Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease

Journal of Immunology

Volumn 191, Issue 9, 2013, Pages 4868-4879

  Datta, Arnab ^a   Alexander, Robert ^a   Sulikowski, Michal G ^a   Nicholson, Andrew G ^b   Maher, Toby M ^b   Scotton, Chris J ^a   Chambers, Rachel C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN C JUN; RECEPTOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THYMIC STROMAL LYMPHOPOIETIN; THYMIC STROMAL LYMPHOPOIETIN RECEPTOR; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CRLF2 PROTEIN, HUMAN; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 7; SMALL INTERFERING RNA; STAT3 PROTEIN;

ARTICLE; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG FIBROBLAST; MOLECULAR PATHOLOGY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; CHEMOTAXIS; FIBROBLAST; FIBROSIS; IMMUNOLOGY; INFLAMMATION; LUNG; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SECRETION (PROCESS);

CELLS, CULTURED; CHEMOKINE CCL2; CHEMOTAXIS; CYTOKINES; FIBROBLASTS; FIBROSIS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INFLAMMATION; INTERLEUKIN-7; LUNG; RECEPTORS, CYTOKINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84885967370     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300588     Document Type: Article

References (86)

1. Ngoc, P. L., D. R. Gold, A. O. Tzianabos, S. T. Weiss, and J. C. Celedón. 2005. Cytokines, allergy, and asthma. Curr. Opin. Allergy Clin. Immunol. 5: 161-166.
2. Heller, F., A. Fromm, A. H. Gitter, J. Mankertz, and J. D. Schulzke. 2008. Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function. Mucosal Immunol. 1(Suppl 1): S58-S61.
3. Murray, L. A., R. L. Argentieri, F. X. Farrell, M. Bracht, H. Sheng, B. Whitaker, H. Beck, P. Tsui, K. Cochlin, H. L. Evanoff, et al 2008. Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFβ1, IL-13 and CCL2. Int. J. Biochem. Cell Biol. 40: 2174-2182.
4. Fuschiotti, P. 2011. Role of IL-13 in systemic sclerosis. Cytokine 56: 544-549.
5. Weng, H. L., Y. Liu, J. L. Chen, T. Huang, L. J. Xu, P. Godoy, J. H. Hu, C. Zhou, F. Stickel, A. Marx, et al. 2009. The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin-13 as driving forces in fibrogenesis. Hepatology 50: 230-243.
6. Zhou, B., M. R. Comeau, T. De Smedt, H. D. Liggitt, M. E. Dahl, D. B. Lewis, D. Gyarmati, T. Aye, D. J. Campbell, and S. F. Ziegler. 2005. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6: 1047-1053.
7. Yoo, J., M. Omori, D. Gyarmati, B. Zhou, T. Aye, A. Brewer, M. R. Comeau, D. J. Campbell, and S. F. Ziegler. 2005. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J. Exp. Med. 202: 541-549.
8. + B cells in vitro and signals via a novel mechanism. J. Immunol. 162: 677-683.
9. + B cells and produces a novel growth factor affecting B and T lineage cells. Exp. Hematol. 22: 321-328.
10. Soumelis, V., P. A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma, et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3: 673-680.
11. Ying, S., B. O'Connor, J. Ratoff, Q. Meng, K. Mallett, D. Cousins, D. Robinson, G. Zhang, J. Zhao, T. H. Lee, and C. Corrigan. 2005. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J. Immunol. 174: 8183-8190.
12. Taylor, B. C., C. Zaph, A. E. Troy, Y. Du, K. J. Guild, M. R. Comeau, and D. Artis. 2009. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206: 655-667.
13. Ito, T., Y. H. Wang, O. Duramad, T. Hori, G. J. Delespesse, N. Watanabe, F. X. Qin, Z. Yao, W. Cao, and Y. J. Liu. 2005. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202: 1213-1223.
