Hazard assessment and risk analysis of two new synthetic vitreous fibers

Regulatory Toxicology and Pharmacology

Volumn 30, Issue 1, 1999, Pages 54-74

  Maxim, L Daniel ^a   Mast, Richard W ^a   Utell, M J ^b   Yu, C P ^c   Boymel, Paul M ^d   Zoitos, Bruce K ^d   Cason, James E ^d  

^a EVEREST CONSULTING ASSOCIATES   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d Unifrax Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM OXIDE; CARCINOGEN; MAGNESIUM OXIDE; OXIDE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; BIOASSAY; BIODEGRADATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; DISSOLUTION; FIBER; HALF LIFE TIME; LUNG FIBROSIS; LUNG TUMOR; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; REVIEW; RISK ASSESSMENT; SOLUBILITY;

EID: 0032845066     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1314     Document Type: Article

References (128)

1. Athanassopoulos A. D., Triantis K. P. Assessing aggregate cost efficiency and the related policy implications for Greek local municipalities. Information. 36:1998;66-83.
2. Bauer J. F., Law B. D., Hesterberg T. W. Dual pH durability studies of man-made vitreous fiber (MMVF). Environ. Health Perspect. 102:1994;61-65.
3. Bellmann B., Muhle H., Kamstrup O., Draeger U. F. Investigations of the durability of man-made vitreous fibers in rat lungs. Environ. Health Perspect. 102:1994;185-189.
4. Bellmann B., Muhle H., Pott F., König H., Klöppel H., Spurny K. Persistence of man-made mineral fibres (MMVF) and asbestos in rat lungs. Ann. Occup. Hyg. 31:1987;693-709.
5. Belsley D. A., Kuh E., Welsch R. E. Regression Diagnostics: Identifying Influential Data and Sources of Collinearity. 1980;Wiley, New York.
6. Bernstein D. M. The scientific and health-related reasons for fiber classification by the EC. VD1 Berichte NR. 1417:1998;111-128.
7. Bernstein, D. M. 1997, Correlation Between Short-Term Biopersistence and Chronic Toxicity Studies. A report to Dr. Juan Riego-Sintes, Joint Research Centre, Environment Institute, European Chemicals Bureau, Ispra, Italy.
8. Bernstein D. M., Morscheidt C., de Meringo A., Schumm M., Grimm H. G., Teichert U., Thevenaz P., Mellon L. The biopersistence of fibers following inhalation and intratracheal instillation exposure. Ann. Occup. Hyg. 41:1997;224-230.
9. Bernstein D. M., Morscheidt C., Grimm H. G., Thévenaz P., Teichert U. The evaluation of soluble fibers using the inhalation biopersistence model, a nine-fiber comparison. Inhal. Toxicol. 8:1996;345-385.
10. Bernstein D. M., Morscheidt C., Tiesler H., Grimm H. G., Thevenaz P., Teichert U. Evaluation of the biopersistence of commercial and experimental fibers following inhalation. Inhal. Toxicol. 7:1995a;1031-1058.
11. Bernstein D. M., Thevenaz P., Fleissner H., Anderson R., Hesterberg T., Mast R. Evaluation of the oncogenic potential of man-made vitreous fibers: the inhalation model. Ann. Occup. Hyg. 39:1995b;661-672.
12. Bernstein D. M., Drew R. T., Kuschner M. Experimental approaches for exposure to sized glass fibers. Environ. Health Perspect. 34:1980;47-57.
13. Berry G. Models for mesothelioma incidence following exposure to fibers in terms of timing and duration of exposure and the biopersistence of the fibers. Inhal. Toxicol. 11:1999;111-130.
14. Bignon J., Saracci R., Touray J. C. Report of a workshop on biopersistence of respirable synthetic fibres and minerals. Environ. Health Perspect. 102:1994;1-292.
15. Brown R. C., Davis J. M. G., Douglas D., Gruber V. F., Hoskins J. A., Ilgren E. B., Johnson N. F., Rossiter C. E., Wagner J. C. Carcinogenicity of the insulation wools: Reassessment of the IARC evaluation. Regul. Toxicol. Pharmacol. 14:1991;12-23.
