-
1
-
-
80051688850
-
The state of hepatitis B and C in Europe: Report from the hepatitis B and C summit conference
-
A. Hatzakis, S. Wait, J. Bruix The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference * J Viral Hepat 18 Suppl 1 2011 1 16
-
(2011)
J Viral Hepat
, vol.18
, Issue.SUPPL. 1
, pp. 1-16
-
-
Hatzakis, A.1
Wait, S.2
Bruix, J.3
-
2
-
-
70349410396
-
Acute hepatitis C virus infection in young adult injection drug users: A prospective study of incident infection, resolution, and reinfection
-
K. Page, J.A. Hahn, J. Evans Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection J Infect Dis 200 2009 1216 1226
-
(2009)
J Infect Dis
, vol.200
, pp. 1216-1226
-
-
Page, K.1
Hahn, J.A.2
Evans, J.3
-
3
-
-
38049106332
-
Acute hepatitis C in a contemporary US cohort: Modes of acquisition and factors influencing viral clearance
-
C.C. Wang, E. Krantz, J. Klarquist Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance J Infect Dis 196 2007 1474 1482
-
(2007)
J Infect Dis
, vol.196
, pp. 1474-1482
-
-
Wang, C.C.1
Krantz, E.2
Klarquist, J.3
-
4
-
-
84860264398
-
Long-term effects of antiviral therapy in patients with chronic hepatitis C
-
T. Kagawa, E.B. Keeffe Long-term effects of antiviral therapy in patients with chronic hepatitis C Hepat Res Treat 2010 2010 562 578
-
(2010)
Hepat Res Treat
, vol.2010
, pp. 562-578
-
-
Kagawa, T.1
Keeffe, E.B.2
-
5
-
-
33644547392
-
Antiviral therapy for chronic hepatitis C: Past, present, and future
-
N. Hayashi, T. Takehara Antiviral therapy for chronic hepatitis C: past, present, and future J Gastroenterol 41 2006 17 27
-
(2006)
J Gastroenterol
, vol.41
, pp. 17-27
-
-
Hayashi, N.1
Takehara, T.2
-
6
-
-
22544470874
-
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
-
T. Wakita, T. Pietschmann, T. Kato Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Nat Med 11 2005 791 796
-
(2005)
Nat Med
, vol.11
, pp. 791-796
-
-
Wakita, T.1
Pietschmann, T.2
Kato, T.3
-
7
-
-
33644862356
-
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
-
B.D. Lindenbach, P. Meuleman, A. Ploss Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro Proc Natl Acad Sci U S A 103 2006 3805 3809
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3805-3809
-
-
Lindenbach, B.D.1
Meuleman, P.2
Ploss, A.3
-
8
-
-
78951472169
-
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome
-
A. Merz, G. Long, M.S. Hiet Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome J Biol Chem 286 2011 3018 3032
-
(2011)
J Biol Chem
, vol.286
, pp. 3018-3032
-
-
Merz, A.1
Long, G.2
Hiet, M.S.3
-
9
-
-
61849160363
-
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
-
A.W. Tai, Y. Benita, L.F. Peng A functional genomic screen identifies cellular cofactors of hepatitis C virus replication Cell Host Microbe 5 2009 298 307
-
(2009)
Cell Host Microbe
, vol.5
, pp. 298-307
-
-
Tai, A.W.1
Benita, Y.2
Peng, L.F.3
-
10
-
-
0346103657
-
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
-
J. Ye, C. Wang, R. Sumpter Jr Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation Proc Natl Acad Sci U S A 100 2003 15865 15870
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15865-15870
-
-
Ye, J.1
Wang, C.2
Sumpter, Jr.R.3
-
11
-
-
79958815982
-
Unique ties between hepatitis C virus replication and intracellular lipids
-
E. Herker, M. Ott Unique ties between hepatitis C virus replication and intracellular lipids Trends Endocrinol Metab 22 2011 241 248
-
(2011)
Trends Endocrinol Metab
, vol.22
, pp. 241-248
-
-
Herker, E.1
Ott, M.2
-
12
-
-
74249112787
-
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
-
R.E. Lanford, E.S. Hildebrandt-Eriksen, A. Petri Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
-
(2010)
Science
, vol.327
, pp. 198-201
-
-
Lanford, R.E.1
Hildebrandt-Eriksen, E.S.2
Petri, A.3
-
13
-
-
0037301154
-
Hepatitis C virus genetic variability: Pathogenic and clinical implications
-
J.M. Pawlotsky Hepatitis C virus genetic variability: pathogenic and clinical implications Clin Liver Dis 7 2003 45 66
-
(2003)
Clin Liver Dis
, vol.7
, pp. 45-66
-
-
Pawlotsky, J.M.1
-
14
-
-
77953013128
-
Rapid emergence of protease inhibitor resistance in hepatitis C virus
-
30ra2
-
L. Rong, H. Dahari, R.M. Ribeiro Rapid emergence of protease inhibitor resistance in hepatitis C virus Sci Transl Med 2 2010 30ra2
-
(2010)
Sci Transl Med
, vol.2
-
-
Rong, L.1
Dahari, H.2
Ribeiro, R.M.3
-
15
-
-
58149388300
-
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
-
T. Kuntzen, J. Timm, A. Berical Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients Hepatology 48 2008 1769 1778
-
(2008)
Hepatology
, vol.48
, pp. 1769-1778
-
-
Kuntzen, T.1
Timm, J.2
Berical, A.3
-
16
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
J.G. McHutchison, G.T. Everson, S.C. Gordon Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection N Engl J Med 360 2009 1827 1838
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
17
-
-
77950817619
-
Telaprevir for previously treated chronic HCV infection
-
J.G. McHutchison, M.P. Manns, A.J. Muir Telaprevir for previously treated chronic HCV infection N Engl J Med 362 2010 1292 1303
-
