Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon

Archives of Toxicology

Volumn 87, Issue 11, 2013, Pages 2013-2022

  Duan, Huawei ^a   He, Zhini ^b   Ma, Junxiang ^a   Zhang, Bo ^b   Sheng, Zhiguo ^c   Bin, Ping ^a   Cheng, Juan ^a   Niu, Yong ^a   Dong, Haiyan ^a   Lin, Han ^d   Dai, Yufei ^a   Zhu, Benzhan ^c   Chen, Wen ^b   Xiao, Yongmei ^b   Zheng, Yuxin ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^d Anshan Thousand Steel Machinery Manufacture Co Ltd   (China)

Author keywords

DNA adducts; Genomic instability; Global methylation; O6 methylguanine DNA methyltransferase (MGMT); Polycyclic aromatic hydrocarbon

Indexed keywords

1 HYDROXYPYRENE; BISULFITE; BLEOMYCIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; POLYCYCLIC AROMATIC HYDROCARBON;

ADULT; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA ADDUCT; DNA METHYLATION; DNA STRUCTURE; DRUG SENSITIVITY; GENETIC DAMAGE; GENOMIC INSTABILITY; HUMAN; IN VITRO STUDY; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS TEST; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING;

ADULT; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELLS, CULTURED; CHINA; CHROMOSOMAL INSTABILITY; COMET ASSAY; DNA DAMAGE; DNA METHYLATION; GENOMIC INSTABILITY; HUMANS; LYMPHOCYTES; MALE; METALLURGY; METHYLATION; MUTAGENS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OCCUPATIONAL EXPOSURE; POLYCYCLIC COMPOUNDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PYRENES; STEEL; SULFITES;

EID: 84885956914     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1046-0     Document Type: Article

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