Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection

Experimental and Clinical Psychopharmacology

Volumn 18, Issue 4, 2010, Pages 316-321

  Alvares, Gail A ^a   Hickie, Ian B ^a   Guastella, Adam J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Neuropeptide; Ostracism; Oxytocin; Social rejection; Stress

Indexed keywords

OXYTOCIN; PLACEBO;

ADULT; ANXIETY; ARTICLE; BEHAVIOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLOW UP; FUNDAMENTAL NEEDS QUESTIONNAIRE; GAME; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SELF ESTEEM; SELF REPORT; SEX DIFFERENCE; SOCIAL REJECTION; SOCIAL STRESS; THREAT;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTERNET; INTERPERSONAL RELATIONS; MALE; MIDDLE AGED; OXYTOCICS; OXYTOCIN; REJECTION (PSYCHOLOGY); SEX CHARACTERISTICS; SOCIAL BEHAVIOR; SOCIAL PERCEPTION; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 77955839969     PISSN: 10641297     EISSN: 19362293     Source Type: Journal    
DOI: 10.1037/a0019719     Document Type: Article

References (41)

1. Amico J.A., Seif S.M., Robinson A.G. Elevation of oxytocin and the oxytocin-associated neurophysin in the plasma of normal women during midcycle. Journal of Clinical Endocrinology and Metabolism 1981, 53:1229-1232.
2. Bartz J.A., Hollander E. The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior. Hormones and Behavior 2006, 50:518-528.
3. Baumgartner T., Heinrichs M., Vonlanthen A., Fischbacher U., Fehr E. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 2008, 58:639-650.
4. Blackhart G.C., Eckel L.A., Tice D.M. Salivary cortisol in response to acute social rejection and acceptance by peers. Biological Psychology 2007, 75:267-276.
5. Broadhead W.E., Kaplan B.H., James S.A., Wagner E.H., Schoenbach V.J., Grimson R., et al. The epidemiological evidence for a relationship between social support and health. American Journal of Epidemiology 1983, 117:521-537.
6. Carleton R.N., McCreary D.R., Norton P.J., Asmundson G.J.G. Brief Fear of Negative Evaluation scale - Revised. Depression and Anxiety 2006, 23:297-303.
7. Carter C.S., Altemus M. Integrative functions of lactational hormones in social behavior and stress management. Annals of the New York Academy of Sciences 1997, 807:164-174.
8. Cohen S., Wills T.A. Stress, social support, and the buffering hypothesis. Psychological Bulletin 1985, 98:310-357.
9. Declerck C.H., Boone C., Kiyonari T. Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information. Hormones & Behavior 2010, 57:368-374.
10. Ditzen B., Schaer M., Gabriel B., Bodenmann G., Ehlert U., Heinrichs M., et al. Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry 2009, 65:728-731.
11. Domes G., Heinrichs M., Michel A., Berger C., Herpertz S. Oxytocin improves " mind-reading" in humans. Biological Psychiatry 2007, 61:731-733.
12. Donaldson Z.R., Young L.J. Oxytocin, vasopressin, and the neurogenetics of sociality. Science 2008, 322:900-904.
13. Gimpl G., Fahrenholz F. The oxytocin receptor system: Structure, function, and regulation. Physiological Reviews 2001, 81:629-683.
14. Gonsalkorale K., Williams K.D. The KKK won't let me play: Ostracism even by a despised outgroup hurts. European Journal of Social Psychology 2007, 37:1176-1186.
15. Grippo A., Trahanas D., Zimmerman R., Porges S., Carter C. Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation. Psychoneuroendocrinology 2009, 34:1542-1553.
16. Guastella A.J., Howard A.L., Dadds M.R., Mitchell P.B., Carson D.S. A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 2009, 34:917-923.
17. Guastella A.J., Mitchell P.B., Dadds M.R. Oxytocin increases gaze to the eye-region of human faces. Biological Psychiatry 2008, 63:3-5.
18. Guastella A.J., Mitchell P.B., Mathews F. Oxytocin enhances the encoding of positive social memories in humans. Biological Psychiatry 2008, 64:256-258.