(2010)
N Engl J Med
, vol.362
, pp. 1292-1303
-
-
McHutchison, J.G.1
Manns, M.P.2
Muir, A.J.3
-
18
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
I.M. Jacobson, J.G. McHutchison, G. Dusheiko Telaprevir for previously untreated chronic hepatitis C virus infection N Engl J Med 364 2011 2405 2416
-
(2011)
N Engl J Med
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
-
19
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
F. Poordad, J. McCone Jr, B.R. Bacon Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med 364 2011 1195 1206
-
(2011)
N Engl J Med
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone, Jr.J.2
Bacon, B.R.3
-
20
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
B.R. Bacon, S.C. Gordon, E. Lawitz Boceprevir for previously treated chronic HCV genotype 1 infection N Engl J Med 364 2011 1207 1217
-
(2011)
N Engl J Med
, vol.364
, pp. 1207-1217
-
-
Bacon, B.R.1
Gordon, S.C.2
Lawitz, E.3
-
21
-
-
79959561437
-
Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
-
V. Garg, R. van Heeswijk, J.E. Lee Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus Hepatology 54 2011 20 27
-
(2011)
Hepatology
, vol.54
, pp. 20-27
-
-
Garg, V.1
Van Heeswijk, R.2
Lee, J.E.3
-
22
-
-
84863393745
-
Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons
-
[Epub ahead of print]
-
D.L. Thomas, J.G. Bartlett, M.G. Peters Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons Clin Infect Dis 2012 Feb 4 [Epub ahead of print]
-
(2012)
Clin Infect Dis
-
-
Thomas, D.L.1
Bartlett, J.G.2
Peters, M.G.3
-
23
-
-
34247594930
-
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
-
C. Sarrazin, T.L. Kieffer, D. Bartels Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir Gastroenterology 132 2007 1767 1777
-
(2007)
Gastroenterology
, vol.132
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
-
24
-
-
73149113353
-
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
-
S. Susser, C. Welsch, Y. Wang Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients Hepatology 50 2009 1709 1718
-
(2009)
Hepatology
, vol.50
, pp. 1709-1718
-
-
Susser, S.1
Welsch, C.2
Wang, Y.3
-
25
-
-
33749360242
-
Rapid decline of viral RNA in hepatitis C patients treated with VX-950: A phase Ib, placebo-controlled, randomized study
-
H.W. Reesink, S. Zeuzem, C.J. Weegink Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study Gastroenterology 131 2006 997 1002
-
(2006)
Gastroenterology
, vol.131
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
-
26
-
-
80052116134
-
Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
-
e1
-
G.R. Foster, C. Hezode, J.P. Bronowicki Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections Gastroenterology 141 2011 881 889 e1
-
(2011)
Gastroenterology
, vol.141
, pp. 881-889
-
-
Foster, G.R.1
Hezode, C.2
Bronowicki, J.P.3
-
27
-
-
80052123459
-
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
-
J.M. Gottwein, T.K. Scheel, T.B. Jensen Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses Gastroenterology 141 2011 1067 1079
-
(2011)
Gastroenterology
, vol.141
, pp. 1067-1079
-
-
Gottwein, J.M.1
Scheel, T.K.2
Jensen, T.B.3
-
28
-
-
79960460175
-
Activity of telaprevir or in combination with peginterferon-alfa-2a and ribavirin the treatment-nave genotype 4 hepatitis-C patients: Final results of Study C210
-
Y. Benhamou, J. Moussali, V. Raziu Activity of telaprevir or in combination with peginterferon-alfa-2a and ribavirin the treatment-nave genotype 4 hepatitis-C patients: final results of Study C210 Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
-
(2010)
Presented As the American Association for the Study of Liver Diseases, Boston, MA
-
-
Benhamou, Y.1
Moussali, J.2
Raziu, V.3
-
29
-
-
80051920720
-
Second-wave protease inhibitors: Choosing an heir
-
S. Ciesek, T. von Hahn, M.P. Manns Second-wave protease inhibitors: choosing an heir Clin Liver Dis 15 2011 597 609
-
(2011)
Clin Liver Dis
, vol.15
, pp. 597-609
-
-
Ciesek, S.1
Von Hahn, T.2
Manns, M.P.3
-
30
-
-
79958830099
-
Hepatitis C virus resistance to protease inhibitors
-
P. Halfon, S. Locarnini Hepatitis C virus resistance to protease inhibitors J Hepatol 55 2011 192 206
-
(2011)
J Hepatol
, vol.55
, pp. 192-206
-
-
Halfon, P.1
Locarnini, S.2
-
31
-
-
65749112245
-
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
-
T.I. Lin, O. Lenz, G. Fanning In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor Antimicrobial agents and chemotherapy 53 2009 1377 1385
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 1377-1385
-
-
Lin, T.I.1
Lenz, O.2
Fanning, G.3
-
32
-
-
84955633838
-
Efficacy and safety of TMC435 in combination with PEG-interferon alpha-2A and ribavirin in treatment naive genotype 1 HCV patients: 24 week interim results from the PILLAR trial
-
M.W. Fried, M. Buti, G.J. Dore Efficacy and safety of TMC435 in combination with PEG-interferon alpha-2A and ribavirin in treatment naive genotype 1 HCV patients: 24 week interim results from the PILLAR trial Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
-
(2010)
Presented As the American Association for the Study of Liver Diseases, Boston, MA
-
-
Fried, M.W.1
