Ripoptosome: A novel IAP-regulated cell death-signalling platform

Journal of Molecular Cell Biology

Volumn 3, Issue 6, 2011, Pages 324-326

  Imre, Gergely ^a   Larisch, Sarit ^b   Rajalingam, Krishnaraj ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF HAIFA   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL DEATH; HUMAN; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION;

CELL DEATH; HUMANS; NEOPLASMS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 83455245162     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjr034     Document Type: Article

References (13)

1. Bader, M., and Steller, H. (2009). Regulation of cell death by the ubiquitin-proteasome system. Curr. Opin. Cell Biol. 21, 878-884.
2. Edison, N., Zuri, D., Maniv, I., et al. (2011). The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo. Cell Death Differ. doi: 10.1038/cdd.2011.112.
3. Feoktistova, M., Geserick, P., Kellert, B., et al. (2011). cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-463.
4. Galluzzi, L., Kepp, O., and Kroemer, G. (2009). RIP kinases initiate programmed necrosis. J. Mol. Cell Biol. 1, 8-10.
5. Rajalingam, K., Sharma, M., Paland, N., et al. (2006). IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2, e114.
6. Scaffidi, P., Misteli, T., and Bianchi, M.E. (2002). Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195.
7. Srinivasula, S.M., and Ashwell, J.D. (2008). IAPs: What's in a name? Mol. Cell 30, 123-135.
8. Tenev, T., Bianchi, K., Darding, M., et al. (2011). The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 43, 432-448.
9. Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., et al. (2010). Molecular mechanisms of necroptosis: An ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700-714.
10. Varfolomeev, E.E., Schuchmann, M., Luria, V., et al. (1998). Targeted disruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9, 267-276.
11. Varfolomeev, E., Blankenship, J.W., Wayson, S.M., et al. (2007). IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131, 669-681.
12. Vaux, D.L., and Silke, J. (2003). Mammalian mitochondrial IAP binding proteins. Biochem. Biophys. Res. Commun. 304, 499-504.
13. Vucic, D., Dixit, V.M., and Wertz, I.E. (2011). Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 12, 439-452.