16. Brown S. K. Characterization of the fiber diameter distributions of synthetic mineral fiber products and their dusts. Am. Ind. Hyg. Assoc. J. 53:1992;27-33.
17. Burge P. S., Calvert I. A., Trethowan W. N., Harrington J. M. Are the respiratory health effects found in manufacture of ceramic fibers due to the dust rather than the exposure to fibres. Occup. Environ. Med. 52:1995;105-109.
18. Coin P. G., Roggli V. L., Brody A. R. Persistence of long, thin chrysotile asbestos fibers in the lungs of rats. Environ. Health Perspect. 102:1994;197-199.
19. Collier C. G., Morris K. J. The behavior of glass fibers in the rat following intra peritoneal injection. Regul. Toxicol. Pharmacol. 20:1994;S89-S103.
20. Cook R. D. Detection of influential observations in linear regression. Technometrics. 19:1977;15-18.
21. Cook R. D., Weisberg S. Confidence curves in nonlinear regression. J. Am. Stat. Assoc. 85:1990;544-551.
22. Davis J. M. G., Brown D. M., Cullen R. T., Donaldson K., Jones A. D., Miller B. G., McIntosh C., Searl A. A comparison of methods of determining and predicting pathogenicity of mineral fibers. Inhal. Toxicol. 8:1996;747-770.
23. Davis J. M. G. Experimental studies on mineral fibre carcinogenesis: an overview. Brown R. C., Hoskins J. A., Johnson N. F. Mechanisms in Fiber Carcinogenesis. 1991a;51-58 Plenum, New York.
24. Davis J. M. G. Information obtained from fiber-induced lesions in animals. Liddell D., Miller K. Mineral Fibers and Health. 1991b;250-260 CRC Press, Boca Raton.
25. Davis J. M. G., Jones A. D., Miller B. G. Experimental studies in rats on the effects of asbestos inhalation coupled with the inhalation of titanium dioxide or quartz. Int. J. Exp. Pathol. 72:1991;501-525.
26. Davis J. M. G. Experimental data relating to the importance of fibre type, size, deposition, dissolution, and migration. Bignon J., Peto J., Saracci R. Non-occupational Exposure to Mineral Fibres. 1989;33-45 IARC Scientific PublicationsInternational Agency for Research on Cancer, Lyon.
27. Davis J. M. G., Jones A. D. Comparisons of the pathogenicity of long and short fibres of chrysotile asbestos in rats. Br. J. Exp. Pathol. 69:1988;717-737.
28. Davis J. M. G., Addison J., Bolton R. E., Donaldson K., Jones A. D. The pathogenicity of long versus short fiber samples of amosite asbestos administered to rats by inhalation and intra peritoneal injection. Br. J. Exp. Pathol. 69:1986;717-737.
29. Davis J. M. G. A review of experimental evidence for the carcinogenicity of man-made vitreous fibres. Scand. J. Work Environ. Health. 12:1986;12-17.
30. Davis J. M. G., Addison J., Bolton R. E., Donaldson K., Jones A. D., Wright A. The pathologic effects of fibrous ceramic aluminum silicate glass administered to rats by inhalation or peritoneal injection. Biological Effects of Man-Made Mineral Fibres. 1984;World Health OrganizationRegional Office for Europe, Copenhagen.
31. Dodgson J., Cherrie J., Groat S. Estimates of past exposure to respirable man-made mineral fibres in the European insulation wool industry. Ann. Occup. Hyg. 31:1987;567-582.
32. Eastes W., Hadley J. G. A mathematical model of fiber carcinogenicity and fibrosis in inhalation and intra peritoneal experiments in rats. Inhal. Toxicol. 8:1996;323-343.
33. Eastes W., Hadley J. G. Dissolution of fibers inhaled by rats. Inhal. Toxicol. 7:1995;179-196.
34. Eastes W., Morris K. J., Morgan A., Launder K. A., Collier C. G., Davis J. A., Mattson S. M., Hadley J. G. Dissolution of glass fibers in the rat lung following intratracheal instillation. Inhal. Toxicol. 7:1995;197-213.
