The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling

Journal of Hepatology

Volumn 59, Issue 5, 2013, Pages 942-948

  Goto, Kaku ^a,b,c   Lin, Wenyu ^a   Zhang, Leiliang ^a   Jilg, Nikolaus ^a   Shao, Run Xuan ^a   Schaefer, Esperance A K ^a   Zhao, Hong ^a   Fusco, Dahlene N ^a   Peng, Lee F ^a   Kato, Naoya ^b   Chung, Raymond T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

Fibrosis; HCV; Kinase; Metformin; NUAK2; SMAD; SNARK; TGF beta

Indexed keywords

CYCLOSPORIN A; LUCIFERASE; MESSENGER RNA; METFORMIN; PHOSPHOTRANSFERASE; SMALL INTERFERING RNA; SNARK KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LIVER BIOPSY; MUTAGENESIS; MUTANT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPLICON; VIRUS REPLICATION; WESTERN BLOTTING; WILD TYPE;

CSA; CYCLOSPORIN A; FIBROSIS; HCC; HCV; HEPATOCELLULAR CARCINOMA; HOST-TARGETING ANTIVIRALS; HTAS; JAPANESE FULMINANT HEPATITIS 1; JFH1; KINASE; METFORMIN; NUAK2; SMAD; SNARK; SUCROSE-NON-FERMENTING PROTEIN KINASE 1/AMP-ACTIVATED PROTEIN KINASE-RELATED PROTEIN KINASE; SUSTAINED VIROLOGICAL RESPONSE; SVR; TGF-BETA; TGF-Β; TRANSFORMING GROWTH FACTOR BETA;

BIOPSY; CELL LINE; GENE EXPRESSION REGULATION; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER; METFORMIN; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; VIRUS REPLICATION;

EID: 84885960464     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.06.025     Document Type: Article

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