Buti, M.2
Dore, G.J.3
-
33
-
-
84872240702
-
TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients: Final analysis of the PILLAR phase IIb study
-
M.W. Fried, M. Buti, G.J. Dore TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients: final analysis of the PILLAR phase IIb study Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Fried, M.W.1
Buti, M.2
Dore, G.J.3
-
34
-
-
68649125015
-
TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection
-
Y.S. Tsantrizos TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection Curr Opin Invest Drugs 10 2009 871 881
-
(2009)
Curr Opin Invest Drugs
, vol.10
, pp. 871-881
-
-
Tsantrizos, Y.S.1
-
36
-
-
79960860112
-
Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon alpha-2a and ribavirin in patients with hepatitis C
-
N. Forestier, D. Larrey, P. Marcellin Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon alpha-2a and ribavirin in patients with hepatitis C J Infect Dis 204 2011 601 608
-
(2011)
J Infect Dis
, vol.204
, pp. 601-608
-
-
Forestier, N.1
Larrey, D.2
Marcellin, P.3
-
37
-
-
80051916510
-
Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients
-
E.J. Gane, R. Rouzier, C. Stedman Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients J Hepatol 55 2011 972 979
-
(2011)
J Hepatol
, vol.55
, pp. 972-979
-
-
Gane, E.J.1
Rouzier, R.2
Stedman, C.3
-
38
-
-
78049527728
-
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
-
E.J. Gane, S.K. Roberts, C.A. Stedman Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial Lancet 376 2010 1467 1475
-
(2010)
Lancet
, vol.376
, pp. 1467-1475
-
-
Gane, E.J.1
Roberts, S.K.2
Stedman, C.A.3
-
39
-
-
81855228070
-
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
-
quiz e14
-
S. Zeuzem, T. Asselah, P. Angus Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection Gastroenterology 141 2011 2047 2055 quiz e14
-
(2011)
Gastroenterology
, vol.141
, pp. 2047-2055
-
-
Zeuzem, S.1
Asselah, T.2
Angus, P.3
-
40
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
C. Sarrazin, S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
-
(2010)
Gastroenterology
, vol.138
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
41
-
-
77951210464
-
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435
-
O. Lenz, T. Verbinnen, T.I. Lin In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435 Antimicrob Agents Chemother 54 2010 1878 1887
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 1878-1887
-
-
Lenz, O.1
Verbinnen, T.2
Lin, T.I.3
-
42
-
-
28244461263
-
Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase
-
G. Kukolj, G.A. McGibbon, G. McKercher Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase J Biol Chem 280 2005 39260 39267
-
(2005)
J Biol Chem
, vol.280
, pp. 39260-39267
-
-
Kukolj, G.1
McGibbon, G.A.2
McKercher, G.3
-
43
-
-
57049112290
-
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
-
S. Ali, V. Leveque, S. Le Pogam Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479 Antimicrob Agents Chemother 52 2008 4356 4369
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 4356-4369
-
-
Ali, S.1
Leveque, V.2
Le Pogam, S.3
-
44
-
-
38349194473
-
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups
-
K. Klumpp, G. Kalayanov, H. Ma 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups J Biol Chem 283 2008 2167 2175
-
(2008)
J Biol Chem
, vol.283
, pp. 2167-2175
-
-
Klumpp, K.1
Kalayanov, G.2
Ma, H.3
-
45
-
-
81255184396
-
HCV nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA
-
A.M. Lam, C. Espiritu, S. Bansal HCV nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA J Virol 85 2011 12334 12342
-
(2011)
J Virol
, vol.85
, pp. 12334-12342
-
-
Lam, A.M.1
Espiritu, C.2
Bansal, S.3
-
46
-
-
78349268362
-
RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients
-
S. Le Pogam, A. Seshaadri, A. Ewing RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients J Infect Dis 202 2010 1510 1519
-
(2010)
J Infect Dis
, vol.202
, pp. 1510-1519
-
-
Le Pogam, S.1
Seshaadri, A.2
Ewing, A.3
-
47
-
-
79960449078
-
High rates of early viral reponse, promising safety profile and lack of resistance-related breakthrough in HCV GT 1/4 patients treated with RG7128 plus PEGIFN Alfa-2a/RBV: Planned week 12 interim analysis from the PROPEL Study
-
D.M. Jensen, H. Wedemeyer, R.W. Herring High rates of early viral reponse, promising safety profile and lack of resistance-related breakthrough in HCV GT 1/4 patients treated with RG7128 plus PEGIFN Alfa-2a/RBV: planned week 12 interim analysis from the PROPEL Study Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
-
(2010)
Presented As the American Association for the Study of Liver Diseases, Boston, MA
-
-
Jensen, D.M.1
Wedemeyer, H.2
Herring, R.W.3
-
48
-
-
84860277463
-
Once daily PSI-7977 plus PegIFN/RBV in a phase 2B trial: Rapid virologic suppression in treatment-nave patients with HCV GT2/GT3
-
Berlin, Germany, April
-
Lalezari J, Lawitz E, Rodriguez-Torres M, et al. Once daily PSI-7977 plus PegIFN/RBV in a phase 2B trial: rapid virologic suppression in treatment-nave patients with HCV GT2/GT3. Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011.