35. Esmen N. A., Hammad Y. Y. Recent studies of the environment in ceramic fibre production. Proceedings of the World Health Organization International Agency for Research on Cancer Conference on the Biological Effects of Man-Made Mineral Fibres. 1984;WHO, Copenhagen. p. 1222-1231.
36. Off. J. Eur. Comm. L343:1997;19-33.
37. Fayerweather W. E., Bender J. R., Hadley J. G., Eastes W. Quantitative risk assessment for a glass fiber insulation product. Regul. Toxicol. Pharmacol. 25:1997;103-120.
38. Fisher G. L., McNeill K. L., Smith J. T. Pulmonary response to intratracheally instilled silicon nitride in rats. Inhal. Toxicol. 1:1989;227-241.
39. Forster H. The behavior of mineral fibres in physiological solutions. Biological Effects of Man-Made Mineral Fibres. 1984;World Health Organization, Copenhagen. p. 261-267.
40. Fraunhofer Institut Toxikologie und Aerosolforschung, 1998, Draft, Interim Report on Short-Term Inhalation Study with RCF1a in Rats. Sponsored by the European Ceramic Fibres Industry Association (ECFIA), Paris.
41. Hammad Y., Simmons W., Abel-Kader H., Reynolds C., Weill H. Effect of chemical composition on pulmonary clearance of man-made mineral fibers. Ann. Occup. Hyg. 22:1988;769-779.
42. Hamilton R. D., Miiller W. C., Christensen D. R., Anderson R., Hesterberg T. W. Characterization of exposure and dose of man-made vitreous fiber in experimental studies. Environ. Health Perspect. 102:1994;109-112.
43. Hesterberg T. W., Chase G., Axten C., Miller W. C., Musselman R. P., Kamstrup O., Hadley J., Morscheidt C., Bernstein D. M., Thevenaz P. Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation. Toxicol. Appl. Pharmacol. 151:1998;262-275.
44. Hesterberg T., Miiller W., Hart G., Bauer J., Hamilton R. Physical and chemical transformation of synthetic vitreous fibres in the lung and in vitro. J. Occup. Health Safety. 12:1996a;345-355.
45. Hesterberg T. W., Miiller W. C., Musselman R. P., Kamstrup O., Hamilton R. D., Thevenaz P. Biopersistence of man-made vitreous fibers and crocidolite asbestos in the rat lung following inhalation. Fundam. Appl. Toxicol. 29:1996b;267-279.
46. Hesterberg T. W., Hart G. A. A comparison of human exposures to fiberglass with those used in a recent rat chronic inhalation study. Regul. Toxicol. Pharmacol. 20:1994;S35-S46.
47. Hesterberg T. W., Miiller W. C., Mast R., McConnell E. E., Bernstein D. M., Anderson R. Relationship between lung biopersistence and biological effects of man-made vitreous fibers after chronic inhalation in rats. Environ. Health Perspect. 102:1994a;133-137.
48. Hesterberg T. W., Miiller W. C., Thevenaz P., Anderson R. Chronic inhalation studies of man-made vitreous fibres: Characterization of fibres in the exposure aerosol and lungs. Ann. Occup. Hyg. 39:1994b;637-653.
49. Hesterberg T. W., Miiller W. C., McConnell E. E., Chevalier J., Hadley J. G., Bernstein D. M., Thevenaz P., Anderson R. Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats. Fundam. Appl. Toxicol. 20:1993;464-476.
50. Hesterberg T. W. Evaluating the Biopersistence of Man-Made Fibers. 1992.
51. Hesterberg T. W., Vu V., Chase G. R., McConnell E. E., Bunn W. B., Anderson R. A. Use of animal models to study man-made fiber carcinogenesis. Brinkley W., Lechner J., Harris C. Current Communications in Molecular Biology: Cellular and Molecular Aspects of Fiber Carcinogenesis. 1991;183-205 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
52. Monographs on the Evaluation of Carcinogenic Risk to Humans. 1988;IARC, Lyon.
53. Man-Made Mineral Fibres. 1988;World Health Organization (WHO), Geneva.
54. Johnson N. F. An overview of animal models for assessing synthetic vitreous fibers (SVFs) safety. Regul. Toxicol. Pharmacol. 20:1994;S7-S21.
