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Volumn 56, Issue 4, 2011, Pages 595-603

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program

Author keywords

Developmental therapeutics; IGF 1 receptor inhibitor; Preclinical testing

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 754807; UNCLASSIFIED DRUG;

EID: 79551630554     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22741     Document Type: Article
Times cited : (65)

References (45)
  • 1
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions. Oncogene 2009; 28: 3009-3021.
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 2
    • 62849105383 scopus 로고    scopus 로고
    • The insulin-like growth factor system and sarcomas
    • Rikhof B, de Jong S, Suurmeijer AJ, et al. The insulin-like growth factor system and sarcomas. J Pathol 2009; 217: 469-482.
    • (2009) J Pathol , vol.217 , pp. 469-482
    • Rikhof, B.1    de Jong, S.2    Suurmeijer, A.J.3
  • 3
    • 67649389647 scopus 로고    scopus 로고
    • Development of IGF-IR Inhibitors in Pediatric Sarcomas
    • Kolb EA, Gorlick R. Development of IGF-IR Inhibitors in Pediatric Sarcomas. Curr Oncol Rep 2009; 11: 307-313.
    • (2009) Curr Oncol Rep , vol.11 , pp. 307-313
    • Kolb, E.A.1    Gorlick, R.2
  • 4
    • 0034523626 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation
    • Hermanto U, Zong CS, Wang LH. Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation. Cell Growth Differ 2000; 11: 655-664.
    • (2000) Cell Growth Differ , vol.11 , pp. 655-664
    • Hermanto, U.1    Zong, C.S.2    Wang, L.H.3
  • 5
    • 33746840153 scopus 로고    scopus 로고
    • IGF-I mediated survival pathways in normal and malignant cells
    • Kurmasheva RT, Houghton PJ. IGF-I mediated survival pathways in normal and malignant cells. Biochim Biophys Acta 2006; 1766: 1-22.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 1-22
    • Kurmasheva, R.T.1    Houghton, P.J.2
  • 6
    • 61449097712 scopus 로고    scopus 로고
    • The role of IGF-1R in pediatric malignancies
    • Kim SY, Toretsky JA, Scher D, et al. The role of IGF-1R in pediatric malignancies. Oncologist 2009; 14: 83-91.
    • (2009) Oncologist , vol.14 , pp. 83-91
    • Kim, S.Y.1    Toretsky, J.A.2    Scher, D.3
  • 7
    • 65549161522 scopus 로고    scopus 로고
    • Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma
    • Avnet S, Sciacca L, Salerno M, et al. Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. Cancer Res 2009; 69: 2443-2452.
    • (2009) Cancer Res , vol.69 , pp. 2443-2452
    • Avnet, S.1    Sciacca, L.2    Salerno, M.3
  • 8
    • 33846458639 scopus 로고    scopus 로고
    • Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    • Zhang H, Pelzer AM, Kiang DT, et al. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res 2007; 67: 391-397.
    • (2007) Cancer Res , vol.67 , pp. 391-397
    • Zhang, H.1    Pelzer, A.M.2    Kiang, D.T.3
  • 9
    • 73149120253 scopus 로고    scopus 로고
    • BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
    • Carboni JM, Wittman M, Yang Z, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 2009; 8: 3341-3349.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3341-3349
    • Carboni, J.M.1    Wittman, M.2    Yang, Z.3
  • 10
    • 72249089981 scopus 로고    scopus 로고
    • Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development
    • Wittman MD, Carboni JM, Yang Z, et al. Discovery of a 2, 4-disubstituted pyrrolo[1, 2-f][1, 2, 4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 2009; 52: 7360-7363.
    • (2009) J Med Chem , vol.52 , pp. 7360-7363
    • Wittman, M.D.1    Carboni, J.M.2    Yang, Z.3
  • 11
    • 34147135644 scopus 로고    scopus 로고
    • A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations
    • Frgala T, Kalous O, Proffitt RT, et al. A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. Mol Cancer Ther 2007; 6: 886-897.
    • (2007) Mol Cancer Ther , vol.6 , pp. 886-897
    • Frgala, T.1    Kalous, O.2    Proffitt, R.T.3
  • 12
    • 36849020943 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
    • Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 37-45.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 37-45
    • Houghton, P.J.1    Morton, C.L.2    Kolb, E.A.3
  • 13
    • 0038380346 scopus 로고    scopus 로고
    • Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells
    • Hailey J, Maxwell E, Koukouras K, et al. Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells. Mol Cancer Ther 2002; 1: 1349-1353.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1349-1353
    • Hailey, J.1    Maxwell, E.2    Koukouras, K.3
  • 14
    • 0023731771 scopus 로고
    • Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents
    • Friedman HS, Colvin OM, Skapek SX, et al. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res 1988; 48: 4189-4195.
    • (1988) Cancer Res , vol.48 , pp. 4189-4195
    • Friedman, H.S.1    Colvin, O.M.2    Skapek, S.X.3
  • 15
    • 2342531648 scopus 로고    scopus 로고
    • Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
    • Liem NL, Papa RA, Milross CG, et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood 2004; 103: 3905-3914.
