Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function

Biological Chemistry

Volumn 391, Issue 2-3, 2010, Pages 181-186

  Wohlmann, Andreas ^a   Sebastian, Katrin ^a   Borowski, Andreas ^a   Krause, Sebastian ^a,b   Friedrich, Karlheinz ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b INVIGATE GmbH   (Germany)

Author keywords

Asthma bronchiale; Cytokine receptors; JAK STAT signaling

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; PROTEIN TYROSINE KINASE; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; THYMIC STROMAL LYMPHOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ARTICLE; ATOPY; CONTROLLED STUDY; CYTOPLASM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; HUMANS; JANUS KINASE 1; JANUS KINASE 2; MICE; PROTEIN KINASE INHIBITORS; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 77749343026     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.029     Document Type: Article

References (22)

1. Allakhverdi, Z., Comeau, M.R., Jessup, H.K., Yoon, B.R., Brewer, A., Chartier, S., Paquette, N., Ziegler, S.F., Sarfati, M., and Delespesse, G. (2007). Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 204, 253-258.
2. Auernhammer, C.J., Bousquet, C., and Melmed, S. (1999). Auto-regulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. USA 96, 6964-6969.
3. Carpino, N., Thierfelder, W.E., Chang, M.S., Saris, C., Turner, S.J., Ziegler, S.F., and Ihle, J.N. (2004). Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol. Cell. Biol. 24, 2584-2592.
4. Cramer, A., Kleiner, S., Westermann, M., Meissner, A., Lange, A., and Friedrich, K. (2005). Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. J. Cell. Biochem. 95, 805-816.
5. Friedrich, K., Kammer, W., Erhardt, I., Brändlein, S., Sebald, W., and Moriggl, R. (1999). Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphory-lation, and can contribute to both cell proliferation and gene regulation. Int. Immunol. 11, 1283-1294.
6. Fujitani, Y., Hibi, M., Fukada, T., Takahashi-Tezuka, M., Yoshida, H., Yamaguchi, T., Sugiyama, K., Yamanaka, Y., Nakajima, K., and Hirano, T. (1997) An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene 14, 751-761.
7. Greiser, J.S., Stross, C., Heinrich, P.C., Behrmann, I., and Hermanns, H.M. (2002). Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling. J. Biol. Chem. 277, 26959-26965.
8. Isaksen, D.E., Baumann, H., Trobridge, P.A., Farr, A.G., Levin, S.D., and Ziegler, S.F. (1999). Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. J. Immunol. 163, 5971-5977.
9. Isaksen, D.E., Baumann, H., Zhou, B., Nivollet, S., Farr, A.G., Levin, S.D., and Ziegler, S.F. (2002). Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction. J. Immunol. 168, 3288-3294.
10. Krause, S., Behrends, J., Borowski, A., Lohrmann, J., Lang, S., Myrtek, D., Lorenzen, T., Virchow, J.C., Luttmann, W., and Friedrich, K. (2006). Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor α1. Mol. Immunol. 43, 1799-1807.
11. + B cells in vitro and signals via a novel mechanism. J. Immunol. 162, 677-683.
12. Pandey, A., Ozaki, K., Baumann, H., Levin, S.D., Puel, A., Farr, A.G., Ziegler, S.F., Leonard, W.J., and Lodish, H.F. (2000). Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat. Immunol. 1, 59-64.
13. Park, L.S., Martin, U., Garka, K., Gliniak, B., Di Santo, J.P., Muller, W., Largaespada, D.A., Copeland, N.G., Jenkins, N.A., Farr, A.G., et al. (2000). Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192, 659-670.
14. Pedranzini, L., Dechow, T., Berishaj, M., Comenzo, R., Zhou, P., Azare, J., Bornmann, W., and Bromberg, J. (2006). Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 66, 9714-9721.
15. Quentmeier, H., Drexler, H.G., Fleckenstein, D., Zaborski, M., Armstrong, A., Sims, J.E., and Lyman, S.D. (2001). Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia 15, 1286-1292.
16. Reche, P.A., Soumelis, V., Gorman, D.M., Clifford, T., Liu, M., Travis, M., Zurawski, S.M., Johnston, J., Liu, Y.J., Spits, H., et al. (2001). Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J. Immunol. 167, 336-343.
17. Schreiner, S.J., Schiavone, A.P., and Smithgall, T.E. (2002). Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J. Biol. Chem. 277, 45680-45687.
18. Sebastian, K., Borowski, A., Kuepper, M., and Friedrich, K. (2008). Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma. Cell Commun. Signal. 6, 5.
19. Soumelis, V., Reche, P.A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., et al. (2002). Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3, 673-680.
20. Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M., and Kitamura, T. (2001). Molecular cloning of a human novel type I cytokine receptor related to Δ1/TSLPR. Cytogenet. Cell Genet. 93, 23-25.
21. Zhang, W., Wang, J., Wang, Q., Chen, G., Zhang, J., Chen, T., Wan, T., Zhang, Y., and Cao, X. (2001). Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem. Biophys. Res. Commun. 281, 878-883.
22. Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D., Aye, T., Campbell, D.J., and Ziegler, S.F. (2005). Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6, 1047-1053.