14. Wang, Y. H., T. Ito, Y. H. Wang, B. Homey, N. Watanabe, R. Martin, C. J. Barnes, B. W. McIntyre, M. Gilliet, R. Kumar, et al 2006. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 24: 827-838.
15. + T cell development. J. Exp. Med. 200: 159-168.
16. Kitajima, M., H. C. Lee, T. Nakayama, and S. F. Ziegler. 2011. TSLP enhances the function of helper type 2 cells. Eur. J. Immunol. 41: 1862-1871.
17. Park, L. S., U. Martin, K. Garka, B. Gliniak, J. P. Di Santo, W. Muller, D. A. Largaespada, N. G. Copeland, N. A. Jenkins, A. G. Farr, et al. 2000. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192: 659-670.
18. Pandey, A., K. Ozaki, H. Baumann, S. D. Levin, A. Puel, A. G. Farr, S. F. Ziegler, W. J. Leonard, and H. F. Lodish. 2000. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat. Immunol. 1: 59-64.
19. Wohlmann, A., K. Sebastian, A. Borowski, S. Krause, and K. Friedrich. 2010. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. Biol. Chem. 391: 181-186.
20. + regulatory T cells in human thymus. Nature 436: 1181-1185.
21. Kouzaki, H., S. M. O'Grady, C. B. Lawrence, and H. Kita. 2009. Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2. J. Immunol. 183: 1427-1434.
22. Kato, A., S. Favoreto, Jr., P. C. Avila, and R. P. Schleimer. 2007. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol. 179: 1080-1087.
23. Vu, A. T., T. Baba, X. Chen, T. A. Le, H. Kinoshita, Y. Xie, S. Kamijo, K. Hiramatsu, S. Ikeda, H. Ogawa, et al Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway. J. Allergy Clin. Immunol. 126: 985-993, 993 e981-983.
24. Humphreys, N. E., D. Xu, M. R. Hepworth, F. Y. Liew, and R. K. Grencis. 2008. IL-33, a potent inducer of adaptive immunity to intestinal nematodes. J. Immunol. 180: 2443-2449.
25. Bleck, B., D. B. Tse, M. A. Curotto de Lafaille, F. Zhang, and J. Reibman. 2008. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin. J. Clin. Immunol. 28: 147-156.
26. Nakamura, Y., M. Miyata, T. Ohba, T. Ando, K. Hatsushika, F. Suenaga, N. Shimokawa, Y. Ohnuma, R. Katoh, H. Ogawa, and A. Nakao. 2008. Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H) 2-type immune responses and airway inflammation. J. Allergy Clin. Immunol. 122: 1208-1214.
27. Lee, H. C., and S. F. Ziegler. 2007. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkB. Proc. Natl. Acad. Sci. USA 104: 914-919.
28. Zhang, K., L. Shan, M. S. Rahman, H. Unruh, A. J. Halayko, and A. S. Gounni. 2007. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L375-L382.
29. Okayama, Y., S. Okumura, H. Sagara, K. Yuki, T. Sasaki, N. Watanabe, M. Fueki, K. Sugiyama, K. Takeda, T. Fukuda, et al. 2009. FCεRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells. Eur. Respir. J. 34: 425-435.
30. Redhu, N. S., A. Saleh, A. J. Halayko, A. S. Ali, and A. S. Gounni. 2011. Essential role of NF-κB and AP-1 transcription factors in TNF-a-induced TSLP expression in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 300: L479-L485.
31. Olkhanud, P. B., Y. Rochman, M. Bodogai, E. Malchinkhuu, K. Wejksza, M. Xu, R. E. Gress, C. Hesdorffer, W. J. Leonard, and A. Biragyn. 2011. Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J. Immunol. 186: 5656-5662.
32. De Monte, L., M. Reni, E. Tassi, D. Clavenna, I. Papa, H. Recalde, M. Braga, V. Di Carlo, C. Doglioni, and M. P. Protti. 2011. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J. Exp. Med. 208: 469-478.
