메뉴 건너뛰기




Volumn 142, Issue 6, 2012, Pages

Anti-hepatitis C virus drugs in development

Author keywords

Host Targeted Anti Virals; NS5A Inhibitors; NS5B Inhibitors; Protease Inhibitors

Indexed keywords

ABT 072; ABT 333; ABT 450; ACH 1625; ANTIVIRUS AGENT; ASUNAPREVIR; BI 201335; BI 207127; BOCEPREVIR; CYCLOPHILIN INHIBITOR; DACLATASVIR; DANOPREVIR; FILIBUVIR; GS 9256; GS 9451; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IDX 184; MERICITABINE; MK 5172; NARLAPREVIR; PEGINTERFERON ALPHA; PLACEBO; PSI 7977; RIBAVIRIN; RITONAVIR; SETROBUVIR; SIMEPREVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANIPREVIR; VX 222;

EID: 84860307792     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.02.015     Document Type: Article
Times cited : (88)

References (116)
  • 1
    • 80051688850 scopus 로고    scopus 로고
    • The state of hepatitis B and C in Europe: Report from the hepatitis B and C summit conference
    • A. Hatzakis, S. Wait, J. Bruix The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference * J Viral Hepat 18 Suppl 1 2011 1 16
    • (2011) J Viral Hepat , vol.18 , Issue.SUPPL. 1 , pp. 1-16
    • Hatzakis, A.1    Wait, S.2    Bruix, J.3
  • 2
    • 70349410396 scopus 로고    scopus 로고
    • Acute hepatitis C virus infection in young adult injection drug users: A prospective study of incident infection, resolution, and reinfection
    • K. Page, J.A. Hahn, J. Evans Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection J Infect Dis 200 2009 1216 1226
    • (2009) J Infect Dis , vol.200 , pp. 1216-1226
    • Page, K.1    Hahn, J.A.2    Evans, J.3
  • 3
    • 38049106332 scopus 로고    scopus 로고
    • Acute hepatitis C in a contemporary US cohort: Modes of acquisition and factors influencing viral clearance
    • C.C. Wang, E. Krantz, J. Klarquist Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance J Infect Dis 196 2007 1474 1482
    • (2007) J Infect Dis , vol.196 , pp. 1474-1482
    • Wang, C.C.1    Krantz, E.2    Klarquist, J.3
  • 4
    • 84860264398 scopus 로고    scopus 로고
    • Long-term effects of antiviral therapy in patients with chronic hepatitis C
    • T. Kagawa, E.B. Keeffe Long-term effects of antiviral therapy in patients with chronic hepatitis C Hepat Res Treat 2010 2010 562 578
    • (2010) Hepat Res Treat , vol.2010 , pp. 562-578
    • Kagawa, T.1    Keeffe, E.B.2
  • 5
    • 33644547392 scopus 로고    scopus 로고
    • Antiviral therapy for chronic hepatitis C: Past, present, and future
    • N. Hayashi, T. Takehara Antiviral therapy for chronic hepatitis C: past, present, and future J Gastroenterol 41 2006 17 27
    • (2006) J Gastroenterol , vol.41 , pp. 17-27
    • Hayashi, N.1    Takehara, T.2
  • 6
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • T. Wakita, T. Pietschmann, T. Kato Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Nat Med 11 2005 791 796
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3
  • 7
    • 33644862356 scopus 로고    scopus 로고
    • Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
    • B.D. Lindenbach, P. Meuleman, A. Ploss Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro Proc Natl Acad Sci U S A 103 2006 3805 3809
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3805-3809
    • Lindenbach, B.D.1    Meuleman, P.2    Ploss, A.3
  • 8
    • 78951472169 scopus 로고    scopus 로고
    • Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome
    • A. Merz, G. Long, M.S. Hiet Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome J Biol Chem 286 2011 3018 3032
    • (2011) J Biol Chem , vol.286 , pp. 3018-3032
    • Merz, A.1    Long, G.2    Hiet, M.S.3
  • 9
    • 61849160363 scopus 로고    scopus 로고
    • A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
    • A.W. Tai, Y. Benita, L.F. Peng A functional genomic screen identifies cellular cofactors of hepatitis C virus replication Cell Host Microbe 5 2009 298 307
    • (2009) Cell Host Microbe , vol.5 , pp. 298-307
    • Tai, A.W.1    Benita, Y.2    Peng, L.F.3
  • 10
    • 0346103657 scopus 로고    scopus 로고
    • Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
    • J. Ye, C. Wang, R. Sumpter Jr Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation Proc Natl Acad Sci U S A 100 2003 15865 15870
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15865-15870
    • Ye, J.1    Wang, C.2    Sumpter, Jr.R.3
  • 11
    • 79958815982 scopus 로고    scopus 로고
    • Unique ties between hepatitis C virus replication and intracellular lipids
