-
2
-
-
56249123993
-
Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway
-
doi:10.1158/1535-7163.MCT-08-0530
-
Akiyama, T., Dass, C. R., and Choong, P. F. (2008). Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway. Mol. Cancer Ther. 7, 3461-3469. doi:10.1158/1535-7163.MCT-08-0530
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 3461-3469
-
-
Akiyama, T.1
Dass, C.R.2
Choong, P.F.3
-
3
-
-
54949093656
-
Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma)
-
doi:10.1517/13543784.17.11.1703
-
Anderson, P., Kopp, L., Anderson, N., Cornelius, K., Herzog, C., Hughes, D., et al. (2008). Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma). Expert Opin. Investig. Drugs 17, 1703-1715. doi:10.1517/13543784.17.11.1703
-
(2008)
Expert Opin. Investig. Drugs
, vol.17
, pp. 1703-1715
-
-
Anderson, P.1
Kopp, L.2
Anderson, N.3
Cornelius, K.4
Herzog, C.5
Hughes, D.6
-
4
-
-
79952319155
-
Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the Children's Oncology Group Phase I Consortium
-
doi:10.1200/JCO.2010.30.7231
-
Aplenc, R., Blaney, S. M., Strauss, L. C., Balis, F. M., Shusterman, S., Ingle, A. M., et al. (2012). Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the Children's Oncology Group Phase I Consortium. J. Clin. Oncol. 29, 839-844. doi:10.1200/JCO.2010.30.7231
-
(2012)
J. Clin. Oncol.
, vol.29
, pp. 839-844
-
-
Aplenc, R.1
Blaney, S.M.2
Strauss, L.C.3
Balis, F.M.4
Shusterman, S.5
Ingle, A.M.6
-
5
-
-
84864928386
-
Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23364
-
Batra, V., Maris, J. M., Kang, M. H., Reynolds, C. P., Houghton, P. J., Alexander, D., et al. (2012). Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 749-752. doi:10.1002/pbc.23364
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 749-752
-
-
Batra, V.1
Maris, J.M.2
Kang, M.H.3
Reynolds, C.P.4
Houghton, P.J.5
Alexander, D.6
-
6
-
-
0035892895
-
Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma
-
doi:10.1002/1097-0142(20011215)92:12<3062::AID-CNCR10161>3.0.CO;2-X
-
Benassi, M. S., Molendini, L., Gamberi, G., Magagnoli, G., Ragazzini, P., Gobbi, G. A., et al. (2001). Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. Cancer 92, 3062-3067. doi:10.1002/1097-0142(20011215)92:12<3062::AID-CNCR10161>3.0.CO;2-X
-
(2001)
Cancer
, vol.92
, pp. 3062-3067
-
-
Benassi, M.S.1
Molendini, L.2
Gamberi, G.3
Magagnoli, G.4
Ragazzini, P.5
Gobbi, G.A.6
-
7
-
-
80054055727
-
Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT)
-
abstr. 10005
-
Blay, J., Chawla, S. P., Ray-Coquard, I. L., Le Cesne, A., Staddon, A. P., and Milhem, M. M. (2011). Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT). J. Clin. Oncol. 29(Suppl.), abstr. 10005.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.SUPPL.
-
-
Blay, J.1
Chawla, S.P.2
Ray-Coquard, I.L.3
Le Cesne, A.4
Staddon, A.P.5
Milhem, M.M.6
-
8
-
-
37549041711
-
A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group Study
-
doi:10.1002/pbc.21132
-
Bond, M., Bernstein, M. L., Pappo, A., Schultz, K. R., Krailo, M., Blaney, S. M., et al. (2008). A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group Study. Pediatr. Blood Cancer 50, 254-258. doi:10.1002/pbc.21132
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 254-258
-
-
Bond, M.1
Bernstein, M.L.2
Pappo, A.3
Schultz, K.R.4
Krailo, M.5
Blaney, S.M.6
-
9
-
-
84865213266
-
MEK genomics in development and disease
-
Bromberg-White, J. L., Andersen, N. J., and Duesbery, N. S. (2012). MEK genomics in development and disease. Brief Funct. Genomics 11, 300-310.
-
(2012)
Brief Funct. Genomics
, vol.11
, pp. 300-310
-
-
Bromberg-White, J.L.1
Andersen, N.J.2
Duesbery, N.S.3
-
10
-
-
84922667389
-
Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors
-
doi:10.1111/vco.12018 [Epub ahead of print].
-
Cannon, C. M., Pozniak, J., Scott, M. C., Ito, D., Gorden, B. H., Graef, A. J., et al. (2013). Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors. Vet. Comp. Oncol. doi:10.1111/vco.12018 [Epub ahead of print].
-
(2013)
Vet. Comp. Oncol.
-
-
Cannon, C.M.1
Pozniak, J.2
Scott, M.C.3
Ito, D.4
Gorden, B.H.5
Graef, A.J.6
-
11
-
-
77950470724
-
Initial testing of topotecan by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22352
-
Carol, H., Houghton, P. J., Morton, C. L., Kolb, E. A., Gorlick, R., Reynolds, C. P., et al. (2010a). Initial testing of topotecan by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 54, 707-715. doi:10.1002/pbc.22352
-
(2010)
Pediatr. Blood Cancer
, vol.54
, pp. 707-715
-
-
Carol, H.1
Houghton, P.J.2
Morton, C.L.3
Kolb, E.A.4
Gorlick, R.5
Reynolds, C.P.6
-
12
-
-
78049246448
-
Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program
-
doi:10.1002/pbc.22710
-
Carol, H., Morton, C. L., Gorlick, R., Kolb, E. A., Keir, S. T., Reynolds, C. P., et al. (2010b). Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. Pediatr. Blood Cancer 55, 1329-1337. doi:10.1002/pbc.22710
-
(2010)
Pediatr. Blood Cancer
, vol.55
, pp. 1329-1337
-
-
Carol, H.1
Morton, C.L.2
Gorlick, R.3
Kolb, E.A.4
Keir, S.T.5
Reynolds, C.P.6
-
13
-
-
84873710768
-
Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.24235
-
Carol, H., Reynolds, C. P., Kang, M. H., Keir, S. T., Maris, J. M., Gorlick, R., et al. (2013). Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer doi:10.1002/pbc.24235
-
(2013)
Pediatr. Blood Cancer
-
-
Carol, H.1
Reynolds, C.P.2
Kang, M.H.3
Keir, S.T.4
Maris, J.M.5
Gorlick, R.6
-
14
-
-
84861520898
-
Spatial regulation of receptor tyrosine kinases in development and cancer
-
doi:10.1038/nrc3277
-
Casaletto, J. B., and McClatchey, A. I. (2012). Spatial regulation of receptor tyrosine kinases in development and cancer. Nat. Rev. Cancer 12, 387-400. doi:10.1038/nrc3277
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 387-400
-
-
Casaletto, J.B.1
McClatchey, A.I.2
-
15
-
-
84855556875
-
Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
-
doi:10.1200/JCO.2011.35.6329
-
Chawla, S. P., Staddon, A. P., Baker, L. H., Schuetze, S. M., Tolcher, A. W., D'Amato, G. Z., et al. (2012). Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J. Clin. Oncol. 30, 78-84. doi:10.1200/JCO.2011.35.6329
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 78-84
-
-
Chawla, S.P.1
Staddon, A.P.2
Baker, L.H.3
Schuetze, S.M.4
Tolcher, A.W.5
D'Amato, G.Z.6
-
16
-
-
70349329714
-
Smac mimetics as new cancer therapeutics
-
doi:10.1097/CAD.0b013e32832ced78
-
Chen, D. J., and Huerta, S. (2009). Smac mimetics as new cancer therapeutics. Anticancer Drugs 20, 646-658. doi:10.1097/CAD.0b013e32832ced78
-
(2009)
Anticancer Drugs
, vol.20
, pp. 646-658
-
-
Chen, D.J.1
Huerta, S.2
-
17
-
-
84861491693
-
Src kinase inhibitors: promising cancer therapeutics?
