STAT6 transcription factor binding sites with mismatches within the canonical 5′-TTC...GAA-3′ motif involved in regulation of δ- and μ-opioid receptors

Journal of Neurochemistry

Volumn 91, Issue 6, 2004, Pages 1493-1500

  Börner, Christine ^a   Wöltje, Michael ^a,b   Höllt, Volker ^a   Kraus, Jürgen ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Cytokines; Gene regulation; Transcription factors

Indexed keywords

CYTOKINE; DELTA OPIATE RECEPTOR; DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; OPIATE; RECOMBINANT INTERLEUKIN 4; RECOMBINANT PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR;

ANALGESIA; ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; GENETIC TRANSCRIPTION; GLIOMA CELL; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

AMINO ACID MOTIFS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; INTERLEUKIN-4; LEUKOCYTES; MICE; MOLECULAR SEQUENCE DATA; NEURONS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; RECOMBINANT PROTEINS; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; UP-REGULATION;

ANIMALIA; MURINAE;

EID: 10644229197     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02846.x     Document Type: Article

References (31)

1. Bielinska A., Shivdasani R. A., Zhang L. Q. and Nabel G. J. (1990) Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science 250, 997-1000.
2. Cahill C. M., Morinville A., Hoffert C., O'Donnell D. and Beaudet A. (2003) Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain control. Pain 101, 199-208.
3. Cunha F. Q., Poole S., Lorenzetti B. B., Veiga F. H. and Ferreira S. H. (1999) Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. Br. J. Pharmacol. 126, 45-50.
4. Darnell J. E. Jr (1997) STATs and gene regulation. Science 277, 1630-1635.
5. Decker T. and Meinke A. (1997) Jaks, Stats and the immune system. Immunobiology 198, 99-111.
6. Decker T., Kovarik P. and Meinke A. (1997) GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17, 121-134.
7. Dumon S., Santos S. C., Debierre-Grockiego F., Gouilleux-Gruart V., Cocault L., Boucheron C., Mollat P., Gisselbrecht S. and Gouilleux F. (1999) IL-3 dependent regulation of Bcl-xL gene expression by STATS in a bone marrow derived cell line. Oncogene 18, 4191-4199.
8. Hou J., Schindler U., Henzel W. J., Ho T. C., Brasseur M. and McKnight S. L. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science 265, 1701-1706.
9. Ihle J. N. (2001) The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13, 211-217.
10. Ji R. R., Zhang Q., Law P. Y., Low H. H., Elde R. and Hokfelt T. (1995) Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J. Neurosci. 15, 8156-8166.
11. Kang C. and Inouye M. (1993) One-step insertion of oligonucleotide linkers or adapters to DNA using unphosphorylated oligonucleotides. Biotechniques 15, 659-668.
12. Kraus J., Borner C., Giannini E., Hickfang K., Braun H., Mayer P., Hoehe M. R., Ambrosch A., Konig W. and Hollt V. (2001) Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276, 43 901-43 908.
13. Kraus J., Borner C., Giannini E. and Hollt V. (2003a) The role of nuclear factor kappa b in tumor necrosis factor-regulated transcription of the human μ-opioid receptor gene. Mol. Pharmacol. 64, 876-884.
14. Kraus J., Bomer C. and Hollt V. (2003b) Distinct palindromic extensions of the 5′-TTC...GAA-3′ motif allow STAT6 binding in vivo. Faseb J. 17, 304-306.
15. Lee D. K., Carrasco J., Hidalgo J. and Andrews G. K. (1999) Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem. J. 337, 59-65.
16. Luckow B. and Schutz G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15, 5490.
17. Mikita T., Campbell D., Wu P., Williamson K. and Schindler U. (1996) Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell Biol. 16, 5811-5820.
18. Morishita R., Higaki J., Tomita N. and Ogihara T. (1998) Application of transcription factor 'decoy' strategy as means of gene therapy and study of gene expression in cardiovascular disease. Circ. Res. 82, 1023-1028.
19. Peterson P. K., Molitor T. W. and Chao C. C. (1998) The opioid-cytokine connection. J. Neuroimmunol. 83, 63-69.
20. Pol O. and Puig M. M. (2004) Expression of opioid receptors during peripheral inflammation. Curr. Top. Med. Chem. 4, 51-61.
21. Pol O., Alameda F. and Puig M. M. (2001) Inflammation enhances mu-opioid receptor transcription and expression in mice intestine. Mol. Pharmacol. 60, 894-899.
22. Pol O., Palacio J. R. and Puig M. M. (2003) The Expression of delta- and kappa-Opioid Receptor Is Enhanced during Intestinal Inflammation in Mice. J. Pharmacol. Exp Ther 306, 455-462.
23. Seidel H. M., Milocco L. H., Lamb P., Darnell J. E. Jr, Stein R. B. and Rosen J. (1995) Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl Acad. Sci. USA 92, 3041-3045.
24. Sharp B. M., McKean D. J., McAllen K. and Shahabi N. A. (1998) Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells. Ann. NY Acad. Sci. 840, 420-424.
25. Singh V. K., Bajpai K., Narayan P., Yadav V. S., Dhawan V. C., Haq W., Mathur K. B. and Agarwal S. S. (1999) Delta-opioid receptor antagonist inhibits immunomodulation by Met-enkephalin analogs. Neuroimmunomodulation 6, 355-360.
26. Stein C., Hassan A. H., Przewlocki R., Gramsch C., Peter K. and Herz A. (1990) Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl Acad. Sci. USA 87, 5935-5939.
27. Stein C., Machelska H., Binder W. and Schafer M. (2001) Peripheral opioid analgesia. Curr. Opin. Pharmacol. 1, 62-65.
28. Vannier E., Miller L. C. and Dinarello C. A. (1992) Coordinated anti-inflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc. Natl Acad. Sci. USA 89, 4076-4080.
29. Vidal E. L., Patel N. A., Wu G., Fiala M. and Chang S. L. (1998) Interleukin-1 induces the expression of mu opioid receptors in endothelial cells. Immunopharmacology 38, 261-266.
30. Woltje M., Kraus J. and Hollt V. (2000) Regulation of mouse delta-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2. J. Neurochem. 74, 1355-1362.
31. Zollner C., Shaqura M. A., Bopaiah C. P., Mousa S., Stein C. and Schafer M. (2003) Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol. Pharmacol. 64, 202-210.