    • E. Herker, M. Ott Unique ties between hepatitis C virus replication and intracellular lipids Trends Endocrinol Metab 22 2011 241 248
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 241-248
    • Herker, E.1    Ott, M.2
  • 12
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • R.E. Lanford, E.S. Hildebrandt-Eriksen, A. Petri Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3
  • 13
    • 0037301154 scopus 로고    scopus 로고
    • Hepatitis C virus genetic variability: Pathogenic and clinical implications
    • J.M. Pawlotsky Hepatitis C virus genetic variability: pathogenic and clinical implications Clin Liver Dis 7 2003 45 66
    • (2003) Clin Liver Dis , vol.7 , pp. 45-66
    • Pawlotsky, J.M.1
  • 14
    • 77953013128 scopus 로고    scopus 로고
    • Rapid emergence of protease inhibitor resistance in hepatitis C virus
    • 30ra2
    • L. Rong, H. Dahari, R.M. Ribeiro Rapid emergence of protease inhibitor resistance in hepatitis C virus Sci Transl Med 2 2010 30ra2
    • (2010) Sci Transl Med , vol.2
    • Rong, L.1    Dahari, H.2    Ribeiro, R.M.3
  • 15
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • T. Kuntzen, J. Timm, A. Berical Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients Hepatology 48 2008 1769 1778
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 16
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • J.G. McHutchison, G.T. Everson, S.C. Gordon Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection N Engl J Med 360 2009 1827 1838
    • (2009) N Engl J Med , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 17
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • J.G. McHutchison, M.P. Manns, A.J. Muir Telaprevir for previously treated chronic HCV infection N Engl J Med 362 2010 1292 1303
    • (2010) N Engl J Med , vol.362 , pp. 1292-1303
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 18
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • I.M. Jacobson, J.G. McHutchison, G. Dusheiko Telaprevir for previously untreated chronic hepatitis C virus infection N Engl J Med 364 2011 2405 2416
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 19
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • F. Poordad, J. McCone Jr, B.R. Bacon Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med 364 2011 1195 1206
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, Jr.J.2    Bacon, B.R.3
  • 20
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • B.R. Bacon, S.C. Gordon, E. Lawitz Boceprevir for previously treated chronic HCV genotype 1 infection N Engl J Med 364 2011 1207 1217
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 21
    • 79959561437 scopus 로고    scopus 로고
    • Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
    • V. Garg, R. van Heeswijk, J.E. Lee Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus Hepatology 54 2011 20 27
    • (2011) Hepatology , vol.54 , pp. 20-27
    • Garg, V.1    Van Heeswijk, R.2    Lee, J.E.3
  • 22
    • 84863393745 scopus 로고    scopus 로고
    • Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons
    • [Epub ahead of print]
    • D.L. Thomas, J.G. Bartlett, M.G. Peters Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons Clin Infect Dis 2012 Feb 4 [Epub ahead of print]
    • (2012) Clin Infect Dis
    • Thomas, D.L.1    Bartlett, J.G.2    Peters, M.G.3
  • 23
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • C. Sarrazin, T.L. Kieffer, D. Bartels Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir Gastroenterology 132 2007 1767 1777
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3
  • 24
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • S. Susser, C. Welsch, Y. Wang Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients Hepatology 50 2009 1709 1718
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3
  • 25
    • 33749360242 scopus 로고    scopus 로고
    • Rapid decline of viral RNA in hepatitis C patients treated with VX-950: A phase Ib, placebo-controlled, randomized study
    • H.W. Reesink, S. Zeuzem, C.J. Weegink Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study Gastroenterology 131 2006 997 1002
    • (2006) Gastroenterology , vol.131 , pp. 997-1002
    • Reesink, H.W.1    Zeuzem, S.2    Weegink, C.J.3
  • 26
    • 80052116134 scopus 로고    scopus 로고
    • Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
    • e1