-
doi:10.1615/CritRevOncog.v17.i2.20
-
Creedon, H., and Brunton, V. G. (2012). Src kinase inhibitors: promising cancer therapeutics? Crit. Rev. Oncog. 17, 145-159. doi:10.1615/CritRevOncog.v17.i2.20
-
(2012)
Crit. Rev. Oncog.
, vol.17
, pp. 145-159
-
-
Creedon, H.1
Brunton, V.G.2
-
18
-
-
33845323729
-
Sunitinib
-
discussion 2267-2268. doi:10.2165/00003495-200666170-00007
-
Deeks, E. D., and Keating, G. M. (2006). Sunitinib. Drugs 66, 2255-2266; discussion 2267-2268. doi:10.2165/00003495-200666170-00007
-
(2006)
Drugs
, vol.66
, pp. 2255-2266
-
-
Deeks, E.D.1
Keating, G.M.2
-
19
-
-
33745182564
-
PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation
-
doi:10.1016/j.ejca.2006.03.007
-
Diaz-Montero, C. M., Wygant, J. N., and McIntyre, B. W. (2006). PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur. J. Cancer 42, 1491-1500. doi:10.1016/j.ejca.2006.03.007
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 1491-1500
-
-
Diaz-Montero, C.M.1
Wygant, J.N.2
McIntyre, B.W.3
-
20
-
-
79960983264
-
Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a Children's Oncology Group Study
-
doi:10.1158/1078-0432.CCR-11-0237
-
Dubois, S. G., Shusterman, S., Ingle, A. M., Ahern, C. H., Reid, J. M., Wu, B., et al. (2011). Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. Clin. Cancer Res. 17, 5113-5122. doi:10.1158/1078-0432.CCR-11-0237
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5113-5122
-
-
Dubois, S.G.1
Shusterman, S.2
Ingle, A.M.3
Ahern, C.H.4
Reid, J.M.5
Wu, B.6
-
21
-
-
84859801305
-
Tolerability and pharmacokinetic profile of a sunitinib powder formulation in pediatric patients with refractory solid tumors: a Children's Oncology Group Study
-
doi:10.1007/s00280-011-1798-2
-
DuBois, S. G., Shusterman, S., Reid, J. M., Ingle, A. M., Ahern, C. H., Baruchel, S., et al. (2012). Tolerability and pharmacokinetic profile of a sunitinib powder formulation in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. Cancer Chemother. Pharmacol. 69, 1021-1027. doi:10.1007/s00280-011-1798-2
-
(2012)
Cancer Chemother. Pharmacol.
, vol.69
, pp. 1021-1027
-
-
DuBois, S.G.1
Shusterman, S.2
Reid, J.M.3
Ingle, A.M.4
Ahern, C.H.5
Baruchel, S.6
-
22
-
-
84864044404
-
Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the Children's Oncology Group
-
doi:10.1200/JCO.2011.37.4546
-
Ebb, D., Meyers, P., Grier, H., Bernstein, M., Gorlick, R., Lipshultz, S. E., et al. (2012). Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the Children's Oncology Group. J. Clin. Oncol. 30, 2545-2551. doi:10.1200/JCO.2011.37.4546
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 2545-2551
-
-
Ebb, D.1
Meyers, P.2
Grier, H.3
Bernstein, M.4
Gorlick, R.5
Lipshultz, S.E.6
-
23
-
-
34249999670
-
Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma
-
doi:10.1097/CCO.0b013e328122d73f
-
Ferrari, S., and Palmerini, E. (2007). Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma. Curr. Opin. Oncol. 19, 341-346. doi:10.1097/CCO.0b013e328122d73f
-
(2007)
Curr. Opin. Oncol.
, vol.19
, pp. 341-346
-
-
Ferrari, S.1
Palmerini, E.2
-
24
-
-
77955900071
-
Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group Phase I Consortium Report
-
doi:10.1200/JCO.2009.25.9119
-
Fouladi, M., Park, J. R., Stewart, C. F., Gilbertson, R. J., Schaiquevich, P., Sun, J., et al. (2010). Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group Phase I Consortium Report. J. Clin. Oncol. 28, 3623-3629. doi:10.1200/JCO.2009.25.9119
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 3623-3629
-
-
Fouladi, M.1
Park, J.R.2
Stewart, C.F.3
Gilbertson, R.J.4
Schaiquevich, P.5
Sun, J.6
-
25
-
-
79951865371
-
A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors
-
doi:10.1200/JCO.2010.30.9674
-
Fox, E., Aplenc, R., Bagatell, R., Chuk, M. K., Dombi, E., Goodspeed, W., et al. (2010). A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors. J. Clin. Oncol. 28, 5174-5181. doi:10.1200/JCO.2010.30.9674
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 5174-5181
-
-
Fox, E.1
Aplenc, R.2
Bagatell, R.3
Chuk, M.K.4
Dombi, E.5
Goodspeed, W.6
-
26
-
-
79958716819
-
The cyclin-dependent kinase inhibitor SCH 727965 (dinaciclib) induces the apoptosis of osteosarcoma cells
-
doi:10.1158/1535-7163.MCT-11-0167
-
Fu, W., Ma, L., Chu, B., Wang, X., Bui, M. M., Gemmer, J., et al. (2011). The cyclin-dependent kinase inhibitor SCH 727965 (dinaciclib) induces the apoptosis of osteosarcoma cells. Mol. Cancer Ther. 10, 1018-1027. doi:10.1158/1535-7163.MCT-11-0167
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1018-1027
-
-
Fu, W.1
Ma, L.2
Chu, B.3
Wang, X.4
Bui, M.M.5
Gemmer, J.6
-
27
-
-
80054809459
-
Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
-
doi:10.1007/s10637-010-9479-2
-
