Inhibition of microsomal cortisol production by (-)-epigallocatechin-3-gallate through a redox shift in the endoplasmic reticulum-A potential new target for treating obesity-related diseases

BioFactors

Volumn 39, Issue 5, 2013, Pages 534-541

  Szelényi, Péter ^a   Révész, Katalin ^a   Konta, Laura ^a   Tüttõ, Anna ^a   Mandl, József ^a   Kereszturi, Éva ^a   Csala, Miklós ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

( ) epigallocatechin 3 gallate; 11 hydroxysteroid dehydrogenase type 1; Diabetes; Endoplasmic reticulum; Redox shift; Selective inhibitor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTISONE; EPIGALLOCATECHIN GALLATE; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HYDROCORTISONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE SYNTHESIS; HYDROCORTISONE BLOOD LEVEL; LIPID PEROXIDATION; LIVER MICROSOME; MALE; METABOLIC SYNDROME X; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

(-)-EPIGALLOCATECHIN-3-GALLATE; 11Β-HYDROXYSTEROID DEHYDROGENASE TYPE 1; DIABETES; ENDOPLASMIC RETICULUM; REDOX SHIFT; SELECTIVE INHIBITOR;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ANTIPORTERS; CATECHIN; CORTISONE; ENDOPLASMIC RETICULUM; GLUCOSEPHOSPHATE DEHYDROGENASE; HYDROCORTISONE; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; MONOSACCHARIDE TRANSPORT PROTEINS; NADP; OBESITY; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

EID: 84886444983     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1095     Document Type: Article

References (35)