    • G.R. Foster, C. Hezode, J.P. Bronowicki Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections Gastroenterology 141 2011 881 889 e1
    • (2011) Gastroenterology , vol.141 , pp. 881-889
    • Foster, G.R.1    Hezode, C.2    Bronowicki, J.P.3
  • 27
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    • J.M. Gottwein, T.K. Scheel, T.B. Jensen Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses Gastroenterology 141 2011 1067 1079
    • (2011) Gastroenterology , vol.141 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3
  • 28
    • 79960460175 scopus 로고    scopus 로고
    • Activity of telaprevir or in combination with peginterferon-alfa-2a and ribavirin the treatment-nave genotype 4 hepatitis-C patients: Final results of Study C210
    • Y. Benhamou, J. Moussali, V. Raziu Activity of telaprevir or in combination with peginterferon-alfa-2a and ribavirin the treatment-nave genotype 4 hepatitis-C patients: final results of Study C210 Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
    • (2010) Presented As the American Association for the Study of Liver Diseases, Boston, MA
    • Benhamou, Y.1    Moussali, J.2    Raziu, V.3
  • 29
    • 80051920720 scopus 로고    scopus 로고
    • Second-wave protease inhibitors: Choosing an heir
    • S. Ciesek, T. von Hahn, M.P. Manns Second-wave protease inhibitors: choosing an heir Clin Liver Dis 15 2011 597 609
    • (2011) Clin Liver Dis , vol.15 , pp. 597-609
    • Ciesek, S.1    Von Hahn, T.2    Manns, M.P.3
  • 30
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • P. Halfon, S. Locarnini Hepatitis C virus resistance to protease inhibitors J Hepatol 55 2011 192 206
    • (2011) J Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 31
    • 65749112245 scopus 로고    scopus 로고
    • In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
    • T.I. Lin, O. Lenz, G. Fanning In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor Antimicrobial agents and chemotherapy 53 2009 1377 1385
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , pp. 1377-1385
    • Lin, T.I.1    Lenz, O.2    Fanning, G.3
  • 32
    • 84955633838 scopus 로고    scopus 로고
    • Efficacy and safety of TMC435 in combination with PEG-interferon alpha-2A and ribavirin in treatment naive genotype 1 HCV patients: 24 week interim results from the PILLAR trial
    • M.W. Fried, M. Buti, G.J. Dore Efficacy and safety of TMC435 in combination with PEG-interferon alpha-2A and ribavirin in treatment naive genotype 1 HCV patients: 24 week interim results from the PILLAR trial Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
    • (2010) Presented As the American Association for the Study of Liver Diseases, Boston, MA
    • Fried, M.W.1    Buti, M.2    Dore, G.J.3
  • 34
    • 68649125015 scopus 로고    scopus 로고
    • TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection
    • Y.S. Tsantrizos TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection Curr Opin Invest Drugs 10 2009 871 881
    • (2009) Curr Opin Invest Drugs , vol.10 , pp. 871-881
    • Tsantrizos, Y.S.1
  • 36
    • 79960860112 scopus 로고    scopus 로고
    • Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon alpha-2a and ribavirin in patients with hepatitis C
    • N. Forestier, D. Larrey, P. Marcellin Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon alpha-2a and ribavirin in patients with hepatitis C J Infect Dis 204 2011 601 608
    • (2011) J Infect Dis , vol.204 , pp. 601-608
    • Forestier, N.1    Larrey, D.2    Marcellin, P.3
  • 37
    • 80051916510 scopus 로고    scopus 로고
    • Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients
    • E.J. Gane, R. Rouzier, C. Stedman Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients J Hepatol 55 2011 972 979
    • (2011) J Hepatol , vol.55 , pp. 972-979
    • Gane, E.J.1    Rouzier, R.2    Stedman, C.3
  • 38
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • E.J. Gane, S.K. Roberts, C.A. Stedman Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial Lancet 376 2010 1467 1475
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.3
  • 39
    • 81855228070 scopus 로고    scopus 로고
    • Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
    • quiz e14
    • S. Zeuzem, T. Asselah, P. Angus Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection Gastroenterology 141 2011 2047 2055 quiz e14
    • (2011) Gastroenterology , vol.141 , pp. 2047-2055
    • Zeuzem, S.1    Asselah, T.2    Angus, P.3
  • 40
