Identification of a novel substrate for TNFα-induced kinase NUAK2

Biochemical and Biophysical Research Communications

Volumn 365, Issue 3, 2008, Pages 541-547

  Yamamoto, Hiroyuki ^a   Takashima, Seiji ^a   Shintani, Yasunori ^a   Yamazaki, Satoru ^b   Seguchi, Osamu ^b   Nakano, Atsushi ^b   Higo, Shuichiro ^a   Kato, Hisakazu ^a   Liao, Yulin ^b   Asano, Yoshihiro ^a   Minamino, Tetsuo ^a   Matsumura, Yasushi ^a   Takeda, Hiroshi ^a   Kitakaze, Masafumi ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

In vitro kinase assay; Myosin phosphatase; Myosin phosphatase target subunit 1 (MYPT1); NUAK family; SNF1 like kinase 2 (NUAK2); TNF

Indexed keywords

MYOSIN PHOSPHATASE TARGET 1 PROTEIN; NUAK FAMILY SNF1 LIKE KINASE 2; PHOSPHOTRANSFERASE; PROTEIN; RHO KINASE; THREONINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL STRESS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION;

AMINO ACID SEQUENCE; CELL LINE; HUMANS; MOLECULAR SEQUENCE DATA; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SUBSTRATE SPECIFICITY; THREONINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 36549041770     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.11.013     Document Type: Article

References (19)

1. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., and Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J. 9 (1995) 899-909
2. Lefebvre D.L., Bai Y., Shahmolky N., Sharma M., Poon R., Drucker D.J., and Rosen C.F. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Biochem. J. 355 (2001) 297-305
3. Lefebvre D.L., and Rosen C.F. Regulation of SNARK activity in response to cellular stresses. Biochim. Biophys. Acta 1724 (2005) 71-85
4. Legembre P., Schickel R., Barnhart B.C., and Peter M.E. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. J. Biol. Chem. 279 (2004) 46742-46747
5. Asano Y., Takashima S., Asakura M., Shintani Y., Liao Y., Minamino T., Asanuma H., Sanada S., Kim J., Ogai A., Fukushima T., Oikawa Y., Okazaki Y., Kaneda Y., Sato M., Miyazaki J., Kitamura S., Tomoike H., Kitakaze M., and Hori M. Lamr1 functional retroposon causes right ventricular dysplasia in mice. Nat. Genet. 36 (2004) 123-130
6. Soker S., Takashima S., Miao H.Q., Neufeld G., and Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 (1998) 735-745
7. Minamino T., Gaussin V., DeMayo F.J., and Schneider M.D. Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein. Circ. Res. 88 (2001) 587-592
8. Kimura K., Ito M., Amano M., Chihara K., Fukata Y., Nakafuku M., Yamamori B., Feng J., Nakano T., Okawa K., Iwamatsu A., and Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273 (1996) 245-248
9. Berwick D.C., and Tavare J.M. Identifying protein kinase substrates: hunting for the organ-grinder's monkeys. Trends Biochem. Sci. 29 (2004) 227-232
10. Kim C., Xuong N.H., and Taylor S.S. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science 307 (2005) 690-696
11. Matsumura F. Regulation of myosin II during cytokinesis in higher eukaryotes. Trends Cell Biol. 15 (2005) 371-377
12. Ito M., Nakano T., Erdodi F., and Hartshorne D.J. Myosin phosphatase: structure, regulation and function. Mol. Cell Biochem. 259 (2004) 197-209
13. Johnson D., Cohen P., Chen M.X., Chen Y.H., and Cohen P.T. Identification of the regions on the M110 subunit of protein phosphatase 1 M that interact with the M21 subunit and with myosin. Eur. J. Biochem. 244 (1997) 931-939
14. Feng J., Ito M., Ichikawa K., Isaka N., Nishikawa M., Hartshorne D.J., and Nakano T. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J. Biol. Chem. 274 (1999) 37385-37390
15. MacDonald J.A., Borman M.A., Muranyi A., Somlyo A.V., Hartshorne D.J., and Haystead T.A. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. Proc. Natl. Acad. Sci. USA 98 (2001) 2419-2424
16. Muranyi A., MacDonald J.A., Deng J.T., Wilson D.P., Haystead T.A., Walsh M.P., Erdodi F., Kiss E., Wu Y., and Hartshorne D.J. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem. J. 366 (2002) 211-216
17. Muranyi A., Zhang R., Liu F., Hirano K., Ito M., Epstein H.F., and Hartshorne D.J. Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. FEBS Lett. 493 (2001) 80-84
18. Velasco G., Armstrong C., Morrice N., Frame S., and Cohen P. Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1 M at Thr850 induces its dissociation from myosin. FEBS Lett. 527 (2002) 101-104
19. Tanaka J., Ito M., Feng J., Ichikawa K., Hamaguchi T., Nakamura M., Hartshorne D.J., and Nakano T. Interaction of myosin phosphatase target subunit 1 with the catalytic subunit of type 1 protein phosphatase. Biochemistry 37 (1998) 16697-16703