55. Johnson N. F. The limitations of inhalation, intratracheal, and intracoelomic routes of administration for identifying hazardous fibrous materials. Warheit D. Fiber Toxicology. 1993;43-72 Academic Press, New York.
56. Kamstrup O., Davis J. M. G., Ellehauge A., Guldberg M. The biopersistence and pathogenicity of man-made vitreous fibres after short- and long-term inhalation. Ann. Occup. Hyg. 42:1998;191-199.
57. Klingholz R., Steinkopft B. The reactions of MMVF in a physiological model fluid and in water. Biological Effects of Man-Made Mineral Fibres. 1984;World Health Organization, Copenhagen. p. 60-86.
58. Law B. D., Bunn W. B., Hesterberg T. W. Solubility of polymeric and man-made vitreous fibers in Gambles solution. Inhal. Toxicol. 2:1990;321-339.
59. Lehuede, P, Archer, F, and, de Meringo, A. 1994. Unpublished. [, Cited in, Zoitos, et al, 1997].
60. Leineweber J. P. Solubility of fibres in vitro and in vivo. Biological Effects of Man-Made Mineral Fibres, Proceedings of a WHO/IARC Conference. 1984;. p. 87-101.
61. Lemasters G., Lockey J., Rice C., McKay R., Hansen K., Lu J., Levin L., Gartside P. Radiographic changes among workers manufacturing refractory ceramic fibre and Products. Ann. Occup. Hyg. 38:1994;745-751.
62. Lockey J. E., Levin L. S., Lemasters G. K., McKay R. T., Rice C. H., Hansen K. R., Papes D. M., Simpson S., Medvedovic M. Longitudinal estimates of pulmonary function in refractory ceramic fiber manufacturing workers. Am. J. Respir. Crit. Care Med. 157:1998;1226-1233.
63. Lockey J., Lemasters G., Rice C., Hansen K., Levin L., Shipley R., Spitz H., Wiot J. Refractory ceramic fiber exposure and pleural plaques. Am. J. Respir. Crit. Care Med. 154:1996;1405-1410.
64. Lockey J., Wiese N. Health effects of synthetic vitreous fibers. Clin. Chest Med. 13:1992;329-339.
65. Luoto K., Holopainen M., Perander M., Karppinen K., Savolainen K. M. Cellular effects of particles-impact of dissolution on toxicity of man-made mineral fibers. Centr. Eur. J. Pub. Health. 4:1996;29-32.
66. Luoto K., Holopainen M., Perander M., Karppinen K., Savolainen K. M. Dissolution of man-made vitreous fibers in rat alveolar macrophage culture and Gamble's saline solution: Influence of different media and chemical composition of the fibers. Environ. Health Perspect. 102:1994;103-107.
67. Marsh G. M., Enterline P. E., Stone R. A., Henderson V. L. Mortality among a cohort of U.S. man-made mineral fiber workers: 1985 follow-up. J. Occup. Med. 32:1990;594-604.
68. Mast R. W., McConnell E. E., Anderson R., Chevalier J., Kotin P., Bernstein D. M., Thevenaz P., Glass L. R., Miller W. C., Hesterberg T. W. Studies on the chronic toxicity (inhalation) of four types of refractory ceramic fiber in male Fischer 344 rats. Inhal. Toxicol. 7:1995a;425-467.
69. Mast R. W., McConnell E. E., Hesterberg T. W., Chevalier J., Kotin P., Thevenaz P., Bernstein D. M., Glass L. R., Miiller W., Anderson R. Multiple dose chronic inhalation study of size-separated kaolin refractory fiber in male Fischer 344 rats. Inhal. Toxicol. 7:1995b;469-502.
70. Mast R. W., Utell M. J. Man-made vitreous fibers. Zenz C., Dickerson O. B., Horvath E. P. Occupational Medicine. 1994;185-193 Mosby, St. Louis.
71. Mattson S. M. Glass fiber dissolution in simulated lung fluid and measures needed to improve consistency and correspondence to in vivo dissolution: Workshop on biopersistence of respirable synthetic fibres and miners, Lyon, France, September 7-9, 1992. Environ. Health Perspect. 102:1994;87-91.