33. Hartgring, S. A., C. R. Willis, C. E. Dean, Jr., F. Broere, W. van Eden, J. W. Bijlsma, F. P. Lafeber, and J. A. van Roon. 2011. Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis. Arthritis Rheum. 63: 1878-1887.
34. Koyama, K., T. Ozawa, K. Hatsushika, T. Ando, S. Takano, M. Wako, F. Suenaga, Y. Ohnuma, T. Ohba, R. Katoh, et al. 2007. A possible role for TSLP in inflammatory arthritis. Biochem. Biophys. Res. Commun. 357: 99-104.
35. Oh, M. H., S. Y. Oh, J. Yu, A. C. Myers, W. J. Leonard, Y. J. Liu, Z. Zhu, and T. Zheng. 2011. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J. Immunol. 186: 7232-7242.
36. Reche, P. A., V. Soumelis, D. M. Gorman, T. Clifford, M. Liu Mr, S. M. Travis, J. Zurawski, Y. J. Johnston, H. Liu, Spits, et al. 2001. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J. Immunol. 167: 336-343.
37. Datta, A., C. J. Scotton, and R. C. Chambers. 2011. Novel therapeutic approaches for pulmonary fibrosis. Br. J. Pharmacol. 163: 141-172.
38. Strieter, R. M. 2008. What differentiates normal lung repair and fibrosis? Inflammation, resolution of repair, and fibrosis. Proc. Am. Thorac. Soc. 5: 305-310.
39. Belperio, J. A., M. Dy, M. D. Burdick, Y. Y. Xue, K. Li, J. A. Elias, and M. P. Keane. 2002. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 27: 419-427.
40. Borowski, A., M. Kuepper, U. Horn, U. Knüpfer, G. Zissel, K. Höhne, W. Luttmann, S. Krause, J. C. Virchow, Jr., and K. Friedrich. 2008. Interleukin13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts. Clin. Exp. Allergy 38: 619-628.
41. Marchal-Sommé, J., Y. Uzunhan, S. Marchand-Adam, D. Valeyre, V. Soumelis, B. Crestani, and P. Soler. 2006. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J. Immunol. 176: 5735-5739.
42. 8-mediated activation of TGF-b. J. Clin. Invest. 121: 2863-2875.
43. Karpus, W. J., N. W. Lukacs, K. J. Kennedy, W. S. Smith, S. D. Hurst, and T. A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158: 4129-4136.
44. + T cell activation. J. Immunol. 160: 4606-4614.
45. Gu, L., S. Tseng, R. M. Horner, C. Tam, M. Loda, and B. J. Rollins. 2000. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 404: 407-411.
46. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12: 991-1045.
47. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521.
48. Lois, C., E. J. Hong, S. Pease, E. J. Brown, and D. Baltimore. 2002. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295: 868-872.
49. Hillion, J., S. Dhara, T. F. Sumter, M. Mukherjee, F. Di Cello, A. Belton, J. Turkson, S. Jaganathan, L. Cheng, Z. Ye, et al 2008. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an Achilles heel for hematopoietic malignancies? Cancer Res. 68: 10121-10127.
50. Keerthisingam, C. B., R. G. Jenkins, N. K. Harrison, N. A. HernandezRodriguez, H. Booth, G. J. Laurent, S. L. Hart, M. L. Foster, and R. J. McAnulty. 2001. Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-b in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 158: 1411-1422.
51. Scotton, C. J., M. A. Krupiczojc, M. Königshoff, P. F. Mercer, Y. C. Lee, N. Kaminski, J. Morser, J. M. Post, T. M. Maher, A. G. Nicholson, et al 2009. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J. Clin. Invest. 119: 2550-2563.
