Exposure to the saturated free fatty acid palmitate alters BV-2 microglia inflammatory response

Journal of Molecular Neuroscience

Volumn 51, Issue 3, 2013, Pages 805-812

  Tracy, Linda M ^a   Bergqvist, Filip ^a   Ivanova, Elena V ^a   Jacobsen, Kristin T ^a   Iverfeldt, Kerstin ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Alternative activation; C EBP ; Classical activation; IL 1 ; IL 6; Inflammation; Microglia; Palmitate

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN DELTA; CYTOKINE; FATTY ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PALMITIC ACID;

ARTICLE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INFLAMMATION; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; OBESITY; PHAGOCYTOSIS;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CELL LINE; CYTOKINES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; PALMITIC ACID; PHAGOCYTOSIS; RNA, MESSENGER;

EID: 84885950294     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0068-7     Document Type: Article

References (29)

1. Biessels GJ, Kappelle LJ, Utrecht Diabetic Encephalopathy Study Group (2005) Increased risk of Alzheimer's disease in type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochem Soc Trans 33:1041-1044
2. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237
3. Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98
4. Cai D (2013) Neuroinflammation and neurodegeneration in overnutrition-induced diseases. Trends Endocrinol Metab 24:40-47
5. Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4:399-418
6. Ejarque-Ortiz A, Gresa-Arribas N, Straccia M, Mancera P, Sola C, Tusell JM, Serratosa J, Saura J (2010) CCAAT/enhancer binding protein delta in microglial activation. J Neurosci Res 88:1113-23
7. Haversen L, Danielsson KN, Fogelstrand L, Wiklund O (2009) Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202:382-393
8. Jüttler E, Tarabin V, Schwaninger M (2002) Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity. Neuroscientist 8:268-275
9. Kappe C, Tracy LM, Patrone C, Iverfeldt K, Sjoholm A (2012) GLP-1 secretion by microglial cells and decreased CNS expression in obesity. J Neuroinflammation 9:276
10. Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Nagren K, Solin O, Nuutila P (2010) Increased brain fatty acid uptake in metabolic syndrome. Diabetes 59:2171-2177
11. Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (2004) CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol Aging 25:991-999
12. Little JP, Madeira JM, Klegeris A (2012) The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation. J Alzheimers Dis 30(Suppl 2):S179-83
13. Litvak V, Ramsey SA, Rust AG, Zak DE, Kennedy KA, Lampano AE, Nykter M, Shmulevich I, Aderem A (2009) Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol 10:437-443
14. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
15. Morris MC, Evans DA, Tangney CC, Bienias JL, Schneider JA, Wilson RS, Scherr PA (2006) Dietary copper and high saturated and trans fat intakes associated with cognitive decline. Arch Neurol 63:1085-1088
16. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS (2004) Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 62:1573-1579
17. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM (1999) Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 53:1937-1942
18. Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ (2010) Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol 219:25-32
19. Prieur X, Mok CY, Velagapudi VR, Nunez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Oresic M, Ricote M, Vidal-Puig A (2011) Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 60:797-809
20. Ramberg V, Tracy LM, Samuelsson M, Nilsson LN, Iverfeldt K (2011) The CCAAT/enhancer binding protein (C/EBP) delta is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-beta peptide. J Neuroinflammation 8:34
21. Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE (2013) Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem 288:2923-2932
22. Solfrizzi V, D'Introno A, Colacicco AM, Capurso C, Del Parigi A, Capurso S, Gadaleta A, Capurso A, Panza F (2005) Dietary fatty acids intake: possible role in cognitive decline and dementia. Exp Gerontol 40:257-270
23. Stein B, Cogswell PC, Baldwin AS Jr (1993) Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction. Mol Cell Biol 13:3964-3974
24. Tak PP, Firestein GS (2001) NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107:7-11
25. Valente T, Straccia M, Gresa-Arribas N, Dentesano G, Tusell JM, Serratosa J, Mancera P, Sola C, Saura J (2013) CCAAT/enhancer binding protein delta regulates glial proinflammatory gene expression. Neurobiol Aging, in press
26. Wang Z, Liu D, Wang F, Liu S, Zhao S, Ling EA, Hao A (2012) Saturated fatty acids activate microglia via toll-like receptor 4/NF-kappaB signalling. Br J Nutr 107:229-241
27. Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12:408-415
28. Yin M, Yang SQ, Lin HZ, Lane MD, Chatterjee S, Diehl AM (1996) Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. J Biol Chem 271:17974-17978
29. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972-978