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Volumn , Issue , 2010, Pages 517-556

(Q)SAR Analysis of Genotoxic and Nongenotoxic Carcinogens: A State - of - the - Art Overview

Author keywords

(Q)SAR analysis and modeling and (Q)SAR in cancer hazard risk assessment; (Q)SAR analysis of genotoxic and nongenotoxic carcinogens state of the art overview; Methods for informing cancer risk quantification

Indexed keywords


EID: 84886000890     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470622728.ch20     Document Type: Chapter
Times cited : (10)

References (123)
  • 2
    • 0345280812 scopus 로고    scopus 로고
    • Infl uence of the surfactant concentration on the body distribution of nanoparticles
    • Araujo , L. , Lobenberg , R. , and Kreuter , J. ( 1999 ). Infl uence of the surfactant concentration on the body distribution of nanoparticles . J Drug Target 6 , 373 - 385 .
    • (1999) J Drug Target , vol.6 , pp. 373-385
    • Araujo, L.1    Lobenberg, R.2    Kreuter, J.3
  • 4
    • 0024352294 scopus 로고
    • Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fi bers
    • Barrett , J. C. , Lamb , P. W. , and Wiseman , R. W. ( 1989 ). Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fi bers . Environ Health Perspect 81 , 81 - 89 .
    • (1989) Environ Health Perspect , vol.81 , pp. 81-89
    • Barrett, J.C.1    Lamb, P.W.2    Wiseman, R.W.3
  • 6
    • 20044383057 scopus 로고    scopus 로고
    • Structure - activity relationship studies of chemical mutagens and carcinogens: mechanistic investigations and prediction approaches
    • Benigni , R. ( 2005 ). Structure - activity relationship studies of chemical mutagens and carcinogens: mechanistic investigations and prediction approaches . Chem Rev 105 , 1767 - 1800 .
    • (2005) Chem Rev , vol.105 , pp. 1767-1800
    • Benigni, R.1
  • 7
    • 49849084348 scopus 로고    scopus 로고
    • Structure alerts for carcinogenicity, and the Salmonella assay system: A novel insight through the chemical relational databases technology
    • Benigni , R. , and Bossa , C. ( 2008 ). Structure alerts for carcinogenicity, and the Salmonella assay system: A novel insight through the chemical relational databases technology . Mutat Res 659 , 248 - 261 .
    • (2008) Mutat Res , vol.659 , pp. 248-261
    • Benigni, R.1    Bossa, C.2
  • 9
    • 0347052775 scopus 로고    scopus 로고
    • The second National Toxicology Program comparative exercise on the prediction of rodent carcinogenicity: Defi nitive results
    • Benigni , R. , and Zito , R. ( 2004 ). The second National Toxicology Program comparative exercise on the prediction of rodent carcinogenicity: Defi nitive results . Mutat Res 566 , 49 - 63 .
    • (2004) Mutat Res , vol.566 , pp. 49-63
    • Benigni, R.1    Zito, R.2
  • 10
    • 0027763648 scopus 로고
    • Hepatic peroxisome proliferation in rodents and its signifi cance for humans
    • Bentley , P. , Calder , I. , Elcombe , C. , Grasso , P. , Stringer , D. , and Wiegand , H. J. ( 1993 ). Hepatic peroxisome proliferation in rodents and its signifi cance for humans . Food Chem Toxicol 31 , 857 - 907 .
    • (1993) Food Chem Toxicol , vol.31 , pp. 857-907
    • Bentley, P.1    Calder, I.2    Elcombe, C.3    Grasso, P.4    Stringer, D.5    Wiegand, H.J.6
  • 12
    • 34547925585 scopus 로고    scopus 로고
    • Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages
    • Blake , D. J. , Bolin , C. M. , Cox , D. P. , Cardozo-Pelaez , F. , and Pfau , J. C. ( 2007 ). Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages . Toxicol Sci 99 , 277 - 288 .
    • (2007) Toxicol Sci , vol.99 , pp. 277-288
    • Blake, D.J.1    Bolin, C.M.2    Cox, D.P.3    Cardozo-Pelaez, F.4    Pfau, J.C.5
  • 14
    • 0022450859 scopus 로고
    • Studies on surface properties of asbestos. I. Active sites on surface of chrysotile and amphiboles
    • Bonneau , L. , Suquet , H. , Malard , C. , and Pezerat , H. ( 1986b ). Studies on surface properties of asbestos. I. Active sites on surface of chrysotile and amphiboles . Environ Res 41 , 251 - 267 .
    • (1986) Environ Res , vol.41 , pp. 251-267
    • Bonneau, L.1    Suquet, H.2    Malard, C.3    Pezerat, H.4
  • 15
    • 0025967574 scopus 로고
    • Characteristics of chemical binding to alpha 2u-globulin in vitro - Evaluating structure-activity - relationships
    • Borghoff , S. J. , Miller , A. B. , Bowen , J. P. , and Swenberg , J. A. ( 1991 ). Characteristics of chemical binding to alpha 2u-globulin in vitro - Evaluating structure-activity - relationships . Toxicol Appl Pharmacol 107 , 228 - 238 .
