisal of its pharmacological properties and clinical efficacy in epilepsy. Drugs. 47:1994;332-372.
    • (1994) Drugs , vol.47 , pp. 332-372
    • Davis, R.1    Peters, D.H.2    McTavish, D.3
  • 6
    • 0024495739 scopus 로고
    • Urinary excretion of valproate and some metabolites in chronically treated patients
    • Dickinson R.G., Hooper W.D., Dunstan P.R., Eadie M.J. Urinary excretion of valproate and some metabolites in chronically treated patients. Ther. Drug Monit. 11:1989;127-133.
    • (1989) Ther. Drug Monit. , vol.11 , pp. 127-133
    • Dickinson, R.G.1    Hooper, W.D.2    Dunstan, P.R.3    Eadie, M.J.4
  • 7
    • 0024546064 scopus 로고
    • Valproic acid hepatic fatalites: II: US experience since 1984
    • Dreifuss F.E., Langer D.H., Moline K.A., Maxwell K.E. Valproic acid hepatic fatalites: II: US experience since 1984. Neurology. 39:1989;201-207.
    • (1989) Neurology , vol.39 , pp. 201-207
    • Dreifuss, F.E.1    Langer, D.H.2    Moline, K.A.3    Maxwell, K.E.4
  • 8
    • 0023135810 scopus 로고
    • Vaplroic acid hepatic fatalities: A retrospective review
    • Dreifuss F.E., Santilli N., Langer D.H. et al. Vaplroic acid hepatic fatalities: a retrospective review. Neurology. 36:1987;379-385.
    • (1987) Neurology , vol.36 , pp. 379-385
    • Dreifuss, F.E.1    Santilli, N.2    Langer, D.H.3
  • 9
    • 0023864274 scopus 로고
    • Valproate-associated hepatotoxicity and its biochemical mechanisms
    • Eadie M.J., Hooper W.D., Dickinson R.G. Valproate-associated hepatotoxicity and its biochemical mechanisms. Med. Toxicol. 3:1988;85-106.
    • (1988) Med. Toxicol. , vol.3 , pp. 85-106
    • Eadie, M.J.1    Hooper, W.D.2    Dickinson, R.G.3
  • 11
    • 0026527844 scopus 로고
    • Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry
    • Fisher E., Wittfoht W., Nau H. Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry. Biomed. Chromatogr. 6:1992;24-29.
    • (1992) Biomed. Chromatogr. , vol.6 , pp. 24-29
    • Fisher, E.1    Wittfoht, W.2    Nau, H.3
  • 12
    • 0018379006 scopus 로고
    • Reye-like syndrome associated with valproic acid therapy
    • Gerber N., Dickinson R.G., Harland R.C. et al. Reye-like syndrome associated with valproic acid therapy. J. Pediatr. 95:1979;142-145.
    • (1979) J. Pediatr. , vol.95 , pp. 142-145
    • Gerber, N.1    Dickinson, R.G.2    Harland, R.C.3
  • 14
    • 0030048917 scopus 로고    scopus 로고
    • Effect of felbamate on valproic acid disposition in healthy volunteers: Inhibition of β-oxidation
    • Hooper W.D., Franklin M.E., Glue P. et al. Effect of felbamate on valproic acid disposition in healthy volunteers: inhibition of β-oxidation. Epilepsia. 37:1996;91-97.
    • (1996) Epilepsia , vol.37 , pp. 91-97
    • Hooper, W.D.1    Franklin, M.E.2    Glue, P.3
  • 15
    • 0002647306 scopus 로고    scopus 로고
    • Urinary metabolites of valproic acid in epileptic patients
    • Katayama H., Watanabe M., Yoshitomi H. et al. Urinary metabolites of valproic acid in epileptic patients. Biol. Pharm. Bull. 21:1998;304-307.
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 304-307
    • Katayama, H.1    Watanabe, M.2    Yoshitomi, H.3
  • 16
    • 0022124848 scopus 로고
    • Hepatotoxizität unter valproinsäure behandlung
    • Keulen F.P., Kochen W. Hepatotoxizität unter valproinsäure behandlung. Klin. Pädiatr. 197:1985;431-436.