Garrett, C. R., Coppola, D., Wenham, R. M., Cubitt, C. L., Neuger, A. M., Frost, T. J., et al. (2011). Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT. Invest. New Drugs 29, 1381-1389. doi:10.1007/s10637-010-9479-2
-
(2011)
Invest. New Drugs
, vol.29
, pp. 1381-1389
-
-
Garrett, C.R.1
Coppola, D.2
Wenham, R.M.3
Cubitt, C.L.4
Neuger, A.M.5
Frost, T.J.6
-
28
-
-
38649105118
-
Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study
-
doi:10.1200/JCO.2007.11.9230
-
Glade Bender, J. L., Adamson, P. C., Reid, J. M., Xu, L., Baruchel, S., Shaked, Y., et al. (2008). Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. J. Clin. Oncol. 26, 399-405. doi:10.1200/JCO.2007.11.9230
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 399-405
-
-
Glade Bender, J.L.1
Adamson, P.C.2
Reid, J.M.3
Xu, L.4
Baruchel, S.5
Shaked, Y.6
-
29
-
-
69849094782
-
Initial testing (stage 1) of lapatinib by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21989
-
Gorlick, R., Kolb, E. A., Houghton, P. J., Morton, C. L., Phelps, D., Schaiquevich, P., et al. (2009). Initial testing (stage 1) of lapatinib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 53, 594-598. doi:10.1002/pbc.21989
-
(2009)
Pediatr. Blood Cancer
, vol.53
, pp. 594-598
-
-
Gorlick, R.1
Kolb, E.A.2
Houghton, P.J.3
Morton, C.L.4
Phelps, D.5
Schaiquevich, P.6
-
30
-
-
84863870086
-
Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23412
-
Gorlick, R., Maris, J. M., Houghton, P. J., Lock, R., Carol, H., Kurmasheva, R. T., et al. (2012a). Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 518-524. doi:10.1002/pbc.23412
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 518-524
-
-
Gorlick, R.1
Maris, J.M.2
Houghton, P.J.3
Lock, R.4
Carol, H.5
Kurmasheva, R.T.6
-
31
-
-
84863299833
-
Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.24073
-
Gorlick, R., Kolb, E. A., Houghton, P. J., Morton, C. L., Neale, G., Keir, S. T., et al. (2012b). Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 1266-1274. doi:10.1002/pbc.24073
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 1266-1274
-
-
Gorlick, R.1
Kolb, E.A.2
Houghton, P.J.3
Morton, C.L.4
Neale, G.5
Keir, S.T.6
-
32
-
-
84856343533
-
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group Study
-
doi:10.1093/annonc/mdr151
-
Grignani, G., Palmerini, E., Dileo, P., Asaftei, S. D., D'Ambrosio, L., Pignochino, Y., et al. (2012). A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group Study. Ann. Oncol. 23, 508-516. doi:10.1093/annonc/mdr151
-
(2012)
Ann. Oncol.
, vol.23
, pp. 508-516
-
-
Grignani, G.1
Palmerini, E.2
Dileo, P.3
Asaftei, S.D.4
D'Ambrosio, L.5
Pignochino, Y.6
-
33
-
-
79955486858
-
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
-
doi:10.1158/0008-5472.CAN-10-4058
-
Gulhati, P., Bowen, K. A., Liu, J., Stevens, P. D., Rychahou, P. G., Chen, M., et al. (2011). mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res. 71, 3246-3256. doi:10.1158/0008-5472.CAN-10-4058
-
(2011)
Cancer Res.
, vol.71
, pp. 3246-3256
-
-
Gulhati, P.1
Bowen, K.A.2
Liu, J.3
Stevens, P.D.4
Rychahou, P.G.5
Chen, M.6
-
34
-
-
0032774053
-
Expression of bone morphogenetic proteins and receptors in sarcomas
-
doi:10.1097/00003086-199908000-00023
-
Guo, W., Gorlick, R., Ladanyi, M., Meyers, P. A., Huvos, A. G., Bertino, J. R., et al. (1999). Expression of bone morphogenetic proteins and receptors in sarcomas. Clin. Orthop. Relat. Res. 365, 175-183. doi:10.1097/00003086-199908000-00023
-
(1999)
Clin. Orthop. Relat. Res.
, vol.365
, pp. 175-183
-
-
Guo, W.1
Gorlick, R.2
Ladanyi, M.3
Meyers, P.A.4
Huvos, A.G.5
Bertino, J.R.6
-
35
-
-
33749178251
-
Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group Study
-
doi:10.1002/pbc.20739
-
Hawkins, D. S., Bradfield, S., Whitlock, J. A., Krailo, M., Franklin, J., Blaney, S. M., et al. (2006). Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group Study. Pediatr. Blood Cancer 47, 790-794. doi:10.1002/pbc.20739
-
(2006)
Pediatr. Blood Cancer
, vol.47
, pp. 790-794
-
-
Hawkins, D.S.1
Bradfield, S.2
Whitlock, J.A.3
Krailo, M.4
Franklin, J.5
Blaney, S.M.6
-
36
-
-
66149192409
-
Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo
-
doi:10.1158/1078-0432.CCR-08-1657
-
Hingorani, P., Zhang, W., Gorlick, R., and Kolb, E. A. (2009). Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo. Clin. Cancer Res. 15, 3416-3422. doi:10.1158/1078-0432.CCR-08-1657
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3416-3422
-
-
Hingorani, P.1
Zhang, W.2
Gorlick, R.3
Kolb, E.A.4
-
37
-
-
0041386055
-
Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential
-
doi:10.1016/S0736-0266(03)00062-7
-
Hotta, T., Suzuki, H., Nagai, S., Yamamoto, K., Imakiire, A., Takada, E., et al. (2003). Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. J. Orthop. Res. 21, 949-957. doi:10.1016/S0736-0266(03)00062-7
-
(2003)
