Oxytocin increases autonomic cardiac control: Moderation by loneliness

Biological Psychology

Volumn 86, Issue 3, 2011, Pages 174-180

  Norman, Greg J ^a,b   Cacioppo, John T ^b   Morris, John S ^a   Malarkey, William B ^a   Berntson, Gary G ^a   DeVries, A Courtney ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Autonomic; Cortisol; Cytokines; Loneliness; Oxytocin

Indexed keywords

CYTOKINE; OXYTOCIN; STRESS HORMONE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; FEMALE; HEART INNERVATION; HEART PREEJECTION PERIOD; HEART RATE VARIABILITY; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; LONELINESS; MALE; NERVE POTENTIAL; NEUROMODULATION; PARASYMPATHETIC INNERVATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SOCIAL ISOLATION; SYMPATHETIC INNERVATION;

ADULT; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CATECHOLAMINES; CYTOKINES; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; LONELINESS; MALE; MODELS, BIOLOGICAL; OXYTOCICS; OXYTOCIN; PREDICTIVE VALUE OF TESTS; TIME FACTORS; YOUNG ADULT;

EID: 79952314935     PISSN: 03010511     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2010.11.006     Document Type: Article

References (57)

1. Airaksinen K.E. Autonomic mechanisms and sudden death after abrupt coronary occlusion. Annals of Medicine 1999, 31(4):240-245.
2. Aiken L.S., West S.G. Multiple Regression: Testing and Interpreting Interactions 1991, Sage, Thousand Oaks, CA.
3. Beck A. T., Steer R. A., Brown G. K., 1996. BDI-II, Beck depression inventory: manual. 2d ed. Boston: Harcourt Brace.
4. Beck A.X., Epstein N., Brown G., Steer R.A. An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology 1988, 56:893-897.
5. Berntson G.G., Bigger J.T., Eckberg D.L., Grossman P., Kaufmann P.G., Malik M., et al. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology 1997, 34(6):623-648.
6. Berntson G.G., Cacioppo J.T., Quigley K.S., Fabro V.T. Autonomic space and psychophysiological response. Psychophysiology 1994, 31(1):44-61.
7. Berntson G.G., Norman G.J., Hawkley L.C., Cacioppo J.T. Cardiac autonomic balance versus cardiac regulatory capacity. Psychophysiology 2008, 45(4):643-652.
8. Born J., Lange T., Kern W., McGregor G.P., Bickel U., Fehm H.L. Sniffing neuropeptides: a transnasal approach to the human brain. Nature Neuroscience 2002, 5(6):514-516.
9. Cacioppo J.T., Hawkley L.C., Crawford L.E., Ernst J.M., Burleson M.H., Kowalewski R.B., et al. Loneliness and health: potential mechanisms. Psychosomatic Medicine 2002, 64(3):407-417.
10. Cacioppo J.T., Norris C.J., Decety J., Monteleone G., Nusbaum H. In the eye of the beholder: individual differences in perceived social isolation predict regional brain activation to social stimuli. Journal of Cognitive Neuroscience 2009, 21(1):83-92.
11. Cacioppo J.T., Patrick B. Loneliness: Human Nature and the Need for Social Connection 2008, W.W. Norton and Company, New York.
12. Carter C.S., Grippo A.J., Pournajafi-Nazarloo H., Ruscio M.G., Porges S.W. Oxytocin, vasopressin and sociality. Progress in Brain Research 2008, 170:331.
13. Clodi M., Vila G., Geyeregger R., Riedl M., Stulnig T.M., Struck J., et al. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. American Journal of Physiology Endocrinology and Metabolism 2008, 295(3):E686-691.
14. Cohen S., Kamarck T., Mermelstein R. A global measure of perceived stress. Journal of Health and Social Behavior 1983, 24(1):385-396.
15. Costa B., Pini S., Gabelloni P., Abelli M., Lari L., Cardini A., et al. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 2009, 34(10):1506-1514.
16. Dekker J.M., Schouten E.G., Klootwijk P., Pool J., Swenne C.A., Kromhout D. Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. American Journal of Epidemiology 1997, 145(10):899-908.
17. Detillion C.E., Craft T.K., Glasper E.R., Prendergast B.J., DeVries A.C. Social facilitation of wound healing. Psychoneuroendocrinology 2004, 29(8):1004-1011.
18. Ditzen B., Schaer M., Gabriel B., Bodenmann G., Ehlert U., Heinrichs M. Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry 2009, 65(9):728-731.
19. Domes G., Heinrichs M., Glascher J., Buchel C., Braus D.F., Herpertz S.C. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biological Psychiatry 2007, 62(10):1187-1190.
20. Egizio V.B., Jennings J.R., Christie I.C., Sheu L.K., Matthews K.A., Gianaros P.J. Cardiac vagal activity during psychological stress varies with social functioning in older women. Psychophysiology 2008, 45(6):1046-1054.
21. Gilbey M.P., Coote J.H., Fleetwood-Walker S., Peterson D.F. The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones. Brain Research 1982, 251(2):283-290.
22. Gouin J.P., Carter C.S., Pournajafi-Nazarloo H., Glaser R., Malarkey W.B., Loving T.J., et al. Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 2010.
23. Grewen K.M., Girdler S.S., Amico J., Light K.C. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosomatic Medicine 2005, 67(4):531-538.
24. Grippo A.J., Lamb D.G., Carter C.S., Porges S.W. Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors. Biological Psychiatry 2007, 62(10):1162-1170.
25. Grippo A.J., Trahanas D.M., Zimmerman R.R., Porges S.W., Carter C.S. Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation. Psychoneuroendocrinology 2009, 34(10):1542-1553.
26. Guastella A.J., Carson D.S., Dadds M.R., Mitchell P.B., Cox R.E. Does oxytocin influence the early detection of angry and happy faces? Psychoneuroendocrinology 2009, 34(2):220-225.
