-
1
-
-
0033012398
-
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
-
Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 1999; 17: 657-700.
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 657-700
-
-
Berger, E.A.1
Murphy, P.M.2
Farber, J.M.3
-
2
-
-
27644510382
-
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
-
Dorr P,Westby M, Dobbs S et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005; 49: 4721-32.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
-
3
-
-
30744447460
-
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
-
Fatkenheuer G, Pozniak AL, Johnson MA et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med 2005; 11: 1170-2.
-
(2005)
Nat Med
, vol.11
, pp. 1170-1172
-
-
Fatkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
-
4
-
-
54849146700
-
Maraviroc for previously treated patients with R5 HIV-1 infection
-
Gulick RM, Lalezari J, Goodrich J et al. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med 2008; 359: 1429-41.
-
(2008)
N Engl J Med
, vol.359
, pp. 1429-1441
-
-
Gulick, R.M.1
Lalezari, J.2
Goodrich, J.3
-
5
-
-
0037404511
-
Analysis of the mechanism by which the small-molecule CCR5antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry
-
Tsamis F, Gavrilov S, Kajumo F et al. Analysis of the mechanism by which the small-molecule CCR5antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol 2003; 77: 5201-8.
-
(2003)
J Virol
, vol.77
, pp. 5201-5208
-
-
Tsamis, F.1
Gavrilov, S.2
Kajumo, F.3
-
6
-
-
0034625144
-
A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
-
Dragic T, Trkola A, Thompson DA et al. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci USA 2000; 97: 5639-44.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5639-5644
-
-
Dragic, T.1
Trkola, A.2
Thompson, D.A.3
-
7
-
-
54849145400
-
Subgroupanalyses ofmaraviroc in previously treated R5 HIV-1 infection
-
Fatkenheuer G, Nelson M, Lazzarin A et al. Subgroupanalyses ofmaraviroc in previously treated R5 HIV-1 infection. N Engl J Med 2008; 359: 1442-55.
-
(2008)
N Engl J Med
, vol.359
, pp. 1442-1455
-
-
Fatkenheuer, G.1
Nelson, M.2
Lazzarin, A.3
-
8
-
-
33646443202
-
Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is fromapretreatmentCXCR4-usingvirus reservoir
-
Westby M, Lewis M, Whitcomb J et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is fromapretreatmentCXCR4-usingvirus reservoir.JVirol2006;80:4909-20.
-
(2006)
JVirol
, vol.80
, pp. 4909-4920
-
-
Westby, M.1
Lewis, M.2
Whitcomb, J.3
-
9
-
-
56549123524
-
Virological correlates associated with treatment failure at week 48 in the Phase 3 study of maraviroc in treatment-naive patients
-
Boston, MA Abstract 40LB. CROI, LLC, Alexandria, VA, USA
-
Heera J, Saag M, Ive P et al. Virological correlates associated with treatment failure at week 48 in the Phase 3 study of maraviroc in treatment-naive patients. In: Abstracts of the Fifteenth Conference on Retroviruses and Opportunistic Infections, Boston, MA, 2008. Abstract 40LB. CROI, LLC, Alexandria, VA, USA.
-
(2008)
Abstracts of the Fifteenth Conference on Retroviruses and Opportunistic Infections
-
-
Heera, J.1
Saag, M.2
Ive, P.3
-
10
-
-
67651055421
-
Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing
-
Archer J, Braverman MS, Taillon BE et al. Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing. AIDS 2009; 23: 1209-18.
-
(2009)
AIDS
, vol.23
, pp. 1209-1218
-
-
Archer, J.1
Braverman, M.S.2
Taillon, B.E.3
-
11
-
-
33847237614
-
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
-
Westby M, Smith-Burchnell C, Mori J et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J Virol 2007; 81: 2359-71.
-
(2007)
J Virol
, vol.81
, pp. 2359-2371
-
-
Westby, M.1
Smith-Burchnell, C.2
Mori, J.3
-
12
-
-
34047271098
-
HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
-
Pugach P, Marozsan AJ, Ketas TJ et al. HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology 2007; 361: 212-28.
-
(2007)
Virology
, vol.361
, pp. 212-228
-
-
Pugach, P.1
Marozsan, A.J.2
Ketas, T.J.3
-
13
-
-
49149118151
-
In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject
-
Tsibris AM, Sagar M, Gulick RM et al. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol 2008; 82: 8210-4.
-
(2008)
J Virol
, vol.82
, pp. 8210-8214
-
-
Tsibris, A.M.1
Sagar, M.2
Gulick, R.M.3
-
14
-
-
70049098271
-
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry
-
Berro R, Sanders RW, Lu M et al. Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry. PLoS Pathog 2009; 5: e1000548.
