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Volumn 30, Issue SUPPL.2, 2012, Pages

The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: Exploring a possible link between obesity-related metabolic impairments and neuroinflammation

Author keywords

Alzheimer's disease; metabolic syndrome X; microglia; neurodegeneration; palmitic acid

Indexed keywords

INTERLEUKIN 8; LINOLEIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; OLEIC ACID; PALMITIC ACID; STRESS ACTIVATED PROTEIN KINASE;

EID: 84862980662     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111262     Document Type: Article
Times cited : (38)

References (36)
  • 1
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • Profenno LA, Porsteinsson AP, Faraone SV (2010) Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 67, 505-512.
    • (2010) Biol Psychiatry , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 4
    • 0036227542 scopus 로고    scopus 로고
    • Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • Peila R, Rodriguez BL, Launer LJ (2002) Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 51, 1256-1262. (Pubitemid 34438377)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 5
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block ML, Zecca L, HongJS (2007) Microglia-mediated neu-rotoxicity: Uncovering the molecular mechanisms. Nat Rev Neurosci 8, 57-69. (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 7
    • 34248400478 scopus 로고    scopus 로고
    • Therapeutic approaches to inflammation in neurodegenerative disease
    • DOI 10.1097/WCO.0b013e3280adc943, PII 0001905220070600000018
    • Klegeris A, McGeer EG, McGeer PL (2007) Therapeutic approaches to inflammation in neurodegenerative disease. Curr Opin Neurol 20, 351-357. (Pubitemid 46743120)
    • (2007) Current Opinion in Neurology , vol.20 , Issue.3 , pp. 351-357
    • Klegeris, A.1    McGeer, E.G.2    McGeer, P.L.3
  • 10
    • 77649209729 scopus 로고    scopus 로고
    • Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids
    • Lee JY, Zhao L, Hwang DH (2010) Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids. Nutr Rev 68, 38-61.
    • (2010) Nutr Rev , vol.68 , pp. 38-61
    • Lee, J.Y.1    Zhao, L.2    Hwang, D.H.3
  • 11
    • 78650773537 scopus 로고    scopus 로고
    • Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
    • Dasu MR, Jialal I (2011) Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 300, E145-E154.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Dasu, M.R.1    Jialal, I.2
  • 12
    • 58549105701 scopus 로고    scopus 로고
    • Inductionof proinflammatory cytokines by long-chain saturated fatty acids in human macrophages
    • Haversen L, Danielsson KN, Fogelstrand L, Wiklund O (2009) Inductionof proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202, 382-393.
    • (2009) Atherosclerosis , vol.202 , pp. 382-393
    • Haversen, L.1    Danielsson, K.N.2    Fogelstrand, L.3    Wiklund, O.4
  • 15
    • 13644255246 scopus 로고    scopus 로고
    • Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system
    • DOI 10.1016/j.neurobiolaging.2004.06.012
    • Klegeris A, Bissonnette CJ, McGeer PL (2005) Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiol Aging 26, 673-682. (Pubitemid 40228759)
    • (2005) Neurobiology of Aging , vol.26 , Issue.5 , pp. 673-682
    • Klegeris, A.1    Bissonnette, C.J.2    McGeer, P.L.3
  • 16
    • 0038678773 scopus 로고    scopus 로고
    • Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor
    • DOI 10.1038/sj.bjp.0705304
    • Klegeris A, Bissonnette CJ, McGeer PL (2003) Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligandsof the cannabinoid-typeCB2 receptor. BrJPharmacol 139, 775-786. (Pubitemid 36819605)
    • (2003) British Journal of Pharmacology , vol.139 , Issue.4 , pp. 775-786
    • Klegeris, A.1    Bissonnette, C.J.2    McGeer, P.L.3
  • 17
    • 34547436306 scopus 로고    scopus 로고
    • Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity
    • DOI 10.1002/jnr.21361
    • Klegeris A, Choi HB, McLarnon JG, McGeerPL (2007) Func-tional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. J Neurosci Res 85, 2207-2215. (Pubitemid 47172152)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.10 , pp. 2207-2215
    • Klegeris, A.1    Choi, H.B.2    McLarnon, J.G.3    McGeer, P.L.4
  • 18
    • 0037686180 scopus 로고    scopus 로고
    • Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP
    • DOI 10.1189/jlb.1002482