    • (1991) Toxicol Appl Pharmacol , vol.107 , pp. 228-238
    • Borghoff, S.J.1    Miller, A.B.2    Bowen, J.P.3    Swenberg, J.A.4
  • 16
    • 0007573980 scopus 로고    scopus 로고
    • Analyzing the genes and peptide growth factors expressed in lung cells in vivo consequent to asbestos exposure and in vitro
    • Brody , A. R. , Liu , J. Y. , Brass , D. , and Corti , M. ( 1997 ). Analyzing the genes and peptide growth factors expressed in lung cells in vivo consequent to asbestos exposure and in vitro . Environ Health Perspect 105 ( Suppl 5 ), 1165 - 1171 .
    • (1997) Environ Health Perspect 105 Suppl , vol.5 , pp. 1165-1171
    • Brody, A.R.1    Liu, J.Y.2    Brass, D.3    Corti, M.4
  • 17
    • 1642500474 scopus 로고    scopus 로고
    • Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafi ne particles
    • Brown , D. M. , Donaldson , K. , Borm , P. J. , Schins , R. P. , Dehnhardt , M. , Gilmour , P. , Jimenez , L. A. , and Stone , V. ( 2004 ). Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafi ne particles . Am J Physiol Lung Cell Mol Physiol 286 , L344 - L353 .
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Brown, D.M.1    Donaldson, K.2    Borm, P.J.3    Schins, R.P.4    Dehnhardt, M.5    Gilmour, P.6    Jimenez, L.A.7    Stone, V.8
  • 18
    • 0035884016 scopus 로고    scopus 로고
    • Size-dependent proinfl ammatory effects of ultrafi ne polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafi nes
    • Brown , D. M. , Wilson , M. R. , MacNee , W. , Stone , V. , and Donaldson , K. ( 2001 ). Size-dependent proinfl ammatory effects of ultrafi ne polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafi nes . Toxicol Appl Pharmacol 175 , 191 - 199 .
    • (2001) Toxicol Appl Pharmacol , vol.175 , pp. 191-199
    • Brown, D.M.1    Wilson, M.R.2    MacNee, W.3    Stone, V.4    Donaldson, K.5
  • 20
    • 0034872044 scopus 로고    scopus 로고
    • Infl ammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates
    • Clouter , A. , Brown, D. , Hohr , D. , Borm, P. , and Donaldson, K. ( 2001). Infl ammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates . Toxicol Sci 63 , 90 - 98 .
    • (2001) Toxicol Sci , vol.63 , pp. 90-98
    • Clouter, A.1    Brown, D.2    Hohr, D.3    Borm, P.4    Donaldson, K.5
  • 22
  • 24
    • 0023822485 scopus 로고
    • Comparisons of the pathogenicity of long and short fi bres of chrysotile asbestos in rats
    • Davis , J. M. , and Jones , A. D. ( 1988 ). Comparisons of the pathogenicity of long and short fi bres of chrysotile asbestos in rats . Br J Exp Pathol 69 , 717 - 737 .
    • (1988) Br J Exp Pathol , vol.69 , pp. 717-737
    • Davis, J.M.1    Jones, A.D.2
  • 26
    • 0842287342 scopus 로고    scopus 로고
    • Probing the cytotoxicity of semiconductor quantum dots
    • Derfus , A. M. , Chan , W. C. W. , and Bhatia , S. N. ( 2004 ). Probing the cytotoxicity of semiconductor quantum dots . Nano Lett 4 , 11 - 18 .
    • (2004) Nano Lett , vol.4 , pp. 11-18
    • Derfus, A.M.1    Chan, W.C.W.2    Bhatia, S.N.3
  • 27
    • 33845620001 scopus 로고    scopus 로고
    • The ToxCast program for prioritizing toxicity testing of environmental chemicals
    • Dix , D. J. , Houck , K. A. , Martin , M. T. , Richard , A. M. , Setzer , R. W. , and Kavlock , R. J. ( 2007 ). The ToxCast program for prioritizing toxicity testing of environmental chemicals . Toxicol Sci 95 , 5 - 12 .
    • (2007) Toxicol Sci , vol.95 , pp. 5-12
    • Dix, D.J.1    Houck, K.A.2    Martin, M.T.3    Richard, A.M.4    Setzer, R.W.5    Kavlock, R.J.6
  • 28
    • 0028845460 scopus 로고
    • Effect of long and short fi bre amosite asbestos on in vitro TNF production by rat alveolar macrophages: The modifying effect of lipopolysaccharide
    • Dogra , S. , and Donaldson , K. ( 1995 ). Effect of long and short fi bre amosite asbestos on in vitro TNF production by rat alveolar macrophages: The modifying effect of lipopolysaccharide . Ind Health 33 , 131 - 141 .
    • (1995) Ind Health , vol.33 , pp. 131-141
    • Dogra, S.1    Donaldson, K.2
  • 29
    • 33745597580 scopus 로고    scopus 로고
    • Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety
    • Donaldson , K. , Aitken , R. , Tran , L. , Stone , V. , Duffin , R. , Forrest , G. , and Alexander , A. ( 2006 ). Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety . Toxicol Sci 92 , 5 - 22 .
    • (2006) Toxicol Sci , vol.92 , pp. 5-22
    • Donaldson, K.1    Aitken, R.2    Tran, L.3    Stone, V.4    Duffin, R.5    Forrest, G.6    Alexander, A.7
  • 30
    • 0030916112 scopus 로고    scopus 로고
    • Induction of micronuclei, hyperdiploidy and chromosomal breakage affecting the centric/pericentric regions of chromosomes 1 and 9 in human amniotic fl uid cells after treatment with asbestos and ceramic fi bers
    • Dopp , E. , Schuler , M. , Schiffmann , D. , and Eastmond , D. A. ( 1997 ). Induction of micronuclei, hyperdiploidy and chromosomal breakage affecting the centric/pericentric regions of chromosomes 1 and 9 in human amniotic fl uid cells after treatment with asbestos and ceramic fi bers . Mutat Res 377 , 77 - 87 .
