Oxytocin

Psychobiological Approaches for Anxiety Disorders: Treatment Combination Strategies

Volumn , Issue , 2012, Pages 123-143

  Heinrichs, Markus ^a   Chen, Frances S ^a   Domes, Gregor ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Emotion recognition; Mental disorders; Neurophysiological bases; OXT and behavior; OXT impaired functioning; OXT, and pharmacological intervention; OXT, social cognition regulation; OXTR polymorphisms; Oxytocin; SAD, fear of negative evaluation

Indexed keywords

EID: 84886220767     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119945901.ch8     Document Type: Chapter

References (105)

1. Adolphs, R. (2002). Recognizing emotion from facial expressions: psychological and neurological mechanisms. Behavioral Cognitive Neuroscience Review, 1(1): 21-62.
2. Altemus, M., Deuster, P. A., Galliven, E., Carter, C. S., and Gold, P. W. (1995). Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. Journal of Clinical Endocrinology and Metabolism, 80(10): 2954-2959.
3. Alvares, G. A., Hickie, I. B., and Guastella, A. J. (2010). Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection. Experiments in Clinical Psychopharmacology, 18(4): 316-321.
4. Andari, E., Duhamel, J. R., Zalla, T., Herbrecht, E., Leboyer, M., and Sirigu, A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proceedings of the National Academy of Science, USA, 107(9): 4389-4394.
5. Anderson, G. M. (2006). Report of altered urinary oxytocin and AVP excretion in neglected orphans should be reconsidered. Journal of Autism and Developmental Disorders, 36(6): 829-830.
6. Bakermans-Kranenburg, M. J. and van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3(2): 128-134.
7. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., and Plumb, I. (2001). The 'Reading the Mind in the Eyes' test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2): 241-251.
8. Bartz, J. A. and Hollander, E. (2008). Oxytocin and experimental therapeutics in autism spectrum disorders. Progress in Brain Research, 170: 451-462.
9. Bartz, J. A., Simeon, D., Hamilton, H. et al. (2010a). Oxytocin can hinder trust and cooperation in borderline personality disorder. Soc Cogn Affect Neurosci, doi: 10.1093/scan/nsq085.
10. Bartz, J. A., Zaki, J., Bolger, N. et al. (2010b). Oxytocin selectively improves empathic accuracy. Psychological Science, 21(10): 1426-1428.
11. Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., and Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 58(4): 639-650.
12. Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., and Fehm, H. L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nature Reviews Neuroscience, 5(6): 514-516.
13. Bradley, B., Westin, D., Mercer, K. et al. (2011). Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African-American sample: moderation by oxytocin receptor gene. Development and Psychopathology, 23(2): 439-452.
14. Buchheim, A., Heinrichs, M., George, C. et al. (2009). Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology, 34(9): 1417-1422.
15. Carter, C. S., Pournajafi-Nazarloo, H., Kramer, K. M. et al. (2007). Oxytocin: behavioral associations and potential as a salivary biomarker. Annals of the New York Academy of Science, 1098: 312-322.
16. Celani, G., Battacchi, W., and Arcidiacono, L. (1999). The understanding of the emotional meaning of facial expressions in people with autism. Journal of Autism and Developmental Disorders, 29(1): 57-66.
17. Chen, F. S., Kumsta, R., and Heinrichs, M. (2011). Oxytocin and intergroup relations: Goodwill is not a fixed pie. Proeedings of the National Academy of Scienmce, USA, 108(13): E45.
18. Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., and Heinrichs, M. (in press). An oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce physiological and psychological responses to stress. Proceedings of the National Academy of Sciences, USA.
19. Costa, B., Pini, S., Gabelloni, P., Abelli, M. et al. (2009) Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34(10): 1506-1514.
20. Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Cai, H. M., and Amico, J. A. (2008). Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosomatic Medicine, 70(9): 967-975.
21. Decaux, G., Soupart, A., and Vassart, G. (2008). Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet, 371(9624): 1624-1632.
22. Declerck, C. H., Boone, C., and Kiyonari, T. (2010). Oxytocin and cooperation under conditions of uncertainty: the modulating role of incentives and social information. Hormones and Behavior, 57(3): 368-374.