72. Maxim L. D., Allshouse J. N., Deadman J., Kleck C., Kostka M., Webster D., Class P., Sébastien P. CARE - A European programme for monitoring and reducing refractory ceramic fibre dust at the workplace: initial results. Gefahrstoffe-Reinhaltung Luft. 58:1998;97-103.
73. Maxim L. D., Kelly W. P., Walters T., Waugh R. A multi-year workplace-monitoring program for refractory ceramic fibers. Regul. Toxicol. Pharmacol. 26:1997;156-171.
74. Maxim L. D., Kelly W. P., Walters T., Waugh R. A multiyear workplace-monitoring program for refractory ceramic fibers. Regul. Toxicol. Pharmacol. 20:1994;S200-S215.
75. McClellan R. O. Assessing health risks of synthetic vitreous fibers: An integrative approach. Regul. Toxicol. Pharmacol. 20:1994;S121-S134.
76. McClellan R. O., Miller F. J., Hesterberg T. W., Warheit D. B., Bunn W. B., Kane A. B., Lippmann M., Mast R. W., McConnell E. E., Reinhardt C. E. Approaches to evaluating the toxicity and carcinogenicity of man-made fibres. Regul. Toxicol. Pharmacol. 16:1992;321-364.
77. McConnell E. E., Musselman R., Kamstrup O., Hesterberg T. W., Chevalier J., Miiller W., Thevenaz P. Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fischer 344/N rats. Inhal. Toxicol. 6:1994;571-614.
78. McConnell E. E., Wagner J. C., Skidmore J. W., Moore J. A. A comparative study of the fibrogenic and carcinogenic effects of UICC chrysotile B asbestos and glass microfibre (JM100). Biological Effects of Man-Made Mineral Fibres. 1984;World Health Organization, Geneva. p. 234-252.
79. Miettinen O. S., Rossiter C. E. Man-made mineral fibers and lung cancer: Epidemiologic evidence regarding the causal hypothesis. Scand. J. Work Environ. Health. 16:1990;221-231.
80. Moolgavkar S. H., Luebeck E. G. A two-mutation model for radiation carcinogenesis in humans and rodents. Iverson O. H. New Frontiers in Cancer Causation. 1993;199-210 Taylor and Francis, Washington.
81. Moolgavkar S. H., Luebeck E. G., Krewski D., Zielinski J. M. Radon, cigarette smoke, and lung cancer: A reanalysis of the Colorado Plateau miner's data. Epidemiology. 4:1993;204-217.
82. Moolgavkar S. H., Cross F. T., Luebeck G., Dagle G. E. A two-mutation model for radon-induced lung tumors in rats. Radiat. Res. 121:1990;28-37.
83. Moolgavkar S. H., Luebeck E. G. Two-event model for carcinogenesis: Biological, mathematical, and statistical considerations. Risk Anal. 10:1990;323-341.
84. Moolgavkar S. H., Knudson A. G. Mutation and cancer: A model for human carcinogenesis. J. Natl. Cancer Inst. 66:1981;1037-1052.
85. Morgan A. In-vivo evaluation of chemical biopersistence of man-made mineral fibers. Environ. Health Perspect. 102:1994;127-131.
86. Mostellier F., Rourke R. E. K. Sturdy Statistics Nonparametrics and Order Statistics. 1973;Addison-Wesley, Reading.
87. Muhle, H, Bellmann, B, Pohlmann, G, Creutzenberg, O, Bartsch, W, Ernst, H, and, Rittinghausen, S. 1998, Short-Term Inhalation Study with RCF-1a in Rats: Interim Report, Fraunhofer Institut Toxikologie und Aerosolforschung, Hanover, Germany.
88. Muhle H., Bellmann B. Significance of the biodurability of man-made vitreous fibers to risk assessment. Environ. Health Perspect. 102:1997;1045-1047.
89. Muhle, H. 1996, Study of the in-Vivo Solubility of Vitreous Silicate Fibre Dusts, Fraunhofer Institute for Toxicology and Aerosol Research, Interim Report to the Federal Institute for Occupational Safety, Dortmund, Germany.
