The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways

Apoptosis

Volumn 18, Issue 11, 2013, Pages 1348-1362

  Wang, Di ^a   Zhao, Ming ^a   Chen, Guozhu ^a   Cheng, Xiang ^a   Han, Xiaoxi ^b   Lin, Song ^a   Zhang, Xuhui ^a   Yu, Xiaodan ^a  

^a Beijing Institute of Basic Medical Sciences   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Necroptosis; RIP1; Signal transduction; TNF ; Vorinostat

Indexed keywords

FLICE INHIBITORY PROTEIN; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; VORINOSTAT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NECROPTOSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AUTOPHAGY; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; FIBROBLASTS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; MAP KINASE KINASE 4; MICE; NECROSIS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84886405768     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0866-y     Document Type: Article

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