52. Thorley, A. J., P. Goldstraw, A. Young, and T. D. Tetley. 2005. Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3a)induced dendritic cell migration. Am. J. Respir. Cell Mol. Biol. 32: 262-267.
53. Mercer, P. F., R. H. Johns, C. J. Scotton, M. A. Krupiczojc, M. Königshoff, D. C. Howell, R. J. McAnulty, A. Das, A. J. Thorley, T. D. Tetley, et al 2009. Pulmonary epithelium is a prominent source of proteinase-activated receptor1-inducible CCL2 in pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 179: 414-425.
54. Falk, W., R. H. Goodwin, Jr., and E. J. Leonard. 1980. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33: 239-247.
55. Oikonomou, N., V. Harokopos, J. Zalevsky, C. Valavanis, A. Kotanidou, D. E. Szymkowski, G. Kollias, and V. Aidinis. 2006. Soluble TNF mediates the transition from pulmonary inflammation to fibrosis. PLoS One 1: e108.
56. Piguet, P. F., C. Ribaux, V. Karpuz, G. E. Grau, and Y. Kapanci. 1993. Expression and localization of tumor necrosis factor-a and its mRNA in idiopathic pulmonary fibrosis. Am. J. Pathol. 143: 651-655.
57. Harada, M., T. Hirota, A. I. Jodo, S. Doi, M. Kameda, K. Fujita, A. Miyatake, T. Enomoto, E. Noguchi, S. Yoshihara, et al. 2009. Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 40: 368-374.
58. Barr, R. K., I. Boehm, P. V. Attwood, P. M. Watt, and M. A. Bogoyevitch. 2004. The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK. J. Biol. Chem. 279: 36327-36338.
59. Shan, L., N. S. Redhu, A. Saleh, A. J. Halayko, J. Chakir, and A. S. Gounni. 2010. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J. Immunol. 184: 7134-7143.
60. Deng, X., P. F. Mercer, C. J. Scotton, A. Gilchrist, and R. C. Chambers. 2008. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol. Biol. Cell 19: 2520-2533.
61. Buckley, C. D., D. Pilling, J. M. Lord, A. N. Akbar, D. Scheel-Toellner, and M. Salmon. 2001. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 22: 199-204.
62. Li, Y. L., H. J. Li, F. Ji, X. Zhang, R. Wang, J. Q. Hao, W. X. Bi, and L. Dong. 2010. Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. J. Asthma 47: 117-123.
63. Wallace, W. A., E. A. Ramage, D. Lamb, and S. E. Howie. 1995. A type 2 (Th2 like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA). Clin. Exp. Immunol. 101: 436-441.
64. Usategui, A., G. Criado, E. Izquierdo, M. J. Del Rey, P. E. Carreira, P. Ortiz, W. J. Leonard, and J. L. Pablos. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann. Rheum. Dis. In press.
65. Christmann, R. B., A. Mathes, A. J. Affandi, C. Padilla, B. Nazari, A. M. Bujor, G. Stifano, and R. Lafyatis. 2013. Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor b. Arthritis Rheum. 65: 1335-1346.
66. Bantsimba-Malanda, C., J. Marchal-Sommé, D. Goven, O. Freynet, L. Michel, B. Crestani, and P. Soler. 2010. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Am. J. Respir. Crit. Care Med. 182: 385-395.
67. Marchal-Sommé, J., Y. Uzunhan, S. Marchand-Adam, M. Kambouchner, D. Valeyre, B. Crestani, and P. Soler. 2007. Dendritic cells accumulate in human fibrotic interstitial lung disease. Am. J. Respir. Crit. Care Med. 176: 1007-1014.
68. Constant, S. L., J. L. Brogdon, D. A. Piggott, C. A. Herrick, I. Visintin, N. H. Ruddle, and K. Bottomly. 2002. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J. Clin. Invest. 110: 1441-1448.