    • (1997) Mutat Res , vol.377 , pp. 77-87
    • Dopp, E.1    Schuler, M.2    Schiffmann, D.3    Eastmond, D.A.4
  • 32
    • 84928945540 scopus 로고    scopus 로고
    • The importance of surface area and specifi c reactivity in the acute pulmonary infl ammatory response to particles
    • Duffin, R. , Tran , C. L. , Clouter , A. , Brown , D. M. , MacNee , W. , Stone , V. , and Donaldson , K. ( 2002 ). The importance of surface area and specifi c reactivity in the acute pulmonary infl ammatory response to particles . Ann Occup Hyg 46 , 242 - 245 .
    • (2002) Ann Occup Hyg , vol.46 , pp. 242-245
    • Duffin, R.1    Tran, C.L.2    Clouter, A.3    Brown, D.M.4    MacNee, W.5    Stone, V.6    Donaldson, K.7
  • 33
    • 61449164867 scopus 로고    scopus 로고
    • Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
    • Ellinger-Ziegelbauer , H. , Aubrecht , J. , Kleinjans , J. C. , and Ahr , H. J. ( 2009 ). Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity . Toxicol Lett 186 , 36 - 44 .
    • (2009) Toxicol Lett , vol.186 , pp. 36-44
    • Ellinger-Ziegelbauer, H.1    Aubrecht, J.2    Kleinjans, J.C.3    Ahr, H.J.4
  • 34
    • 37149025669 scopus 로고    scopus 로고
    • Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies
    • Ellinger-Ziegelbauer , H. , Gmuender , H. , Bandenburg , A. , and Ahr , H. J. ( 2008 ). Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies . Mutat Res 637 , 23 - 39 .
    • (2008) Mutat Res , vol.637 , pp. 23-39
    • Ellinger-Ziegelbauer, H.1    Gmuender, H.2    Bandenburg, A.3    Ahr, H.J.4
  • 38
    • 0031216476 scopus 로고    scopus 로고
    • Surface reactivity in the pathogenic response to particulates
    • Fubini , B. ( 1997 ). Surface reactivity in the pathogenic response to particulates . Environ Health Perspect 105 ( Suppl 5 ), 1013 - 1020 .
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL 5 , pp. 1013-1020
    • Fubini, B.1
  • 39
    • 40049088000 scopus 로고    scopus 로고
    • PPARalpha: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
    • Gonzalez , F. J. , and Shah , Y. M. ( 2008 ). PPARalpha: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators . Toxicology 246 , 2 - 8 .
    • (2008) Toxicology , vol.246 , pp. 2-8
    • Gonzalez, F.J.1    Shah, Y.M.2
  • 40
    • 0025163754 scopus 로고
    • Cytotoxicity of long and short crocidolite asbestos fi bers in vitro and in vivo
    • Goodglick , L. A. , and Kane , A. B. ( 1990 ). Cytotoxicity of long and short crocidolite asbestos fi bers in vitro and in vivo . Cancer Res 50 , 5153 - 5163 .
    • (1990) Cancer Res , vol.50 , pp. 5153-5163
    • Goodglick, L.A.1    Kane, A.B.2
  • 41
    • 3242775472 scopus 로고    scopus 로고
    • Toxicity of gold nanoparticles functionalized with cationic and anionic side chains
    • Goodman , C. M. , McCusker , C. D. , Yilmaz , T. , and Rotello , V. M. ( 2004 ). Toxicity of gold nanoparticles functionalized with cationic and anionic side chains . Bioconjug Chem 15 , 897 - 900 .
    • (2004) Bioconjug Chem , vol.15 , pp. 897-900
    • Goodman, C.M.1    McCusker, C.D.2    Yilmaz, T.3    Rotello, V.M.4
  • 43
    • 84907035692 scopus 로고
    • Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide
    • Heinrich , U. , Fuhst , R. , Rittinghausen , S. , Creutzenberg , O. , Bellmann , B. , Koch , W. , and Levsen , K. ( 1995 ). Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide . Inhal Toxicol 7 , 533 - 556 .
    • (1995) Inhal Toxicol , vol.7 , pp. 533-556
    • Heinrich, U.1    Fuhst, R.2    Rittinghausen, S.3    Creutzenberg, O.4    Bellmann, B.5    Koch, W.6    Levsen, K.7
  • 44
    • 8344269524 scopus 로고    scopus 로고
    • Data mining and knowledge discovery in predictive toxicology
    • Helma , C. ( 2004 ). Data mining and knowledge discovery in predictive toxicology . SAR QSAR Environ Res 15 , 367 - 383 .
    • (2004) SAR QSAR Environ Res , vol.15 , pp. 367-383
    • Helma, C.1
  • 45
    • 33845808673 scopus 로고    scopus 로고
    • Transcriptional profi les in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil
    • Hester , S. D. , Wolf , D. C. , Nesnow , S. , and Thai , S. F. ( 2006 ). Transcriptional profi les in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil . Toxicol Pathol 34 , 879 - 894 .
