Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress

Molecular Pharmacology

Volumn 84, Issue 5, 2013, Pages 751-762

  Schrock, Joel M ^b   Spino, Christina M ^a   Longen, Charles G ^a   Stabler, Stacy M ^b   Marino, Jacqueline C ^b   Pasternak, Gavril W ^b   Kim, Felix J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ( 4 IODOPHENYL) 3 ( 2 ADAMANTYL)GUANIDINE; 1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; ACTIVATING TRANSCRIPTION FACTOR 4; AUTOPHAGY PROTEIN 5; BECLIN 1; GUANIDINE DERIVATIVE; HALOPERIDOL; INOSITOL; INOSITOL REQUIRING ENZYME 1ALPHA; N ALLYLNORMETAZOCINE; PENTAZOCINE; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CYTOPROTECTION; ENDOPLASMIC RETICULUM STRESS; HUMANS; LIGANDS; PHAGOSOMES; RECEPTORS, SIGMA; RNA, SMALL INTERFERING; UNFOLDED PROTEIN RESPONSE;

EID: 84886004810     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.087809     Document Type: Article

References (53)

1. ydar E, Onganer P, Perrett R, Djamgoz MB, and Palmer CP (2006) The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell lines. Cancer Lett 242:245-257. (Pubitemid 44488625)
2. Aydar E, Palmer CP, Klyachko VA, and Jackson MB (2002) The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34:399-410. (Pubitemid 34465498)
3. Bernales S, McDonald KL, and Walter P (2006) Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4:e423.
4. Bernales S, Schuck S, and Walter P (2007) ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy 3:285-287. (Pubitemid 46752700)
5. Berthois Y, Bourrié B, Galiègue S, Vidal H, Carayon P, Martin PM, and Casellas P (2003) SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. Br J Cancer 88:438-446. (Pubitemid 36308157)
6. Brent PJ, Pang G, Little G, Dosen PJ, and Van Helden DF (1996) The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+]i in colon and mammary adenocarcinoma cells. Biochem Biophys Res Commun 219:219-226.
7. Brimson JM, Brown CA, and Safrany ST (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol 164(2b):772-780.
8. Crawford KW and Bowen WD (2002) Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 62:313-322. (Pubitemid 34074021)
9. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, and Fan Y et al. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10:51-64.
10. Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, and Glossmann H (1996) Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA 93:8072-8077. (Pubitemid 26277167)
11. Hayashi T and Su TP (2007) Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca (2+) signaling and cell survival. Cell 131:596-610. (Pubitemid 350017760)
12. Hayashi T and Su TP (2008) An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand. Expert Opin Ther Targets 12:45-58. (Pubitemid 351247161)
13. He C and Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67-93.
14. Hippert MM, O'Toole PS, and Thorburn A (2006) Autophagy in cancer: good, bad, or both? Cancer Res 66:9349-9351.
15. Hosokawa N, Hara Y, and Mizushima N (2006) Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 580:2623-2629.
16. Høyer-Hansen M and Jäättelä M (2007) Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14:1576-1582. (Pubitemid 47278843)
17. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, and Weissman JS et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323:1693-1697.
18. Kim FJ, Schrock JM, Spino CM, Marino JC, and Pasternak GW (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426:177-182.
19. Kim I, Xu W, and Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7:1013-1030.
20. Kimes AS, Wilson AA, Scheffel U, Campbell BG, and London ED (1992) Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3- (1-adamantyl) guanidine, a ligand for sigma binding sites. J Med Chem 35:4683-4689. (Pubitemid 23033718)
21. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, and Ballabio A et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175. (Pubitemid 351231180)
22. Kuma A, Matsui M, and Mizushima N (2007) LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy 3:323-328. (Pubitemid 46986336)
23. Levine B and Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477. (Pubitemid 38456176)
24. Levine B and Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27-42.