J. Orthop. Res.
, vol.21
, pp. 949-957
-
-
Hotta, T.1
Suzuki, H.2
Nagai, S.3
Yamamoto, K.4
Imakiire, A.5
Takada, E.6
-
38
-
-
83455253885
-
Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program
-
doi:10.1002/pbc.22935
-
Houghton, P. J., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., Morton, C. L., et al. (2012a). Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program. Pediatr. Blood Cancer 58, 191-199. doi:10.1002/pbc.22935
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 191-199
-
-
Houghton, P.J.1
Gorlick, R.2
Kolb, E.A.3
Lock, R.4
Carol, H.5
Morton, C.L.6
-
39
-
-
84863154799
-
Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23167
-
Houghton, P. J., Kang, M. H., Reynolds, C. P., Morton, C. L., Kolb, E. A., Gorlick, R., et al. (2012b). Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 58, 636-639. doi:10.1002/pbc.23167
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 636-639
-
-
Houghton, P.J.1
Kang, M.H.2
Reynolds, C.P.3
Morton, C.L.4
Kolb, E.A.5
Gorlick, R.6
-
40
-
-
83455188335
-
Testing of the topoisomerase 1 inhibitor Genz-644282 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23016
-
Houghton, P. J., Lock, R., Carol, H., Morton, C. L., Gorlick, R., Anders Kolb, E., et al. (2012c). Testing of the topoisomerase 1 inhibitor Genz-644282 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 58, 200-209. doi:10.1002/pbc.23016
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 200-209
-
-
Houghton, P.J.1
Lock, R.2
Carol, H.3
Morton, C.L.4
Gorlick, R.5
Anders Kolb, E.6
-
41
-
-
77951747892
-
Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22367
-
Houghton, P. J., Morton, C. L., Gorlick, R., Kolb, E. A., Keir, S. T., Reynolds, C. P., et al. (2010a). Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 54, 921-926. doi:10.1002/pbc.22367
-
(2010)
Pediatr. Blood Cancer
, vol.54
, pp. 921-926
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
Kolb, E.A.4
Keir, S.T.5
Reynolds, C.P.6
-
42
-
-
73949122305
-
Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
-
doi:10.1158/1535-7163.MCT-09-0952
-
Houghton, P. J., Morton, C. L., Gorlick, R., Lock, R. B., Carol, H., Reynolds, C. P., et al. (2010b). Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program. Mol. Cancer Ther. 9, 101-112. doi:10.1158/1535-7163.MCT-09-0952
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 101-112
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
Lock, R.B.4
Carol, H.5
Reynolds, C.P.6
-
43
-
-
40449091406
-
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21296
-
Houghton, P. J., Morton, C. L., Kolb, E. A., Gorlick, R., Lock, R., Carol, H., et al. (2008a). Initial testing (stage 1) of the mTOR inhibitor rapamycin by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 799-805. doi:10.1002/pbc.21296
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 799-805
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
Gorlick, R.4
Lock, R.5
Carol, H.6
-
44
-
-
36849020943
-
Initial testing (stage 1) of the proteasome inhibitor bortezomib by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21214
-
Houghton, P. J., Morton, C. L., Kolb, E. A., Lock, R., Carol, H., Reynolds, C. P., et al. (2008b). Initial testing (stage 1) of the proteasome inhibitor bortezomib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 37-45. doi:10.1002/pbc.21214
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 37-45
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
Lock, R.4
Carol, H.5
Reynolds, C.P.6
-
45
-
-
34447249881
-
The Pediatric Preclinical Testing Program: description of models and early testing results
-
doi:10.1002/pbc.21078
-
Houghton, P. J., Morton, C. L., Tucker, C., Payne, D., Favours, E., Cole, C., et al. (2007). The Pediatric Preclinical Testing Program: description of models and early testing results. Pediatr. Blood Cancer 49, 928-940. doi:10.1002/pbc.21078
-
(2007)
Pediatr. Blood Cancer
, vol.49
, pp. 928-940
-
-
Houghton, P.J.1
Morton, C.L.2
Tucker, C.3
Payne, D.4
Favours, E.5
Cole, C.6
-
46
-
-
0029102733
-
Chemotherapy in osteosarcoma. Basis for application and antagonism to implementation; early controversies surrounding its implementation
-
Jaffe, N., Patel, S. R., and Benjamin, R. S. (1995). Chemotherapy in osteosarcoma. Basis for application and antagonism to implementation; early controversies surrounding its implementation. Hematol. Oncol. Clin. North Am. 9, 825-840.
-
(1995)
Hematol. Oncol. Clin. North Am.
, vol.9
, pp. 825-840
-
-
Jaffe, N.1
Patel, S.R.2
Benjamin, R.S.3
-
47
-
-
80053062871
-
Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma
-
doi:10.1200/JCO.2010.33.0670
-
Juergens, H., Daw, N. C., Geoerger, B., Ferrari, S., Villarroel, M., Aerts, I., et al. (2011). Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma. J. Clin. Oncol. 29, 4534-4540. doi:10.1200/JCO.2010.33.0670
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 4534-4540
-
-
Juergens, H.1
Daw, N.C.2
Geoerger, B.3
Ferrari, S.4
Villarroel, M.5
Aerts, I.6
-
48
-
-
84861203569
-
Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23154
-
Kang, M. H., Reynolds, C. P., Houghton, P. J., Alexander, D., Morton, C. L., Kolb, E. A., et al. (2012). Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 185-188. doi:10.1002/pbc.23154
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 185-188
-
-
Kang, M.H.1
Reynolds, C.P.2
Houghton, P.J.3
Alexander, D.4
Morton, C.L.5
Kolb, E.A.6
-
49
-
-
60549098640
-
Sorafenib: a review of its use in advanced hepatocellular carcinoma
-
doi:10.2165/00003495-200969020-00006
-
Keating, G. M., and Santoro, A. (2009). Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 69, 223-240. doi:10.2165/00003495-200969020-00006
-
(2009)
Drugs
, vol.69
, pp. 223-240
-
-
Keating, G.M.1
Santoro, A.2
-
50
-
-
77958598570
-
Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22712
-
Keir, S. T., Maris, J. M., Lock, R., Kolb, E. A., Gorlick, R., Carol, H., et al. (2010). Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 55, 1126-1133. doi:10.1002/pbc.22712
-
(2010)
Pediatr. Blood Cancer
, vol.55
, pp. 1126-1133
-
-
Keir, S.T.1
Maris, J.M.2
Lock, R.3
Kolb, E.A.4
Gorlick, R.5
Carol, H.6
-
51
-
-
67651205908
-
Initial testing (stage 1) of vorinostat (SAHA) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21988
-
Keshelava, N., Houghton, P. J., Morton, C. L., Lock, R. B., Carol, H., Keir, S. T., et al. (2009). Initial testing (stage 1) of vorinostat (SAHA) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 53, 505-508. doi:10.1002/pbc.21988
-
(2009)
Pediatr. Blood Cancer
, vol.53
, pp. 505-508
-
-
Keshelava, N.1
Houghton, P.J.2
Morton, C.L.3
Lock, R.B.4
Carol, H.5
Keir, S.T.6
-
52
-
-
42349094624
-
Initial testing of dasatinib by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21450
-
Kolb, E. A., Gorlick, R., Houghton, P. J., Morton, C. L., Lock, R. B., Tajbakhsh, M., et al. (2008a). Initial testing of dasatinib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 1198-1206. doi:10.1002/pbc.21450
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 1198-1206
-
-
Kolb, E.A.1
Gorlick, R.2
Houghton, P.J.3
Morton, C.L.4
Lock, R.B.5
Tajbakhsh, M.6
-
53
-
-
42349083307
-
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21450
-
Kolb, E. A., Gorlick, R., Houghton, P. J., Morton, C. L., Lock, R., Carol, H., et al. (2008b). Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 1190-1197. doi:10.1002/pbc.21450
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 1190-1197
-
-
Kolb, E.A.1
Gorlick, R.2
Houghton, P.J.3
Morton, C.L.4
Lock, R.5
Carol, H.6
-
54
-
-
77957071661
-
Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22576
-
Kolb, E. A., Gorlick, R., Houghton, P. J., Morton, C. L., Neale, G., Keir, S. T., et al. (2010). Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 55, 668-677. doi:10.1002/pbc.22576
-
(2010)
Pediatr. Blood Cancer
, vol.55
, pp. 668-677
-
-
Kolb, E.A.1
Gorlick, R.2
Houghton, P.J.3
Morton, C.L.4
Neale, G.5
Keir, S.T.6
-
55
-
-
79551630554
-
Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program
-
doi:10.1002/pbc.22741
-
Kolb, E. A., Gorlick, R., Lock, R., Carol, H., Morton, C. L., Keir, S. T., et al. (2011). Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr. Blood Cancer 56, 595-603. doi:10.1002/pbc.22741
-
(2011)
Pediatr. Blood Cancer
, vol.56
, pp. 595-603
-
-
Kolb, E.A.1
Gorlick, R.2
Lock, R.3
Carol, H.4
Morton, C.L.5
Keir, S.T.6
-
56
-
-
84863241091
-
Initial testing (stage 1) by the Pediatric Preclinical Testing Program of RO4929097, a gamma-secretase inhibitor targeting notch signaling
-
doi:10.1002/pbc.23290
-
Kolb, E. A., Gorlick, R., Keir, S. T., Maris, J. M., Lock, R., Carol, H., et al. (2012a). Initial testing (stage 1) by the Pediatric Preclinical Testing Program of RO4929097, a gamma-secretase inhibitor targeting notch signaling. Pediatr. Blood Cancer 58, 815-818. doi:10.1002/pbc.23290
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 815-818
-
-
Kolb, E.A.1
Gorlick, R.2
Keir, S.T.3
Maris, J.M.4
Lock, R.5
Carol, H.6
-
57
-
-
84863278693
-
Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23157
-
Kolb, E. A., Gorlick, R., Maris, J. M., Keir, S. T., Morton, C. L., Wu, J., et al. (2012b). Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 58, 729-735. doi:10.1002/pbc.23157
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 729-735
-
-
Kolb, E.A.1
Gorlick, R.2
Maris, J.M.3
Keir, S.T.4
Morton, C.L.5
Wu, J.6
-
58
-
-
84879198533
-
Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the Pediatric Preclinical Testing Program
-
[Epub ahead of print]. doi:10.1002/pbc.24517
-
Kolb, E. A., Gorlick, R., Reynolds, C. P., Kang, M. H., Carol, H., Lock, R., et al. (2013). Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer. [Epub ahead of print]. doi:10.1002/pbc.24517
-
(2013)
Pediatr. Blood Cancer.
