-
1
-
-
0023236126
-
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme
-
Jentsch S, McGrath JP, Varshavsky A (1987) The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 329:131-134.
-
(1987)
Nature
, vol.329
, pp. 131-134
-
-
Jentsch, S.1
McGrath, J.P.2
Varshavsky, A.3
-
2
-
-
57149115173
-
Discovery of cellular regulation by protein degradation
-
Varshavsky A (2008) Discovery of cellular regulation by protein degradation. J Biol Chem 283:34469-34489.
-
(2008)
J Biol Chem
, vol.283
, pp. 34469-34489
-
-
Varshavsky, A.1
-
3
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper JW, Elledge SJ (2007) The DNA damage response: Ten years after. Mol Cell 28:739-745.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
5
-
-
33847688859
-
Repair of alkylated DNA: Recent advances
-
Sedgwick B, Bates PA, Paik J, Jacobs SC, Lindahl T (2007) Repair of alkylated DNA: Recent advances. DNA Repair 6:429-442.
-
(2007)
DNA Repair
, vol.6
, pp. 429-442
-
-
Sedgwick, B.1
Bates, P.A.2
Paik, J.3
Jacobs, S.C.4
Lindahl, T.5
-
6
-
-
0034650703
-
Crystal structure of the human O6-alkylguanine-DNA alkyltransferase
-
Wibley JEA, Pegg AE, Moody PCE (2000) Crystal structure of the human O6-alkylguanine-DNA alkyltransferase. Nucl Acids Res 28:393-401.
-
(2000)
Nucl Acids Res
, vol.28
, pp. 393-401
-
-
Wibley, J.E.A.1
Pegg, A.E.2
Moody, P.C.E.3
-
7
-
-
0026650587
-
The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: Its promoter and entire coding sequence, regulation and in vivo biological functions
-
Xiao W, Samson L (1992) The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: Its promoter and entire coding sequence, regulation and in vivo biological functions. Nucl Acids Res 20:3599-3606.
-
(1992)
Nucl Acids Res
, vol.20
, pp. 3599-3606
-
-
Xiao, W.1
Samson, L.2
-
8
-
-
0037194597
-
6-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein
-
6-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. Oncogene 21:5940-5945.
-
(2002)
Oncogene
, vol.21
, pp. 5940-5945
-
-
Srivenugopal, K.S.1
Ali-Osman, F.2
-
10
-
-
38449106894
-
HECT E3s and human disease
-
Scheffner M, Staub O (2007) HECT E3s and human disease. BMC Biochemistry 8 (Suppl. I):S6.
-
(2007)
BMC Biochemistry
, vol.8
, Issue.SUPPL. I
-
-
Scheffner, M.1
Staub, O.2
-
11
-
-
1842485068
-
Spalog and sequelog: Neutral terms for spatial and sequence similarity
-
Varshavsky A (2004) Spalog and sequelog: Neutral terms for spatial and sequence similarity. Curr Biol 14:R181-R183.
-
(2004)
Curr Biol
, vol.14
-
-
Varshavsky, A.1
-
12
-
-
0025177276
-
6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae
-
6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae. J Biol Chem 265:20-25.
-
(1990)
J Biol Chem
, vol.265
, pp. 20-25
-
-
Sassanfar, M.1
Samson, L.2
-
13
-
-
3042999556
-
6- methylguanine-DNA methyltransferase (MGMT) gene
-
6- methylguanine-DNA methyltransferase (MGMT) gene. Cell Mol Biol 41:545-553.
-
(1995)
Cell Mol Biol
, vol.41
, pp. 545-553
-
-
Joo, J.H.1
-
14
-
-
0023003380
-
In vivo half-life of a protein is a function of its amino-terminal residue
-
Bachmair A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Science 234:179-186.
-
(1986)
Science
, vol.234
, pp. 179-186
-
-
Bachmair, A.1
Finley, D.2
Varshavsky, A.3
-
15
-
-
0029861143
-
The N-end rule: Functions, mysteries, uses
-
Varshavsky A (1996) The N-end rule: Functions, mysteries, uses. Proc Natl Acad Sci USA 93:12142-12149.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12142-12149
-
-
Varshavsky, A.1
-
16
-
-
33947713897
-
The N-end rule pathway of regulated proteolysis: Prokaryotic and eukaryotic strategies
-
Mogk A, Schmidt R, Bukau B (2007) The N-end rule pathway of regulated proteolysis: Prokaryotic and eukaryotic strategies. Trends Cell Biol 17:165-172.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 165-172
-
-
Mogk, A.1
Schmidt, R.2
Bukau, B.3
-
17
-
-
35548974677
-
The mammalian N-end rule pathway: New insights into its components and physiological roles
-
Tasaki T, Kwon YT (2007) The mammalian N-end rule pathway: New insights into its components and physiological roles. Trends Biochem Sci 32:520-528.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 520-528
-
-
Tasaki, T.1
Kwon, Y.T.2
-
18
-
-
27144557281
-
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators
-
Hu R-G, et al. (2005) The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature 437:981-986.
-
(2005)
Nature
, vol.437
, pp. 981-986
-
-
Hu, R.-G.1
-
19
-
-
53049096418
-
Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway
-
Xia Z, Webster A, Du F, Piatkov K, Ghislain M, Varshavsky A (2008) Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway. J Biol Chem 283:24011-24028.
-
(2008)
J Biol Chem
, vol.283
, pp. 24011-24028
-
-
Xia, Z.1
Webster, A.2
Du, F.3
Piatkov, K.4
Ghislain, M.5
Varshavsky, A.6
-
20
-
-
0033485869
-
The E2-E3 interaction in the N-end rule pathway: The RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain
-
Xie Y, Varshavsky A (1999) The E2-E3 interaction in the N-end rule pathway: The RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain. EMBO J 18:6832-6844.