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • C. Sarrazin, S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 41
    • 77951210464 scopus 로고    scopus 로고
    • In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435
    • O. Lenz, T. Verbinnen, T.I. Lin In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435 Antimicrob Agents Chemother 54 2010 1878 1887
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1878-1887
    • Lenz, O.1    Verbinnen, T.2    Lin, T.I.3
  • 42
    • 28244461263 scopus 로고    scopus 로고
    • Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase
    • G. Kukolj, G.A. McGibbon, G. McKercher Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase J Biol Chem 280 2005 39260 39267
    • (2005) J Biol Chem , vol.280 , pp. 39260-39267
    • Kukolj, G.1    McGibbon, G.A.2    McKercher, G.3
  • 43
    • 57049112290 scopus 로고    scopus 로고
    • Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
    • S. Ali, V. Leveque, S. Le Pogam Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479 Antimicrob Agents Chemother 52 2008 4356 4369
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4356-4369
    • Ali, S.1    Leveque, V.2    Le Pogam, S.3
  • 44
    • 38349194473 scopus 로고    scopus 로고
    • 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups
    • K. Klumpp, G. Kalayanov, H. Ma 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups J Biol Chem 283 2008 2167 2175
    • (2008) J Biol Chem , vol.283 , pp. 2167-2175
    • Klumpp, K.1    Kalayanov, G.2    Ma, H.3
  • 45
    • 81255184396 scopus 로고    scopus 로고
    • HCV nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA
    • A.M. Lam, C. Espiritu, S. Bansal HCV nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA J Virol 85 2011 12334 12342
    • (2011) J Virol , vol.85 , pp. 12334-12342
    • Lam, A.M.1    Espiritu, C.2    Bansal, S.3
  • 46
    • 78349268362 scopus 로고    scopus 로고
    • RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients
    • S. Le Pogam, A. Seshaadri, A. Ewing RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients J Infect Dis 202 2010 1510 1519
    • (2010) J Infect Dis , vol.202 , pp. 1510-1519
    • Le Pogam, S.1    Seshaadri, A.2    Ewing, A.3
  • 47
    • 79960449078 scopus 로고    scopus 로고
    • High rates of early viral reponse, promising safety profile and lack of resistance-related breakthrough in HCV GT 1/4 patients treated with RG7128 plus PEGIFN Alfa-2a/RBV: Planned week 12 interim analysis from the PROPEL Study
    • D.M. Jensen, H. Wedemeyer, R.W. Herring High rates of early viral reponse, promising safety profile and lack of resistance-related breakthrough in HCV GT 1/4 patients treated with RG7128 plus PEGIFN Alfa-2a/RBV: planned week 12 interim analysis from the PROPEL Study Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
    • (2010) Presented As the American Association for the Study of Liver Diseases, Boston, MA
    • Jensen, D.M.1    Wedemeyer, H.2    Herring, R.W.3
  • 51
    • 80051931997 scopus 로고    scopus 로고
    • An overview of emerging therapies for the treatment of chronic hepatitis C
    • J.A. Ilyas, J.M. Vierling An overview of emerging therapies for the treatment of chronic hepatitis C Clin Liver Dis 15 2011 515 536
    • (2011) Clin Liver Dis , vol.15 , pp. 515-536
    • Ilyas, J.A.1    Vierling, J.M.2
  • 52
    • 56149086621 scopus 로고    scopus 로고
    • Avoiding therapeutic pitfalls: The rational use of specifically targeted agents against hepatitis C infection
    • B.H. McGovern, B.K. Abu Dayyeh, R.T. Chung Avoiding therapeutic pitfalls: the rational use of specifically targeted agents against hepatitis C infection Hepatology 48 2008 1700 1712
    • (2008) Hepatology , vol.48 , pp. 1700-1712
    • McGovern, B.H.1    Abu Dayyeh, B.K.2    Chung, R.T.3
  • 53
    • 80052070428 scopus 로고    scopus 로고
    • The HCV NS5B nucleoside and non-nucleoside inhibitors
    • F.E. Membreno, E.J. Lawitz The HCV NS5B nucleoside and non-nucleoside inhibitors Clin Liver Dis 15 2011 611 626
    • (2011) Clin Liver Dis , vol.15 , pp. 611-626
    • Membreno, F.E.1    Lawitz, E.J.2
  • 56
    • 79960390342 scopus 로고    scopus 로고
    • Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052
    • R.A. Fridell, D. Qiu, L. Valera Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052 J Virol 85 2011 7312 7320
    • (2011) J Virol , vol.85 , pp. 7312-7320
    • Fridell, R.A.1    Qiu, D.2    Valera, L.3
  • 57
    • 77956294587 scopus 로고    scopus 로고
    • Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes
    • P. Ferraris, E. Blanchard, P. Roingeard Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes J Gen Virol 91 2010 2230 2237
    • (2010) J Gen Virol , vol.91 , pp. 2230-2237
    • Ferraris, P.1    Blanchard, E.2    Roingeard, P.3
  • 58
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: Tales of a promiscuous protein
    • A. Macdonald, M. Harris Hepatitis C virus NS5A: tales of a promiscuous protein J Gen Virol 85 2004 2485 2502
    • (2004) J Gen Virol , vol.85 , pp. 2485-2502
    • MacDonald, A.1    Harris, M.2
  • 59
    • 34047174776 scopus 로고    scopus 로고
    • HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines
    • K.H. Lan, K.L. Lan, W.P. Lee HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines J Hepatol 46 2007 759 767
    • (2007) J Hepatol , vol.46 , pp. 759-767
    • Lan, K.H.1    Lan, K.L.2    Lee, W.P.3
  • 60
    • 80051939098 scopus 로고    scopus 로고
    • The NS5A replication complex inhibitors: Difference makers?
    • R.G. Gish, N.A. Meanwell The NS5A replication complex inhibitors: difference makers? Clin Liver Dis 15 2011 627 639
    • (2011) Clin Liver Dis , vol.15 , pp. 627-639
    • Gish, R.G.1    Meanwell, N.A.2
  • 61
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • M. Gao, R.E. Nettles, M. Belema Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature 465 2010 96 100
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.E.2    Belema, M.3
  • 62
    • 81155127803 scopus 로고    scopus 로고
    • First report of SVR12 for a NS5A replication complex inhibitor, BMS-790052 in combination with peg-IFN-alfa-2a and RBV: Phase 2a trial in treatment-naive HCV-genotype 1 subjects
    • Berlin. March 30-April 3.
    • Pol S, Ghalib RH, Rustgi VK, et al. First report of SVR12 for a NS5A replication complex inhibitor, BMS-790052 in combination with peg-IFN-alfa-2a and RBV: phase 2a trial in treatment-naive HCV-genotype 1 subjects. 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011). Berlin. March 30-April 3.
    • 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011)
    • Pol, S.1    Ghalib, R.H.2    Rustgi, V.K.3
  • 63
    • 82455188181 scopus 로고    scopus 로고
    • Multiple ascending dose study of BMS-790052, an NS5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1
    • R.E. Nettles, M. Gao, M. Bifano Multiple ascending dose study of BMS-790052, an NS5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1 Hepatology 54 2011 1956 1965
    • (2011) Hepatology , vol.54 , pp. 1956-1965
    • Nettles, R.E.1    Gao, M.2    Bifano, M.3
  • 64
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • R.A. Fridell, C. Wang, J.H. Sun Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations Hepatology 54 2011 1924 1935
    • (2011) Hepatology , vol.54 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.2    Sun, J.H.3
  • 65
    • 84872608402 scopus 로고    scopus 로고
    • Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% SVR12 in HCV genotype 1b-infected null reponders
    • J. Chayama, S. Takahashi, Y. Kawakami Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% SVR12 in HCV genotype 1b-infected null reponders Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Chayama, J.1    Takahashi, S.2    Kawakami, Y.3
  • 66
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • D. Ge, J. Fellay, A.J. Thompson Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 67
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • V. Suppiah, M. Moldovan, G. Ahlenstiel IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy Nat Genet 41 2009 1100 1104
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 68
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • 45 e1-e7
    • A. Rauch, Z. Kutalik, P. Descombes Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study Gastroenterology 138 2010 1338 1345 45 e1-e7
    • (2010) Gastroenterology , vol.138 , pp. 1338-1345
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3
  • 69
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Y. Tanaka, N. Nishida, M. Sugiyama Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Nat Genet 41 2009 1105 1109
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 70
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • D.L. Thomas, C.L. Thio, M.P. Martin Genetic variation in IL28B and spontaneous clearance of hepatitis C virus Nature 461 2009 798 801
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 71
