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Volumn 99, Issue 3, 2013, Pages 555-565

Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains

Author keywords

Apolipoprotein E; Atherosclerosis; Caveolin 1; Leptin; Neointima; Reactive oxygen species; Smooth muscle cells

Indexed keywords

APOLIPOPROTEIN E; CAVEOLIN; CAVEOLIN 1; LEPTIN; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; LOW DENSITY LIPOPROTEIN RECEPTOR; SMALL INTERFERING RNA;

EID: 84886391654     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt126     Document Type: Article
Times cited : (41)

References (45)
  • 2
    • 33847625379 scopus 로고    scopus 로고
    • Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance
    • Bodary PF, Shen Y, Ohman M, Bahrou KL, Vargas FB, Cudney SS et al. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 2007;27:70-76.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 70-76
    • Bodary, P.F.1    Shen, Y.2    Ohman, M.3    Bahrou, K.L.4    Vargas, F.B.5    Cudney, S.S.6
  • 6
    • 22544470917 scopus 로고    scopus 로고
    • Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor
    • WuKK, WuTJ, Chin J, Mitnaul LJ, Hernandez M, CaiTQet al. Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor. Atherosclerosis 2005;181:251-259.
    • (2005) Atherosclerosis , vol.181 , pp. 251-259
    • Wu, K.K.1    Wu, T.J.2    Chin, J.3    Mitnaul, L.J.4    Hernandez, M.5    Cai, T.Q.6
  • 7
    • 38049035408 scopus 로고    scopus 로고
    • Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice
    • Chiba T, Shinozaki S, Nakazawa T, Kawakami A, Ai M, Kaneko E et al. Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice. Atherosclerosis 2008; 196:68-75.
    • (2008) Atherosclerosis , vol.196 , pp. 68-75
    • Chiba, T.1    Shinozaki, S.2    Nakazawa, T.3    Kawakami, A.4    Ai, M.5    Kaneko, E.6
  • 8
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setala, K.4    Walsh, A.5    Verstuyft, J.G.6
  • 9
    • 0023759190 scopus 로고
    • Expression of apolipoprotein e by cultured vascular smooth muscle cells is controlled by growth state
    • Majack RA, Castle CK, Goodman LV, Weisgraber KH, MahleyRW, Shooter EM et al. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. J Cell Biol 1988;107:1207-1213.
    • (1988) J Cell Biol , vol.107 , pp. 1207-1213
    • Majack, R.A.1    Castle, C.K.2    Goodman, L.V.3    Weisgraber, K.H.4    Mahley, R.W.5    Shooter, E.M.6
  • 10
    • 2442706719 scopus 로고    scopus 로고
    • Vascular apolipoprotein e expression and recruitment from circulation to modulate smooth muscle cell response to endothelial denudation
    • MooreZW, ZhuB, KuhelDG, HuiDY. Vascular apolipoprotein e expression and recruitment from circulation to modulate smooth muscle cell response to endothelial denudation. Am J Pathol 2004;164:2109-2116.
    • (2004) Am J Pathol , vol.164 , pp. 2109-2116
    • Moore, Z.W.1    Zhu, B.2    Kuhel, D.G.3    Hui, D.Y.4
  • 11
    • 0032493648 scopus 로고    scopus 로고
    • Apolipoprotein e inhibits plateletderived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase
    • Ishigami M, Swertfeger DK, Granholm NA, Hui DY. Apolipoprotein E inhibits plateletderived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J Biol Chem 1998;273:20156-20161.
    • (1998) J Biol Chem , vol.273 , pp. 20156-20161
    • Ishigami, M.1    Swertfeger, D.K.2    Granholm, N.A.3    Hui, D.Y.4
  • 12
    • 0033635187 scopus 로고    scopus 로고
    • Apolipoprotein e inhibits neointimal hyperplasia after arterial injury in mice
    • Zhu B, Kuhel DG, Witte DP, Hui DY. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. Am J Pathol 2000;157:1839-1848.
    • (2000) Am J Pathol , vol.157 , pp. 1839-1848
    • Zhu, B.1    Kuhel, D.G.2    Witte, D.P.3    Hui, D.Y.4
  • 14
    • 50949121487 scopus 로고    scopus 로고
    • Brain apolipoprotein E: An important regulator of food intake in rats
