Inhibition of NF-κB by opioids in T cells

Journal of Immunology

Volumn 191, Issue 9, 2013, Pages 4640-4647

  Borner, Christine ^a   Kraus, Jurgen ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UBIQUITIN SPECIFIC PROTEASE 15; UNCLASSIFIED DRUG; DEUBIQUITINASE; I KAPPA B KINASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; USP15 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; HUMAN CELL; NERVE CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; GENETICS; INFLAMMATION; JURKAT CELL LINE; METABOLISM; RNA INTERFERENCE;

ANALGESICS, OPIOID; CALCIUM; CELLS, CULTURED; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERLEUKIN-8; JURKAT CELLS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; RECEPTORS, OPIOID, MU; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTORS; UBIQUITIN-SPECIFIC PROTEASES; UBIQUITINATION;

EID: 84886042724     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300320     Document Type: Article

References (38)

1. Philippe, D., L. Dubuquoy, H. Groux, V. Brun, M. T. Chuoï-Mariot, C. Gaveriaux-Ruff, J. F. Colombel, B. L. Kieffer, and P. Desreumaux. 2003. Anti-inflammatory properties of the m opioid receptor support its use in the treatment of colon inflammation. J. Clin. Invest. 111: 1329-1338.
2. + T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J. Immunol. 175: 6361-6367.
3. Mousa, S. A., R. H. Straub, M. Schäfer, and C. Stein. 2007. b-Endorphin, Metenkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis. Ann. Rheum. Dis. 66: 871-879.
4. Kieffer, B. L., and C. J. Evans. 2009. Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology 56(Suppl. 1): 205-212.
5. Kaltschmidt, B., and C. Kaltschmidt. 2009. NF-κB in the nervous system. Cold Spring Harb. Perspect. Biol. 1: a001271.
6. Hayden, M. S., and S. Ghosh. 2011. NF-κB in immunobiology. Cell Res. 21: 223-244.
7. Kunsch, C., R. K. Lang, C. A. Rosen, and M. F. Shannon. 1994. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6. J. Immunol. 153: 153-164.
8. Chaly, Y. V., R. S. Selvan, K. V. Fegeding, T. S. Kolesnikova, and N. N. Voitenok. 2000. Expression of IL-8 gene in human monocytes and lymphocytes: differential regulation by TNF and IL-1. Cytokine 12: 636-643.
9. Tsaprouni, L. G., K. Ito, I. M. Adcock, and N. Punchard. 2007. Suppression of lipopolysaccharide- and tumour necrosis factor-a-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. Clin. Exp. Immunol. 150: 151-157.
10. Roy, S., K. J. Cain, R. B. Chapin, R. G. Charboneau, and R. A. Barke. 1998. Morphine modulates NFkB activation in macrophages. Biochem. Biophys. Res. Commun. 245: 392-396.
11. Wang, J., R. A. Barke, R. Charboneau, and S. Roy. 2005. Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J. Immunol. 174: 426-434.
12. Wang, J., R. A. Barke, R. Charboneau, R. Schwendener, and S. Roy. 2008. Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-κB signaling. J. Immunol. 180: 3594-3600.
13. Baud, V., and M. Karin. 2001. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11: 372-377.
14. Mormina, M. E., S. Thakur, A. Molleman, C. J. Whelan, and A. R. Baydoun. 2006. Cannabinoid signalling in TNF-a induced IL-8 release. Eur. J. Pharmacol. 540: 183-190.
15. Huang, Y. T., S. L. Pan, J. H. Guh, Y. L. Chang, F. Y. Lee, S. C. Kuo, and C. M. Teng. 2005. YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells. Mol. Cancer Ther. 4: 1628-1635.
16. Altman, R., D. D. Motton, R. S. Kota, and J. C. Rutledge. 2008. Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARa and NF-κB. Vascul. Pharmacol. 48: 76-84.
17. Börner, C., V. Höllt, and J. Kraus. 2012. Mechanisms of the inhibition of nuclear factor-κB by morphine in neuronal cells. Mol. Pharmacol. 81: 587-597.
18. Börner, C., B. Warnick, M. Smida, R. Hartig, J. A. Lindquist, B. Schraven, V. Höllt, and J. Kraus. 2009. Mechanisms of opioid-mediated inhibition of human T cell receptor signaling. J. Immunol. 183: 882-889.
