On the relevance of brown adipose tissue in children

Annals of the New York Academy of Sciences

Volumn 1302, Issue 1, 2013, Pages 24-29

  Ponrartana, Skorn ^a   Hu, Houchun H ^a   Gilsanz, Vicente ^a,b  

^a Departments of Radiology   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Brown adipose tissue; Children; MRI; Musculoskeletal development

Indexed keywords

GLUCOSE; TRACER;

ARTICLE; BODY FAT; BROWN ADIPOSE TISSUE; CHILD; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CYTOLOGY; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; MUSCLE MASS; NUCLEAR MAGNETIC RESONANCE IMAGING; PUBERTY; RELIABILITY; SEASON; SEXUAL MATURATION; SKELETAL MUSCLE; TEMPERATURE; WHITE ADIPOSE TISSUE;

EID: 84885927684     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12195     Document Type: Article

References (47)

1. Gessner, K. 1551. Conradi Gesneri medici Tiguine Historiae Animalium Lib I de Quadripedibus uiuparis [History of Animals, Book 1 of Four-Legged Uniparous] Tiguri: Apud Christophorum Froschouerum.
2. Smith, R.E. 1961. The thermogenic activity of the hibernating gland in the cold-acclimated rat. Physiologist 4: 113.
3. Ouellet, V. et al. 2012. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J. Clin. Invest. 122: 545-552.
4. Aherne, W. & D. Hull. 1966. Brown adipose tissue and heat production in the newborn infant. J. Pathol. Bacteriol. 91: 223-234.
5. Heaton, J.M. 1972. The distribution of brown adipose tissue in the human. J. Anat. 112: 35-39.
6. Cypess, A.M. et al. 2009. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360: 1509-1517.
7. Gilsanz, V. et al. 2012. Changes in brown adipose tissue in boys and girls during childhood and puberty. J. Pediatr. 160: 604-609, e601.
8. Gelfand, M.J. et al. 2005. Pre-medication to block [(18)F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients. Pediatr. Radiol. 35: 984-990.
9. Gilsanz, V. et al. 2011. Functional brown adipose tissue is related to muscle volume in children and adolescents. J. Pediatr. 158: 722-726.
10. Drubach, L.A. et al. 2011. Pediatric brown adipose tissue: detection, epidemiology, and differences from adults. J. Pediatr. 159: 939-944.
11. Pace, L. et al. 2010. Determinants of physiologic (18)F-FDG uptake in brown adipose tissue in sequential PET/CT examinations. Mol. Imaging Biol. 13: 1029-1035.
12. Saito, M. et al. 2009. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58: 1526-1531.
13. Lee, P. et al. 2010. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 299: E601-E606.
14. Zvonic, S. et al. 2006. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55: 962-970.
15. van der Veen, D. R. et al. 2012. A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging. Obesity (Silver Spring). 20: 1527-1529.
16. Lowell, B.B. et al. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366: 740-742.
17. Feldmann, H.M. et al. 2009. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9: 203-209.
18. Zhou, Z. et al. 2003. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35: 49-56.
19. Cheng, W.Y., Z.H. Zhu & M. Ouyang. 2009. Patterns and characteristics of brown adipose tissue uptake of 18F-FDG positron emission tomograph/computed tomography imaging. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31: 370-373.
20. Hu, H.H. et al. 2013. Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI. J. Magn. Reson. Imaging. DOI: 10.1002/jmri.24053.
21. Chalfant, J.S. et al. 2012. Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy. Am. J. Clin. Nutr. 95: 1144-1149.
22. Gilsanz, V. et al. 2012. The depiction of brown adipose tissue is related to disease status in pediatric patients with lymphoma. Am. J. Roentgenol. 198: 909-913.
23. Salles, G. et al. 1996. Elevated circulating levels of TNFalpha and its p55 soluble receptor are associated with an adverse prognosis in lymphoma patients. Br. J. Haematol. 93: 352-359.
24. Nisoli, E. et al. 1997. Tumor necrosis factor-alpha induces apoptosis in rat brown adipocytes. Cell Death Differ. 4: 771-778.
25. Romanatto, T. et al. 2009. Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J. Biol. Chem. 284: 36213-36222.
26. Tsoli, M. et al. 2012. Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice. Cancer Res. 72: 4372-4382.
27. Rousseau, C. et al. 2006. Brown fat in breast cancer patients: analysis of serial (18)F-FDG PET/CT scans. Eur. J. Nucl. Med. Mol. Imaging 33: 785-791.
28. Pizzo, P.A. & D.G. Poplack. 2006. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins.
29. Kajimura, S., P. Seale & B.M. Spiegelman. 2010. Transcriptional control of brown fat development. Cell Metab. 11: 257-262.
30. Farmer, S.R. 2008. Brown fat and skeletal muscle: unlikely cousins? Cell 134: 726-727.
31. Rodriguez-Cuenca, S. et al. 2007. Sex steroid receptor expression profile in brown adipose tissue. Effects of hormonal status. Cell Physiol. Biochem. 20: 877-886.
32. Bostrom, P. et al. 2012. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463-468.
33. Seebacher, F. & E.J. Glanville. 2010. Low levels of physical activity increase metabolic responsiveness to cold in a rat (Rattus fuscipes). PLoS One 5: e13022.
34. Xu, X. et al. 2011. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300: R1115-R1125.
35. Seger, R.L. et al. 2011. Investigating the mechanism for maintaining eucalcemia despite immobility and anuria in the hibernating American black bear (Ursus americanus). Bone 49: 1205-1212.
36. Lean, M.E. 1989. Brown adipose tissue in humans. Proc. Nutr. Soc. 48: 243-256.
37. Feigelman, S. 2007. The first year. In Nelson Textbook of Pediatrics. R.M. Kliegman, R.E. Behrman, H.B. Jenson & B.F. Stanton, Eds.: 43-48. Saunders. Philadelphia: Elsevier.
38. Tseng, Y.H. et al. 2008. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure Nature 454: 1000-1004.
39. Calo, E. et al. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466: 1110-1114.
40. Olmsted-Davis, E. et al. 2007. Hypoxic adipocytes pattern early heterotopic bone formation. Am. J. Pathol. 170: 620-632.
41. Zanotti, S. et al. 2009. Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. J. Endocrinol. 201: 263-274.
42. Bredella, M.A. et al. 2012. Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women. J. Clin. Endocrinol. Metab. 97: E584-590.
43. Ponrartana, S. et al. 2012. Brown adipose tissue and its relationship to bone structure in pediatric patients. J. Clin. Endocrinol Metab. 97: 2693-2698.
44. Lee, P., K.K. Ho & J.R. Greenfield. 2011. Hot fat in a cool man: infrared thermography and brown adipose tissue. Diabetes Obes. Metab. 13: 92-93.
45. Chen, Y.I. et al. 2012. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring) 20: 1519-1526.
46. Bartelt, A. et al. 2011. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17: 200-205.
47. Hu, H.H. et al. 2012. Characterization of human brown adipose tissue of chemical-shift water-fat magnetic resonance imaging. Am. J. Roentgen. 200: 177-183.