    • Klegeris A, McGeer PL (2003) Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. J Leukoc Biol 73, 369-378. (Pubitemid 36790853)
    • (2003) Journal of Leukocyte Biology , vol.73 , Issue.3 , pp. 369-378
    • Klegeris, A.1    McGeer, P.L.2
  • 19
    • 40849118624 scopus 로고    scopus 로고
    • α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
    • DOI 10.1016/j.neurobiolaging.2006.11.013, PII S0197458006004362
    • Klegeris A, Pelech S, Giasson BI, Maguire J, Zhang H, McGeer EG, McGeer PL (2008) Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol Aging 29, 739-752. (Pubitemid 351400820)
    • (2008) Neurobiology of Aging , vol.29 , Issue.5 , pp. 739-752
    • Klegeris, A.1    Pelech, S.2    Giasson, B.I.3    Maguire, J.4    Zhang, H.5    McGeer, E.G.6    McGeer, P.L.7
  • 21
    • 4344637311 scopus 로고    scopus 로고
    • 2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: Mechanisms and implications
    • Si Q, Zhao ML, Morgan AC, Brosnan CF, Lee SC (2004) 15-deoxy-Delta12, 14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: Mechanisms and implications. J Immunol 173, 3504-3513. (Pubitemid 39142061)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3504-3513
    • Si, Q.1    Zhao, M.-L.2    Morgan, A.C.A.3    Brosnan, C.F.4    Lee, S.C.5
  • 22
    • 78649660058 scopus 로고    scopus 로고
    • Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signalingin L6skeletal muscle cells: Roleof oxidative stress
    • Yuzefovych L, Wilson G, Rachek L (2010) Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signalingin L6skeletal muscle cells: Roleof oxidative stress. Am J Physiol Endocrinol Metab 299, E1096-E1105.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Yuzefovych, L.1    Wilson, G.2    Rachek, L.3
  • 23
    • 64249110579 scopus 로고    scopus 로고
    • Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity
    • Hashioka S, Klegeris A, McGeer PL (2009) Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity. Exp Neu-rol 217, 177-183.
    • (2009) Exp Neu-rol , vol.217 , pp. 177-183
    • Hashioka, S.1    Klegeris, A.2    McGeer, P.L.3
  • 24
    • 0023738916 scopus 로고
    • A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
    • Decker T, Lohmann-Matthes ML (1988) A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 115, 61-69.
    • (1988) J Immunol Methods , vol.115 , pp. 61-69
    • Decker, T.1    Lohmann-Matthes, M.L.2
  • 27
    • 79955758735 scopus 로고    scopus 로고
    • Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: Implications for insulin resistance
    • Hu W, Ross J, Geng T, Brice SE, Cowart LA (2011) Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: Implications for insulin resistance. J Biol Chem 286, 16596-16605.
    • (2011) J Biol Chem , vol.286 , pp. 16596-16605
    • Hu, W.1    Ross, J.2    Geng, T.3    Brice, S.E.4    Cowart, L.A.5
  • 29
    • 2342555602 scopus 로고    scopus 로고
    • Dietary fat intake and 6-year cognitive change in an older biracial community population
    • Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS (2004) Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 62, 1573-1579. (Pubitemid 38608198)
    • (2004) Neurology , vol.62 , Issue.9 , pp. 1573-1579
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Wilson, R.S.5
  • 32
    • 33644750396 scopus 로고    scopus 로고
    • 2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    • DOI 10.2337/diabetes.54.suppl-2.S73
    • Hotamisligil GS (2005) Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 (Suppl 2) , S73-S78. (Pubitemid 43343334)
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 34
    • 52049127007 scopus 로고    scopus 로고
    • Fatty acids differentially modify the expression of urokinase type plasminogen activator receptor in monocytes
    • Assmann A, Mohlig M, Osterhoff M, Pfeiffer AF, Spranger J (2008) Fatty acids differentially modify the expression of urokinase type plasminogen activator receptor in monocytes. Biochem Biophys Res Commun 376, 196-199.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 196-199
    • Assmann, A.1    Mohlig, M.2    Osterhoff, M.3    Pfeiffer, A.F.4    Spranger, J.5
  • 35
    • 77953521826 scopus 로고    scopus 로고
    • Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
    • Bilbo SD, Tsang V (2010) Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J 24, 2104-2115.
    • (2010) FASEB J , vol.24 , pp. 2104-2115
    • Bilbo, S.D.1    Tsang, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.