    • Shen L, Tso P, Woods SC, Clegg DJ, Barber KL, Carey K et al. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes 2008;57:2092-2098.
    • (2008) Diabetes , vol.57 , pp. 2092-2098
    • Shen, L.1    Tso, P.2    Woods, S.C.3    Clegg, D.J.4    Barber, K.L.5    Carey, K.6
  • 15
    • 67649505383 scopus 로고    scopus 로고
    • Up-regulation of apolipoprotein e by leptin in the hypothalamus of mice and rats
    • Shen L, Tso P, Wang DQ, Woods SC, Davidson WS, Sakai R et al. Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiol Behav 2009;98: 223-228.
    • (2009) Physiol Behav , vol.98 , pp. 223-228
    • Shen, L.1    Tso, P.2    Wang, D.Q.3    Woods, S.C.4    Davidson, W.S.5    Sakai, R.6
  • 16
    • 0033886373 scopus 로고    scopus 로고
    • Oxidant signaling in vascular cell growth, death, and survival : A reviewof the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
    • Irani K. Oxidant signaling in vascular cell growth, death, and survival : a reviewof the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res 2000;87:179-183.
    • (2000) Circ Res , vol.87 , pp. 179-183
    • Irani, K.1
  • 17
    • 38149026339 scopus 로고    scopus 로고
    • Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases
    • Brandes RP, Schroder K. Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases. Trends Cardiovasc Med 2008;18:15-19.
    • (2008) Trends Cardiovasc Med , vol.18 , pp. 15-19
    • Brandes, R.P.1    Schroder, K.2
  • 18
    • 0032887708 scopus 로고    scopus 로고
    • Codistribution ofNOSand caveolin throughout peripheral vasculature and skeletal muscle of hamsters
    • Segal SS, Brett SE, SessaWC.Codistribution ofNOSand caveolin throughout peripheral vasculature and skeletal muscle of hamsters. Am J Physiol 1999;277:H1167-H1177.
    • (1999) Am J Physiol , vol.277 , pp. H1167-H1177
    • Segal, S.S.1    Brett, S.E.2    Sessa, W.C.3
  • 19
    • 0017737576 scopus 로고
    • Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice
    • Yen TT, Allan JA, Pearson DV, Schinitsky MR. Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice. Experientia 1977;33:995-996.
    • (1977) Experientia , vol.33 , pp. 995-996
    • Yen, T.T.1    Allan, J.A.2    Pearson, D.V.3    Schinitsky, M.R.4
  • 20
    • 38949207552 scopus 로고    scopus 로고
    • Macrophage-derived apolipoprotein e ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice
    • Atkinson RD, Coenen KR, Plummer MR, Gruen ML, Hasty AH. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 2008;294:E284-E290.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E284-E290
    • Atkinson, R.D.1    Coenen, K.R.2    Plummer, M.R.3    Gruen, M.L.4    Hasty, A.H.5
  • 21
    • 84869505095 scopus 로고    scopus 로고
    • Leptin treatment inhibits the progression of atherosclerosis by attenuating hypercholesterolemia in type 1 diabetic Ins2+/Akita:apoE-/-mice
    • Jun JY, Zhexi M, Pyla R, Segar L. Leptin treatment inhibits the progression of atherosclerosis by attenuating hypercholesterolemia in type 1 diabetic Ins2+/Akita:apoE-/-mice. Atherosclerosis 2012;225:341-347.
    • (2012) Atherosclerosis , vol.225 , pp. 341-347
    • Jun, J.Y.1    Zhexi, M.2    Pyla, R.3    Segar, L.4
  • 22
    • 0035206659 scopus 로고    scopus 로고
    • Leptin stimulates rat aortic smooth muscle cell proliferation and migration
    • Oda A, Taniguchi T, Yokoyama M. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 2001;47:141-150.
    • (2001) Kobe J Med Sci , vol.47 , pp. 141-150
    • Oda, A.1    Taniguchi, T.2    Yokoyama, M.3
  • 24
    • 56649086772 scopus 로고    scopus 로고
    • Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity
    • Chen JX, Stinnett A. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Lab Invest 2008;88:1316-1328.
    • (2008) Lab Invest , vol.88 , pp. 1316-1328
    • Chen, J.X.1    Stinnett, A.2
  • 25
    • 0037783377 scopus 로고    scopus 로고