    • (2006) Toxicol Pathol , vol.34 , pp. 879-894
    • Hester, S.D.1    Wolf, D.C.2    Nesnow, S.3    Thai, S.F.4
  • 46
    • 0032210689 scopus 로고    scopus 로고
    • The importance of fi ber biopersistence and lung dose in determining the chronic inhalation effects of X607, RCF1, and chrysotile asbestos in rats
    • Hesterberg , T. W. , Hart , G. A. , Chevalier , J. , Miiller , W. C. , Hamilton , R. D. , Bauer , J. , and Thevenaz , P. ( 1998 ). The importance of fi ber biopersistence and lung dose in determining the chronic inhalation effects of X607, RCF1, and chrysotile asbestos in rats . Toxicol Appl Pharmacol 153 , 68 - 82 .
    • (1998) Toxicol Appl Pharmacol , vol.153 , pp. 68-82
    • Hesterberg, T.W.1    Hart, G.A.2    Chevalier, J.3    Miiller, W.C.4    Hamilton, R.D.5    Bauer, J.6    Thevenaz, P.7
  • 48
    • 84886019098 scopus 로고
    • IARC, Overall evaluation of carcinogenicity . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . International Agency for Research on Cancer, Suppl. 7 . Lyon, France
    • IARC ( 1987 ). Overall evaluation of carcinogenicity . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . International Agency for Research on Cancer, Suppl. 7 . Lyon, France .
    • (1987)
  • 49
    • 84885972705 scopus 로고
    • Peroxisome proliferation and its role in carcinogenesis: Views and expert opinions of an IARC working group, 1994.
    • IARC , Lyon, 7 - 11 December
    • IARC ( 1994 ). Peroxisome proliferation and its role in carcinogenesis: Views and expert opinions of an IARC working group, Lyon, 7 - 11 December 1994. IARC Technical Publication No. 24 , http://monographs.iarc.fr/ENG/Publications/techrep24/IARCrep24.pdf .
    • (1994) IARC Technical Publication No. 24
  • 50
    • 84886049168 scopus 로고    scopus 로고
    • Mechanisms of fi bre carcinogenesis
    • IARC
    • IARC ( 1996 ). Mechanisms of fi bre carcinogenesis . IARC Scientifi c Publications 140 , 1 - 135 .
    • (1996) IARC Scientifi c Publications , vol.140 , pp. 1-135
  • 51
    • 0003322578 scopus 로고    scopus 로고
    • Silica, Some Silicates, Coal Dust and para-Aramid Fibrils
    • IARC
    • IARC ( 1997 ). Silica, Some Silicates, Coal Dust and para-Aramid Fibrils . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 68 , http://monographs.iarc.fr/ENG/Monographs/vol68/index.php .
    • (1997) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.68
  • 52
    • 0008848732 scopus 로고    scopus 로고
    • Species differences in thyroid, kidney and urinary bladder carcinogenesis
    • IARC
    • IARC ( 1999a ). Species differences in thyroid, kidney and urinary bladder carcinogenesis . IARC Sci Pub 147 , 1 - 225 .
    • (1999) IARC Sci Pub , vol.147 , pp. 1-225
  • 53
    • 0041986371 scopus 로고    scopus 로고
    • Surgical implants and other foreign bodies
    • IARC
    • IARC ( 1999b ). Surgical implants and other foreign bodies . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 74 , http://monographs.iarc.fr/ENG/Monographs/vol74/index.php .
    • (1999) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.74
  • 54
    • 84885966583 scopus 로고    scopus 로고
    • Man-made vitreous fi bers . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
    • IARC, Lyon, France.
    • IARC ( 2002 ). Man-made vitreous fi bers . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . International Agency for Research on Cancer 81 , Lyon, France.
    • (2002) International Agency for Research on Cancer 81
  • 55
    • 0003415155 scopus 로고    scopus 로고
    • Carbon black . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
    • IARC, .
    • IARC ( 2006 ). Carbon black . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . International Agency for Research on Cancer 93 , Lyon, France. http://monographs.iarc.fr/ENG/Meetings/93-carbonblack.pdf .
    • (2006) International Agency for Research on Cancer 93
  • 56
    • 0343446141 scopus 로고    scopus 로고
    • The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report
    • ILSI
    • ILSI ( 2000 ). The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report. ILSI Risk Science Institute Workshop Participants . Inhal Toxicol 12 , 1 - 17.
    • (2000) ILSI Risk Science Institute Workshop Participants . Inhal Toxicol , vol.12 , pp. 1-17
  • 58
    • 0031217594 scopus 로고    scopus 로고
    • Mechanisms of fi ber-induced genotoxicity
    • Jaurand , M. C. ( 1997 ). Mechanisms of fi ber-induced genotoxicity . Environ Health Perspect 105 ( Suppl 5 ), 1073 - 1084 .
    • (1997) Environ Health Perspect 105 ( Suppl , vol.5 , pp. 1073-1084
    • Jaurand, M.C.1
  • 64
    • 3042517028 scopus 로고    scopus 로고
    • Rodent carcinogenicity of peroxisome proliferators and issues on human relevance
    • Lai , D. Y. ( 2004 ). Rodent carcinogenicity of peroxisome proliferators and issues on human relevance . J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 22 , 37 - 55 .
    • (2004) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev , vol.22 , pp. 37-55
    • Lai, D.Y.1
  • 68
    • 1542726626 scopus 로고    scopus 로고
    • Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    • Lam , C. W. , James , J. T. , McCluskey , R. , and Hunter , R. L. ( 2004 ). Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation . Toxicol Sci 77 , 126 - 134 .
