Genetic Evidence Supporting a Critical Role of Endothelial Caveolin-1 during the Progression of Atherosclerosis

Cell Metabolism

Volumn 10, Issue 1, 2009, Pages 48-54

  Fernández Hernando, Carlos ^a   Yu, Jun ^a   Suárez, Yajaira ^a   Rahner, Christoph ^a   Dávalos, Alberto ^a   Lasunción, Miguel A ^b,c,d   Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

HUMDISEASE

Indexed keywords

APOLIPOPROTEIN E; CAVEOLIN 1; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; KNOCKOUT MOUSE; LIPID TRANSPORT; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CAVEOLIN 1; CHOLESTEROL, LDL; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NITRIC OXIDE;

MUS; MUS MUSCULUS;

EID: 67649452503     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.06.003     Document Type: Article

References (34)

1. Busse R., and Fleming I. Endothelial dysfunction in atherosclerosis. J. Vasc. Res. 33 (1996) 181-194
2. Cogger V.C., Arias I.M., Warren A., McMahon A.C., Kiss D.L., Avery V.M., and Le Couteur D.G. The response of fenestrations, actin, and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (2008) G137-G145
3. Cohen A.W., Razani B., Wang X.B., Combs T.P., Williams T.M., Scherer P.E., and Lisanti M.P. Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am. J. Physiol. Cell Physiol. 285 (2003) C222-C235
4. Drab M., Verkade P., Elger M., Kasper M., Lohn M., Lauterbach B., Menne J., Lindschau C., Mende F., Luft F.C., et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293 (2001) 2449-2452
5. Frank P.G., and Lisanti M.P. Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia. Curr. Opin. Lipidol. 15 (2004) 523-529
6. Frank P.G., Lee H., Park D.S., Tandon N.N., Scherer P.E., and Lisanti M.P. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 98-105
7. Frank P.G., Cheung M.W., Pavlides S., Llaverias G., Park D.S., and Lisanti M.P. Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H677-H686
8. Frank P.G., Pavlides S., Cheung M.W., Daumer K., and Lisanti M.P. Role of caveolin-1 in the regulation of lipoprotein metabolism. Am. J. Physiol. Cell Physiol. 295 (2008) C242-C248
9. Fraser R., Dobbs B.R., and Rogers G.W. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology 21 (1995) 863-874
10. Galbiati F., Engelman J.A., Volonte D., Zhang X.L., Minetti C., Li M., Hou Jr. H., Kneitz B., Edelmann W., and Lisanti M.P. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J. Biol. Chem. 276 (2001) 21425-21433
11. Galkina E., and Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2292-2301
12. García-Cardeña G., Fan R., Stern D.F., Liu J., and Sessa W.C. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J. Biol. Chem. 271 (1996) 27237-27240
13. Glass C.K., and Witztum J.L. Atherosclerosis. the road ahead. Cell 104 (2001) 503-516
14. Hassan G.S., Jasmin J.F., Schubert W., Frank P.G., and Lisanti M.P. Caveolin-1 deficiency stimulates neointima formation during vascular injury. Biochemistry 43 (2004) 8312-8321
15. Hassan G.S., Williams T.M., Frank P.G., and Lisanti M.P. Caveolin-1 deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H2393-H2401
16. Hilmer S.N., Cogger V.C., Fraser R., McLean A.J., Sullivan D., and Le Couteur D.G. Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology 42 (2005) 1349-1354
17. Jamieson H.A., Cogger V.C., Twigg S.M., McLennan S.V., Warren A., Cheluvappa R., Hilmer S.N., Fraser R., de Cabo R., and Le Couteur D.G. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia 50 (2007) 1969-1976
18. Kuhlencordt P.J., Gyurko R., Han F., Scherrer-Crosbie M., Aretz T.H., Hajjar R., Picard M.H., and Huang P.L. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104 (2001) 448-454
19. Le Couteur D.G., Cogger V.C., McCuskey R.S., De Cabo R., Smedsrød B., Sorensen K.K., Warren A., and Fraser R. Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Ann. N Y Acad. Sci. 1114 (2007) 79-87
20. Li J., Scherl A., Medina F., Frank P.G., Kitsis R.N., Tanowitz H.B., Sotgia F., and Lisanti M.P. Impaired phagocytosis in caveolin-1 deficient macrophages. Cell Cycle 4 (2005) 1599-1607
21. Liu P., Rudick M., and Anderson R.G. Multiple functions of caveolin-1. J. Biol. Chem. 277 (2002) 41295-41298
22. Ogi M., Yokomori H., Oda M., Yoshimura K., Nomura M., Ohshima S., Akita M., Toda K., and Ishii H. Distribution and localization of caveolin-1 in sinusoidal cells in rat liver. Med. Electron Microsc. 36 (2003) 33-40
23. Otway S., and Robinson D.S. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J. Physiol. 190 (1967) 321-332
24. Parolini I., Sargiacomo M., Galbiati F., Rizzo G., Grignani F., Engelman J.A., Okamoto T., Ikezu T., Scherer P.E., Mora R., et al. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J. Biol. Chem. 274 (1999) 25718-25725
25. Peterson T.E., Guicciardi M.E., Gulati R., Kleppe L.S., Mueske C.S., Mookadam M., Sowa G., Gores G.J., Sessa W.C., and Simari R.D. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signalling from a proliferative to an apoptotic pathway. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1521-1527
26. Razani B., Engelman J.A., Wang X.B., Schubert W., Zhang X.L., Marks C.B., Macaluso F., Russell R.G., Li M., Pestell R.G., et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276 (2001) 38121-38138
27. Razani B., Combs T.P., Wang X.B., Frank P.G., Park D.S., Russell R.G., Li M., Tang B., Jelicks L.A., Scherer P.E., and Lisanti M.P. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277 (2002) 8635-8647
28. Rodriguez-Feo J.A., Hellings W.E., Moll F.L., De Vries J.P., van Middelaar B.J., Algra A., Sluijter J., Velema E., van der Broek T., Sessa W.C., et al. Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease. PLoS ONE 3 (2008) e2612
29. Schubert W., Frank P.G., Woodman S.E., Hyogo H., Cohen D.E., Chow C.W., and Lisanti M.P. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J. Biol. Chem. 277 (2002) 40091-40098
30. Schwencke C., Schmeisser A., Walter C., Wachter R., Pennach S., Weck B., Braun-Dullaeus R.C., Kasper M., and Strasser R.H. Decreased caveolin-1 in atheroma: loss of antiproliferative control of vascular smooth muscle cells in atherosclerosis. Cardiovasc. Res. 68 (2005) 128-135
31. Sessa W.C. eNOS at a glance. J. Cell Sci. 117 (2004) 2427-2429
32. Simionescu M., and Simionescu N. Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology. Cell Biol. Rev. 25 (1991) 1-78
33. Vasile E., Simionescu M., and Simionescu N. Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ. J. Cell Biol. 96 (1983) 1677-1689
34. Yu J., Bergaya S., Murata T., Alp I.F., Bauer M.P., Lin M.I., Drab M., Kurzchalia T.V., Stan R.V., and Sessa W.C. Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J. Clin. Invest. 116 (2006) 1284-1291