-
-
Kolb, E.A.1
Gorlick, R.2
Reynolds, C.P.3
Kang, M.H.4
Carol, H.5
Lock, R.6
-
59
-
-
84873869465
-
Aurora kinase inhibitors: progress towards the clinic
-
doi:10.1007/s10637-012-9798-6
-
Kollareddy, M., Zheleva, D., Dzubak, P., Brahmkshatriya, P. S., Lepsik, M., and Hajduch, M. (2012). Aurora kinase inhibitors: progress towards the clinic. Invest. New Drugs 30, 2411-2432. doi:10.1007/s10637-012-9798-6
-
(2012)
Invest. New Drugs
, vol.30
, pp. 2411-2432
-
-
Kollareddy, M.1
Zheleva, D.2
Dzubak, P.3
Brahmkshatriya, P.S.4
Lepsik, M.5
Hajduch, M.6
-
60
-
-
42349109916
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21433
-
Lock, R., Carol, H., Houghton, P. J., Morton, C. L., Kolb, E. A., Gorlick, R., et al. (2008). Initial testing (stage 1) of the BH3 mimetic ABT-263 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 1181-1189. doi:10.1002/pbc.21433
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 1181-1189
-
-
Lock, R.1
Carol, H.2
Houghton, P.J.3
Morton, C.L.4
Kolb, E.A.5
Gorlick, R.6
-
61
-
-
84863338259
-
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program
-
doi:10.1002/pbc.23176
-
Lock, R. B., Carol, H., Morton, C. L., Keir, S. T., Reynolds, C. P., Kang, M. H., et al. (2012). Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. Pediatr. Blood Cancer 58, 916-923. doi:10.1002/pbc.23176
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 916-923
-
-
Lock, R.B.1
Carol, H.2
Morton, C.L.3
Keir, S.T.4
Reynolds, C.P.5
Kang, M.H.6
-
62
-
-
79955722714
-
A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma
-
doi:10.1002/pbc.23021
-
Lugowska, I., Wozniak, W., Klepacka, T., Michalak, E., and Szamotulska, K. (2011). A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. Pediatr. Blood Cancer 57, 63-68. doi:10.1002/pbc.23021
-
(2011)
Pediatr. Blood Cancer
, vol.57
, pp. 63-68
-
-
Lugowska, I.1
Wozniak, W.2
Klepacka, T.3
Michalak, E.4
Szamotulska, K.5
-
63
-
-
84862907964
-
Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group
-
doi:10.1200/JCO.2011.37.4355
-
Malempati, S., Weigel, B., Ingle, A. M., Ahern, C. H., Carroll, J. M., Roberts, C. T., et al. (2012). Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. J. Clin. Oncol. 30, 256-262. doi:10.1200/JCO.2011.37.4355
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 256-262
-
-
Malempati, S.1
Weigel, B.2
Ingle, A.M.3
Ahern, C.H.4
Carroll, J.M.5
Roberts, C.T.6
-
64
-
-
3543035771
-
Biology and therapeutic advances for pediatric osteosarcoma
-
doi:10.1634/theoncologist.9-4-422
-
Marina, N., Gebhardt, M., Teot, L., and Gorlick, R. (2004). Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9, 422-441. doi:10.1634/theoncologist.9-4-422
-
(2004)
Oncologist
, vol.9
, pp. 422-441
-
-
Marina, N.1
Gebhardt, M.2
Teot, L.3
Gorlick, R.4
-
65
-
-
38549164180
-
Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21232
-
Maris, J. M., Courtright, J., Houghton, P. J., Morton, C. L., Gorlick, R., Kolb, E. A., et al. (2008a). Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 50, 581-587. doi:10.1002/pbc.21232
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 581-587
-
-
Maris, J.M.1
Courtright, J.2
Houghton, P.J.3
Morton, C.L.4
Gorlick, R.5
Kolb, E.A.6
-
66
-
-
44149115014
-
Initial testing (stage 1) of sunitinib by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21535
-
Maris, J. M., Courtright, J., Houghton, P. J., Morton, C. L., Kolb, E. A., Lock, R., et al. (2008b). Initial testing (stage 1) of sunitinib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 51, 42-48. doi:10.1002/pbc.21535
-
(2008)
Pediatr. Blood Cancer
, vol.51
, pp. 42-48
-
-
Maris, J.M.1
Courtright, J.2
Houghton, P.J.3
Morton, C.L.4
Kolb, E.A.5
Lock, R.6
-
67
-
-
77952703733
-
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
-
doi:10.1002/pbc.22430
-
Maris, J. M., Morton, C. L., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., et al. (2010). Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr. Blood Cancer 55, 26-34. doi:10.1002/pbc.22430
-
(2010)
Pediatr. Blood Cancer
, vol.55
, pp. 26-34
-
-
Maris, J.M.1
Morton, C.L.2
Gorlick, R.3
Kolb, E.A.4
Lock, R.5
Carol, H.6
-
68
-
-
84862281808
-
The genetics of osteosarcoma
-
627254. doi:10.1155/2012/627254
-
Martin, J. W., Squire, J. A., and Zielenska, M. (2012). The genetics of osteosarcoma. Sarcoma 2012, 627254. doi:10.1155/2012/627254
-
(2012)
Sarcoma
, vol.2012
-
-
Martin, J.W.1
Squire, J.A.2
Zielenska, M.3
-
69
-
-
77952087785
-
Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma
-
doi:10.1002/gcc.20761
-
Mejia-Guerrero, S., Quejada, M., Gokgoz, N., Gill, M., Parkes, R. K., Wunder, J. S., et al. (2010). Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosomes Cancer 49, 518-525. doi:10.1002/gcc.20761
-
(2010)
Genes Chromosomes Cancer
, vol.49
, pp. 518-525
-
-
Mejia-Guerrero, S.1
Quejada, M.2
Gokgoz, N.3
Gill, M.4
Parkes, R.K.5
Wunder, J.S.6
-
70
-
-
0025665155
-
Frequency and structure of p53 rearrangements in human osteosarcoma
-
Miller, C. W., Aslo, A., Tsay, C., Slamon, D., Ishizaki, K., Toguchida, J., et al. (1990). Frequency and structure of p53 rearrangements in human osteosarcoma. Cancer Res. 50, 7950-7954.