    • (2004) Toxicol Sci , vol.77 , pp. 126-134
    • Lam, C.W.1    James, J.T.2    McCluskey, R.3    Hunter, R.L.4
  • 70
    • 0003411354 scopus 로고
    • Chemistry and Biology of N-Nitroso Compounds
    • Cambridge University Press , Cambridge
    • Lijinsky , W. ( 1992 ). Chemistry and Biology of N-Nitroso Compounds , Cambridge University Press , Cambridge .
    • (1992)
    • Lijinsky, W.1
  • 72
    • 34447534415 scopus 로고    scopus 로고
    • Toxicogenomic study of triazole fungicides and perfl uoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity
    • Martin , M. T. , Brennan , R. J. , Hu , W. , Ayanoglu , E. , Lau , C. , Ren , H. , Wood , C. R. , Corton , J. C. , Kavlock , R. J. , and Dix , D. J. ( 2007 ). Toxicogenomic study of triazole fungicides and perfl uoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity . Toxicol Sci 97 , 595 - 613 .
    • (2007) Toxicol Sci , vol.97 , pp. 595-613
    • Martin, M.T.1    Brennan, R.J.2    Hu, W.3    Ayanoglu, E.4    Lau, C.5    Ren, H.6    Wood, C.R.7    Corton, J.C.8    Kavlock, R.J.9    Dix, D.J.10
  • 73
    • 64049119418 scopus 로고    scopus 로고
    • Profi ling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database
    • Martin , M. T. , Judson , R. S. , Reif , D. M. , Kavlock , R. J. , and Dix , D. J. ( 2009 ). Profi ling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database . Environ Health Perspect 117 , 392 - 399 .
    • (2009) Environ Health Perspect , vol.117 , pp. 392-399
    • Martin, M.T.1    Judson, R.S.2    Reif, D.M.3    Kavlock, R.J.4    Dix, D.J.5
  • 75
    • 37449006161 scopus 로고    scopus 로고
    • Structure - activity relationship analysis tools: Validation and applicability in predicting carcinogens
    • Mayer , J. , Cheeseman , M. A. , and Twaroski , M. L. ( 2008 ). Structure - activity relationship analysis tools: Validation and applicability in predicting carcinogens . Regul Toxicol Pharmacol 50 , 50 - 58 .
    • (2008) Regul Toxicol Pharmacol , vol.50 , pp. 50-58
    • Mayer, J.1    Cheeseman, M.A.2    Twaroski, M.L.3
  • 78
    • 0025029246 scopus 로고
    • In vitro studies on the biologic effects of fi bers: Correlation with in vivo bioassays
    • Mossman , B. T. ( 1990 ). In vitro studies on the biologic effects of fi bers: Correlation with in vivo bioassays . Environ Health Perspect 88 , 319 - 322 .
    • (1990) Environ Health Perspect , vol.88 , pp. 319-322
    • Mossman, B.T.1
  • 79
    • 0037289178 scopus 로고    scopus 로고
    • Size effect of intratracheally instilled particles on pulmonary infl ammation and vascular thrombosis
    • Nemmar , A. , Hoylaerts , M. F. , Hoet , P. H. , Vermylen , J. , and Nemery , B. ( 2003 ). Size effect of intratracheally instilled particles on pulmonary infl ammation and vascular thrombosis . Toxicol Appl Pharmacol 186 , 38 - 45 .
    • (2003) Toxicol Appl Pharmacol , vol.186 , pp. 38-45
    • Nemmar, A.1    Hoylaerts, M.F.2    Hoet, P.H.3    Vermylen, J.4    Nemery, B.5
  • 80
    • 84885980426 scopus 로고    scopus 로고
    • Prioritization of environmental, health, and safety research needs for engineered nanoscale materials
    • NSTC
    • NSTC ( 2007 ). Prioritization of environmental, health, and safety research needs for engineered nanoscale materials . Nanotechnology Environmental and Health Implications Working Group, National Science and Technology Council (NSTC) , http://www.nano.gov/Prioritization_EHS_Research_Needs_Engineered_Nanoscale_Materials.pdf , 1 - 8 .
    • (2007) Nanotechnology Environmental and Health Implications Working Group, National Science and Technology Council (NSTC) , pp. 1-8
  • 82
    • 0035140471 scopus 로고    scopus 로고
    • Pulmonary effects of inhaled ultrafi ne particles
    • Oberdörster , G. ( 2001 ). Pulmonary effects of inhaled ultrafi ne particles . Int Arch Occup Environ Health 74 , 1 - 8 .
    • (2001) Int Arch Occup Environ Health , vol.74 , pp. 1-8
    • Oberdörster, G.1
  • 83
    • 0028104529 scopus 로고
    • Correlation between particle size, in vivo particle persistence, and lung injury
    • Oberdörster , G. , Ferin , J. , and Lehnert , B. E. ( 1994 ). Correlation between particle size, in vivo particle persistence, and lung injury . Environ Health Perspect 102 ( Suppl 5 ), 173 - 179 .
    • (1994) Environ Health Perspect 102 ( Suppl , vol.5 , pp. 173-179
    • Oberdörster, G.1    Ferin, J.2    Lehnert, B.E.3
  • 85
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: An emerging discipline evolving from studies of ultrafi ne particles .
    • Oberdörster , G. , Oberdörster , E. , and Oberdörster , J. ( 2005b ). Nanotoxicology: An emerging discipline evolving from studies of ultrafi ne particles . Environ Health Perspect 113 , 823 - 839 .
