Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats

Physiology and Behavior

Volumn 98, Issue 1-2, 2009, Pages 223-228

  Shen, Ling ^a,b   Tso, Patrick ^a,b   Wang, David Q H ^d   Woods, Stephen C ^a,c   Davidson, W Sean ^a,b   Sakai, Randall ^a,c   Liu, Min ^a,b  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b Laboratory Medicine   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apolipoprotein; Food intake; Obesity

Indexed keywords

APOLIPOPROTEIN E; LEPTIN RECEPTOR; MESSENGER RNA; RECOMBINANT LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DRUG MECHANISM; FOOD INTAKE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; WEIGHT REDUCTION;

ANIMALS; APOLIPOPROTEINS E; ASTROCYTES; BODY WEIGHT; EATING; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; RATS; RATS, LONG-EVANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 67649505383     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2009.05.013     Document Type: Article

References (36)

1. Seeley R.J., and Woods S.C. Monitoring of stored and available fuel by the CNS: implications for obesity. Nat Rev Neurosci 4 (2003) 901-909
2. Konturek S.J., Konturek J.W., Pawlik T., and Brzozowski T. Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol 55 (2004) 137-154
3. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240 (1988) 622-630
4. Boyles J.K., Pitas R.E., Wilson E., Mahley R.W., and Taylor J.M. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76 (1985) 1501-1513
5. Lee Y., Aono M., Laskowitz D., Warner D.S., and Pearlstein R.D. Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. Neurochem Int 44 (2004) 107-118
6. Gutman C.R., Strittmatter W.J., Weisgraber K.H., and Matthew W.D. Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. J Neurosci 17 (1997) 6114-6121
7. Cedazo-Minguez A., and Cowburn R.F. Apolipoprotein E: a major piece in the Alzheimer's disease puzzle. J Cell Mol Med 5 (2001) 254-266
8. Shen L., Tso P., Woods S.C., Clegg D.J., Barber K.L., Carey K., et al. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes 57 (2008) 2092-2098
9. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
10. Schreyer S.A., Vick C., Lystig T.C., Mystkowski P., and LeBoeuf R.C. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metabol 282 (2002) E207-E214
11. Sadowski M.J., Pankiewicz J., Scholtzova H., Mehta P.D., Prelli F., Quartermain D., et al. Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Proc Natl Acad Sci U S A 103 (2006) 18787-18792
12. Moore Z.W., and Hui D.Y. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46 (2005) 2083-2090
13. Liu M., Maiorano N., Shen L., Pearson K., Tajima D., Zhang D.M., et al. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiol Behav 78 (2003) 149-155
14. Chavez M., Seeley R.J., and Woods S.C. A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents. Behav Neurosci 109 (1995) 547-550
15. Shen L., Pearson K.J., Xiong Y., Lo C.M., Tso P., Woods S.C., et al. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiol Behav 95 (2008) 161-167
16. Liu M., Shen L., Liu Y., Tajima D., Sakai R., Woods S.C., et al. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Endocrinology 145 (2004) 3232-3238
17. Kimelberg H.K., and Norenberg M.D. Astrocytes. Sci Am 260 (1989) 66-72 74, 76
18. Ransom C.B., and Sontheimer H. Biophysical and pharmacological characterization of inwardly rectifying K+ currents in rat spinal cord astrocytes. J Neurophysiol 73 (1995) 333-346
19. van den Pol A.N., Finkbeiner S.M., and Cornell-Bell A.H. Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro. J Neurosci 12 (1992) 2648-2664
20. Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200 (2002) 629-638
21. Brown A.M., and Ransom B.R. Astrocyte glycogen and brain energy metabolism. Glia 55 (2007) 1263-1271
22. Teige I., Liu Y., and Issazadeh-Navikas S. IFN-beta inhibits T cell activation capacity of central nervous system APCs. J Immunol 177 (2006) 3542-3553
23. Laskowitz D.T., Goel S., Bennett E.R., and Matthew W.D. Apolipoprotein E suppresses glial cell secretion of TNF alpha. J Neuroimmunol 76 (1997) 70-74
24. Lynch J.R., Morgan D., Mance J., Matthew W.D., and Laskowitz D.T. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 114 (2001) 107-113
25. Woods S.C. Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol 286 (2004) G7-13
26. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
27. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (1996) 632-635
28. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 (1996) 491-495
29. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., and Saper C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395 (1998) 535-547
30. Huang Z.H., Luque R.M., Kineman R.D., and Mazzone T. Nutritional regulation of adipose tissue apolipoprotein E expression. Am J Physiol Endocrinol Metabol 293 (2007) E203-E209
31. Shen L., Carey K., Wang D.Q., Woods S.C., and Liu M. Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats. Brain Res (2009)
32. Hayek T., Oiknine J., Brook J.G., and Aviram M. Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice. Biochem Biophys Res Commun 201 (1994) 1567-1574
33. Raber J., Akana S.F., Bhatnagar S., Dallman M.F., Wong D., and Mucke L. Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. J Neurosci 20 (2000) 2064-2071
34. Hoe H.S., Harris D.C., and Rebeck G.W. Multiple pathways of apolipoprotein E signaling in primary neurons. J Neurochem 93 (2005) 145-155
35. Cheunsuang O., and Morris R. Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52 (2005) 228-233
36. Beffert U., Stolt P.C., and Herz J. Functions of lipoprotein receptors in neurons. J Lipid Res 45 (2004) 403-409