    • (2004) Blood , vol.103 , pp. 3905-3914
    • Liem, N.L.1    Papa, R.A.2    Milross, C.G.3
  • 16
    • 34447249881 scopus 로고    scopus 로고
    • The pediatric preclinical testing program: Description of models and early testing results
    • Houghton PJ, Morton CL, Tucker C, et al. The pediatric preclinical testing program: Description of models and early testing results. Pediatr Blood Cancer 2007; 49: 928-940.
    • (2007) Pediatr Blood Cancer , vol.49 , pp. 928-940
    • Houghton, P.J.1    Morton, C.L.2    Tucker, C.3
  • 17
    • 77957218340 scopus 로고
    • Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells
    • Pollak M, Richard M. Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. J Natl Cancer Inst 1990; 82: 1349-1352.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1349-1352
    • Pollak, M.1    Richard, M.2
  • 18
    • 0035842534 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells
    • Bostedt KT, Schmid C, Ghirlanda-Keller C, et al. Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells. Exp Cell Res 2001; 271: 368-377.
    • (2001) Exp Cell Res , vol.271 , pp. 368-377
    • Bostedt, K.T.1    Schmid, C.2    Ghirlanda-Keller, C.3
  • 19
    • 5444242379 scopus 로고    scopus 로고
    • IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma
    • MacEwen EG, Pastor J, Kutzke J, et al. IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 2004; 92: 77-91.
    • (2004) J Cell Biochem , vol.92 , pp. 77-91
    • MacEwen, E.G.1    Pastor, J.2    Kutzke, J.3
  • 20
    • 0026101018 scopus 로고
    • Insulin-like growth factor II-mediated proliferation of human neuroblastoma
    • El-Badry OM, Helman LJ, Chatten J, et al. Insulin-like growth factor II-mediated proliferation of human neuroblastoma. J Clin Invest 1991; 87: 648-657.
    • (1991) J Clin Invest , vol.87 , pp. 648-657
    • El-Badry, O.M.1    Helman, L.J.2    Chatten, J.3
  • 21
    • 0345491971 scopus 로고    scopus 로고
    • Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
    • Weber A, Huesken C, Bergmann E, et al. Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. Clin Cancer Res 2003; 9: 5683-5692.
    • (2003) Clin Cancer Res , vol.9 , pp. 5683-5692
    • Weber, A.1    Huesken, C.2    Bergmann, E.3
  • 22
    • 0023768544 scopus 로고
    • The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma
    • Sandberg AC, Engberg C, Lake M, et al. The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma. Neurosci Lett 1988; 93: 114-119.
    • (1988) Neurosci Lett , vol.93 , pp. 114-119
    • Sandberg, A.C.1    Engberg, C.2    Lake, M.3
  • 23
    • 0030029754 scopus 로고    scopus 로고
    • Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA
    • Resnicoff M, Li W, Basak S, et al. Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA. Cancer Immunol Immunother 1996; 42: 64-68.
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 64-68
    • Resnicoff, M.1    Li, W.2    Basak, S.3
  • 24
    • 0026575130 scopus 로고
    • Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry
    • Antoniades HN, Galanopoulos T, Neville-Golden J, et al. Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry. Int J Cancer 1992; 50: 215-222.
    • (1992) Int J Cancer , vol.50 , pp. 215-222
    • Antoniades, H.N.1    Galanopoulos, T.2    Neville-Golden, J.3
  • 25
    • 0036278440 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor activity in human medulloblastomas
    • Del Valle L, Enam S, Lassak A, et al. Insulin-like growth factor I receptor activity in human medulloblastomas. Clin Cancer Res 2002; 8: 1822-1830.
    • (2002) Clin Cancer Res , vol.8 , pp. 1822-1830
    • Del Valle, L.1    Enam, S.2    Lassak, A.3
  • 26
    • 0028363159 scopus 로고
    • Diverse roles of insulin-like growth factors in pediatric solid tumors
    • Hirschfeld S, Helman L. Diverse roles of insulin-like growth factors in pediatric solid tumors. In Vivo 1994; 8: 81-90.
    • (1994) In Vivo , vol.8 , pp. 81-90
    • Hirschfeld, S.1    Helman, L.2
  • 27
    • 0346725866 scopus 로고    scopus 로고
    • The role of the IGF axis in hepatocarcinogenesis
    • Scharf JG, Braulke T. The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 2003; 35: 685-693.
    • (2003) Horm Metab Res , vol.35 , pp. 685-693
    • Scharf, J.G.1    Braulke, T.2
  • 28
    • 0033951995 scopus 로고    scopus 로고
    • The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models
    • Gidding CE, Germain GS, Dilling MB, et al. The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models. Cancer Chemother Pharmacol 2000; 45: 21-30.
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 21-30
    • Gidding, C.E.1    Germain, G.S.2    Dilling, M.B.3
  • 29
    • 0037439835 scopus 로고    scopus 로고
    • Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways
    • Thimmaiah KN, Easton J, Huang S, et al. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. Cancer Res 2003; 63: 364-374.
    • (2003) Cancer Res , vol.63 , pp. 364-374
    • Thimmaiah, K.N.1    Easton, J.2    Huang, S.3
  • 30
    • 0032865667 scopus 로고    scopus 로고