90. Muhle H., Bellmann B., Pott F. Comparative investigations of the biodurability of mineral fibers in the rat lung. Environ. Health Perspect. 102:1994;163-168.
91. Musselman R. P., Miiller W. C., Eastes W., Hadley J. G., Kamstrup O., Thevenaz P., Hesterberg T. W. Biopersistence of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures. Environ. Health Perspect. 102:1994;139-143.
92. NIEHS Workshop on Fibre Toxicology Research Needs. 1989.
93. Man-Made Vitreous Fibers: Nomenclature, Chemical and Physical Properties. 1993;Refractory Ceramic Fibers Coalition (RCFC), Washington.
94. Oberdörster G., Ferin J., Lehnert B. E. Correlation between particle size, in-vivo particle persistence, and lung injury. Environ. Health Perspect. 102:1994;173-179.
95. Oberdörster G., Ferin J., Morrow P. Volume loading of alveolar macrophages (AM): A possible basis for diminished AM-mediated particle clearance. Exp. Lung Res. 18:1992;87-104.
96. Commission Directive 97/69/ED. L:1997;343/19-343/24.
97. Pott F., Roller M., Rippe R. M., Germann P. G., Bellmann B. Tumours by the intra peritoneal and intra pleural routes and their significance for the classification of mineral fibres. Brown R. C. Mechanisms in Fibre Carcinogenesis. 1991;Plenum, New York.
98. Pott, F., Roller, M., Ziem, U., Reiffer, F. J., Bellmann, B., Rosenbruch, M., and Huth, F.1989. Carcinogenicity studies on natural and man-made fibres with the intra peritoneal test in rats. In Non-Occupational Exposure to Mineral Fibres (J. Bignon, J. Peto, and R. Saracci, Eds.), IARC Scientific Publication No. 90, pp. 173-179. IARC, Lyon, France.
99. Potter R. M., Mattson S. M. Glass fiber dissolution in a physiological saline solution. Glasstech. Ber. 64:1991;16-28.
100. Report of the Dutch Expert Committee on Occupational Standards (DECOS), 1995, Man-Made Mineral Fibers (MMMF): Health Based Recommended Occupational Exposure Limits, DECOS Report No. 1995/02WGD, The Hague, September 8, 1995.
101. Rossiter, C. E. 1990, Memorandum to Deutsche Forschungsgemeinschaft Kommission zur Prüfung gesundheitsschädlicher Arbeitssoffe: Carcinogenicity of Fibres in Experimental Animals with Special Reference to the Insulation Wools. Commentary and criticism of the proposal by Professor Pott concerning the use of the intra-peritoneal test for the assessment of carcinogenicity, Beaconsfield, UK.
102. Scholze H. Durability investigations on siliceous man-made mineral fibers: A critical review. Glasstech. Ber. 64:1988;161-171.
103. Scholze H., Conradt R. An in-vitro study of the chemical durability of siliceous fibres. Ann. Occup. Hyg. 31:1987;683-692.
104. Sciences International, Inc. (SII), 1998, Quantitative risk assessment of refractory ceramic fibers in the occupational environment.
105. Sebastian K., Böhm T. A Comparative Study of the Biopersistence of MMVF In-Vitro and In-Vivo. 1998;Fraunhofer-Institut für Silicatforschung (ISC), Würzburg.
106. Shannon H. S., Jamieson E., Julian J. A., Muir D. C. F., Walsh C. Mortality experience of Ontario glass fibre workers - Extended follow-up. Ann. Occup. Hyg. 31:1987;657-662.
107. Shannon H. S., Jamieson E., Julian J. A., Muir D. C. F. Mortality of glass filament (textile) workers. Br. J. Ind. Med. 47:1990;533-536.
108. Simonato L., Fletcher A. C., Cherrie J., Andersen A., Bertazzi P. A., Charnay N., Claude J., Dodgson J., Esteve J., Frentzel-Beyme R., Gardner M. J., Jensen O., Olsen J., Teppo L., Winkelmann R., Westerholm P., Winter P. D., Zochetti C., Saracci R. The International Agency for Research on Cancer historical cohort study of MMMF production workers in seven European countries: Extension of the follow-up. Ann. Occup. Hyg. 31:1987;603-623.