27. Heinrichs M., Baumgartner T., Kirschbaum C., Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry 2003, 54(12):1389-1398.
28. Higa K.T., Mori E., Viana F.F., Morris M., Michelini L.C. Baroreflex control of heart rate by oxytocin in the solitary-vagal complex. American Journal of Physiology Regulatory Integrative and Comparative Physiology 2002, 282(2):R537-545.
29. Holmbeck G.N. Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations. Journal of Pediatric Psychology 2002, 27(1):87-96.
30. House J.S., Landis K.R., Umberson D. Social relationships and health. Science 1988, 241(4865):540-545.
31. Huber D., Veinante P., Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005, 308(5719):245-248.
32. James J.E. Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosomatic Medicine 2004, 66:63-71.
33. Kosfeld M., Heinrichs M., Zak P.J., Fischbacher U., Fehr E. Oxytocin increases trust in humans. Nature 2005, 435(7042):673-676.
34. Loup F., Tribollet E., Dubois-Dauphin M., Dreifuss J.J. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Research 1991, 555(2):220-232.
35. Lucht M.J., Barnow S., Sonnenfeld C., Rosenberger A., Grabe H.J., Schroeder W., et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuropsychopharmacology and Biological Psychiatry 2009, 33(5):860-866.
36. Mancia G., Bousquet P., Elghozi J.L., Esler M., Grassi G., Julius S., Reid J., Van Zwieten P.A. The sympathetic nervous system and the metabolic syndrome. Journal of Hypertension 2007, 25:909-920.
37. Manuck S.B., Kaplan J.R., Adams M.R., Clarkson T.B. Effects of stress and the sympathetic nervous system on coronary artery atherosclerosis in the cynomolgus macaque. American Heart Journal 1988, 116(1(Pt 2)):328-333.
38. Masi C.M., Hawkley L.C., Rickett E.M., Cacioppo J.T. Respiratory sinus arrhythmia and diseases of aging: obesity, diabetes mellitus, and hypertension. Biological Psychology 2007, 74(2):212-223.
39. Meinlschmidt G., Heim C. Sensitivity to intranasal oxytocin in adult men with early parental separation. Biological Psychiatry 2007, 61(9):1109-1111.
40. Norman G.J., Cacioppo J.T., Morris J.S., Malarkey W.B., Karelina K., DeVries A.C., et al. Selective influences of oxytocin on the evaluative processing of social stimuli. Psychopharmacology 2010, [Epub ahead of print].
41. Norman G.J., Karelina K., Zhang N., Morris J.S., DeVries A.C. Social interaction prevents the development of depressive-like behavior following nerve injury: a potential role for oxytocin. Psychosomatic Medicine 2010, [Epub ahead of print].
42. Orth-Gomer K., Rosengren A., Wilhelmsen L. Lack of social support and incidence of coronary heart disease in middle-aged Swedish men. Psychosomatic Medicine 1993, 55(1):37-43.
43. Pardini B.J., Lund D.D., Schmid P.G. Organization of the sympathetic postganglionic innervation of the rat heart. Journal of the Autonomic Nervous System 1989, 28(3):193-201.
44. Patterson A.C., Veenstra G. Loneliness and risk of mortality: a longitudinal investigation in Alameda County, California. Social Science & Medicine 2010, 71:181-186.
45. Porges S.W. The polyvagal theory. Phylogenetic substrates of a social nervous system. International Journal of Psychophysiology 2001, 42(2):123-146.
46. Rodrigues S.M., Saslow L.R., Garcia N., John O.P., Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences, United States America 2009, [Epub ahead of print].
47. Russell D., Peplau L.A., Cutrona C.E. The revised UCLA Loneliness Scale: Concurrent and discriminant validity evidence. Journal of Personality and Social Psychology 1980, 39:472-480.
48. Sherwood A., Allen M.T., Fahrenberg J., Kelsey R.M., Lovallo W.R., van Doornen L.J. Methodological guidelines for impedance cardiography. Psychophysiology 1990, 27(1):1-23.
49. Spielberger C.D., Gorsuch R.L., Lushene R.E. Manual for the State-Trait Anxiety Inventory (Self-Evaluation Questionnaire) 1970, Consulting Psychologists Press, Palo Alto, CA.
50. Szeto A., Nation D.A., Mendez A.J., Dominguez-Bendala J., Brooks L.G., Schneiderman N., et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiology Endocrinology and Metabolism 2008, 295(6):E1495-1501.
51. Thayer J.F., Lane R.D. The role of vagal function in the risk for cardiovascular disease and mortality. Biological Psychology 2007, 74(2):224-242.
52. Thayer J.F., Sternberg E. Beyond heart rate variability: vagal regulation of allostatic systems. Annals of the New York Academy of Sciences 2006, 1088:361-372.
53. Thayer J.F., Yamamoto S.S., Brosschot J.F. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. International Journal of Cardiology 2009, 141(2):122-131.
54. Theodoridou A., Rowe A.C., Penton-Voak I.S., Rogers P.J. Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Hormones and Behavior 2009, 56(1):128-132.
55. Tribollet E., Dubois-Dauphin M., Dreifuss J.J., Barberis C., Jard S. Oxytocin receptors in the central nervous system. Distribution, development, and species differences. Annals of the New York Academy of Sciences 1992, 652:29-38.
56. Watson D., Clark L.A., Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology 1988, 54(6):1063-1070.
57. Weil Z.M., Norman G.J., Barker J.M., Su A.J., Nelson R.J., Devries A.C. Social isolation potentiates cell death and inflammatory responses after global ischemia. Molecular Psychiatry 2008, 13(10):913-915.