69. Oh, K., H. B. Park, O. J. Byoun, D. M. Shin, E. M. Jeong, Y. W. Kim, Y. S. Kim, G. Melino, I. G. Kim, and D. S. Lee. 2011. Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. J. Exp. Med. 208: 1707-1719.
70. Wilkin, F., X. Duhant, C. Bruyns, N. Suarez-Huerta, J. M. Boeynaems, and B. Robaye. 2001. The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells. J. Immunol. 166: 7172-7177.
71. Gasse, P., N. Riteau, S. Charron, S. Girre, L. Fick, V. Pétrilli, J. Tschopp, V. Lagente, V. F. Quesniaux, B. Ryffel, and I. Couillin. 2009. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 179: 903-913.
72. Riteau, N., P. Gasse, L. Fauconnier, A. Gombault, M. Couegnat, L. Fick, J. Kanellopoulos, V. F. Quesniaux, S. Marchand-Adam, B. Crestani, et al. 2010. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 182: 774-783.
73. Weninger, W., H. S. Carlsen, M. Goodarzi, F. Moazed, M. A. Crowley, E. S. Baekkevold, L. L. Cavanagh, and U. H. von Andrian. 2003. Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J. Immunol. 170: 4638-4648.
74. Cose, S., C. Brammer, K. M. Khanna, D. Masopust, and L. Lefrançois. 2006. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 36: 1423-1433.
75. Parsonage, G., F. Falciani, A. Burman, A. Filer, E. Ross, M. Bofill, S. Martin, M. Salmon, and C. D. Buckley. 2003. Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thromb. Haemost. 90: 688-697.
76. Smith, R. S., T. J. Smith, T. M. Blieden, and R. P. Phipps. 1997. Fibroblasts as sentinel cells: synthesis of chemokines and regulation of inflammation. Am. J. Pathol. 151: 317-322.
77. Kujawski, M., M. Kortylewski, H. Lee, A. Herrmann, H. Kay, and H. Yu. 2008. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J. Clin. Invest. 118: 3367-3377.
78. Lee, H. Y., S. Y. Lee, S. D. Kim, J. W. Shim, H. J. Kim, Y. S. Jung, J. Y. Kwon, S. H. Baek, J. Chung, and Y. S. Bae. 2011. Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. J. Immunol. 186: 4347-4353.
79. Schröer, N., J. Pahne, B. Walch, C. Wickenhauser, and S. Smola. 2011. Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression. Cancer Res. 71: 87-97.
80. Parsonage, G., A. D. Filer, O. Haworth, G. B. Nash, G. E. Rainger, M. Salmon, and C. D. Buckley. 2005. A stromal address code defined by fibroblasts. Trends Immunol. 26: 150-156.
81. Andersson-Sjöland, A., C. G. de Alba, K. Nihlberg, C. Becerril, R. Ramírez, A. Pardo, G. Westergren-Thorsson, and M. Selman. 2008. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int. J. Biochem. Cell Biol. 40: 2129-2140.
82. Qin, S., G. LaRosa, J. J. Campbell, H. Smith-Heath, N. Kassam, X. Shi, L. Zeng, E. C. Buthcher, and C. R. Mackay. 1996. Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential. Eur. J. Immunol. 26: 640-647.
83. Loetscher, P., M. Seitz, M. Baggiolini, and B. Moser. 1996. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J. Exp. Med. 184: 569-577.
84. Luzina, I. G., N. W. Todd, A. T. Iacono, and S. P. Atamas. 2008. Roles of T lymphocytes in pulmonary fibrosis. J. Leukoc. Biol. 83: 237-244.
85. Denton, C. P., and V. H. Ong. 2013. Targeted therapies for systemic sclerosis. Nat. Rev. Rheumatol. 9: 451-464.
86. Keir, G. J., T. M. Maher, D. M. Hansell, C. P. Denton, V. H. Ong, S. Singh, A. U. Wells, and E. A. Renzoni. 2012. Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy. Eur. Respir. J. 40: 641-648.