-
(1990)
Cancer Res.
, vol.50
, pp. 7950-7954
-
-
Miller, C.W.1
Aslo, A.2
Tsay, C.3
Slamon, D.4
Ishizaki, K.5
Toguchida, J.6
-
71
-
-
70350457821
-
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2
-
doi:10.1002/path.2603
-
Mohseny, A. B., Szuhai, K., Romeo, S., Buddingh, E. P., Briaire-de Bruijn, I., de Jong, D., et al. (2009). Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. J. Pathol. 219, 294-305. doi:10.1002/path.2603
-
(2009)
J. Pathol.
, vol.219
, pp. 294-305
-
-
Mohseny, A.B.1
Szuhai, K.2
Romeo, S.3
Buddingh, E.P.4
Briaire-de Bruijn, I.5
de Jong, D.6
-
72
-
-
77955122126
-
Initial testing of the replication competent Seneca Valley virus (NTX-010) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22535
-
Morton, C. L., Houghton, P. J., Kolb, E. A., Gorlick, R., Reynolds, C. P., Kang, M. H., et al. (2010). Initial testing of the replication competent Seneca Valley virus (NTX-010) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 55, 295-303. doi:10.1002/pbc.22535
-
(2010)
Pediatr. Blood Cancer
, vol.55
, pp. 295-303
-
-
Morton, C.L.1
Houghton, P.J.2
Kolb, E.A.3
Gorlick, R.4
Reynolds, C.P.5
Kang, M.H.6
-
73
-
-
84863116086
-
Combination testing of cediranib (AZD2171) against childhood cancer models by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23159
-
Morton, C. L., Maris, J. M., Keir, S. T., Gorlick, R., Kolb, E. A., Billups, C. A., et al. (2012). Combination testing of cediranib (AZD2171) against childhood cancer models by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 58, 566-571. doi:10.1002/pbc.23159
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 566-571
-
-
Morton, C.L.1
Maris, J.M.2
Keir, S.T.3
Gorlick, R.4
Kolb, E.A.5
Billups, C.A.6
-
74
-
-
33847693960
-
Comparative biology of human and canine osteosarcoma
-
Mueller, F., Fuchs, B., and Kaser-Hotz, B. (2007). Comparative biology of human and canine osteosarcoma. Anticancer Res. 27, 155-164.
-
(2007)
Anticancer Res.
, vol.27
, pp. 155-164
-
-
Mueller, F.1
Fuchs, B.2
Kaser-Hotz, B.3
-
75
-
-
84872470330
-
A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group Phase I Consortium Study (ADVL0916)
-
doi:10.1002/pbc.24271
-
Muscal, J. A., Thompson, P. A., Horton, T. M., Ingle, A. M., Ahern, C. H., McGovern, R. M., et al. (2013). A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group Phase I Consortium Study (ADVL0916). Pediatr. Blood Cancer 60, 390-395. doi:10.1002/pbc.24271
-
(2013)
Pediatr. Blood Cancer
, vol.60
, pp. 390-395
-
-
Muscal, J.A.1
Thompson, P.A.2
Horton, T.M.3
Ingle, A.M.4
Ahern, C.H.5
McGovern, R.M.6
-
76
-
-
80052831572
-
Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer
-
doi:10.1158/1078-0432.CCR-10-2979
-
Naing, A., Kurzrock, R., Burger, A., Gupta, S., Lei, X., Busaidy, N., et al. (2012). Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. Clin. Cancer Res. 17, 6052-6060. doi:10.1158/1078-0432.CCR-10-2979
-
(2012)
Clin. Cancer Res.
, vol.17
, pp. 6052-6060
-
-
Naing, A.1
Kurzrock, R.2
Burger, A.3
Gupta, S.4
Lei, X.5
Busaidy, N.6
-
77
-
-
84858116745
-
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
-
639038.
-
Namlos, H. M., Kresse, S. H., Muller, C. R., Henriksen, J., Holdhus, R., Saeter, G., et al. (2012). Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern. Sarcoma 639038.
-
(2012)
Sarcoma
-
-
Namlos, H.M.1
Kresse, S.H.2
Muller, C.R.3
Henriksen, J.4
Holdhus, R.5
Saeter, G.6
-
78
-
-
0031868951
-
CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations
-
doi:10.1016/S0002-9440(10)65556-3
-
Nielsen, G. P., Burns, K. L., Rosenberg, A. E., and Louis, D. N. (1998). CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. Am. J. Pathol. 153, 159-163. doi:10.1016/S0002-9440(10)65556-3
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 159-163
-
-
Nielsen, G.P.1
Burns, K.L.2
Rosenberg, A.E.3
Louis, D.N.4
-
79
-
-
83255163333
-
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study
-
doi:10.1200/JCO.2010.34.0000
-
Pappo, A. S., Patel, S. R., Crowley, J., Reinke, D. K., Kuenkele, K. P., Chawla, S. P., et al. (2011). R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J. Clin. Oncol. 29, 4541-4547. doi:10.1200/JCO.2010.34.0000
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 4541-4547
-
-
Pappo, A.S.1
Patel, S.R.2
Crowley, J.3
Reinke, D.K.4
Kuenkele, K.P.5
Chawla, S.P.6
-
80
-
-
77955485400
-
Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor
-
doi:10.1158/1535-7163.MCT-10-0324
-
Parry, D., Guzi, T., Shanahan, F., Davis, N., Prabhavalkar, D., Wiswell, D., et al. (2010). Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol. Cancer Ther. 9, 2344-2353. doi:10.1158/1535-7163.MCT-10-0324
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2344-2353
-
-
Parry, D.1
Guzi, T.2
Shanahan, F.3
Davis, N.4
Prabhavalkar, D.5
Wiswell, D.6
-
81
-
-
84877334055
-
The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models
-
doi:10.1158/1078-0432.CCR-12-2293
-
Pignochino, Y., Dell'aglio, C., Basirico, M., Capozzi, F., Soster, M., Marchio, S., et al. (2013). The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models. Clin. Cancer Res. 19, 2117-2131. doi:10.1158/1078-0432.CCR-12-2293
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2117-2131
-
-
Pignochino, Y.1
Dell'aglio, C.2
Basirico, M.3
Capozzi, F.4
Soster, M.5
Marchio, S.6
-
82
-
-
79951816312
-
Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors
-
doi:10.1158/1078-0432.CCR-10-2621
-
Quek, R., Wang, Q., Morgan, J. A., Shapiro, G. I., Butrynski, J. E., Ramaiya, N., et al. (2011). Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin. Cancer Res. 17, 871-879. doi:10.1158/1078-0432.CCR-10-2621
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 871-879
-
-
Quek, R.1
Wang, Q.2
Morgan, J.A.3
Shapiro, G.I.4
Butrynski, J.E.5