-
(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference
-
-
Lalezari, J.1
Lawitz, E.2
Rodriguez-Torres, M.3
-
50
-
-
84860302896
-
Once daily PSI-7977 plus RBV: Pegylated interferon alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or 3
-
E. Gane, C.A. Stedman, R.H. Hyland Once daily PSI-7977 plus RBV: pegylated interferon alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or 3 Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 6, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Gane, E.1
Stedman, C.A.2
Hyland, R.H.3
-
51
-
-
80051931997
-
An overview of emerging therapies for the treatment of chronic hepatitis C
-
J.A. Ilyas, J.M. Vierling An overview of emerging therapies for the treatment of chronic hepatitis C Clin Liver Dis 15 2011 515 536
-
(2011)
Clin Liver Dis
, vol.15
, pp. 515-536
-
-
Ilyas, J.A.1
Vierling, J.M.2
-
52
-
-
56149086621
-
Avoiding therapeutic pitfalls: The rational use of specifically targeted agents against hepatitis C infection
-
B.H. McGovern, B.K. Abu Dayyeh, R.T. Chung Avoiding therapeutic pitfalls: the rational use of specifically targeted agents against hepatitis C infection Hepatology 48 2008 1700 1712
-
(2008)
Hepatology
, vol.48
, pp. 1700-1712
-
-
McGovern, B.H.1
Abu Dayyeh, B.K.2
Chung, R.T.3
-
53
-
-
80052070428
-
The HCV NS5B nucleoside and non-nucleoside inhibitors
-
F.E. Membreno, E.J. Lawitz The HCV NS5B nucleoside and non-nucleoside inhibitors Clin Liver Dis 15 2011 611 626
-
(2011)
Clin Liver Dis
, vol.15
, pp. 611-626
-
-
Membreno, F.E.1
Lawitz, E.J.2
-
56
-
-
79960390342
-
Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052
-
R.A. Fridell, D. Qiu, L. Valera Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052 J Virol 85 2011 7312 7320
-
(2011)
J Virol
, vol.85
, pp. 7312-7320
-
-
Fridell, R.A.1
Qiu, D.2
Valera, L.3
-
57
-
-
77956294587
-
Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes
-
P. Ferraris, E. Blanchard, P. Roingeard Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes J Gen Virol 91 2010 2230 2237
-
(2010)
J Gen Virol
, vol.91
, pp. 2230-2237
-
-
Ferraris, P.1
Blanchard, E.2
Roingeard, P.3
-
58
-
-
4544336360
-
Hepatitis C virus NS5A: Tales of a promiscuous protein
-
A. Macdonald, M. Harris Hepatitis C virus NS5A: tales of a promiscuous protein J Gen Virol 85 2004 2485 2502
-
(2004)
J Gen Virol
, vol.85
, pp. 2485-2502
-
-
MacDonald, A.1
Harris, M.2
-
59
-
-
34047174776
-
HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines
-
K.H. Lan, K.L. Lan, W.P. Lee HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines J Hepatol 46 2007 759 767
-
(2007)
J Hepatol
, vol.46
, pp. 759-767
-
-
Lan, K.H.1
Lan, K.L.2
Lee, W.P.3
-
60
-
-
80051939098
-
The NS5A replication complex inhibitors: Difference makers?
-
R.G. Gish, N.A. Meanwell The NS5A replication complex inhibitors: difference makers? Clin Liver Dis 15 2011 627 639
-
(2011)
Clin Liver Dis
, vol.15
, pp. 627-639
-
-
Gish, R.G.1
Meanwell, N.A.2
-
61
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
M. Gao, R.E. Nettles, M. Belema Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature 465 2010 96 100
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
-
62
-
-
81155127803
-
First report of SVR12 for a NS5A replication complex inhibitor, BMS-790052 in combination with peg-IFN-alfa-2a and RBV: Phase 2a trial in treatment-naive HCV-genotype 1 subjects
-
Berlin. March 30-April 3.
-
Pol S, Ghalib RH, Rustgi VK, et al. First report of SVR12 for a NS5A replication complex inhibitor, BMS-790052 in combination with peg-IFN-alfa-2a and RBV: phase 2a trial in treatment-naive HCV-genotype 1 subjects. 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011). Berlin. March 30-April 3.