    • (1985) Klin. Pädiatr. , vol.197 , pp. 431-436
    • Keulen, F.P.1    Kochen, W.2
  • 17
    • 0020589798 scopus 로고
    • Abnormal metabolism of valproic acid in severe hepatic failure
    • Kochen W., Schneider A., Ritz A. Abnormal metabolism of valproic acid in severe hepatic failure. Eur. J. Pediatr. 141:1983;30-35.
    • (1983) Eur. J. Pediatr. , vol.141 , pp. 30-35
    • Kochen, W.1    Schneider, A.2    Ritz, A.3
  • 18
    • 0027973087 scopus 로고
    • Severe hepatotoxicity during valproate therapy: An update and report of eight new fatalaties
    • König A., Siemes H., Blaker F. et al. Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalaties. Epilepsia. 35:1994;1005-1015.
    • (1994) Epilepsia , vol.35 , pp. 1005-1015
    • König, A.1    Siemes, H.2    Blaker, F.3
  • 19
    • 0021985846 scopus 로고
    • Altered metabolic profiles of valproic acid in a patient with Reye's syndrome
    • Kuhara T., Inoue Y., Matsumoto M. et al. Altered metabolic profiles of valproic acid in a patient with Reye's syndrome. Clin. Chim. Acta. 145:1985;135-142.
    • (1985) Clin. Chim. Acta , vol.145 , pp. 135-142
    • Kuhara, T.1    Inoue, Y.2    Matsumoto, M.3
  • 20
    • 0025212696 scopus 로고
    • Markedly increased ω-oxidation of valproate in fulminant hepatic failure
    • Kuhara T., Inoue Y., Matsumoto M. et al. Markedly increased ω-oxidation of valproate in fulminant hepatic failure. Epilepsia. 31:1990;214-217.
    • (1990) Epilepsia , vol.31 , pp. 214-217
    • Kuhara, T.1    Inoue, Y.2    Matsumoto, M.3
  • 22
    • 0024549456 scopus 로고
    • Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques
    • Rettenmeier A.W., Howald W.N., Levy R.H. et al. Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques. Biomed. Environ. Mass Spectrom. 18:1989;192-199.
    • (1989) Biomed. Environ. Mass Spectrom , vol.18 , pp. 192-199
    • Rettenmeier, A.W.1    Howald, W.N.2    Levy, R.H.3
  • 23
    • 0029079640 scopus 로고
    • CYP4 isozyme specificity and the relationship between ω- hydroxylation and terminal desaturation of valproic acid
    • Rettie A.E., Sheffels P.R., Korzekwa K.R. et al. CYP4 isozyme specificity and the relationship between ω- hydroxylation and terminal desaturation of valproic acid. Biochemistry. 34:1995;7889-7895.
    • (1995) Biochemistry , vol.34 , pp. 7889-7895
    • Rettie, A.E.1    Sheffels, P.R.2    Korzekwa, K.R.3
  • 24
    • 0017264974 scopus 로고
    • On the mechanisms of some hypoglycaemic actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid: A way out of the present confusion
    • Sherratt H.S.A., Osmundsen H. On the mechanisms of some hypoglycaemic actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid: a way out of the present confusion. Biochem. Pharmacol. 25:1976;743-750.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 743-750
    • Sherratt, H.S.A.1    Osmundsen, H.2
  • 25
    • 0027522968 scopus 로고
    • Valproate (VPA) metabolites in various clinical conditions of probable valproate-associated hepatotoxicity
    • Siemes H., Nau H., Schultze K. et al. Valproate (VPA) metabolites in various clinical conditions of probable valproate-associated hepatotoxicity. Epilepsia. 34:1993;332-346.
    • (1993) Epilepsia , vol.34 , pp. 332-346
    • Siemes, H.1    Nau, H.2    Schultze, K.3
  • 27
    • 0020420283 scopus 로고
    • Valproate-induced hepatic injury: Analysis of 23 fatal cases
    • Zimmerman H.J., Ishak K.G. Valproate-induced hepatic injury: analysis of 23 fatal cases. Hepatology. 2:1982;591.
    • (1982) Hepatology , vol.2 , pp. 591
    • Zimmerman, H.J.1    Ishak, K.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.