    • High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma
    • Fukuzawa R, Umezawa A, Ochi K, et al. High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma. Int J Cancer 1999; 82: 490-497.
    • (1999) Int J Cancer , vol.82 , pp. 490-497
    • Fukuzawa, R.1    Umezawa, A.2    Ochi, K.3
  • 31
    • 17744417798 scopus 로고    scopus 로고
    • Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice
    • Scotlandi K, Benini S, Nanni P, et al. Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice. Cancer Res 1998; 58: 4127-4131.
    • (1998) Cancer Res , vol.58 , pp. 4127-4131
    • Scotlandi, K.1    Benini, S.2    Nanni, P.3
  • 32
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
    • Scotlandi K, Benini S, Sarti M, et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target. Cancer Res 1996; 56: 4570-4574.
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3
  • 33
    • 0033870294 scopus 로고    scopus 로고
    • Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma
    • de Alava E, Panizo A, Antonescu CR, et al. Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma. Am J Pathol 2000; 156: 849-855.
    • (2000) Am J Pathol , vol.156 , pp. 849-855
    • de Alava, E.1    Panizo, A.2    Antonescu, C.R.3
  • 34
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A, Tirode F, Cohen P, et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004; 24: 7275-7283.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3
  • 35
    • 0031704545 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma
    • Burrow S, Andrulis IL, Pollak M, et al. Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. J Surg Oncol 1998; 69: 21-27.
    • (1998) J Surg Oncol , vol.69 , pp. 21-27
    • Burrow, S.1    Andrulis, I.L.2    Pollak, M.3
  • 36
    • 0026721016 scopus 로고
    • Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy
    • Pollak M, Sem AW, Richard M, et al. Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy. J Natl Cancer Inst 1992; 84: 966-971.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 966-971
    • Pollak, M.1    Sem, A.W.2    Richard, M.3
  • 37
    • 42349083307 scopus 로고    scopus 로고
    • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
    • Kolb EA, Gorlick R, Houghton PJ, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 1190-1197.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 1190-1197
    • Kolb, E.A.1    Gorlick, R.2    Houghton, P.J.3
  • 38
    • 0036164295 scopus 로고    scopus 로고
    • Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
    • Vorwerk P, Wex H, Hohmann B, et al. Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia. Mol Pathol 2002; 55: 40-45.
    • (2002) Mol Pathol , vol.55 , pp. 40-45
    • Vorwerk, P.1    Wex, H.2    Hohmann, B.3
  • 39
    • 67649400543 scopus 로고    scopus 로고
    • Pediatric Preclinical Testing Program (PPTP) evaluation of the fully human anti-IGF-1R antibody IMC-A12
    • 176 (Abstr #558)
    • Kolb EA, Morton C, Houghton PJ, et al. Pediatric Preclinical Testing Program (PPTP) evaluation of the fully human anti-IGF-1R antibody IMC-A12. Eur J Cancer Suppl 2008; 6: 176 (Abstr #558).
    • (2008) Eur J Cancer Suppl , vol.6
    • Kolb, E.A.1    Morton, C.2    Houghton, P.J.3
  • 40
    • 42349083307 scopus 로고    scopus 로고
    • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
    • Kolb EA, Gorlick R, Houghton PJ, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 1190-1197.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 1190-1197
    • Kolb, E.A.1    Gorlick, R.2    Houghton, P.J.3
  • 41
    • 77951747892 scopus 로고    scopus 로고
    • Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
    • Houghton PJ, Morton CL, Gorlick R, et al. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2010; 54: 921-926.
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 921-926
    • Houghton, P.J.1    Morton, C.L.2    Gorlick, R.3
  • 42
    • 68849085354 scopus 로고    scopus 로고
    • Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor
    • Carden CP, Molife LR, de Bono JS. Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor. Mol Cancer Ther 2009; 8: 2077-2078.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2077-2078
    • Carden, C.P.1    Molife, L.R.2    de Bono, J.S.3
  • 43
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 2009; 69: 161-170.
    • (2009) Cancer Res , vol.69 , pp. 161-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 44
    • 69949106121 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
    • Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res 2009; 15: 5445-5456.
    • (2009) Clin Cancer Res , vol.15 , pp. 5445-5456
    • Desbois-Mouthon, C.1    Baron, A.2    Blivet-Van Eggelpoel, M.J.3
  • 45
    • 40449120461 scopus 로고    scopus 로고
    • Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer
    • Chakraborty AK, Liang K, DiGiovanna MP. Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer. Cancer Res 2008; 68: 1538-1545.
    • (2008) Cancer Res , vol.68 , pp. 1538-1545
    • Chakraborty, A.K.1    Liang, K.2    DiGiovanna, M.P.3


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