-
46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011)
-
-
Pol, S.1
Ghalib, R.H.2
Rustgi, V.K.3
-
63
-
-
82455188181
-
Multiple ascending dose study of BMS-790052, an NS5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1
-
R.E. Nettles, M. Gao, M. Bifano Multiple ascending dose study of BMS-790052, an NS5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1 Hepatology 54 2011 1956 1965
-
(2011)
Hepatology
, vol.54
, pp. 1956-1965
-
-
Nettles, R.E.1
Gao, M.2
Bifano, M.3
-
64
-
-
82455192239
-
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
-
R.A. Fridell, C. Wang, J.H. Sun Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations Hepatology 54 2011 1924 1935
-
(2011)
Hepatology
, vol.54
, pp. 1924-1935
-
-
Fridell, R.A.1
Wang, C.2
Sun, J.H.3
-
65
-
-
84872608402
-
Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% SVR12 in HCV genotype 1b-infected null reponders
-
J. Chayama, S. Takahashi, Y. Kawakami Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% SVR12 in HCV genotype 1b-infected null reponders Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Chayama, J.1
Takahashi, S.2
Kawakami, Y.3
-
66
-
-
70349292099
-
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
-
D. Ge, J. Fellay, A.J. Thompson Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
-
(2009)
Nature
, vol.461
, pp. 399-401
-
-
Ge, D.1
Fellay, J.2
Thompson, A.J.3
-
67
-
-
70349548852
-
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
-
V. Suppiah, M. Moldovan, G. Ahlenstiel IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy Nat Genet 41 2009 1100 1104
-
(2009)
Nat Genet
, vol.41
, pp. 1100-1104
-
-
Suppiah, V.1
Moldovan, M.2
Ahlenstiel, G.3
-
68
-
-
77949831342
-
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
-
45 e1-e7
-
A. Rauch, Z. Kutalik, P. Descombes Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study Gastroenterology 138 2010 1338 1345 45 e1-e7
-
(2010)
Gastroenterology
, vol.138
, pp. 1338-1345
-
-
Rauch, A.1
Kutalik, Z.2
Descombes, P.3
-
69
-
-
70349533037
-
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
-
Y. Tanaka, N. Nishida, M. Sugiyama Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Nat Genet 41 2009 1105 1109
-
(2009)
Nat Genet
, vol.41
, pp. 1105-1109
-
-
Tanaka, Y.1
Nishida, N.2
Sugiyama, M.3
-
70
-
-
70349966196
-
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
-
D.L. Thomas, C.L. Thio, M.P. Martin Genetic variation in IL28B and spontaneous clearance of hepatitis C virus Nature 461 2009 798 801
-
(2009)
Nature
, vol.461
, pp. 798-801
-
-
Thomas, D.L.1
Thio, C.L.2
Martin, M.P.3
-
71
-
-
78049469161
-
A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
-
92 e1
-
H.L. Tillmann, A.J. Thompson, K. Patel A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice Gastroenterology 139 2010 1586 1592 92 e1
-
(2010)
Gastroenterology
, vol.139
, pp. 1586-1592
-
-
Tillmann, H.L.1
Thompson, A.J.2
Patel, K.3
-
72
-
-
0037243222
-
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
-
S.V. Kotenko, G. Gallagher, V.V. Baurin IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Nat Immunol 4 2003 69 77
-
(2003)
Nat Immunol
, vol.4
, pp. 69-77
-
-
Kotenko, S.V.1
Gallagher, G.2
Baurin, V.V.3
-
73
-
-
0037236826
-
IL-28, IL-29 and their class II cytokine receptor IL-28R
-
P. Sheppard, W. Kindsvogel, W. Xu IL-28, IL-29 and their class II cytokine receptor IL-28R Nat Immunol 4 2003 63 68
-
(2003)
Nat Immunol
, vol.4
, pp. 63-68
-
-
Sheppard, P.1
Kindsvogel, W.2
Xu, W.3
-
74
-
-
68949110201
-
Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
-
H.H. Gad, C. Dellgren, O.J. Hamming Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family J Biol Chem 284 2009 20869 20875
-
(2009)
J Biol Chem
, vol.284
, pp. 20869-20875
-
-
Gad, H.H.1
Dellgren, C.2
Hamming, O.J.3
-
75
-
-
79960462492
-
IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
-
L. Zhang, N. Jilg, R.X. Shao IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway J Hepatol 55 2011 289 298
-
(2011)
J Hepatol
, vol.55
, pp. 289-298
-
-
Zhang, L.1
Jilg, N.2
Shao, R.X.3
-
76
-
-
33750631014
-
Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
-
S.E. Doyle, H. Schreckhise, K. Khuu-Duong Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes Hepatology 44 2006 896 906
-
(2006)
Hepatology
, vol.44
, pp. 896-906
-
-
Doyle, S.E.1
Schreckhise, H.2
Khuu-Duong, K.3
-
77
-
-
33845605155
-
Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
-