109. Smith D. M., Ortiz L. W., Archuleta R. F., Johnson N. F. Long-term health effects in hamsters and rats exposed chronically to man-made vitreous fibres. Ann. Occup. Med. 31:1987;731-754.
110. SYSTAT 7.0 for Windows Statistics. 1996.
111. Spurny K. R. Measurement and analysis of chemically changed mineral fibers after experiments in-vitro and in-vivo. Environ. Health Perspect. 51:1983;343-355.
112. Timbrell V. Deposition and retention of fibers in the human lung. Ann. Occup. Hyg. 26:1982;347-369.
113. Timbrell V. Aerodynamic considerations and other aspects of glass fiber. Occupational Exposure to Fibrous Glass. 1976;U.S. Department of Health, Education, and Welfare, Washington. p. 33-50.
114. Timbrell V., Skidmore J. W. Significance of fiber length in experimental asbestosis. Biologische Wirkungen des Asbestos. 1968;Internationale Konferenz, Dresden. p. 52-56.
115. Trethowan W. N., Burge P. S., Rossiter C. E., Harrington J. M., Calvert I. A. Study of the respiratory health of employees in seven European plants that manufacture ceramic fibers. Occup. Environ. Med. 52:1995;97-104.
116. Health Hazard Assessment of Nonasbestos Fibers. 1988;Health and Environmental Review DivisionOffice of Toxic Substances, Washington.
117. Utell, M, and, Walker, A. M. 1998. Findings from the University of Cincinnati.
118. Wagner J. C., Berry G., Timbrell V. Mesothelioma in rats after inoculation with asbestos and other materials. Br. J. Cancer. 28:1973;175-185.
119. Wong O., Foliart D., Trent L. S. A case-control study of lung cancer in a cohort of workers potentially exposed to slag wool fibers. Br. J. Ind. Med. 48:1991;818-824.
120. Yu, C. P. 1998. Personal communication.
121. Yu C. P., Dai Y. T., Boymel P. M., Zoitos B. K., Oberdörster G., Utell M. J. A clearance model of man-made vitreous fibers (MMVFs) in the rat lung. Inhal. Toxicol. 10:1998;253-274.
122. Yu C. P., Ding Y. J., Zhang L., Oberdörster G., Mast R. W., Maxim L. D., Utell M. J. Retention modeling of refractory ceramic fibers (RCF) in humans. Regul. Toxicol. Pharmacol. 25:1997;18-25.
123. Yu C. P., Ding Y. J., Zhang L., Oberdörster G., Mast R. W., Maxim L. D., Utell M. J. A clearance model of refractory ceramic fibers (RCF) in the rat lung including fiber dissolution and breakage. J. Aerosol Sci. 27:1996;151-160.
124. Yu C. P., Ding J., Zhang L., Oberdörster G., Mast R. W., Glass L. R., Utell M. J. Deposition and clearance modeling of inhaled kaolin refractory ceramic fibers (RCF) in hamsters - Comparison between species. Inhal. Toxicol. 7:1995a;165-177.
125. Yu C. P., Zhang L., Oberdörster G., Mast R. W., Maxim D., Utell M. J. Deposition of refractory ceramic fibers (RCF) in the human respiratory tract and comparison with rodent studies. Aerosol Sci. Technol. 23:1995b;291-300.
126. Yu C. P., Zhang L., Oberdörster G., Mast R. W., Glass L. R., Utell M. J. Deposition modeling of refractory ceramic fibers in the rat lung. J. Aerosol Sci. 25:1994;407-417.
127. Velleman P. F., Welsch R. E. Efficient computing of regression diagnostics. Am. Stat. 35:1981;234-242.
128. Zoitos B. K., de Meringo A., Rouyer E., Thélohan, Bauer J., Law B., Boymel P. M., Olson J. R., Christensen V. R., Guldberg M., Koenig A. R., Perander M. In-vitro measurement of fiber dissolution rate relevant to biopersistence at neutral pH: An interlaboratory round robin. Inhal. Toxicol. 9:1997;525-540.