    • 78049469161 scopus 로고    scopus 로고
    • A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    • 92 e1
    • H.L. Tillmann, A.J. Thompson, K. Patel A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice Gastroenterology 139 2010 1586 1592 92 e1
    • (2010) Gastroenterology , vol.139 , pp. 1586-1592
    • Tillmann, H.L.1    Thompson, A.J.2    Patel, K.3
  • 72
    • 0037243222 scopus 로고    scopus 로고
    • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    • S.V. Kotenko, G. Gallagher, V.V. Baurin IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Nat Immunol 4 2003 69 77
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, S.V.1    Gallagher, G.2    Baurin, V.V.3
  • 73
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • P. Sheppard, W. Kindsvogel, W. Xu IL-28, IL-29 and their class II cytokine receptor IL-28R Nat Immunol 4 2003 63 68
    • (2003) Nat Immunol , vol.4 , pp. 63-68
    • Sheppard, P.1    Kindsvogel, W.2    Xu, W.3
  • 74
    • 68949110201 scopus 로고    scopus 로고
    • Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
    • H.H. Gad, C. Dellgren, O.J. Hamming Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family J Biol Chem 284 2009 20869 20875
    • (2009) J Biol Chem , vol.284 , pp. 20869-20875
    • Gad, H.H.1    Dellgren, C.2    Hamming, O.J.3
  • 75
    • 79960462492 scopus 로고    scopus 로고
    • IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
    • L. Zhang, N. Jilg, R.X. Shao IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway J Hepatol 55 2011 289 298
    • (2011) J Hepatol , vol.55 , pp. 289-298
    • Zhang, L.1    Jilg, N.2    Shao, R.X.3
  • 76
    • 33750631014 scopus 로고    scopus 로고
    • Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
    • S.E. Doyle, H. Schreckhise, K. Khuu-Duong Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes Hepatology 44 2006 896 906
    • (2006) Hepatology , vol.44 , pp. 896-906
    • Doyle, S.E.1    Schreckhise, H.2    Khuu-Duong, K.3
  • 77
    • 33845605155 scopus 로고    scopus 로고
    • Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • T. Marcello, A. Grakoui, G. Barba-Spaeth Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics Gastroenterology 131 2006 1887 1898
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3
  • 78
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • C. Sommereyns, S. Paul, P. Staeheli, T. Michiels IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo PLoS Pathogens 4 2008 e1000017
    • (2008) PLoS Pathogens , vol.4 , pp. 1000017
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 79
    • 77955873433 scopus 로고    scopus 로고
    • Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
    • A.J. Muir, M.L. Shiffman, A. Zaman Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection Hepatology 52 2010 822 832
    • (2010) Hepatology , vol.52 , pp. 822-832
    • Muir, A.J.1    Shiffman, M.L.2    Zaman, A.3
  • 81
    • 0023927002 scopus 로고
    • Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus
    • S. Teraoka, S. Mishiro, K. Ebihara Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus Transpl Proc 20 1988 868 876
    • (1988) Transpl Proc , vol.20 , pp. 868-876
    • Teraoka, S.1    Mishiro, S.2    Ebihara, K.3
  • 82
    • 67649412015 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
    • X. Hanoulle, A. Badillo, J.M. Wieruszeski Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B J Biol Chem 284 2009 13589 13601
    • (2009) J Biol Chem , vol.284 , pp. 13589-13601
    • Hanoulle, X.1    Badillo, A.2    Wieruszeski, J.M.3
  • 83
    • 75749110945 scopus 로고    scopus 로고
    • SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro
    • S. Hopkins, B. Scorneaux, Z. Huang SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro Antimicrob Agents Chemother 54 2010 660 672
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 660-672
    • Hopkins, S.1    Scorneaux, B.2    Huang, Z.3
  • 84
    • 84860270361 scopus 로고    scopus 로고
    • Resistance selection following 15 days of monotherapy with SCY-635 a non-immunosuppressive cyclophilin inhibitor with potent anti-HCV activity
    • Vienna, Austria. April 14-18
    • Hopkins S, Mosier S, Harris R, et al. Resistance selection following 15 days of monotherapy with SCY-635 a non-immunosuppressive cyclophilin inhibitor with potent anti-HCV activity. 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010). Vienna, Austria. April 14-18, 2010.