Ramaiya, N.6
-
83
-
-
84882428581
-
Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines
-
doi:10.1038/oncsis.2012.34
-
Rettew, A. N., Young, E. D., Lev, D. C., Kleinerman, E. S., Abdul-Karim, F. W., Getty, P. J., et al. (2012). Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines. Oncogenesis 1, e34. doi:10.1038/oncsis.2012.34
-
(2012)
Oncogenesis
, vol.1
-
-
Rettew, A.N.1
Young, E.D.2
Lev, D.C.3
Kleinerman, E.S.4
Abdul-Karim, F.W.5
Getty, P.J.6
-
84
-
-
79961189979
-
Initial testing of lenalidomide by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.22877
-
Reynolds, C. P., Kang, M. H., Keir, S. T., Gorlick, R., Kolb, E. A., Lock, R., et al. (2011). Initial testing of lenalidomide by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 57, 606-611. doi:10.1002/pbc.22877
-
(2011)
Pediatr. Blood Cancer
, vol.57
, pp. 606-611
-
-
Reynolds, C.P.1
Kang, M.H.2
Keir, S.T.3
Gorlick, R.4
Kolb, E.A.5
Lock, R.6
-
85
-
-
84861335102
-
Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma
-
doi:10.1016/j.ejca.2012.03.022
-
Schuetze, S. M., Zhao, L., Chugh, R., Thomas, D. G., Lucas, D. R., Metko, G., et al. (2012). Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma. Eur. J. Cancer 48, 1347-1353. doi:10.1016/j.ejca.2012.03.022
-
(2012)
Eur. J. Cancer
, vol.48
, pp. 1347-1353
-
-
Schuetze, S.M.1
Zhao, L.2
Chugh, R.3
Thomas, D.G.4
Lucas, D.R.5
Metko, G.6
-
86
-
-
84875803717
-
Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial
-
doi:10.1016/S1470-2045(13)70049-4
-
Schwartz, G. K., Tap, W. D., Qin, L. X., Livingston, M. B., Undevia, S. D., Chmielowski, B., et al. (2013). Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol. 14, 371-382. doi:10.1016/S1470-2045(13)70049-4
-
(2013)
Lancet Oncol.
, vol.14
, pp. 371-382
-
-
Schwartz, G.K.1
Tap, W.D.2
Qin, L.X.3
Livingston, M.B.4
Undevia, S.D.5
Chmielowski, B.6
-
87
-
-
36348970313
-
Targeted therapies in Ewing's sarcoma
-
doi:10.1007/978-1-4020-5133-3_2
-
Scotlandi, K. (2006). Targeted therapies in Ewing's sarcoma. Adv. Exp. Med. Biol. 587, 13-22. doi:10.1007/978-1-4020-5133-3_2
-
(2006)
Adv. Exp. Med. Biol.
, vol.587
, pp. 13-22
-
-
Scotlandi, K.1
-
88
-
-
68849096493
-
Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma
-
doi:10.1158/1535-7163.MCT-08-0857
-
Shang, X., Burlingame, S. M., Okcu, M. F., Ge, N., Russell, H. V., Egler, R. A., et al. (2009). Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Mol. Cancer Ther. 8, 2461-2469. doi:10.1158/1535-7163.MCT-08-0857
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2461-2469
-
-
Shang, X.1
Burlingame, S.M.2
Okcu, M.F.3
Ge, N.4
Russell, H.V.5
Egler, R.A.6
-
89
-
-
77952747768
-
Multiple malignant diseases in a patient with Rothmund-Thomson syndrome with RECQL4 mutations: case report and literature review
-
doi:10.1002/ajmg.a.33427
-
Simon, T., Kohlhase, J., Wilhelm, C., Kochanek, M., De Carolis, B., and Berthold, F. (2010). Multiple malignant diseases in a patient with Rothmund-Thomson syndrome with RECQL4 mutations: case report and literature review. Am. J. Med. Genet. A 152A, 1575-1579. doi:10.1002/ajmg.a.33427
-
(2010)
Am. J. Med. Genet. A
, vol.152 A
, pp. 1575-1579
-
-
Simon, T.1
Kohlhase, J.2
Wilhelm, C.3
Kochanek, M.4
De Carolis, B.5
Berthold, F.6
-
90
-
-
84862269393
-
Initial testing of JNJ-26854165 (Serdemetan) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23319
-
Smith, M. A., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., Maris, J. M., et al. (2012a). Initial testing of JNJ-26854165 (Serdemetan) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 329-332. doi:10.1002/pbc.23319
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 329-332
-
-
Smith, M.A.1
Gorlick, R.2
Kolb, E.A.3
Lock, R.4
Carol, H.5
Maris, J.M.6
-
91
-
-
84862269352
-
Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.23357
-
Smith, M. A., Maris, J. M., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., et al. (2012b). Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 59, 246-253. doi:10.1002/pbc.23357
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 246-253
-
-
Smith, M.A.1
Maris, J.M.2
Gorlick, R.3
Kolb, E.A.4
Lock, R.5
Carol, H.6
-
92
-
-
44149091042
-
Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the Pediatric Preclinical Testing Program
-
doi:10.1002/pbc.21508
-
Smith, M. A., Morton, C. L., Phelps, D. A., Kolb, E. A., Lock, R., Carol, H., et al. (2008). Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 51, 34-41. doi:10.1002/pbc.21508
-
(2008)
Pediatr. Blood Cancer
, vol.51
, pp. 34-41
-
-
Smith, M.A.1
Morton, C.L.2
Phelps, D.A.3
Kolb, E.A.4
Lock, R.5
Carol, H.6
-
93
-
-
41549151359
-
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA)
-
doi:10.1007/s11060-007-9505-1
-
Spiller, S. E., Ditzler, S. H., Pullar, B. J., and Olson, J. M. (2008). Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA). J. Neurooncol. 87, 133-141. doi:10.1007/s11060-007-9505-1
-
(2008)
J. Neurooncol.
, vol.87
, pp. 133-141
-
-
Spiller, S.E.1
Ditzler, S.H.2
Pullar, B.J.3
Olson, J.M.4
-
94
-
-
79960744694
-
Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors
-
doi:10.1200/JCO.2010.33.4649
-
Spunt, S. L., Grupp, S. A., Vik, T. A., Santana, V. M., Greenblatt, D. J., Clancy, J., et al. (2011). Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. J. Clin. Oncol. 29, 2933-2940. doi:10.1200/JCO.2010.33.4649
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2933-2940
-
-
Spunt, S.L.1
Grupp, S.A.2
Vik, T.A.3
Santana, V.M.4
Greenblatt, D.J.5
Clancy, J.6
-
95
-
-
37448999906
-
Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia
-
doi:10.1016/j.clinthera.2007.11.005
-
Steinberg, M. (2007). Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. Clin. Ther. 29, 2289-2308. doi:10.1016/j.clinthera.2007.11.005
-
(2007)
Clin. Ther.
