Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal

Molecular Endocrinology

Volumn 27, Issue 11, 2013, Pages 1958-1968

  Kim, So Yong ^a   Jeong, Sookyung ^a   Chah, Kyong Hwa ^a   Jung, Eunyu ^a   Baek, Kwan Hyuck ^a   Kim, Seong Tae ^a   Shim, Jae Hyuck ^b   Chun, Eunyoung ^c   Lee, Ki Young ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROTEIN P50; PROTEIN SERINE THREONINE KINASE; SALT INDUCIBLE KINASE 1; SALT INDUCIBLE KINASE 3; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1 BINDING PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CYTOKINES; GENE EXPRESSION; HEK293 CELLS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4; TRANSCRIPTIONAL ACTIVATION; UBIQUITINATION;

EID: 84886417358     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2013-1240     Document Type: Article

References (27)

1. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011;474:327-336.
2. Crozat K, Vivier E, Dalod M. Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunol Rev. 2009;227:129-149.
3. Baker RG, Hayden MS, Ghosh S. NFB, inflammation, and metabolic disease. Cell Metab. 2011;13:11-22.
4. Emilsson V, Thorleifsson G, Zhang B, et al. Genetics of gene expression and its effect on disease. Nature. 2008;452:423-428.
5. Yang X, Deignan JL, Qi H, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009;41:415-423.
6. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008;8:923-934.
7. Mathis D, Shoelson SE. Immunometabolism: an emerging frontier. Nat Rev Immunol. 2011;11:81-83.
8. Fullerton MD, Steinberg GR, Schertzer JD. Immunometabolism of AMPK in insulin resistance and atherosclerosis. Mol Cell Endocrinol. 2013;366:224-234.
9. Kim SY, Jeong S, Jung E, et al. AMP-activated protein kinase1 as an activating kinase of TGF-β-activated kinase1 has a key role in inflammatory signals. Cell Death. Dis. 2012;3:e357.
10. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23:344-346.
11. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91.
12. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNFfunction. Nature. 1997;389:610-614.
13. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958-969.
14. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122:787-795.
15. Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol. 2008;181:3733-3739.
16. Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci USA. 2012;109:16986-16991.
17. Janssens S, Beyaert R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev. 2003;16:637-646.
18. West AP, Koblansky AA, Ghosh S. Recognition and signaling by toll-like receptors. Annu Rev Cell Dev Biol. 2006;22:409-437.
19. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 2001; 412:346-351.
20. Sato S, Sanjo H, Takeda K, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005;6:1087-1095.
21. Kim SY, Shim JH, Chun E, Lee KY. Reciprocal inhibition between the transforming growth factor-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter protein for TAK1. J Biol Chem. 2012; 287:3381-3391.
22. Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J. TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells. 2005;10:447-454.
23. Skaug B, Jiang X, Chen ZJ. The role of ubiquitin in NFB regulatory pathways. Annu Rev Biochem. 2009;78:769-796.
24. Kanayama A, Seth RB, Sun L, et al. TAB2 and TAB3 activate the NFB pathway through binding to polyubiquitin chains. Mol Cell. 2004;15:535-548.
25. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003;22:6277-6288.
26. Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MAL T1 in T lymphocytes. Mol Cell. 2004;14:289-301.
27. MacKenzie KF, Clark K, Naqvi S, et al. PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol. 2013;190: 565-577.