19. Kraus, J., C. Börner, E. Giannini, and V. Höllt. 2003. The role of nuclear factor kB in tumor necrosis factor-regulated transcription of the human m-opioid receptor gene. Mol. Pharmacol. 64: 876-884.
20. Kraus, J., C. Börner, and V. Höllt. 2003. Distinct palindromic extensions of the 59-TTC. GAA-39 motif allow STAT6 binding in vivo. FASEB J. 17: 304-306.
21. Börner, C., J. Kraus, H. Schröder, H. Ammer, and V. Höllt. 2004. Transcriptional regulation of the human m-opioid receptor gene by interleukin-6. Mol. Pharmacol. 66: 1719-1726.
22. Börner, C., M. Wöltje, V. Höllt, and J. Kraus. 2004. STAT6 transcription factor binding sites with mismatches within the canonical 59-TTC. GAA-39 motif involved in regulation of d- and m-opioid receptors. J. Neurochem. 91: 1493-1500.
23. Börner, C., V. Höllt, and J. Kraus. 2002. Involvement of activator protein-1 in transcriptional regulation of the human mu-opioid receptor gene. Mol. Pharmacol. 61: 800-805.
24. Kraus, J., C. Borner, E. Giannini, K. Hickfang, H. Braun, P. Mayer, M. R. Hoehe, A. Ambrosch, W. Konig, and V. Hollt. 2001. Regulation of m-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276: 43901-43908.
25. Börner, C., M. Smida, V. Höllt, B. Schraven, and J. Kraus. 2009. Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptortriggered signaling. J. Biol. Chem. 284: 35450-35460.
26. Lin, X., Q. Li, Y. J. Wang, Y. W. Ju, Z. Q. Chi, M. W. Wang, and J. G. Liu. 2007. Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kB transcriptional activation in neuroblastoma SH-SY5Y cells. Biochem. J. 406: 215-221.
27. Wang, D., W. Sadée, and J. M. Quillan. 1999. Calmodulin binding to G proteincoupling domain of opioid receptors. J. Biol. Chem. 274: 22081-22088.
28. Börner, C., R. Stumm, V. Höllt, and J. Kraus. 2007. Comparative analysis of m-opioid receptor expression in immune and neuronal cells. J. Neuroimmunol. 188: 56-63.
29. Reyes-Turcu, F. E., K. H. Ventii, and K. D. Wilkinson. 2009. Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu. Rev. Biochem. 78: 363-397.
30. Baker, R. T., X. W. Wang, E. Woollatt, J. A. White, and G. R. Sutherland. 1999. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics 59: 264-274.
31. Schweitzer, K., P. M. Bozko, W. Dubiel, and M. Naumann. 2007. CSN controls NF-κB by deubiquitinylation of IkBa. EMBO J. 26: 1532-1541.
32. Wertz, I. E., K. M. O'Rourke, H. Zhou, M. Eby, L. Aravind, S. Seshagiri, P. Wu, C. Wiesmann, R. Baker, D. L. Boone, et al. 2004. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430: 694-699.
33. Kovalenko, A., C. Chable-Bessia, G. Cantarella, A. Israël, D. Wallach, and G. Courtois. 2003. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424: 801-805.
34. Zhang, J., S. S. Ferguson, L. S. Barak, S. R. Bodduluri, S. A. Laporte, P. Y. Law, and M. G. Caron. 1998. Role for G protein-coupled receptor kinase in agonistspecific regulation of m-opioid receptor responsiveness. Proc. Natl. Acad. Sci. USA 95: 7157-7162.
35. Nandhra, T. S., and R. J. Carson. 2000. beta-endorphin inhibits the production of interleukin-8 by human chorio-decidual cells in culture. Mol. Hum. Reprod. 6: 555-560.
36. Maldonado-Pérez, D., P. Brown, K. Morgan, R. P. Millar, E. A. Thompson, and H. N. Jabbour. 2009. Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway. Biochim. Biophys. Acta 1793: 1315-1324.
37. Mukaida, N., Y. Mahe, and K. Matsushima. 1990. Cooperative interaction of nuclear factor-κB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem. 265: 21128-21133.
38. Mizota, T., H. Tsujikawa, T. Shoda, and K. Fukuda. 2013. Dual modulation of the T-cell receptor-activated signal transduction pathway by morphine in human T lymphocytes. J. Anesth. 27: 80-87.