-
(2009)
PLoS Pathog
, vol.5
-
-
Berro, R.1
Sanders, R.W.2
Lu, M.3
-
15
-
-
64049109934
-
Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor
-
Nolan KM, Del Prete GQ, Jordan AP et al. Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor. J Virol 2009; 83: 3798-809.
-
(2009)
J Virol
, vol.83
, pp. 3798-3809
-
-
Nolan, K.M.1
Del Prete, G.Q.2
Jordan, A.P.3
-
16
-
-
12144289333
-
Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor
-
Kuhmann SE, Pugach P, Kunstman KJ et al. Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. J Virol 2004; 78: 2790-807.
-
(2004)
J Virol
, vol.78
, pp. 2790-2807
-
-
Kuhmann, S.E.1
Pugach, P.2
Kunstman, K.J.3
-
17
-
-
40849085150
-
Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120
-
Ogert RA,Wojcik L, Buontempo C et al. Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120. Virology 2008; 373: 387-99.
-
(2008)
Virology
, vol.373
, pp. 387-399
-
-
Ogert, R.A.1
Wojcik, L.2
Buontempo, C.3
-
18
-
-
70450170953
-
Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc
-
Ogert RA, Ba L, Hou Y et al. Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc. J Virol 2009; 83: 12151-63.
-
(2009)
J Virol
, vol.83
, pp. 12151-12163
-
-
Ogert, R.A.1
Ba, L.2
Hou, Y.3
-
19
-
-
33846574670
-
Isolationandcharacterization ofhuman immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652
-
BabaM, MiyakeH, Wang X et al. Isolationandcharacterization ofhuman immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652. Antimicrob Agents Chemother 2007; 51: 707-15.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 707-715
-
-
Baba, M.1
Miyake, H.2
Wang, X.3
-
20
-
-
55249099476
-
Changes in V3 loop sequence associated with failure of maraviroc treatment in patients enrolled in the MOTIVATE 1 and 2 trials
-
Boston, MA Abstract 871. CROI, LLC, Alexandria, VA, USA
-
Lewis M, Simpson P, Whitcomb J et al. Changes in V3 loop sequence associated with failure of maraviroc treatment in patients enrolled in the MOTIVATE 1 and 2 trials. In: Abstracts of the Fifteenth Conference on Retroviruses and Opportunistic Infections, Boston, MA, 2008. Abstract 871. CROI, LLC, Alexandria, VA, USA.
-
(2008)
Abstracts of the Fifteenth Conference on Retroviruses and Opportunistic Infections
-
-
Lewis, M.1
Simpson, P.2
Whitcomb, J.3
-
21
-
-
84886269577
-
-
San Francisco, CA Abstract 539. CROI, LLC, Alexandria, VA, USA
-
Lewis M, Simpson P, Delogne C et al. Genotypic analysis of the HIV-1 gp120 V3 loop for treatment-experienced patients enrolled into the MOTIVATE studies and who received maraviroc+ optimized background therapy. In: Abstracts of the Seventeenth Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, 2010. Abstract 539. CROI, LLC, Alexandria, VA, USA.
-
(2010)
Abstracts of the Seventeenth Conference on Retroviruses and Opportunistic Infections
-
-
Lewis, M.1
Simpson, P.2
Delogne, C.3
-
22
-
-
84863393752
-
V3 determinants of HIV-1 escape fromtheCCR5inhibitorsmaravirocandvicriviroc
-
Berro R, Klasse PJ, Jakobsen MR et al. V3 determinants of HIV-1 escape fromtheCCR5inhibitorsmaravirocandvicriviroc. Virology2012;427:158-65.
-
(2012)
Virology
, vol.427
, pp. 158-165
-
-
Berro, R.1
Klasse, P.J.2
Jakobsen, M.R.3
-
23
-
-
79953086675
-
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41
-
Anastassopoulou CG, Ketas TJ, Depetris RS et al. Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41. Virology 2011; 413: 47-59.
-
(2011)
Virology
, vol.413
, pp. 47-59
-
-
Anastassopoulou, C.G.1
Ketas, T.J.2
Depetris, R.S.3
-
24
-
-
65249151382
-
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
-
Anastassopoulou CG, Ketas TJ, Klasse PJ et al. Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41. Proc Natl Acad Sci USA 2009; 106: 5318-23.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5318-5323
-
-
Anastassopoulou, C.G.1
Ketas, T.J.2
Klasse, P.J.3
-
25
-
-
84871974796
-
HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120
-
Ratcliff AN, Shi W, Arts EJ. HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120. J Virol 2013; 87: 923-34.
