메뉴 건너뛰기




Volumn , Issue , 2010, Pages 311-328

Influence of Hypoxia on Metastatic Spread

Author keywords

Balance between proteinases and their inhibitors perturbed during tumor cell invasion; Eppendorf pO2 histograph, connection between tumor hypoxia and disease progression in human tumors; Hepatocyte growth factor (HGF), cytokine with roles in normal tissue and tumor cell growth signaling through receptor c MET; Hypoxia influence on metastatic spread; Hypoxia regulated genes and role in metastatic progression; Metastasis mechanism, complex array of genetic and epigenetic changes; Metastasis, process by which tumor cells establishing new growths in body distinct from primary tumor; Tissue structure and function, connected and controlled by tumor cell cell and cell extracellular matrix (ECM) interactions; Tumor microenvironment and metastasis; VEGF A, as vascular permeability factor potent inducer of tumor angiogenesis

Indexed keywords


EID: 84886012308     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470669891.ch14     Document Type: Chapter
Times cited : (2)

References (39)
  • 2
    • 44349100383 scopus 로고    scopus 로고
    • Organ selectivity in metastasis: regulation by chemokines and their receptors
    • Ben-Baruch, A. (2007) Organ selectivity in metastasis: regulation by chemokines and their receptors. Clinical and Experimental Metastasis, 25 (4), 45-56.
    • (2007) Clinical and Experimental Metastasis , vol.25 , Issue.4 , pp. 45-56
    • Ben-Baruch, A.1
  • 3
    • 0035479076 scopus 로고    scopus 로고
    • Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
    • Brizel, D.M., Schroeder, T., Scher, R.L. et al. (2001) Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics, 51 (2), 349-353.
    • (2001) International Journal of Radiation Oncology, Biology, Physics , vol.51 , Issue.2 , pp. 349-353
    • Brizel, D.M.1    Schroeder, T.2    Scher, R.L.3
  • 4
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for likelihood of distant metastases in human soft tissue sarcoma
    • Brizel, D.M., Scully, S.P., Harrelson, J.M. et al. (1996) Tumor oxygenation predicts for likelihood of distant metastases in human soft tissue sarcoma. Cancer Research, 56, 941-943.
    • (1996) Cancer Research , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 5
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • Cairns, R.A. and Hill, R.P. (2004) Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Research, 64 (6), 2054-2061.
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 6
    • 0035893396 scopus 로고    scopus 로고
    • Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    • Cairns, R.A., Kalliomaki, T., and Hill, R.P. (2001) Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Research, 61 (24), 8903-8908.
    • (2001) Cancer Research , vol.61 , Issue.24 , pp. 8903-8908
    • Cairns, R.A.1    Kalliomaki, T.2    Hill, R.P.3
  • 7
    • 0141988559 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor invasion and metastasis: an integrated view
    • Cairns, R.A., Khokha, R. and Hill, R.P. (2003) Molecular mechanisms of tumor invasion and metastasis: an integrated view. Current Molecular Medicine, 3 (7), 659-671.
    • (2003) Current Molecular Medicine , vol.3 , Issue.7 , pp. 659-671
    • Cairns, R.A.1    Khokha, R.2    Hill, R.P.3
  • 8
    • 0035399174 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
    • Canning, M.T., Postovit, L.M., Clarke, S.H., and Graham C.H. (2001) Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Experimental Cell Research, 267 (1), 88-94.
    • (2001) Experimental Cell Research , vol.267 , Issue.1 , pp. 88-94
    • Canning, M.T.1    Postovit, L.M.2    Clarke, S.H.3    Graham, C.H.4
  • 9
    • 57349164238 scopus 로고    scopus 로고
    • Redox mechanisms switch on hypoxiadependent epithelial-mesenchymal transition in cancer cells
    • Cannito, S., Novo, E., Compagnone, A. et al. (2008) Redox mechanisms switch on hypoxiadependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis, 29 (12), 2267-2278.
    • (2008) Carcinogenesis , vol.29 , Issue.12 , pp. 2267-2278
    • Cannito, S.1    Novo, E.2    Compagnone, A.3
  • 10
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers, A.F., Groom, A.C., and Macdonald, I.C. (2002) Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer, 2 (8), 563-572.
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 11
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan, D.A. and Giaccia, A.J. (2007) Hypoxia, gene expression, and metastasis. Cancer and Metastasis Reviews, 26 (2), 333-339.
