Dual modulation of the T-cell receptor-activated signal transduction pathway by morphine in human T lymphocytes

Journal of Anesthesia

Volumn 27, Issue 1, 2013, Pages 80-87

  Mizota, Toshiyuki ^a   Tsujikawa, Hiroshi ^a   Shoda, Takehiro ^a   Fukuda, Kazuhiko ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Erk1 2; Morphine; Nuclear factor B; Opioid induced immunomodulation

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; NALOXONE; PHORBOL 13 ACETATE 12 MYRISTATE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADULT; ANALGESICS, OPIOID; BLOTTING, WESTERN; HUMANS; I-KAPPA B PROTEINS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MORPHINE; NF-KAPPA B; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, OPIOID; RNA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84874108135     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-012-1472-9     Document Type: Article

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