23. reu, C. K., Greer, L. L., Handgraaf, M. J. et al. (2010). The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science, 328 (5984): 1408-1411.
24. De Dreu, C. K., Greer, L. L., Van Kleef, G. A., Shalvi, S., and Handgraaf, M. J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Science, USA, 108 (4): 1262-1266.
25. de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., and Crippa, J. A. (2011). Anxiolytic-like effect of oxytocin in the simulated public speaking test. J Psychopharmacol, doi: 10.1177/0269881111400642.
26. Di Simplicio, M., Massey-Chase, R., Cowen, P., and Harmer, C. (2009). Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers. Journal of Psychopharmacology, 23(3): 241-248.
27. Ditzen, B., Schmidt, S., Strauss, B., Nater, U. M., Ehlert, U., and Heinrichs, M. (2008). Adult attachment and social support interact to reduce psychological but not cortisol responses to stress. Journal of Psychosomatic Research, 64(5): 479-486.
28. Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., and Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biololgical Psychiatry, 65(9): 728-731.
29. Domes, G., Heinrichs, M., Glascher, J., Buchel, C., Braus, D. F., and Herpertz, S. C. (2007a). Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biological Psychiatry, 62(10): 1187-1190.
30. Domes, G., Heinrichs, M., Michel, A., Berger, C., and Herpertz, S. C. (2007b). Oxytocin improves 'mind-reading' in humans. Biological Psychiatry, 61(6): 731-733.
31. Domes, G., Schulze, L., and Herpertz, S. C. (2009). Emotion recognition in borderline personality disorder - a review of the literature. Journal of Personality Disorders, 23(1): 6-19.
32. Domes, G., Lischke, A., Berger, C. et al. (2010). Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology, 35(1): 83-93.
33. Evans, S., Shergill, S. S., and Averbeck, B. B. (2010). Oxytocin decreases aversion to angry faces in an associative learning task. Neuropsychopharmacology, 35(13): 2502-2509.
34. Fehm-Wolfsdorf, G., Born, J., Voigt, K. H., and Fehm, H. L. (1984). Human memory and neurohypophyseal hormones: opposite effects of vasopressin and oxytocin. Psychoneuroendocrinology, 9(3): 285-292.
35. Feifel, D. and Reza, T. (1999). Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating. Psychopharmacology (Berl.), 141(1): 93-98.
36. Feifel, D., Macdonald, K., Nguyen, A. et al. (2010). Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biological Psychiatry, 68(7): 678-680.
37. Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., and Levkovitz, Y. (2010). The effect of intranasal administration of oxytocin on fear recognition. Neuropsychologia, 48(1): 179-184.
38. Gamer, M. and Buchel, C. (2011). Oxytocin specifically enhances valencedependent parasympathetic responses. Psychoneuroendocrinology, doi: 10.1016/j. psyneuen.2011.05.007.
39. Gamer, M., Zurowski, B., and Buchel, C. (2010). Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proceedings of the National Academy of Sciences, USA, 107(20): 9400-9405.
40. Goldman, M., Marlow-O'Connor, M., Torres, I., and Carter, C. S. (2008). Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits. Schizophrenia Research, 98(1-3): 247-255.
41. Goldman, M., Gomes, A. M., Carter, C. S., and Lee, R. (2011). Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia. Psychopharmacology (Berl.), 216(1): 101-110.
42. Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., and Morris, M. (2001). Oxytocin and autistic disorder: alterations in peptide forms. Biolpogical Psychiatry, 50(8): 609-613.
43. Grewen, K. M., Girdler, S. S., Amico, J., and Light, K. C. (2005). Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosomatic Medicine, 67(4): 531-538.
44. Guastella, A. J., Mitchell, P. B., and Dadds, M. R. (2008a). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 63(1): 3-5.
45. Guastella, A. J., Mitchell, P. B., and Mathews, F. (2008b). Oxytocin enhances the encoding of positive social memories in humans. Biological Psychiatry, 64(3): 256-258.
46. Guastella, A. J., Carson, D. S., Dadds, M. R., Mitchell, P. B., and Cox, R. E. (2009a). Does oxytocin influence the early detection of angry and happy faces? Psychoneuroendocrinology, 34(2): 220-225.
47. Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., and Carson, D. S. (2009b). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology, 34(6): 917-923.
48. Guastella, A. J., Einfeld, S. L., Gray, K. M. et al. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67(7): 692-694.
49. Heinrichs, M. and Domes, G. (2008). Neuropeptides and social behavior: effects of oxytocin and vasopressin in humans. Progress in Brain Research, 170: 337-350.