    • (2005) Environ Health Perspect , vol.113 , pp. 823-839
    • Oberdörster, G.1    Oberdörster, E.2    Oberdörster, J.3
  • 88
    • 34748925871 scopus 로고    scopus 로고
    • Half-life of serum elimination of perfl uorooctanesulfonate, perfl uorohexanesulfonate, and perfl uorooctanoate in retired fl uorochemical production workers
    • Olsen , G. W. , Burris , J. M. , Ehresman , D. J. , Froehlich , J. W. , Seacat , A. M. , Butenhoff , J. L. , and Zobel , L. R. ( 2007 ). Half-life of serum elimination of perfl uorooctanesulfonate, perfl uorohexanesulfonate, and perfl uorooctanoate in retired fl uorochemical production workers . Environ Health Perspect 115 , 1298 - 1305 .
    • (2007) Environ Health Perspect , vol.115 , pp. 1298-1305
    • Olsen, G.W.1    Burris, J.M.2    Ehresman, D.J.3    Froehlich, J.W.4    Seacat, A.M.5    Butenhoff, J.L.6    Zobel, L.R.7
  • 89
    • 0028178259 scopus 로고
    • Refractory ceramic fi bers (RCFs) induce germline aneuploidy in Drosophila oocytes
    • Osgood , C. J. ( 1994 ). Refractory ceramic fi bers (RCFs) induce germline aneuploidy in Drosophila oocytes . Mutat Res 324 , 23 - 27 .
    • (1994) Mutat Res , vol.324 , pp. 23-27
    • Osgood, C.J.1
  • 93
    • 0016163108 scopus 로고
    • Tumorigenic effect of fi brous dusts in experimental animals
    • Pott , F. , Huth , F. , and Friedrichs , K. H. ( 1974 ). Tumorigenic effect of fi brous dusts in experimental animals . Environ Health Perspect 9 , 313 - 315 .
    • (1974) Environ Health Perspect , vol.9 , pp. 313-315
    • Pott, F.1    Huth, F.2    Friedrichs, K.H.3
  • 94
    • 45749105529 scopus 로고    scopus 로고
    • Computational molecular modeling for evaluating the toxicity of environmental chemicals: Prioritizing bioassay requirements
    • Rabinowitz , J. R. , Goldsmith , M. R. , Little , S. B. , and Pasquinelli , M. A. ( 2008 ). Computational molecular modeling for evaluating the toxicity of environmental chemicals: Prioritizing bioassay requirements . Environ Health Perspect 116 , 573 - 577 .
    • (2008) Environ Health Perspect , vol.116 , pp. 573-577
    • Rabinowitz, J.R.1    Goldsmith, M.R.2    Little, S.B.3    Pasquinelli, M.A.4
  • 95
    • 0021051308 scopus 로고
    • Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
    • Reddy , J. K. , and Lalwai , N. D. ( 1983 ). Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans . Crit Rev Toxicol 12 , 1 - 58 .
    • (1983) Crit Rev Toxicol , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwai, N.D.2
  • 96
    • 33750245442 scopus 로고    scopus 로고
    • Future of toxicology - Predictive toxicology: An expanded view of " chemical toxicity "
    • Richard , A. M. ( 2006 ). Future of toxicology - Predictive toxicology: An expanded view of " chemical toxicity " . Chem Res Toxicol 19 , 1257 - 1262 .
    • (2006) Chem Res Toxicol , vol.19 , pp. 1257-1262
    • Richard, A.M.1
  • 97
    • 0025052469 scopus 로고
    • A CASE-SAR analysis of polycyclic aromatic hydrocarbon carcinogenicity
    • Richard , A. M. , and Woo , Y. T. ( 1990 ). A CASE-SAR analysis of polycyclic aromatic hydrocarbon carcinogenicity . Mutat Res 242 , 285 - 303 .
    • (1990) Mutat Res , vol.242 , pp. 285-303
    • Richard, A.M.1    Woo, Y.T.2
  • 98
    • 0035977882 scopus 로고    scopus 로고
    • Molecular biology of the Ah receptor and its role in carcinogenesis
    • Safe , S. ( 2001 ). Molecular biology of the Ah receptor and its role in carcinogenesis . Toxicol Lett 120 , 1 - 7 .
    • (2001) Toxicol Lett , vol.120 , pp. 1-7
    • Safe, S.1
  • 99
    • 33745700841 scopus 로고    scopus 로고
    • Correlating nanoscale titania structure with toxicity: A cytotoxicity and infl ammatory response study with human dermal fi broblasts and human lung epithelial cells
    • Sayes , C. M. , Wahi , R. , Kurian , P. A. , Liu , Y. , West , J. L. , Ausman , K. D. , Warheit , D. B. , and Colvin , V. L. ( 2006 ). Correlating nanoscale titania structure with toxicity: A cytotoxicity and infl ammatory response study with human dermal fi broblasts and human lung epithelial cells . Toxicol Sci 92 , 174 - 185 .
    • (2006) Toxicol Sci , vol.92 , pp. 174-185
    • Sayes, C.M.1    Wahi, R.2    Kurian, P.A.3    Liu, Y.4    West, J.L.5    Ausman, K.D.6    Warheit, D.B.7    Colvin, V.L.8
  • 100
    • 0028665499 scopus 로고
    • A review of the durability of inhaled fi bres and options for the design of safer fi bres
    • Searl , A. ( 1994 ). A review of the durability of inhaled fi bres and options for the design of safer fi bres . Ann Occup Hyg 38 , 839 - 855 .