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 12
    • 33646707041 scopus 로고    scopus 로고
    • Effect of antisense hypoxiainducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer
    • Chang, Q., Qin, R., Huang, T., Gao, J., and Feng, Y. (2006) Effect of antisense hypoxiainducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas, 32 (3), 297-305.
    • (2006) Pancreas , vol.32 , Issue.3 , pp. 297-305
    • Chang, Q.1    Qin, R.2    Huang, T.3    Gao, J.4    Feng, Y.5
  • 13
    • 33645735151 scopus 로고    scopus 로고
    • The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha
    • Dayan, F., Roux, D., Brahimi-Horn, M.C., Pouyssegur, J., and Mazure, N.M. (2006) The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Research, 66 (7), 3688-3698.
    • (2006) Cancer Research , vol.66 , Issue.7 , pp. 3688-3698
    • Dayan, F.1    Roux, D.2    Brahimi-Horn, M.C.3    Pouyssegur, J.4    Mazure, N.M.5
  • 14
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxiainduced metastasis
    • Erler, J.T., Bennewith, K.L., Nicolau, M. et al. (2006) Lysyl oxidase is essential for hypoxiainduced metastasis. Nature, 440 (7088), 1222-1226.
    • (2006) Nature , vol.440 , Issue.7088 , pp. 1222-1226
    • Erler, J.T.1    Bennewith, K.L.2    Nicolau, M.3
  • 15
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura, D., Xu, L., Chen, Y., Gohongi, T., Seed, B., and Jain, R.K. (2001) Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Research, 61 (16), 6020-6024.
    • (2001) Cancer Research , vol.61 , Issue.16 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 16
    • 33748150486 scopus 로고    scopus 로고
    • Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    • Fyles, A., Milosevic, M., Pintilie, M. et al. (2006) Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiotherapy and Oncology, 80 (2), 132-137.
    • (2006) Radiotherapy and Oncology , vol.80 , Issue.2 , pp. 132-137
    • Fyles, A.1    Milosevic, M.2    Pintilie, M.3
  • 17
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R.A. and Gillies, R.J. (2004) Why do cancers have high aerobic glycolysis? Nature Reviews Cancer, 4 (11), 891-899.
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 18
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure: an obstacle in cancer therapy
    • Heldin, C.H., Rubin, K., Pietras, K., Ostman, A. (2004) High interstitial fluid pressure: an obstacle in cancer therapy. Nature Reviews Cancer, 4 (10), 806-813.
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 19
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel,M., Schlenger, K., Aral, B.,Mitze, M., Schaffer, U., and Vaupel, P. (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Research, 56, 4509-4515.
    • (1996) Cancer Research , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 20
    • 2642530312 scopus 로고    scopus 로고
    • Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
    • Kalliomaki, T. and Hill, R.P. (2004) Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines. British Journal of Cancer, 90 (9), 1842-1849.
    • (2004) British Journal of Cancer , vol.90 , Issue.9 , pp. 1842-1849
    • Kalliomaki, T.1    Hill, R.P.2
  • 21
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental, K.R., Yu, H., Kass, L. et al. (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell, 139 (5), 891-906.
    • (2009) Cell , vol.139 , Issue.5 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3
  • 22
    • 39549099076 scopus 로고    scopus 로고
    • Interstitial fluid pressure, vascularity andmetastasis in ectopic, orthotopic and spontaneous tumours
    • Lunt, S.J., Kalliomaki, T.M., Brown, A., Yang, V.X., Milosevic, M., and Hill, R.P. (2008) Interstitial fluid pressure, vascularity andmetastasis in ectopic, orthotopic and spontaneous tumours. BMC Cancer, 8 (1), 2.
    • (2008) BMC Cancer , vol.8 , Issue.1 , pp. 2
    • Lunt, S.J.1    Kalliomaki, T.M.2    Brown, A.3    Yang, V.X.4    Milosevic, M.5    Hill, R.P.6
  • 25
    • 0034058373 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation
    • Reshkin, S.J., Bellizzi, A., Albarani, V. et al. (2000) Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation. Journal of Biological Chemistry, 275 (8), 5361-5369.
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.8 , pp. 5361-5369
    • Reshkin, S.J.1    Bellizzi, A.2    Albarani, V.3
  • 26
    • 2942511574 scopus 로고    scopus 로고
    • Role of osteopontin in tumour progression
    • Rittling, S.R. and Chambers, A.F. (2004) Role of osteopontin in tumour progression. British Journal of Cancer, 90 (10), 1877-1881.