T. Marcello, A. Grakoui, G. Barba-Spaeth Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics Gastroenterology 131 2006 1887 1898
-
(2006)
Gastroenterology
, vol.131
, pp. 1887-1898
-
-
Marcello, T.1
Grakoui, A.2
Barba-Spaeth, G.3
-
78
-
-
42949160129
-
IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
-
C. Sommereyns, S. Paul, P. Staeheli, T. Michiels IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo PLoS Pathogens 4 2008 e1000017
-
(2008)
PLoS Pathogens
, vol.4
, pp. 1000017
-
-
Sommereyns, C.1
Paul, S.2
Staeheli, P.3
Michiels, T.4
-
79
-
-
77955873433
-
Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
-
A.J. Muir, M.L. Shiffman, A. Zaman Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection Hepatology 52 2010 822 832
-
(2010)
Hepatology
, vol.52
, pp. 822-832
-
-
Muir, A.J.1
Shiffman, M.L.2
Zaman, A.3
-
80
-
-
84860270365
-
Safety and efficacy of pegylated interferon lambda compared to pegylated interferon alfa 2a in HCV infected patients (G1/2/3) with compensated cirrhosis: EMERGE Phase IIB efficacy and safety results through week 12
-
M. Rodriguez-Torres, J.L. Hillson, P.R. Bacon Safety and efficacy of pegylated interferon lambda compared to pegylated interferon alfa 2a in HCV infected patients (G1/2/3) with compensated cirrhosis: EMERGE Phase IIB efficacy and safety results through week 12 Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
-
(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
-
-
Rodriguez-Torres, M.1
Hillson, J.L.2
Bacon, P.R.3
-
81
-
-
0023927002
-
Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus
-
S. Teraoka, S. Mishiro, K. Ebihara Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus Transpl Proc 20 1988 868 876
-
(1988)
Transpl Proc
, vol.20
, pp. 868-876
-
-
Teraoka, S.1
Mishiro, S.2
Ebihara, K.3
-
82
-
-
67649412015
-
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
-
X. Hanoulle, A. Badillo, J.M. Wieruszeski Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B J Biol Chem 284 2009 13589 13601
-
(2009)
J Biol Chem
, vol.284
, pp. 13589-13601
-
-
Hanoulle, X.1
Badillo, A.2
Wieruszeski, J.M.3
-
83
-
-
75749110945
-
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro
-
S. Hopkins, B. Scorneaux, Z. Huang SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro Antimicrob Agents Chemother 54 2010 660 672
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 660-672
-
-
Hopkins, S.1
Scorneaux, B.2
Huang, Z.3
-
84
-
-
84860270361
-
Resistance selection following 15 days of monotherapy with SCY-635 a non-immunosuppressive cyclophilin inhibitor with potent anti-HCV activity
-
Vienna, Austria. April 14-18
-
Hopkins S, Mosier S, Harris R, et al. Resistance selection following 15 days of monotherapy with SCY-635 a non-immunosuppressive cyclophilin inhibitor with potent anti-HCV activity. 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010). Vienna, Austria. April 14-18, 2010.
-
(2010)
45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010)
-
-
Hopkins, S.1
Mosier, S.2
Harris, R.3
-
85
-
-
78149434641
-
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
-
L. Coelmont, X. Hanoulle, U. Chatterji DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A PloS One 5 2010 e13687
-
(2010)
PloS One
, vol.5
, pp. 13687
-
-
Coelmont, L.1
Hanoulle, X.2
Chatterji, U.3
-
86
-
-
66149129922
-
The cyclophilin inhibitor Debio 025 combined with PEGIFN alpha2a significantly reduces viral load in treatment-naive hepatitis C patients
-
R. Flisiak, S.V. Feinman, M. Jablkowski The cyclophilin inhibitor Debio 025 combined with PEGIFN alpha2a significantly reduces viral load in treatment-naive hepatitis C patients Hepatology 49 2009 1460 1468
-
(2009)
Hepatology
, vol.49
, pp. 1460-1468
-
-
Flisiak, R.1
Feinman, S.V.2
Jablkowski, M.3
-
87
-
-
84860277453
-
Once daily alisporivir IFN-free regimens achieve high rates of early HCV clearance in previously untreated patients with genotype 2 or 3
-
J.M. Pawlotsky, R. Flisiak, J. Rasenack Once daily alisporivir IFN-free regimens achieve high rates of early HCV clearance in previously untreated patients with genotype 2 or 3 Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Pawlotsky, J.M.1
Flisiak, R.2
Rasenack, J.3
-
89
-
-
84860277454
-
Once daily alisporivir (DEB025) plus PegIFNalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients
-
Flisiak R, Pawlotsky J-M, Crabbé R, et al. Once daily alisporivir (DEB025) plus PegIFNalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients. 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011).