-
(2013)
J Virol
, vol.87
, pp. 923-934
-
-
Ratcliff, A.N.1
Shi, W.2
Arts, E.J.3
-
26
-
-
77950311060
-
Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5
-
Armand-Ugon M, Moncunill G, Gonzalez E et al. Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5. J Antimicrob Chemother 2013; 65: 417-24.
-
(2013)
J Antimicrob Chemother
, vol.65
, pp. 417-424
-
-
Armand-Ugon, M.1
Moncunill, G.2
Gonzalez, E.3
-
27
-
-
78149481960
-
Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients
-
Seclen E, Gonzalez Mdel M, Lapaz M et al. Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients. J Antimicrob Chemother 2010; 65: 2502-4.
-
(2010)
J Antimicrob Chemother
, vol.65
, pp. 2502-2504
-
-
Seclen, E.1
Gonzalez Mdel, M.2
Lapaz, M.3
-
28
-
-
55249097908
-
Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients
-
Soulie C, Malet I, Lambert-Niclot S et al. Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients. AIDS 2008; 22: 2212-4.
-
(2008)
AIDS
, vol.22
, pp. 2212-2214
-
-
Soulie, C.1
Malet, I.2
Lambert-Niclot, S.3
-
29
-
-
74149093296
-
Development and performance of a new recombinant virus phenotypic entry assay to determine HIV-1 coreceptor usage
-
Raymond S, Delobel P, Mavigner M et al. Development and performance of a new recombinant virus phenotypic entry assay to determine HIV-1 coreceptor usage. J Clin Virol 2010; 47: 126-30.
-
(2010)
J Clin Virol
, vol.47
, pp. 126-130
-
-
Raymond, S.1
Delobel, P.2
Mavigner, M.3
-
30
-
-
1842415431
-
Coreceptor usage of primaryhuman immunodeficiency virus type 1 isolates varies according to biological phenotype
-
Bjorndal A,DengH, Jansson M et al. Coreceptor usage of primaryhuman immunodeficiency virus type 1 isolates varies according to biological phenotype. J Virol 1997; 71: 7478-87.
-
(1997)
J Virol
, vol.71
, pp. 7478-7487
-
-
Bjorndal, A.1
Deng, H.2
Jansson, M.3
-
31
-
-
0025352187
-
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990; 18: 3587-96.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
-
32
-
-
15844419153
-
Identification of a major co-receptor for primary isolates of HIV-1
-
Deng H, Liu R, Ellmeier W et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996; 381: 661-6.
-
(1996)
Nature
, vol.381
, pp. 661-666
-
-
Deng, H.1
Liu, R.2
Ellmeier, W.3
-
33
-
-
79959338709
-
Genotypic resistance testing in routine clinical care
-
Dunn DT, Coughlin K, Cane PA. Genotypic resistance testing in routine clinical care. Curr Opin HIVAIDS 2011; 6: 251-7.
-
(2011)
Curr Opin HIVAIDS
, vol.6
, pp. 251-257
-
-
Dunn, D.T.1
Coughlin, K.2
Cane, P.A.3
-
34
-
-
84886295640
-
-
Pfizer Inc. Antiviral Drugs Advisory Committee Briefing Document, April 24 (18 May 2013 date last accessed)
-
Pfizer Inc. Maraviroc Tablets NDA 22-128. Antiviral Drugs Advisory Committee Briefing Document, April 24, 2007. http://www.fda.gov/ ohrms/dockets/ac/07/briefing/2007-4283b1-01-pfizer.pdf (18 May 2013, date last accessed).
-
(2007)
Maraviroc Tablets, NDA., 22-128.
-
-
-
35
-
-
64849083122
-
Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities
-
Pugach P, Ray N, Klasse PJ et al. Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities. Virology 2009; 387: 296-302.
-
(2009)
Virology
, vol.387
, pp. 296-302
-
-
Pugach, P.1
Ray, N.2
Klasse, P.J.3
-
36
-
-
0033554726
-
Twosubsets ofmemoryT lymphocytes with distinct homing potentials and effector functions
-
Sallusto F, Lenig D, Forster R et al. Twosubsets ofmemoryT lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-12.
-
(1999)
Nature
, vol.401
, pp. 708-712
-
-
Sallusto, F.1
Lenig, D.2
Forster, R.3
-
37
-
-
0034469552
-
Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection
-
Veazey RS, Mansfield KG, Tham IC et al. Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection. J Virol 2000; 74: 11001-7.
-
(2000)
J Virol
, vol.74
, pp. 11001-11007
-
-
Veazey, R.S.1
Mansfield, K.G.2
Tham, I.C.3
|