    • (2010) 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010)
    • Hopkins, S.1    Mosier, S.2    Harris, R.3
  • 85
    • 78149434641 scopus 로고    scopus 로고
    • DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
    • L. Coelmont, X. Hanoulle, U. Chatterji DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A PloS One 5 2010 e13687
    • (2010) PloS One , vol.5 , pp. 13687
    • Coelmont, L.1    Hanoulle, X.2    Chatterji, U.3
  • 86
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor Debio 025 combined with PEGIFN alpha2a significantly reduces viral load in treatment-naive hepatitis C patients
    • R. Flisiak, S.V. Feinman, M. Jablkowski The cyclophilin inhibitor Debio 025 combined with PEGIFN alpha2a significantly reduces viral load in treatment-naive hepatitis C patients Hepatology 49 2009 1460 1468
    • (2009) Hepatology , vol.49 , pp. 1460-1468
    • Flisiak, R.1    Feinman, S.V.2    Jablkowski, M.3
  • 89
    • 84860277454 scopus 로고    scopus 로고
    • Once daily alisporivir (DEB025) plus PegIFNalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients
    • Flisiak R, Pawlotsky J-M, Crabbé R, et al. Once daily alisporivir (DEB025) plus PegIFNalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients. 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011).
    • 46th Annual Meeting of the European Association for the Study of the Liver (EASL 2011)
    • Flisiak R, P.1
  • 90
    • 84860270364 scopus 로고    scopus 로고
    • Alisporivir - A host-targeting antiviral provides low viral breakthrough rate and high barrier to resistance in HCV genotype 1 treatment-naive patients in the Phase IIb ESSENTIAL study
    • B. Li, J. Snoeck, Y. Tang Alisporivir - a host-targeting antiviral provides low viral breakthrough rate and high barrier to resistance in HCV genotype 1 treatment-naive patients in the Phase IIb ESSENTIAL study Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Li, B.1    Snoeck, J.2    Tang, Y.3
  • 91
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • H. Guo, N.T. Ingolia, J.S. Weissman, D.P. Bartel Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 2010 835 840
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 92
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2009 215 233
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 93
    • 46749124698 scopus 로고    scopus 로고
    • Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome
    • C.L. Jopling, S. Schutz, P. Sarnow Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome Cell Host Microbe 4 2008 77 85
    • (2008) Cell Host Microbe , vol.4 , pp. 77-85
    • Jopling, C.L.1    Schutz, S.2    Sarnow, P.3
  • 94
    • 77953315225 scopus 로고    scopus 로고
    • Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
    • R.K. Jangra, M. Yi, S.M. Lemon Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122 J Virol 84 2010 6615 6625
    • (2010) J Virol , vol.84 , pp. 6615-6625
    • Jangra, R.K.1    Yi, M.2    Lemon, S.M.3
  • 95
    • 84860292138 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo controlled safety and anti-viral proof of concept study of miravirsen, an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 chronic HCV infection
    • H.L. Janssen, H. Reesink, S. Zeuzem A randomized, double-blind, placebo controlled safety and anti-viral proof of concept study of miravirsen, an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 chronic HCV infection Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Janssen, H.L.1    Reesink, H.2    Zeuzem, S.3
  • 96
    • 79960851480 scopus 로고    scopus 로고
    • Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase
    • L.F. Peng, E.A. Schaefer, N. Maloof Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl- coenzyme A synthase J Infect Dis 204 2011 609 616
    • (2011) J Infect Dis , vol.204 , pp. 609-616
    • Peng, L.F.1    Schaefer, E.A.2    Maloof, N.3
  • 97
    • 33745903898 scopus 로고    scopus 로고
    • Different anti-HCV profiles of statins and their potential for combination therapy with interferon
    • M. Ikeda, K. Abe, M. Yamada Different anti-HCV profiles of statins and their potential for combination therapy with interferon Hepatology 44 2006 117 125
    • (2006) Hepatology , vol.44 , pp. 117-125
    • Ikeda, M.1    Abe, K.2    Yamada, M.3
  • 98
    • 34247378117 scopus 로고    scopus 로고
    • Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: A pilot clinical trial
    • J.G. O'Leary, J.L. Chan, C.M. McMahon Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trial Hepatology 45 2007 895 898
    • (2007) Hepatology , vol.45 , pp. 895-898
    • O'Leary, J.G.1    Chan, J.L.2    McMahon, C.M.3
  • 99
    • 44949165396 scopus 로고    scopus 로고
    • Fluvastatin inhibits hepatitis C replication in humans
    • T. Bader, J. Fazili, M. Madhoun Fluvastatin inhibits hepatitis C replication in humans Am J Gastroenterol 103 2008 1383 1389
    • (2008) Am J Gastroenterol , vol.103 , pp. 1383-1389
    • Bader, T.1    Fazili, J.2    Madhoun, M.3
  • 102
    • 81855167442 scopus 로고    scopus 로고
    • Interferon-free treatment regimens for hepatitis C: Are we there yet?