    • C-Src induces phosphorylation and translocation of p47phox: Role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    • Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003;23:981-987.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 981-987
    • Touyz, R.M.1    Yao, G.2    Schiffrin, E.L.3
  • 27
    • 33745843632 scopus 로고    scopus 로고
    • A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites
    • Dang PM, Stensballe A, Boussetta T, Raad H, Dewas C, Kroviarski Y et al. A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J Clin Invest 2006;116:2033-2043.
    • (2006) J Clin Invest , vol.116 , pp. 2033-2043
    • Dang, P.M.1    Stensballe, A.2    Boussetta, T.3    Raad, H.4    Dewas, C.5    Kroviarski, Y.6
  • 28
    • 73849114173 scopus 로고    scopus 로고
    • Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells
    • Manea A, Tanase LI, Raicu M, Simionescu M. Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol 2010;30:105-112.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 105-112
    • Manea, A.1    Tanase, L.I.2    Raicu, M.3    Simionescu, M.4
  • 29
    • 0029091281 scopus 로고
    • Apolipoprotein e deficiency in mice: Gene replacement and prevention of atherosclerosis using adenovirus vectors
    • Kashyap VS, Santamarina-Fojo S, Brown DR, Parrott CL, Applebaum-Bowden D, Meyn S et al. Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors. J Clin Invest 1995;96:1612-1620.
    • (1995) J Clin Invest , vol.96 , pp. 1612-1620
    • Kashyap, V.S.1    Santamarina-Fojo, S.2    Brown, D.R.3    Parrott, C.L.4    Applebaum-Bowden, D.5    Meyn, S.6
  • 30
    • 0033580593 scopus 로고    scopus 로고
    • Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation
    • Hasty AH, Linton MF, Brandt SJ, Babaev VR, Gleaves LA, Fazio S. Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation. Circulation 1999;99:2571-2576.
    • (1999) Circulation , vol.99 , pp. 2571-2576
    • Hasty, A.H.1    Linton, M.F.2    Brandt, S.J.3    Babaev, V.R.4    Gleaves, L.A.5    Fazio, S.6
  • 31
    • 0035900765 scopus 로고    scopus 로고
    • Apolipoprotein e inhibits serumstimulated cell proliferation and enhances serum-independent cell proliferation
    • Ho YY, Deckelbaum RJ, Chen Y, Vogel T, Talmage DA. Apolipoprotein E inhibits serumstimulated cell proliferation and enhances serum-independent cell proliferation. J Biol Chem 2001;276:43455-43462.
    • (2001) J Biol Chem , vol.276 , pp. 43455-43462
    • Ho, Y.Y.1    Deckelbaum, R.J.2    Chen, Y.3    Vogel, T.4    Talmage, D.A.5
  • 32
    • 0035816643 scopus 로고    scopus 로고
    • Apolipoprotein e receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation
    • Swertfeger DK, Hui DY. Apolipoprotein E receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation. J Biol Chem 2001;276:25043-25048.
    • (2001) J Biol Chem , vol.276 , pp. 25043-25048
    • Swertfeger, D.K.1    Hui, D.Y.2
  • 33
    • 77951668726 scopus 로고    scopus 로고
    • Caveolae, caveolins, and cavins: Complex control of cellular signalling and inflammation
    • Chidlow JH Jr, Sessa WC. Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res 2010;86:219-225.
    • (2010) Cardiovasc Res , vol.86 , pp. 219-225
    • Chidlow, J.H.1    Sessa, W.C.2
  • 34
    • 10744223342 scopus 로고    scopus 로고
    • Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway
    • Peterson TE, Guicciardi ME, Gulati R, Kleppe LS, Mueske CS, Mookadam M et al. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol 2003;23:1521-1527.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1521-1527
    • Peterson, T.E.1    Guicciardi, M.E.2    Gulati, R.3    Kleppe, L.S.4    Mueske, C.S.5    Mookadam, M.6
  • 35
    • 0043030323 scopus 로고    scopus 로고
    • Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: Role of endothelin-1