25. Marciniak SJ and Ron D (2006) Endoplasmic reticulum stress signaling in disease. Physiol Rev 86:1133-1149. (Pubitemid 44521649)
26. Martin WR, Eades CG, Thompson JA, Huppler RE, and Gilbert PE (1976) The effects of morphine- and nalorphine-like drugs in the nondependent and morphinedependent chronic spinal dog. J Pharmacol Exp Ther 197:517-532.
27. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, and Gelinas C et al. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137:1062-1075.
28. Mégalizzi V, Decaestecker C, Debeir O, Spiegl-Kreinecker S, Berger W, Lefranc F, Kast RE, and Kiss R (2009) Screening of anti-glioma effects induced by sigma-1 receptor ligands: potential new use for old anti-psychiatric medicines. Eur J Cancer 45:2893-2905.
29. Mégalizzi V, Mathieu V, Mijatovic T, Gailly P, Debeir O, De Neve N, Van Damme M, Bontempi G, Haibe-Kains B, and Decaestecker C et al. (2007) 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia 9:358-369. (Pubitemid 46799979)
30. Mizushima N, Levine B, Cuervo AM, and Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075. (Pubitemid 351317450)
31. Mizushima N and Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542-545. (Pubitemid 350060049)
32. Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, 3rd, Segatori L, and Kelly JW (2008) Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 134:769-781.
33. Narayanan S, Bhat R, Mesangeau C, Poupaert JH, and McCurdy CR (2011) Early development of sigma-receptor ligands. Future Med Chem 3:79-94.
34. Ni M and Lee AS (2007) ER chaperones in mammalian development and human diseases. FEBS Lett 581:3641-3651. (Pubitemid 47082516)
35. Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, and Yoshinaga K et al. (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220-9231. (Pubitemid 44904418)
36. Piergentili A, Amantini C, Del Bello F, Giannella M, Mattioli L, Palmery M, Perfumi M, Pigini M, Santoni G, and Tucci P et al. (2010) Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem 53:1261-1269.
37. Ron D and Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529. (Pubitemid 46985379)
38. Rubinsztein DC, Gestwicki JE, Murphy LO, and Klionsky DJ (2007) Potential therapeutic applications of autophagy. Nat Rev Drug Discov 6:304-312. (Pubitemid 46505881)
39. Ryan-Moro J, Chien CC, Standifer KM, and Pasternak GW (1996) Sigma binding in a human neuroblastoma cell line. Neurochem Res 21:1309-1314. (Pubitemid 26397061)
40. Schröder M and Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74:739-789. (Pubitemid 40995523)
41. Scott RC, Juhász G, and Neufeld TP (2007) Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 17:1-11. (Pubitemid 46027564)
42. Solimini NL, Luo J, and Elledge SJ (2007) Non-oncogene addiction and the stress phenotype of cancer cells. Cell 130:986-988. (Pubitemid 47422308)
43. Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, and Murray K et al. (2004) Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res 64:4875-4886. (Pubitemid 38924532)
44. Su TP, Hayashi T, Maurice T, Buch S, and Ruoho AE (2010) The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci 31:557-566.
45. Szegezdi E, Logue SE, Gorman AM, and Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880-885. (Pubitemid 44523966)
46. Trainor GL (2007) The importance of plasma protein binding in drug discovery. Expert Opin Drug Discov 2:51-64. (Pubitemid 47078697)
47. Vilner BJ, De Costa BR, and Bowen WD (1995a) Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability. J Neurosci 15:117-134.
48. Vilner BJ, John CS, and Bowen WD (1995b) Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Res 55:408-413.
49. Webber JL and Tooze SA (2010) Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. EMBO J 29:27-40.
50. Wolozin BL, Nishimura S, and Pasternak GW (1982) The binding of kappa- and sigma-opiates in rat brain. J Neurosci 2:708-713. (Pubitemid 12064605)
51. Xu C, Bailly-Maitre B, and Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656-2664. (Pubitemid 41434389)
52. Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, and Vangveravong S et al. (2011) Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2:380.
53. Yorimitsu T, Nair U, Yang Z, and Klionsky DJ (2006) Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281:30299-30304. (Pubitemid 44537037)