-
(1999)
EMBO J
, vol.18
, pp. 6832-6844
-
-
Xie, Y.1
Varshavsky, A.2
-
21
-
-
58049196794
-
Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway
-
Hwang C-S, Varshavsky A (2008) Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway. Proc Natl Acad Sci USA 105:19188-19193.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19188-19193
-
-
Hwang, C.-S.1
Varshavsky, A.2
-
22
-
-
0037195103
-
Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain
-
Du F, Navarro-Garcia F, Xia Z, Tasaki T, Varshavsky A (2002) Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain. Proc Natl Acad Sci USA 99:14110-14115.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14110-14115
-
-
Du, F.1
Navarro-Garcia, F.2
Xia, Z.3
Tasaki, T.4
Varshavsky, A.5
-
23
-
-
57649223684
-
Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter
-
Xia Z, Turner GC, Hwang C-S, Byrd C, Varshavsky A (2008) Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter. J Biol Chem 283:28958-28968.
-
(2008)
J Biol Chem
, vol.283
, pp. 28958-28968
-
-
Xia, Z.1
Turner, G.C.2
Hwang, C.-S.3
Byrd, C.4
Varshavsky, A.5
-
25
-
-
0034213352
-
Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway
-
Turner GC, Du F, Varshavsky A (2000) Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature 405:579-583.
-
(2000)
Nature
, vol.405
, pp. 579-583
-
-
Turner1
GC, D.F.2
Varshavsky, A.3
-
27
-
-
0029119522
-
A proteolytic pathway that recognizes ubiquitin as a degradation signal
-
Johnson ES, Ma PC, Ota IM, Varshavsky A (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270:17442-17456.
-
(1995)
J Biol Chem
, vol.270
, pp. 17442-17456
-
-
Johnson, E.S.1
Ma, P.C.2
Ota, I.M.3
Varshavsky, A.4
-
28
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl M, et al. (1999) A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96:635-644.
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
-
29
-
-
33846231904
-
The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins
-
Ju D, Wang X, Xu H, Xie Y (2007) The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins. FEBS Lett 581:265-270.
-
(2007)
FEBS Lett
, vol.581
, pp. 265-270
-
-
Ju, D.1
Wang, X.2
Xu, H.3
Xie, Y.4
-
30
-
-
0034646298
-
Physical association of ubiquitin ligases and the 26S proteasome
-
Xie Y, Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci USA 97:2497-2502.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2497-2502
-
-
Xie, Y.1
Varshavsky, A.2
-
31
-
-
0036904663
-
UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis
-
Xie Y, Varshavsky A (2002) UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis. Nat Cell Biol 4:1003-1007.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 1003-1007
-
-
Xie, Y.1
Varshavsky, A.2
-
32
-
-
33947539481
-
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue
-
Ravid T, Hochstrasser M (2007) Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol 9:422-427.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 422-427
-
-
Ravid, T.1
Hochstrasser, M.2
-
33
-
-
31444434131
-
A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23
-
Ju D, Xie Y (2006) A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23. Biochem Biophys Res Commun 341:648-652.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 648-652
-
-
Ju, D.1
Xie, Y.2
-
34
-
-
21244464796
-
The RAD6 pathway: Control of DNA damage bypass and mutagenesis by ubiquitin and SUMO
-
Ullrich HD (2005) The RAD6 pathway: Control of DNA damage bypass and mutagenesis by ubiquitin and SUMO. ChemBioChem 6:1735-1743.
-
(2005)
ChemBioChem
, vol.6
, pp. 1735-1743
-
-
Ullrich, H.D.1
-
35
-
-
11244343965
-
Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase
-
Wang L, Mao X, Ju D, Xie Y (2004) Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase. J Biol Chem 279:55218-55223.
-
(2004)
J Biol Chem
, vol.279
, pp. 55218-55223
-
-
Wang, L.1
Mao, X.2
Ju, D.3
Xie, Y.4
-
36
-
-
0035853037
-
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit
-
Xie Y, Varshavsky A (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit. Proc Natl Acad Sci USA 98:3056-3061.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3056-3061
-
-
Xie, Y.1
Varshavsky, A.2
-
37
-
-
33646007680
-
Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair
-
Ouyang Y, et al. (2006) Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair. Mut Res 596:64-75.
-
(2006)
Mut Res
, vol.596
, pp. 64-75
-
-
Ouyang, Y.1
-
38
-
-
32544446880
-
6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C
-
6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C. Toxicol Appl Pharmacol 211:97-105.
-
(2006)
Toxicol Appl Pharmacol
, vol.211
, pp. 97-105
-
-
Passagne, I.1
-
39
-
-
0025345753
-
Cis-trans recognition and subunit-specific degradation of short-lived proteins
-
Johnson ES, Gonda DK, Varshavsky A (1990) Cis-trans recognition and subunit-specific degradation of short-lived proteins. Nature 346:287-291.
-
(1990)
Nature
, vol.346
, pp. 287-291
-
-
Johnson, E.S.1
Gonda, D.K.2
Varshavsky, A.3
-
40
-
-
0035912183
-
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability
-
Rao H, Uhlmann F, Nasmyth K, Varshavsky A (2001) Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature 410:955-960.
-
(2001)
Nature
, vol.410
, pp. 955-960
-
-
Rao, H.1
Uhlmann, F.2
Nasmyth, K.3
Varshavsky, A.4
|