-
46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011)
-
-
Flisiak R, P.1
-
90
-
-
84860270364
-
Alisporivir - A host-targeting antiviral provides low viral breakthrough rate and high barrier to resistance in HCV genotype 1 treatment-naive patients in the Phase IIb ESSENTIAL study
-
B. Li, J. Snoeck, Y. Tang Alisporivir - a host-targeting antiviral provides low viral breakthrough rate and high barrier to resistance in HCV genotype 1 treatment-naive patients in the Phase IIb ESSENTIAL study Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Li, B.1
Snoeck, J.2
Tang, Y.3
-
91
-
-
77955644289
-
Mammalian microRNAs predominantly act to decrease target mRNA levels
-
H. Guo, N.T. Ingolia, J.S. Weissman, D.P. Bartel Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 2010 835 840
-
(2010)
Nature
, vol.466
, pp. 835-840
-
-
Guo, H.1
Ingolia, N.T.2
Weissman, J.S.3
Bartel, D.P.4
-
92
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2009 215 233
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
93
-
-
46749124698
-
Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome
-
C.L. Jopling, S. Schutz, P. Sarnow Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome Cell Host Microbe 4 2008 77 85
-
(2008)
Cell Host Microbe
, vol.4
, pp. 77-85
-
-
Jopling, C.L.1
Schutz, S.2
Sarnow, P.3
-
94
-
-
77953315225
-
Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
-
R.K. Jangra, M. Yi, S.M. Lemon Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122 J Virol 84 2010 6615 6625
-
(2010)
J Virol
, vol.84
, pp. 6615-6625
-
-
Jangra, R.K.1
Yi, M.2
Lemon, S.M.3
-
95
-
-
84860292138
-
A randomized, double-blind, placebo controlled safety and anti-viral proof of concept study of miravirsen, an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 chronic HCV infection
-
H.L. Janssen, H. Reesink, S. Zeuzem A randomized, double-blind, placebo controlled safety and anti-viral proof of concept study of miravirsen, an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 chronic HCV infection Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
-
(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
-
-
Janssen, H.L.1
Reesink, H.2
Zeuzem, S.3
-
96
-
-
79960851480
-
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
L.F. Peng, E.A. Schaefer, N. Maloof Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl- coenzyme A synthase J Infect Dis 204 2011 609 616
-
(2011)
J Infect Dis
, vol.204
, pp. 609-616
-
-
Peng, L.F.1
Schaefer, E.A.2
Maloof, N.3
-
97
-
-
33745903898
-
Different anti-HCV profiles of statins and their potential for combination therapy with interferon
-
M. Ikeda, K. Abe, M. Yamada Different anti-HCV profiles of statins and their potential for combination therapy with interferon Hepatology 44 2006 117 125
-
(2006)
Hepatology
, vol.44
, pp. 117-125
-
-
Ikeda, M.1
Abe, K.2
Yamada, M.3
-
98
-
-
34247378117
-
Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: A pilot clinical trial
-
J.G. O'Leary, J.L. Chan, C.M. McMahon Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trial Hepatology 45 2007 895 898
-
(2007)
Hepatology
, vol.45
, pp. 895-898
-
-
O'Leary, J.G.1
Chan, J.L.2
McMahon, C.M.3
-
99
-
-
44949165396
-
Fluvastatin inhibits hepatitis C replication in humans
-
T. Bader, J. Fazili, M. Madhoun Fluvastatin inhibits hepatitis C replication in humans Am J Gastroenterol 103 2008 1383 1389
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 1383-1389
-
-
Bader, T.1
Fazili, J.2
Madhoun, M.3
-
100
-
-
84860292141
-
Potential enhancement of both early (EVR) and sustained (SVR) virological response by fluvastatin in chronic hepatitis C treated with standard pegIFN-ribavirin therapy A pilot study
-
E.F. Georgescu, L. Streba, R. Teodorescu, G. Mateescu, M. Tataru Abagiu Potential enhancement of both early (EVR) and sustained (SVR) virological response by fluvastatin in chronic hepatitis C treated with standard pegIFN-ribavirin therapy A pilot study Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
-
(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
-
-
Georgescu, E.F.1
Streba, L.2
Teodorescu, R.3
Mateescu, G.4
Tataru Abagiu, M.5
-
101
-
-
84860296898
-
Quadruple therapy with BMS-790052, BMS-650032, and PEG-IFN/RBV for 24 weeks results in 100% SVR12 in genotype 1 null responders
-
A.S. Lok, D. Gardiner, E. Lawitz Quadruple therapy with BMS-790052, BMS-650032, and PEG-IFN/RBV for 24 weeks results in 100% SVR12 in genotype 1 null responders Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
-
(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
-
-
Lok, A.S.1
Gardiner, D.2
Lawitz, E.3
-
102
-
-
81855167442
-
Interferon-free treatment regimens for hepatitis C: Are we there yet?