    • (1994) Ann Occup Hyg , vol.38 , pp. 839-855
    • Searl, A.1
  • 102
    • 0017329877 scopus 로고
    • Carcinogenicity of fi brous glass: Pleural response in the rat in relation to fi ber dimension
    • Stanton , M. F. , Laynard , M. , Tegeris , A. , Miller , E. , May , M. , and Kent , E. ( 1977 ). Carcinogenicity of fi brous glass: Pleural response in the rat in relation to fi ber dimension . J Natl Cancer Inst 58 , 587 - 603 .
    • (1977) J Natl Cancer Inst , vol.58 , pp. 587-603
    • Stanton, M.F.1    Laynard, M.2    Tegeris, A.3    Miller, E.4    May, M.5    Kent, E.6
  • 103
    • 0015303808 scopus 로고
    • Mechanisms of mesothelioma induction with asbestos and fi brous glass
    • Stanton , M. F. , and Wrench , C. ( 1972 ). Mechanisms of mesothelioma induction with asbestos and fi brous glass . J Natl Cancer Inst 48 , 797 - 821 .
    • (1972) J Natl Cancer Inst , vol.48 , pp. 797-821
    • Stanton, M.F.1    Wrench, C.2
  • 106
    • 0028978788 scopus 로고
    • Three-dimensional quantitative structure - activity relationships of dioxins and dioxin-like compounds: Model validation and Ah receptor characterization
    • Waller , C. L. , and McKinney , J. D. ( 1995 ). Three-dimensional quantitative structure - activity relationships of dioxins and dioxin-like compounds: Model validation and Ah receptor characterization . Chem Res Toxicol 8 , 847 - 858 .
    • (1995) Chem Res Toxicol , vol.8 , pp. 847-858
    • Waller, C.L.1    McKinney, J.D.2
  • 107
    • 0032807565 scopus 로고    scopus 로고
    • Biological effects of man-made mineral fi bers (II) - Their genetic damages examined by in vitro assay
    • Wang , Q. E. , Han , C. H. , Yang , Y. P. , Wang , H. B. , Wu , W. D. , Liu , S. J. , and Kohyama , N. ( 1999 ). Biological effects of man-made mineral fi bers (II) - Their genetic damages examined by in vitro assay . Ind Health 37 , 342 - 347 .
    • (1999) Ind Health , vol.37 , pp. 342-347
    • Wang, Q.E.1    Han, C.H.2    Yang, Y.P.3    Wang, H.B.4    Wu, W.D.5    Liu, S.J.6    Kohyama, N.7
  • 108
    • 33845771203 scopus 로고    scopus 로고
    • Transcriptional profi les in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil
    • Ward , W. O. , Delker , D. A. , Hester , S. D. , Thai , S. F. , Wolf , D. C. , Allen , J. W. , and Nesnow , S. ( 2006 ). Transcriptional profi les in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil . Toxicol Pathol 34 , 863 - 878 .
    • (2006) Toxicol Pathol , vol.34 , pp. 863-878
    • Ward, W.O.1    Delker, D.A.2    Hester, S.D.3    Thai, S.F.4    Wolf, D.C.5    Allen, J.W.6    Nesnow, S.7
  • 109
    • 0942269167 scopus 로고    scopus 로고
    • Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats
    • Warheit , D. B. , Laurence , B. R. , Reed , K. L. , Roach , D. H. , Reynolds , G. A. , and Webb , T. R. ( 2004 ). Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats . Toxicol Sci 77 , 117 - 125 .
    • (2004) Toxicol Sci , vol.77 , pp. 117-125
    • Warheit, D.B.1    Laurence, B.R.2    Reed, K.L.3    Roach, D.H.4    Reynolds, G.A.5    Webb, T.R.6
  • 110
    • 33846110902 scopus 로고    scopus 로고
    • Pulmonary toxicity study in rats with three forms of ultrafi ne-TiO2 particles: Differential responses related to surface properties
    • Warheit , D. B. , Webb , T. R. , Reed , K. L. , Frerichs , S. , and Sayes , C. M. ( 2007 ). Pulmonary toxicity study in rats with three forms of ultrafi ne-TiO2 particles: Differential responses related to surface properties . Toxicology 230 , 90 - 104 .
    • (2007) Toxicology , vol.230 , pp. 90-104
    • Warheit, D.B.1    Webb, T.R.2    Reed, K.L.3    Frerichs, S.4    Sayes, C.M.5
  • 111
    • 33645823891 scopus 로고    scopus 로고
    • Pulmonary instillation studies with nanoscale TiO 2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area
    • Warheit , D. B. , Webb , T. R. , Sayes , C. M. , Colvin , V. L. , and Reed , K. L. ( 2006 ). Pulmonary instillation studies with nanoscale TiO 2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area . Toxicol Sci 91 , 227 - 236 .
    • (2006) Toxicol Sci , vol.91 , pp. 227-236
    • Warheit, D.B.1    Webb, T.R.2    Sayes, C.M.3    Colvin, V.L.4    Reed, K.L.5
  • 112
    • 55749113514 scopus 로고    scopus 로고
    • Databases applicable to quantitative hazard/risk assessment - Towards a predictive systems toxicology
    • Waters , M. , and Jackson , M. ( 2008 ). Databases applicable to quantitative hazard/risk assessment - Towards a predictive systems toxicology . Toxicol Appl Pharmacol 233 , 34 - 44 .
