Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 3, 2007, Pages 1110-1116

  Zeidan, Asad ^a   Paylor, Ben ^a   Steinhoff, Karly J ^a   Javadov, Sabzali ^a   Rajapurohitam, Venkatesh ^a   Chakrabarti, Subrata ^a   Karmazyn, Morris ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; COFILIN 2; F ACTIN; G ACTIN; LEPTIN; LEPTIN RECEPTOR; LIM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERUM RESPONSE FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DATA ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; MALE; MUSCLE HYPERTROPHY; NONHUMAN; OBESITY; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; PROTEIN SYNTHESIS; RAT; STATISTICAL SIGNIFICANCE; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; CYTOSKELETON; HYPERTROPHY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MUSCLE, SMOOTH, VASCULAR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 34548091302     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.122440     Document Type: Article

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