Novel highly potent and selective σ1 receptor antagonists related to spipethiane

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1261-1269

  Piergentili, Alessandro ^a   Amantini, Consuelo ^a   Del Bello, Fabio ^a   Giannella, Mario ^a   Mattioli, Laura ^a   Palmery, Maura ^b   Perfumi, Marina ^a   Pigini, Maria ^a   Santoni, Giorgio ^a   Tucci, Paolo ^c   Zotti, Margherita ^c   Quaglia, Wilma ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF FOGGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 4 (1 BENZOPYRAN 4 ONE 2 YL)PYRIDINIUM BROMIDE; 1' BENZOYL SPIRO[4H 1,3 BENZODIOXIN 2,4' PIPERIDINE]; 1' BENZOYL SPIRO[4H 3,1 BENZOXATHIIN 2,4' PIPERIDINE]; 1' BENZYL 1,2,3,4 TETRAHYDROSPIRO[NAPHTHALENE 2,4' PIPERIDINE]OXALATE; 1' BENZYL SPIRO[4H 1,3 BENZODIOXIN 2,4' PIPERIDINE]OXALATE; 1' BENZYL SPIRO[4H 3,1 BENZOXATHIIN 2,4' PIPERIDINE]OXALATE; 2 (1 BENZYL PIPERIDIN 4 YL) 1 BENZOPYRAN 4 ONE OXALATE; 2 (1 BENZYL PIPERIDIN 4 YL) 1 BENZOTHIOPYRAN 4 ONE OXALATE; 2 (1 PHENETHYL PIPERIDIN 4 YL) 1 BENZOPYRAN 4 ONE OXALATE; 4 1 BENZOTHIOPYRAN 2 YL 1 BENZYL PIPERIDINE OXALATE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; CYTOSTATIC AGENT; MORPHINE; OPIATE ANTAGONIST; SIGMA 1 OPIATE RECEPTOR; SPIPETHIANE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; ATOM; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL STRAIN MCF 7; CHEMICAL MODIFICATION; CYTOSTASIS; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; MALE; MOLECULE; MOUSE; NONHUMAN; RAT;

ANALGESICS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING, COMPETITIVE; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CEREBRAL CORTEX; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GUINEA PIGS; HUMANS; ILEUM; JURKAT CELLS; MALE; MICE; MOLECULAR STRUCTURE; PAIN MEASUREMENT; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249149392     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901542q     Document Type: Article

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