    • (2008) Toxicol Appl Pharmacol , vol.233 , pp. 34-44
    • Waters, M.1    Jackson, M.2
  • 114
    • 22744437147 scopus 로고
    • Structural and functional criteria for suspecting chemical compounds of carcinogenic activity: State-of-the-art of predictive formalism .
    • Noyes Publications , Park Ridge, IL , pp.
    • Woo , Y. T. , Arcos , J. C. , and Lai , D. Y. ( 1985a ). Structural and functional criteria for suspecting chemical compounds of carcinogenic activity: State-of-the-art of predictive formalism . In Handbook of Carcinogen Testing , Noyes Publications , Park Ridge, IL , pp. 1 - 637 .
    • (1985) In Handbook of Carcinogen Testing , pp. 1-637
    • Woo, Y.T.1    Arcos, J.C.2    Lai, D.Y.3
  • 115
    • 84974803514 scopus 로고    scopus 로고
    • Mechanisms of action of chemical carcinogens and their role in structure - activity relationships (SAR) analysis and risk assessment
    • Benigni , R. , ed., CRC Press , Boca Raton, FL
    • Woo , Y. T. , and Lai , D. ( 2003 ). Mechanisms of action of chemical carcinogens and their role in structure - activity relationships (SAR) analysis and risk assessment . In Quantitative Structure - Activity Relationship (QSAR) Models of Chemical Mutagens and Carcinogens , Benigni , R. , ed., CRC Press , Boca Raton, FL , pp. 41 - 80 .
    • (2003) In Quantitative Structure - Activity Relationship (QSAR) Models of Chemical Mutagens and Carcinogens
    • Woo, Y.T.1    Lai, D.2
  • 117
    • 0003590174 scopus 로고
    • Vol. IIIC : Natural, Metal, Fiber, and Macromolecular Carcinogens , Academic Press , New York
    • Woo , Y. T. , Lai , D. , Arcos , J. C. , and Argus , M. F. ( 1988 ). Chemical Induction of Cancer , Vol. IIIC : Natural, Metal, Fiber, and Macromolecular Carcinogens , Academic Press , New York .
    • (1988) Chemical Induction of Cancer
    • Woo, Y.T.1    Lai, D.2    Arcos, J.C.3    Argus, M.F.4
  • 118
    • 0036179149 scopus 로고    scopus 로고
    • Use of mechanism-based structure - activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products
    • Woo , Y. T. , Lai , D. , McLain , J. L. , Manibusan , M. K. , and Dellarco , V. ( 2002 ). Use of mechanism-based structure - activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products . Environ Health Perspect 110 ( Suppl 1 ), 75 - 87 .
    • (2002) Environ Health Perspect 110 ( Suppl , vol.1 , pp. 75-87
    • Woo, Y.T.1    Lai, D.2    McLain, J.L.3    Manibusan, M.K.4    Dellarco, V.5
  • 119
    • 0003590174 scopus 로고
    • Vol. IIIB : Aliphatic and polyhalogenated carcinogens , Academic Press , Orlando, FL
    • Woo , Y. T. , Lai , D. Y. , Arcos , J. C. , and Arcos , J. C. ( 1985b ). Chemical Induction of Cancer , Vol. IIIB : Aliphatic and polyhalogenated carcinogens , Academic Press , Orlando, FL .
    • (1985) Chemical Induction of Cancer
    • Woo, Y.T.1    Lai, D.Y.2    Arcos, J.C.3    Arcos, J.C.4
  • 120
    • 0029153221 scopus 로고
    • Development of structure - activity relationship rules for predicting carcinogenic potential of chemicals
    • Woo , Y. T. , Lai , D. Y. , Argus , M. F. , and Arcos , J. C. ( 1995 ). Development of structure - activity relationship rules for predicting carcinogenic potential of chemicals . Toxicol Lett 79 , 219 - 228 .
    • (1995) Toxicol Lett , vol.79 , pp. 219-228
    • Woo, Y.T.1    Lai, D.Y.2    Argus, M.F.3    Arcos, J.C.4
  • 121
    • 0032439450 scopus 로고    scopus 로고
    • An integrative approach of combining mechanistically complementary short-term predictive tests as a basis for assessing the carcinogenic potential of chemicals
    • Woo , Y. T. , Lai , D. Y. , Argus , M. F. , and Arcos , J. C. ( 1998 ). An integrative approach of combining mechanistically complementary short-term predictive tests as a basis for assessing the carcinogenic potential of chemicals . J Environ Sci Health C Environ Carcinog Ecotoxicol Rev C16 , 101 - 122 .
    • (1998) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev , vol.C16 , pp. 101-122
    • Woo, Y.T.1    Lai, D.Y.2    Argus, M.F.3    Arcos, J.C.4
  • 122
    • 0141828972 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis
    • Yu , S. , Rao , S. , and Reddy , J. K. ( 2003 ). Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis . Curr Mol Med 3 , 561 - 572 .
    • (2003) Curr Mol Med , vol.3 , pp. 561-572
    • Yu, S.1    Rao, S.2    Reddy, J.K.3
  • 123
    • 45749129400 scopus 로고    scopus 로고
    • Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure - activity relationship models of animal carcinogenicity
    • Zhu , H. , Rusyn , I. , Richard , A. , and Tropsha , A. ( 2008 ). Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure - activity relationship models of animal carcinogenicity . Environ Health Perspect 116 , 506 - 513 .
    • (2008) Environ Health Perspect , vol.116 , pp. 506-513
    • Zhu, H.1    Rusyn, I.2    Richard, A.3    Tropsha, A.4


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