1. Chrousos, G. P. andKino, T. (2009)Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders.Ann. N Y Acad. Sci.1179, 153-166.
2. Gerich, J. E. (1993)Control of glycaemia.Baillieres Clin. Endocrinol. Metab.7, 551-586.
3. Yabaluri, N. andBashyam, M. D. (2010)Hormonal regulation of gluconeogenic gene transcription in the liver.J. Biosci.35, 473-484.
4. Mazziotti, G., Gazzaruso, C., andGiustina, A. (2011)Diabetes in Cushing syndrome: basic and clinical aspects.Trends Endocrinol. Metab.22, 499-506.
5. Marcolongo, P., Senesi, S., Gava, B., Fulceri, R., Sorrentino, V., et al. (2008)Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endoplasmic reticulum.Biochem. Pharmacol.76, 382-390.
6. Tomlinson, J. W., Walker, E. A., Bujalska, I. J., Draper, N., Lavery, G. G., et al. (2004)11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.Endocr. Rev.25, 831-866.
7. Csala, M., Banhegyi, G., andBenedetti, A. (2006)Endoplasmic reticulum: a metabolic compartment.FEBS Lett.580, 2160-2165.
8. Banhegyi, G., Csala, M., andBenedetti, A. (2009)Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum.J. Mol. Endocrinol.42, 283-289.
9. Czegle, I., Piccirella, S., Senesi, S., Csala, M., Mandl, J., et al. (2006)Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum.Mol. Cell. Endocrinol.248, 24-25.
10. Krikorian, A. andKhan, M. (2010)Is metabolic syndrome a mild form of Cushing's syndrome? Rev.Endocr. Metab. Disord.11, 141-145.
11. Czegle, I., Csala, M., Mandl, J., Benedetti, A., Karadi, I., et al. (2012)G6PT-H6PDH-11betaHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome.World J. Hepatol.4, 129-138.
12. Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., et al. (2001)A transgenic model of visceral obesity and the metabolic syndrome.Science294, 2166-2170.
13. Paterson, J. M., Morton, N. M., Fievet, C., Kenyon, C. J., Holmes, M. C., et al. (2004)Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.Proc. Natl. Acad. Sci. U S A101, 7088-7093.
14. Lavery, G. G., Hauton, D., Hewitt, K. N., Brice, S. M., Sherlock, M., et al. (2007)Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase.Endocrinology148, 6100-6106.
15. Rogoff, D., Ryder, J. W., Black, K., Yan, Z., Burgess, S. C., et al. (2007)Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase.Endocrinology148, 5072-5080.
16. Kotelevtsev, Y., Holmes, M. C., Burchell, A., Houston, P. M., Schmoll, D., et al. (1997)11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.Proc. Natl. Acad. Sci. U S A94, 14924-14929.
17. Morton, N. M., Holmes, M. C., Fievet, C., Staels, B., Tailleux, A., et al. (2001)Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.J. Biol. Chem.276, 41293-41300.
18. Ge, R., Huang, Y., Liang, G., andLi, X. (2010)11beta-hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: status and development.Curr. Med. Chem.17, 412-422.
19. Chacko, S. M., Thambi, P. T., Kuttan, R., andNishigaki, I. (2010)Beneficial effects of green tea: a literature review.Chin. Med.5, 13.
20. Cheynier, V. (2005)Polyphenols in foods are more complex than often thought.Am. J. Clin. Nutr.81, 223S-229S.
21. Kao, Y. H., Chang, H. H., Lee, M. J., andChen, C. L. (2006)Tea, obesity, and diabetes.Mol. Nutr. Food Res.50, 188-210.
22. Wolfram, S., Wang, Y., andThielecke, F. (2006)Anti-obesity effects of green tea: from bedside to bench.Mol. Nutr. Food Res.50, 176-187.
23. Thielecke, F. andBoschmann, M. (2009)The potential role of green tea catechins in the prevention of the metabolic syndrome-a review.Phytochemistry70, 11-24.
24. Koyama, Y., Abe, K., Sano, Y., Ishizaki, Y., Njelekela, M., et al. (2004)Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo.Planta Med.70, 1100-1102.
25. Henne, V. andSoling, H. D. (1986)Guanosine 5′-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1, 4, 5-trisphosphate.FEBS Lett.202, 267-273.
26. Burchell, A., Hume, R., andBurchell, B. (1988)A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system.Clin. Chim. Acta173, 183-191.
27. Wills, E. D. (1987) InBiochemical Toxicology, A Practical Approach. ( Snell, K., Mullock, B., eds.). pp127-152, IRL Press, Oxford.
28. Csala, M., Margittai, E., Senesi, S., Gamberucci, A., Banhegyi, G., et al. (2007)Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallate.FEBS Lett.581, 1693-1698.
29. Kereszturi, E., Kalman, F. S., Kardon, T., Csala, M., andBanhegyi, G. (2010)Decreased prereceptorial glucocorticoid activating capacity in starvation due to an oxidative shift of pyridine nucleotides in the endoplasmic reticulum.FEBS Lett.584, 4703-4708.
30. Funder, J. W. (1994)Corticosteroid hormones and signal specificity.Ann. N Y Acad. Sci.746, 1-6; discussion 6-7, 64-67.
31. Hughes, K. A., Manolopoulos, K. N., Iqbal, J., Cruden, N. L., Stimson, R. H., et al. (2012)Recycling between cortisol and cortisone in human splanchnic, subcutaneous adipose, and skeletal muscle tissues in vivo.Diabetes61, 1357-1364.
32. Basu, R., Basu, A., Grudzien, M., Jung, P., Jacobson, P., et al. (2009)Liver is the site of splanchnic cortisol production in obese nondiabetic humans.Diabetes58, 39-45.
33. Mandl, J., Meszaros, T., Banhegyi, G., Hunyady, L., andCsala, M. (2009)Endoplasmic reticulum: nutrient sensor in physiology and pathology.Trends Endocrinol. Metab.20, 194-201.
34. Senesi, S., Legeza, B., Balazs, Z., Csala, M., Marcolongo, P., et al. (2010)Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum: possible implication in the metabolic syndrome.Endocrinology151, 4830-4839.
35. Diederich, S., Grossmann, C., Hanke, B., Quinkler, M., Herrmann, M., et al. (2000)In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I.Eur. J. Endocrinol.142, 200-207.