Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β

Arthritis and Rheumatism

Volumn 65, Issue 5, 2013, Pages 1335-1346

  Christmann, Romy B ^a   Mathes, Allison ^a   Affandi, Alsya J ^a,b   Padilla, Cristina ^a   Nazari, Banafsheh ^a   Bujor, Andreea M ^a   Stifano, Giuseppina ^a   Lafyatis, Robert ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; CD163 ANTIGEN; CD31 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CXCL9 CHEMOKINE; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR ALPHA; MACROPHAGE ELASTASE; MANNOSE RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OSMOTIC PUMP; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; SYSTEMIC SCLEROSIS; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CYTOKINES; FIBROBLASTS; FIBROSIS; GENE EXPRESSION; HUMANS; INTERLEUKIN-13; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLY I-C; RNA, MESSENGER; SCLERODERMA, DIFFUSE; SKIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84876562814     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37859     Document Type: Article

References (27)

1. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, et al, the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969-76.
2. Hasegawa M, Fujimoto M, Kikuchi K, Takehara K,. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol 1997; 24: 328-32.
3. Granel B, Chevillard C, Allanore Y, Arnaud V, Cabantous S, Marquet S, et al. Evaluation of interleukin 13 polymorphisms in systemic sclerosis. Immunogenetics 2006; 58: 693-9.
4. Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, et al. Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum 2011; 63: 1718-28.
5. Li Q, Wang W, Yamada T, Matsumoto K, Sakai K, Bando Y, et al. Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network. Am J Pathol 2011; 179: 1483-93.
6. Comeau MR, Ziegler SF,. The influence of TSLP on the allergic response. Mucosal Immunol 2010; 3: 138-47.
7. Ziegler SF, Artis D,. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol 2010; 11: 289-93.
8. + T cell homeostatic expansion. Nat Immunol 2004; 5: 426-34.
9. Yoo J, Omori M, Gyarmati D, Zhou B, Aye T, Brewer A, et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 2005; 202: 541-9.
10. Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005; 6: 1047-53.
11. Kato A, Favoreto S Jr, Avila PC, Schleimer RP,. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007; 179: 1080-7.
12. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23: 581-90.
13. Furst DE, Clements PJ, Steen VD, Medsger TA Jr, Masi AT, D'Angelo WA, et al. The modified Rodnan skin score is an accurate reflection of skin biopsy thickness in systemic sclerosis. J Rheumatol 1998; 25: 84-8.
14. Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, et al. Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol 2010; 130: 2583-93.
15. Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K,. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 2005; 202: 637-50.
16. Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R,. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol 2008; 128: 871-81.
17. Foss GS, Prydz H,. Interferon regulatory factor 1 mediates the interferon-γ induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1. J Biol Chem 1999; 274: 35196-202.
18. Zeuthen LH, Fink LN, Frokiaer H,. Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-β. Immunology 2008; 123: 197-208.
19. + monocytes/macrophages. Inflamm Res 2011; 60: 605-10.
20. Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002; 3: 673-80.
21. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ,. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 2011; 187: 1207-11.
22. Lau SK, Chu PG, Weiss LM,. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol 2004; 122: 794-801.
23. Wick G, Backovic A, Rabensteiner E, Plank N, Schwentner C, Sgonc R,. The immunology of fibrosis: innate and adaptive responses. Trends Immunol 2010; 31: 110-9.
24. Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, et al. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol 2011; 186: 7232-42.
25. Kuroda E, Kito T, Yamashita U,. Reduced expression of STAT4 and IFN-γ in macrophages from BALB/c mice. J Immunol 2002; 168: 5477-82.
26. Loke P, Nair MG, Parkinson J, Guiliano D, Blaxter M, Allen JE,. IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunol 2002; 3: 7.
27. Urashima M, Sakuma M, Teramoto S, Fuyama Y, Eto Y, Kondo K, et al. Gene expression profiles of peripheral and cord blood mononuclear cells altered by thymic stromal lymphopoietin. Pediatr Res 2005; 57: 563-9.