50. Heinrichs, M., Meinlschmidt, G., Neumann, I. et al. (2001). Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women. Journal of Clinical Endocrinology and Metabolism, 86(10): 4798-4804.
51. Heinrichs, M., Baumgartner, T., Kirschbaum, C., and Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12): 1389-1398.
52. Heinrichs, M., Meinlschmidt, G., Wippich, W., Ehlert, U., and Hellhammer, D. H. (2004). Selective amnesic effects of oxytocin on human memory. Physiological Behavior, 83(1): 31-38.
53. Heinrichs, M., von Dawans, B., and Domes, G. (2009). Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology, 30(4): 548-557.
54. Horley, K., Williams, L.M., Gonsalvez, C., and Gordon, E. (2003). Social phobics do not see eye to eye: a visual scanpath study of emotional expression processing. Anxiety Disorders, 17: 33-44.
55. Horvat-Gordon, M., Granger, D. A., Schwartz, E. B., Nelson, V. J., and Kivlighan, K. T. (2005). Oxytocin is not a valid biomarker when measured in saliva by immunoassay. Physiological Behavior, 84(3): 445-448.
56. Huber, D., Veinante, P., and Stoop, R. (2005).Vasopressinandoxytocinexcitedistinct neuronal populations in the central amygdala. Science, 308(5719): 245-248.
57. Hurlemann, R., Patin, A., Onur, O. A. et al. (2010). Oxytocin enhances amygdaladependent, socially reinforced learning and emotional empathy in humans. Journal of Neuroscience, 30(14): 4999-5007.
58. Insel, T. R. and Young, L. J. (2001). The neurobiology of attachment. Nature Reviews Neuroscience, 2(2): 129-136.
59. Kang, Y. S. and Park, J. H. (2000). Brain uptake and the analgesic effect of oxytocin - its usefulness as an analgesic agent. Archives of Pharmacological Research, 23(4): 391-395.
60. Keri, S. and Benedek, G. (2009). Oxytocin enhances the perception of biological motion in humans. Cognitive Affective Behavioral Neuroscience, 9(3): 237-241.
61. Keri, S., Kiss, I., and Kelemen, O. (2009). Sharing secrets: Oxytocin and trust in schizophrenia. Social Neuroscience, 4(4): 287-293.
62. Kessler, R. C., McGonagle, K. A., Zhao, S. et al. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry, 51(1): 8-19.
63. Kim,H. S., Sherman, D. K., Sasaki, J.Y. et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences,USA, 107(36): 15717-15721.
64. Kirsch, P., Esslinger, C., Chen, Q. et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25(49): 11489-11493.
65. Kirschbaum, C., Pirke, K. M., and Hellhammer, D. H. (1993). The 'Trier Social Stress Test' - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28(1-2): 76-81.
66. Klin, A., Jones, W., Schultz, R., Volkmar, F., and Cohen, D. (2002). Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Archives of General Psychiatry, 59(9): 809-816.
67. Kohler, C. G., Turner, T. H., Bilker, W. B. (2003). Facial emotion recognition in schizophrenia: intensity effects and error pattern. American Journal of Psychiatry, 160(10): 1768-1774.
68. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., and Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042): 673-676, with permission from 2005 Nature Publishing Group.
69. Labuschagne, I., Phan, K. L., Wood, A. et al. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology, 35(12): 2403-2413.
70. Landgraf, R. and Neumann, I. D. (2004). Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Frontiers in Neuroendocrinol, 25(3-4): 150-176.
71. Loup, F., Tribollet, E., Dubois-Dauphin, M., and Dreifuss, J. J. (1991). Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Research, 555(2): 220-232.
72. Lucht, M. J., Barnow, S., Sonnenfeld, C. et al. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuropsychopharmacology and Biological Psychiatry, 33(5): 860-866.
73. Ludwig, M. and Leng, G. (2006). Dendritic peptide release and peptide-dependent behaviors. Nature Reviews Neuroscience, 7(2): 126-136.
74. Marsh, A. A., Yu, H. H., Pine, D. S., and Blair, R. J. (2010). Oxytocin improves specific recognition of positive facial expressions. Psychopharmacology (Berl.), 209(3): 225-232.
75. Meinlschmidt, G. and Heim, C. (2007). Sensitivity to intranasal oxytocin in adult men with early parental separation. Biological Psychiatry, 61(9): 1109-1111.
76. Meyer-Lindenberg, A. (2008). Impact of prosocial neuropeptides on human brain function. Progress in Brain Research, 170: 463-470.
77. Meyer-Lindenberg, A., Domes, G., Kirsch, P., and Heinrichs, M. (2011). Oxytocin and Vasopressin in the human brain: social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12: 524-538.