    • Zeidan A, Broman J, Hellstrand P, Sward K. Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1. Arterioscler Thromb Vasc Biol 2003;23:1528-1534.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1528-1534
    • Zeidan, A.1    Broman, J.2    Hellstrand, P.3    Sward, K.4
  • 37
    • 70450228396 scopus 로고    scopus 로고
    • Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: Role in endocytic and lipase-mediated metabolic pathways
    • Huang ZH, Minshall RD, Mazzone T. Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways. J Biol Chem 2009;284:31512-31522.
    • (2009) J Biol Chem , vol.284 , pp. 31512-31522
    • Huang, Z.H.1    Minshall, R.D.2    Mazzone, T.3
  • 38
    • 0030067984 scopus 로고    scopus 로고
    • Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo
    • Li S, Seitz R, Lisanti MP. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo. J Biol Chem 1996;271:3863-3868.
    • (1996) J Biol Chem , vol.271 , pp. 3863-3868
    • Li, S.1    Seitz, R.2    Lisanti, M.P.3
  • 39
    • 24144471786 scopus 로고    scopus 로고
    • Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: Role in redox signaling and vascular hypertrophy
    • Zuo L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, AlexanderRW. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy. Arterioscler Thromb Vasc Biol 2005;25:1824-1830.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1824-1830
    • Zuo, L.1    Ushio-Fukai, M.2    Ikeda, S.3    Hilenski, L.4    Patrushev, N.5    Alexander, R.W.6
  • 40
    • 84862773017 scopus 로고    scopus 로고
    • Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1
    • Echarri A, Muriel O, PavónDM, Azegrouz H, Escolar F, TerrónMCet al. Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1. J Cell Sci 2012;125: 3097-3113.
    • (2012) J Cell Sci , vol.125 , pp. 3097-3113
    • Echarri, A.1    Muriel, O.2    Pavón, D.M.3    Azegrouz, H.4    Escolar, F.5    Terrón, M.C.6
  • 41
    • 34548091302 scopus 로고    scopus 로고
    • Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK-and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways
    • Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S et al. Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK-and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways. J Pharmacol Exp Ther 2007;322:1110-1116.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1110-1116
    • Zeidan, A.1    Paylor, B.2    Steinhoff, K.J.3    Javadov, S.4    Rajapurohitam, V.5    Chakrabarti, S.6
  • 42
    • 79955459948 scopus 로고    scopus 로고
    • Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeleton reorganization and leads to enhanced migration
    • Schram K, Ganguly R, No EK, Fang X, Thong FSL, Sweeney G. Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeleton reorganization and leads to enhanced migration. Endocrinolgoy 2011;152: 2037-2047.
    • (2011) Endocrinolgoy , vol.152 , pp. 2037-2047
    • Schram, K.1    Ganguly, R.2    No, E.K.3    Fang, X.4    Thong, F.S.L.5    Sweeney, G.6
  • 44
    • 67649452503 scopus 로고    scopus 로고
    • Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    • Fernandez-Hernando C, Yu J, Suarez Y, Rahner C, Davalos A, Lasuncion MA et al. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab 2009;10:48-54.
    • (2009) Cell Metab , vol.10 , pp. 48-54
    • Fernandez-Hernando, C.1    Yu, J.2    Suarez, Y.3    Rahner, C.4    Davalos, A.5    Lasuncion, M.A.6
  • 45
    • 33846191009 scopus 로고    scopus 로고
    • Excessive nitric oxide attenuates leptinmediated signal transducer and activator of transcription 3 activation
    • Jang EH, Park CS, Lee SK, Pie JE, Kang JH. Excessive nitric oxide attenuates leptinmediated signal transducer and activator of transcription 3 activation. Life Sci 2007;80: 609-617.
    • (2007) Life Sci , vol.80 , pp. 609-617
    • Jang, E.H.1    Park, C.S.2    Lee, S.K.3    Pie, J.E.4    Kang, J.H.5


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