    • P. Sharma, A.S. Lok Interferon-free treatment regimens for hepatitis C: are we there yet? Gastroenterology 141 2011 1963 1967
    • (2011) Gastroenterology , vol.141 , pp. 1963-1967
    • Sharma, P.1    Lok, A.S.2
  • 104
    • 84860296900 scopus 로고    scopus 로고
    • Once daily narlaprevir and ritonavir in combination with peginterferon alfa-2b/ribavirin for 12 weeks plus 12 weeks PR in treatment naive patients with HCV gentoype 1 (G1): SVR results from NEXT-1, a Phase 2 Study
    • J.M. Vierling, F. Poordad, E. Lawitz Once daily narlaprevir and ritonavir in combination with peginterferon alfa-2b/ribavirin for 12 weeks plus 12 weeks PR in treatment naive patients with HCV gentoype 1 (G1): SVR results from NEXT-1, a Phase 2 Study Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Vierling, J.M.1    Poordad, F.2    Lawitz, E.3
  • 107
    • 84860277455 scopus 로고    scopus 로고
    • Sustained virologic response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C infection treated wtih Vaniprevir, a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days
    • M.P. Manns, E.J. Gane, M. Rodriguez-Torres Sustained virologic response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C infection treated wtih Vaniprevir, a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days Presented as the American Association for the Study of Liver Diseases, Boston, MA November 2010
    • (2010) Presented As the American Association for the Study of Liver Diseases, Boston, MA
    • Manns, M.P.1    Gane, E.J.2    Rodriguez-Torres, M.3
  • 111
    • 84860270370 scopus 로고    scopus 로고
    • MK-5172, a second generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVs) and exhibits cross-genotype activity
    • D. Graham, A. Acosta, Z. Guo MK-5172, a second generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVs) and exhibits cross-genotype activity Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 5, 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Graham, D.1    Acosta, A.2    Guo, Z.3
  • 112
    • 84860277458 scopus 로고    scopus 로고
    • First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with PEG-inteferon/ribavirin in treatment naive GT 1/3 patients: Interim analysis from the JUMP-C trial
    • P. Pockros, D.M. Jensen, N. Tsai First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with PEG-inteferon/ribavirin in treatment naive GT 1/3 patients: interim analysis from the JUMP-C trial Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany April 2011
    • (2011) Presented at the European Association for the Study of the Liver, International Liver Conference, Berlin, Germany
    • Pockros, P.1    Jensen, D.M.2    Tsai, N.3
  • 116
    • 84860292144 scopus 로고    scopus 로고
    • VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive gentoype 1 HCV patients treated for 12 weeks: ZENITH study, SVR 12 interim analysis
    • D.R. Nelson, E. Gane, I.M. Jacobson VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive gentoype 1 HCV patients treated for 12 weeks: ZENITH study, SVR 12 interim analysis Presented as the American Association for the Study of Liver Diseases, San Francisco, CA November 7, 2011
    • (2011) Presented As the American Association for the Study of Liver Diseases, San Francisco, CA
    • Nelson, D.R.1    Gane, E.2    Jacobson, I.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.