78. Mikolajczak, M., Gross, J. J., Lane, A., Corneille, O., de Timary, P., and Luminet, O. (2010a). Oxytocin makes people trusting, not gullible. Psychological Science, 21(8): 1072-1074.
79. Mikolajczak, M., Pinon, N., Lane, A., de Timary, P., and Luminet, O. (2010b). Oxytocin not only increases trust when money is at stake, but also when confidential information is in the balance. Biological Psychology, 85(1): 182-184.
80. Naber, F., van Ijzendoorn, M. H., Deschamps, P., van Engeland, H., and Bakermans-Kranenburg, M. J. (2010). Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment. Psychoneuroendocrinology, 35(10): 1583-1586.
81. Norman, G. J., Cacioppo, J. T., Morris, J. S. et al. (2010). Selective influences of oxytocin on the evaluative processing of social stimuli. Journal of Psychopharmacology, doi: 10.1177/0269881110367452.
82. Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., and Devries, A. C. (2011). Oxytocin increases autonomic cardiac control: moderation by loneliness. Biological Psychology, 86(3): 174-180.
83. Quirin, M., Kuhl, J., and Dusing, R. (2011). Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities. Psychoneuroendocrinology, 36(6): 898-904.
84. Rimmele, U., Hediger, K., Heinrichs, M., and Klaver, P. (2009). Oxytocin makes a face in memory familiar. Journal of Neuroscience, 29(1): 38-42.
85. Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., and Gilbert, P. (2011). Effects of intranasal oxytocin on 'compassion focused imagery.' Emotion, doi: 10.1037/a0023861.
86. Rodrigues, S., Saslow, L., Garcia, N., John, O., and Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences, USA, 106(50): 21437-31441.
87. Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., and Schachinger, H. (2008). Postlearning intranasal oxytocin modulates human memory for facial identity. Psychoneuroendocrinology, 33(3): 368-374.
88. Scantamburlo, G., Hansenne, M., Fuchs, S. et al. (2007). Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 32(4): 407-410.
89. Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., and Domes, G. (2011). Oxytocin increases recognition of masked emotional faces. Psychoneuroendocrinology, 36(9): 1378-1382.
90. Selten, J. P., and Cantor-Graae, E. (2005). Social defeat: risk factor for schizophrenia? British Journal of Psychiatry, 187: 101-102.
91. Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., and Levkovitz, Y. (2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry, 66(9): 864-870.
92. Simeon, D., Bartz, J., Hamilton, H. et al. (2011). Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2011.03.013.
93. Singer, T., Snozzi, R., Bird, G. et al. (2008). Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain. Emotion, 8(6): 781-791.
94. Stanley, B., and Siever, L. J. (2010). The interpersonal dimension of borderline personality disorder: toward a neuropeptide model. American Journal of Psychiatry, 167(1): 24-39.
95. Tansey, K. E., Brookes, K. J., Hill, M. J. et al. (2010). Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. Neuroscience Letters, 474(3): 163-167.
96. Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A., and Seeman, T. E. (2006). Relation of oxytocin to psychological stress responses and hypothalamicpituitary-adrenocortical axis activity in older women. Psychosomatic Medicine, 68(2): 238-245.
97. Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., and Rogers, P. J. (2009). Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Hormones and Behavior, 56(1): 128-132.
98. Tost, H., Kolachana, B., Hakimi, S. et al. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences, USA, 107(31): 13936-13941.
99. Viviani, D., Charlet, A., van den Burg, E. et al. (2011). Oxytocin selectively gates fear responses through distinct outputs from the central amygdala. Science, 333(6038): 104-107.
100. Winslow, J. T. and Insel, T. R. (2004). Neuroendocrine basis of social recognition. Current Opinions in Neurobiology, 14(2): 248-253.
101. Winton, E. C., Clark, D. M., and Edelmann, R. J. (1995). Social anxiety, fear of negative evaluation and the detection of negative emotion in others. Behavioral Research and Therapy, 33(2): 193-196.
102. Wu, S., Jia, M., Ruan, Y. et al. (2005). Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biological Psychiatry, 58(1):74-77.
103. Young, L. J. and Wang, Z. (2004). The neurobiology of pair bonding. Nature Reviews Neuroscience, 7(10): 1048-1054.
104. Zak, P. J., Kurzban, R., and Matzner, W. T. (2005). Oxytocin is associated with human trustworthiness. Hormones and Behavior, 48(5), 522-527.
105. Zak, P. J., Stanton, A. A., and Ahmadi, S. (2007). Oxytocin increases generosity in humans. PLoS One, 2(11): e1128.