19. Heinrichs M., Baumgartner T., Kirschbaum C., Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry 2003, 54:1389-1398.
20. Insel T.R., Winslow J.T. Central administration of oxytocin modulates the infant rat's response to social isolation. European Journal of Pharmacology 1991, 203:149-152.
21. Kemp A.H., Guastella A.J. Oxytocin: Prosocial Behavior, Social Salience, or Approach-Related Behavior?. Biological Psychiatry 2010, 67:e33-e34.
22. Kosfeld M., Heinrichs M., Zak P.J., Fischbacher U., Fehr E. Oxytocin increases trust in humans. Nature 2005, 435:673-676.
23. Lim M.M., Young L.J. Neuropeptidergic regulation of affiliative behavior and social bonding in animals. Hormones and Behavior 2006, 50:506-517.
24. Lovibond P.F., Lovibond S.H. The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research & Therapy 1995, 33:335-343.
25. Maner J.K., DeWall C.N., Baumeister R.F., Schaller M. Does social exclusion motivate interpersonal reconnection? Resolving the " porcupine problem." Journal of Personality and Social Psychology 2007, 92:42-55.
26. McGregor I.S., Callaghan P.D., Hunt G.E. From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?. British Journal of Pharmacology 2008, 154:358-368.
27. Mitchell M.D., Haynes P.J., Anderson A.B.M., Turnbull A.C. Plasma oxytocin concentrations during the menstrual cycle. European Journal of Obstetrics & Gynecology and Reproductive Biology 1981, 12:195-200.
28. Panksepp J. Oxytocin effects on emotional processes: Separation distress, social bonding, and relationships to psychiatric disorders. Annals of the New York Academy of Sciences 1992, 652:243-252.
29. Petrovic P., Kalisch R., Singer T., Dolan R.J. Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. Journal of Neuroscience 2008, 28:6607-6615.
30. Rimmele U., Hediger K., Heinrichs M., Klaver P. Oxytocin makes a face in memory familiar. Journal of Neuroscience 2009, 29:38-42.
31. Salonia A., Nappi R.E., Pontillo M., Daverio R., Smeraldi A., Briganti A., et al. Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy men. Hormones and Behavior 2005, 47:164-169.
32. Shamay-Tsoory S.G., Fischer M., Dvash J., Harari H., Perach-Bloom N., Levkovitz Y. Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry 2009, 66:864-870.
33. Uchino B.N. Social support and health: A review of physiological processes potentially underlying links to disease outcomes. Journal of Behavioral Medicine 2006, 29:377-387.
34. Uchino B.N., Cacioppo J.T., Kiecolt-Glaser J.K. The relationship between social support and physiological processes: A review with emphasis on underlying mechanisms and implications for health. Psychological Bulletin 1996, 119:488-531.
35. Unkelbach C., Guastella A.J., Forgas J. Oxytocin selectively facilitates recognition of positive sex and relationship words. Psychological Science 2008, 19:102-104.
36. Uvnas-Moberg K. Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 1998, 23:819-835.
37. Williams K.D. Ostracism. Annual Review of Psychology 2007, 58:425-452.
38. Williams K.D., Cheung C.K.T., Choi W. Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology 2000, 79:748-762.
39. Williams K.D., Jarvis B. Cyberball: A program for use in research on interpersonal ostracism and acceptance. Behavior Research Methods 2006, 38:174-180.
40. Zadro L., Williams K.D., Richardson R. How low can you go? Ostracism by a computer is sufficient to lower self-reported levels of belonging, control, self-esteem, and meaningful existence. Journal of Experimental Social Psychology 2004, 40:560-567.
41. Zadro L., Boland C., Richardson R. How long does it last? The persistence of the effects of ostracism in the socially anxious. Journal of Experimental Social Psychology 2006, 42:692-697.