-
P. Sharma, A.S. Lok Interferon-free treatment regimens for hepatitis C: are we there yet? Gastroenterology 141 2011 1963 1967
-
(2011)
Gastroenterology
, vol.141
, pp. 1963-1967
-
-
Sharma, P.1
Lok, A.S.2
-
103
-
-
84860296899
-
SILENC-1: Sustained virologic response (SVR) and safety of BI201335 combined with PEGInterferon alfa-2a and ribavirin (P/R) in treatment naive patients with chronic genotype 1 HCV infection
-
M.S. Sulkowski, E. Ceasu, T. Asselah SILENC-1: sustained virologic response (SVR) and safety of BI201335 combined with PEGInterferon alfa-2a and ribavirin (P/R) in treatment naive patients with chronic genotype 1 HCV infection Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany April 2011
-
(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany
-
-
Sulkowski, M.S.1
Ceasu, E.2
Asselah, T.3
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104
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84860296900
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Once daily narlaprevir and ritonavir in combination with peginterferon alfa-2b/ribavirin for 12 weeks plus 12 weeks PR in treatment naive patients with HCV gentoype 1 (G1): SVR results from NEXT-1, a Phase 2 Study
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J.M. Vierling, F. Poordad, E. Lawitz Once daily narlaprevir and ritonavir in combination with peginterferon alfa-2b/ribavirin for 12 weeks plus 12 weeks PR in treatment naive patients with HCV gentoype 1 (G1): SVR results from NEXT-1, a Phase 2 Study Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 2011
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(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
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Vierling, J.M.1
Poordad, F.2
Lawitz, E.3
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106
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84860292142
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High sustained virological response (SVR) rate after danoprevir for only 14 days associated with PEG-interferon alfa-2a and ribavirin in treatment-naive chronic HCV genotype 1 patients
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D. Larrey, C. Carenco, D. Guyader High sustained virological response (SVR) rate after danoprevir for only 14 days associated with PEG-interferon alfa-2a and ribavirin in treatment-naive chronic HCV genotype 1 patients Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
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Larrey, D.1
Carenco, C.2
Guyader, D.3
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107
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84860277455
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Sustained virologic response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C infection treated wtih Vaniprevir, a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days
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M.P. Manns, E.J. Gane, M. Rodriguez-Torres Sustained virologic response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C infection treated wtih Vaniprevir, a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
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(2010)
Presented As the American Association for the Study of Liver Diseases, Boston, MA
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Manns, M.P.1
Gane, E.J.2
Rodriguez-Torres, M.3
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108
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ABT-450/Ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a and ribavirin after 3-day monotherapy in genotype 1 HCV-infected treatment-nave subjects: 12-week interim efficacy and safety results
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E. Lawitz, I.A. Gaultier, F. Poordad ABT-450/Ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a and ribavirin after 3-day monotherapy in genotype 1 HCV-infected treatment-nave subjects: 12-week interim efficacy and safety results Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
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Lawitz, E.1
Gaultier, I.A.2
Poordad, F.3
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109
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84860277459
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BMS-650032, an NS3 inhibitor, in combination with PEGinterferon alfa-2a and ribavirin in treatment naive subjects with genotype 1 chronic hepatitis C infection
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J.P. Bronowicki, S. Pol, P.J. Thuluvath BMS-650032, an NS3 inhibitor, in combination with PEGinterferon alfa-2a and ribavirin in treatment naive subjects with genotype 1 chronic hepatitis C infection Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
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Bronowicki, J.P.1
Pol, S.2
Thuluvath, P.J.3
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110
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Four-week treatment with GS-9256 and tegobuvir (GS-9190) +/- RBV +/- PEG, results in enhanced viral suppression on follow-up PEG/RBV therapy, in genotype 1a/1b HCV patients
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G.R. Foster, P. Buggisch, P. Marcellin Four-week treatment with GS-9256 and tegobuvir (GS-9190) +/- RBV +/- PEG, results in enhanced viral suppression on follow-up PEG/RBV therapy, in genotype 1a/1b HCV patients Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, March 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, March
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Foster, G.R.1
Buggisch, P.2
Marcellin, P.3
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111
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MK-5172, a second generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVs) and exhibits cross-genotype activity
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D. Graham, A. Acosta, Z. Guo MK-5172, a second generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVs) and exhibits cross-genotype activity Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 5, 2011
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(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
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Graham, D.1
Acosta, A.2
Guo, Z.3
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112
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First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with PEG-inteferon/ribavirin in treatment naive GT 1/3 patients: Interim analysis from the JUMP-C trial
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P. Pockros, D.M. Jensen, N. Tsai First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with PEG-inteferon/ribavirin in treatment naive GT 1/3 patients: interim analysis from the JUMP-C trial Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany April 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany
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Pockros, P.1
Jensen, D.M.2
Tsai, N.3
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113
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PSI-7977 400mg with PEG/RBV provides 93% SVR across GT 1, 2, and 3
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E. Lawitz, J. Lalezari, T. Hassanein PSI-7977 400mg with PEG/RBV provides 93% SVR across GT 1, 2, and 3 Presented at HepDart, Koloa, Hawaii December 6, 2011
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(2011)
Presented at HepDart, Koloa, Hawaii
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Lawitz, E.1
Lalezari, J.2
Hassanein, T.3
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115
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Factors affecting HCV viral load response to the non-nucleoside polymerase inhibitors ABT-072 and ABT-033
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T. Middleton, Y. He, J. Beyer Factors affecting HCV viral load response to the non-nucleoside polymerase inhibitors ABT-072 and ABT-033 Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April 2011
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(2011)
Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany, April
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Middleton, T.1
He, Y.2
Beyer, J.3
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116
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VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive gentoype 1 HCV patients treated for 12 weeks: ZENITH study, SVR 12 interim analysis
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D.R. Nelson, E. Gane, I.M. Jacobson VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive gentoype 1 HCV patients treated for 12 weeks: ZENITH study, SVR 12 interim analysis Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
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(2011)
Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
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Nelson, D.R.1
Gane, E.2
Jacobson, I.M.3
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