    • (2004) British Journal of Cancer , vol.90 , Issue.10 , pp. 1877-1881
    • Rittling, S.R.1    Chambers, A.F.2
  • 27
    • 65549166946 scopus 로고    scopus 로고
    • Bicarbonate increases tumor pH and inhibits spontaneous metastases
    • Robey, I.F., Baggett, B.K., Kirkpatrick, N.D. et al. (2009) Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Research, 69 (6), 2260-2268.
    • (2009) Cancer Research , vol.69 , Issue.6 , pp. 2260-2268
    • Robey, I.F.1    Baggett, B.K.2    Kirkpatrick, N.D.3
  • 28
    • 0034283023 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    • Rofstad, E.K. and Halsor, E.F. (2000) Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Research, 60 (17), 4932-4938.
    • (2000) Cancer Research , vol.60 , Issue.17 , pp. 4932-4938
    • Rofstad, E.K.1    Halsor, E.F.2
  • 29
    • 0037086083 scopus 로고    scopus 로고
    • Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
    • Rofstad, E.K., Rasmussen, H., Galappathi, K., Mathiesen, B., Nilsen, K., and Graff, B.A. (2002a) Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Research, 62 (6), 1847-1853.
    • (2002) Cancer Research , vol.62 , Issue.6 , pp. 1847-1853
    • Rofstad, E.K.1    Rasmussen, H.2    Galappathi, K.3    Mathiesen, B.4    Nilsen, K.5    Graff, B.A.6
  • 30
    • 0036468521 scopus 로고    scopus 로고
    • Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
    • Rofstad, E.K., Tunheim, S.H., Mathiesen, B. et al. (2002b) Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts. Cancer Research, 62 (3), 661-664.
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 661-664
    • Rofstad, E.K.1    Tunheim, S.H.2    Mathiesen, B.3
  • 31
    • 33746149756 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    • Rofstad, E.K., Mathiesen, B., Kindem, K., and Galappathi, K. (2006) Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Research, 66 (13), 6699-6707.
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6699-6707
    • Rofstad, E.K.1    Mathiesen, B.2    Kindem, K.3    Galappathi, K.4
  • 33
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells
    • Schlappack, O.K., Zimmermann, A., Hill, R.P. (1991) Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. British Journal of Cancer, 64 (4), 663-670.
    • (1991) British Journal of Cancer , vol.64 , Issue.4 , pp. 663-670
    • Schlappack, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 34
    • 42449120630 scopus 로고    scopus 로고
    • Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells
    • Subarsky, P. and Hill, R.P. (2008) Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells. Clinical and Experimental Metastasis.
    • (2008) Clinical and Experimental Metastasis.
    • Subarsky, P.1    Hill, R.P.2
  • 35
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan, R. and Graham, C.H. (2007) Hypoxia-driven selection of the metastatic phenotype. Cancer and Metastasis Reviews, 26 (2), 319-331.
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 36
    • 0035501326 scopus 로고    scopus 로고
    • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model
    • Walenta, S., Snyder, S., Haroon, Z.A. (2001) Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. International Journal of Radiation Oncology, Biology, Physics, 51 (3), 840-848.
    • (2001) International Journal of Radiation Oncology, Biology, Physics , vol.51 , Issue.3 , pp. 840-848
    • Walenta, S.1    Snyder, S.2    Haroon, Z.A.3
  • 37
    • 49049110677 scopus 로고    scopus 로고
    • Integrins and the activation of latent transforming growth factor beta1-an intimate relationship
    • Wipff, P.J. and Hinz, B. (2008) Integrins and the activation of latent transforming growth factor beta1-an intimate relationship. European Journal of Cell Biology, 87 (8-9), 601-615.
    • (2008) European Journal of Cell Biology , vol.87 , Issue.8-9 , pp. 601-615
    • Wipff, P.J.1    Hinz, B.2
  • 38
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang, M.H., Wu, M.Z., Chiou, S.H. et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nature Cell Biology, 10 (3), 295-305.
    • (2008) Nature Cell Biology , vol.10 , Issue.3 , pp. 295-305
    • Yang, M.H.1    Wu, M.Z.2    Chiou, S.H.3
  • 39
    • 34548011229 scopus 로고    scopus 로고
    • Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion
    • Zhang, L. and Hill, R.P. (2007) Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. Cancer Research, 67 (16), 7789-7797.
    • (2007) Cancer Research , vol.67 , Issue.16 , pp. 7789-7797
    • Zhang, L.1    Hill, R.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.