, vol.29
, pp. 2289-2308
-
-
Steinberg, M.1
-
96
-
-
84861497210
-
Inhibitors of cell cycle kinases: recent advances and future prospects as cancer therapeutics
-
doi:10.1615/CritRevOncog.v17.i2.40
-
Stone, A., Sutherland, R. L., and Musgrove, E. A. (2012). Inhibitors of cell cycle kinases: recent advances and future prospects as cancer therapeutics. Crit. Rev. Oncog. 17, 175-198. doi:10.1615/CritRevOncog.v17.i2.40
-
(2012)
Crit. Rev. Oncog.
, vol.17
, pp. 175-198
-
-
Stone, A.1
Sutherland, R.L.2
Musgrove, E.A.3
-
97
-
-
80053504901
-
A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors
-
doi:10.1158/1078-0432.CCR-11-1101
-
Tabernero, J., Dirix, L., Schoffski, P., Cervantes, A., Lopez-Martin, J. A., Capdevila, J., et al. (2011). A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors. Clin. Cancer Res. 17, 6313-6321. doi:10.1158/1078-0432.CCR-11-1101
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 6313-6321
-
-
Tabernero, J.1
Dirix, L.2
Schoffski, P.3
Cervantes, A.4
Lopez-Martin, J.A.5
Capdevila, J.6
-
98
-
-
84855885822
-
Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy
-
doi:10.1517/14728222.2011.638626
-
Tognon, C. E., and Sorensen, P. H. (2012). Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opin. Ther. Targets 16, 33-48. doi:10.1517/14728222.2011.638626
-
(2012)
Expert Opin. Ther. Targets
, vol.16
, pp. 33-48
-
-
Tognon, C.E.1
Sorensen, P.H.2
-
99
-
-
0030695913
-
The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
-
doi:10.1074/jbc.272.49.30822
-
Toretsky, J. A., Kalebic, T., Blakesley, V., LeRoith, D., and Helman, L. J. (1997). The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J. Biol. Chem. 272, 30822-30827. doi:10.1074/jbc.272.49.30822
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30822-30827
-
-
Toretsky, J.A.1
Kalebic, T.2
Blakesley, V.3
LeRoith, D.4
Helman, L.J.5
-
100
-
-
77349095970
-
Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours
-
doi:10.1016/j.ejca.2009.12.023
-
van Cruijsen, H., Voest, E. E., Punt, C. J., Hoekman, K., Witteveen, P. O., Meijerink, M. R., et al. (2010). Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours. Eur. J. Cancer 46, 901-911. doi:10.1016/j.ejca.2009.12.023
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 901-911
-
-
van Cruijsen, H.1
Voest, E.E.2
Punt, C.J.3
Hoekman, K.4
Witteveen, P.O.5
Meijerink, M.R.6
-
101
-
-
84879570162
-
Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment
-
doi:10.1186/2045-3329-2-5
-
van Maldegem, A. M., Bhosale, A., Gelderblom, H. J., Hogendoorn, P. C., and Hassan, A. B. (2012). Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment. Clin. Sarcoma Res. 2, 5. doi:10.1186/2045-3329-2-5
-
(2012)
Clin. Sarcoma Res.
, vol.2
, pp. 5
-
-
van Maldegem, A.M.1
Bhosale, A.2
Gelderblom, H.J.3
Hogendoorn, P.C.4
Hassan, A.B.5
-
103
-
-
16844366544
-
Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
-
doi:10.1158/0008-5472.CAN-04-3135
-
Wan, X., Mendoza, A., Khanna, C., and Helman, L. J. (2005). Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 65, 2406-2411. doi:10.1158/0008-5472.CAN-04-3135
-
(2005)
Cancer Res.
, vol.65
, pp. 2406-2411
-
-
Wan, X.1
Mendoza, A.2
Khanna, C.3
Helman, L.J.4
-
104
-
-
76649095657
-
A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts
-
doi:10.1158/1535-7163.MCT-09-0555
-
Wang, Y., Lipari, P., Wang, X., Hailey, J., Liang, L., Ramos, R., et al. (2010). A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts. Mol. Cancer Ther. 9, 410-418. doi:10.1158/1535-7163.MCT-09-0555
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 410-418
-
-
Wang, Y.1
Lipari, P.2
Wang, X.3
Hailey, J.4
Liang, L.5
Ramos, R.6
-
105
-
-
84864474329
-
MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells
-
doi:10.1093/abbs/gms053
-
Wang, B., Fang, L., Zhao, H., Xiang, T., and Wang, D. (2012). MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. Acta Biochim. Biophys. Sin. (Shanghai) 44, 685-691. doi:10.1093/abbs/gms053
-
(2012)
Acta Biochim. Biophys. Sin. (Shanghai)
, vol.44
, pp. 685-691
-
-
Wang, B.1
Fang, L.2
Zhao, H.3
Xiang, T.4
Wang, D.5
-
106
-
-
84868543745
-
A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium Report
-
Widemann, B. C., Kim, A., Fox, E., Baruchel, S., Adamson, P. C., Ingle, A. M., et al. (2012). A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium Report. Clin. Cancer Res. 18, 6011-6022.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 6011-6022
-
-
Widemann, B.C.1
Kim, A.2
Fox, E.3
Baruchel, S.4
Adamson, P.C.5
Ingle, A.M.6
-
107
-
-
0030848527
-
Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk
-
doi:10.1001/jama.278.15.1262
-
Wong, F. L., Boice, J. D. Jr., Abramson, D. H., Tarone, R. E., Kleinerman, R. A., Stovall, M., et al. (1997). Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 278, 1262-1267. doi:10.1001/jama.278.15.1262
-
(1997)
JAMA
, vol.278
, pp. 1262-1267
-
-
Wong, F.L.1
Boice Jr., J.D.2
Abramson, D.H.3
Tarone, R.E.4
Kleinerman, R.A.5
Stovall, M.6
-
108
-
-
0026647228
-
Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q
-
Yamaguchi, T., Toguchida, J., Yamamuro, T., Kotoura, Y., Takada, N., Kawaguchi, N., et al. (1992). Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. Cancer Res. 52, 2419-2423.
-
(1992)
Cancer Res.
, vol.52
, pp. 2419-2423
-
-
Yamaguchi, T.1
Toguchida, J.2
Yamamuro, T.3
Kotoura, Y.4
Takada, N.5
Kawaguchi, N.6
-
109
-
-
79956122399
-
Ras/Raf/MEK/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model
-
Yu, Y., Luk, F., Yang, J. L., and Walsh, W. R. (2011). Ras/Raf/MEK/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model. Anticancer Res. 31, 1147-1152.
-
(2011)
Anticancer Res.
, vol.31
, pp. 1147-1152
-
-
Yu, Y.1
Luk, F.2
Yang, J.L.3
Walsh, W.R.4
-
110
-
-
78149475399
-
Review of the complexities of the PI3K/mTOR pathway presages similar handling of other critical topics
-
doi:10.1093/neuonc/noq083
-
Yung, W. K. A. (2010). Review of the complexities of the PI3K/mTOR pathway presages similar handling of other critical topics. Neuro-oncology 12, 763-764. doi:10.1093/neuonc/noq083
-
(2010)
Neuro-oncology
, vol.12
, pp. 763-764
-
-
Yung, W.K.A.1
|