-
1
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions. Oncogene 2009; 28: 3009-3021.
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
2
-
-
62849105383
-
The insulin-like growth factor system and sarcomas
-
Rikhof B, de Jong S, Suurmeijer AJ, et al. The insulin-like growth factor system and sarcomas. J Pathol 2009; 217: 469-482.
-
(2009)
J Pathol
, vol.217
, pp. 469-482
-
-
Rikhof, B.1
de Jong, S.2
Suurmeijer, A.J.3
-
3
-
-
67649389647
-
Development of IGF-IR Inhibitors in Pediatric Sarcomas
-
Kolb EA, Gorlick R. Development of IGF-IR Inhibitors in Pediatric Sarcomas. Curr Oncol Rep 2009; 11: 307-313.
-
(2009)
Curr Oncol Rep
, vol.11
, pp. 307-313
-
-
Kolb, E.A.1
Gorlick, R.2
-
4
-
-
0034523626
-
Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation
-
Hermanto U, Zong CS, Wang LH. Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation. Cell Growth Differ 2000; 11: 655-664.
-
(2000)
Cell Growth Differ
, vol.11
, pp. 655-664
-
-
Hermanto, U.1
Zong, C.S.2
Wang, L.H.3
-
5
-
-
33746840153
-
IGF-I mediated survival pathways in normal and malignant cells
-
Kurmasheva RT, Houghton PJ. IGF-I mediated survival pathways in normal and malignant cells. Biochim Biophys Acta 2006; 1766: 1-22.
-
(2006)
Biochim Biophys Acta
, vol.1766
, pp. 1-22
-
-
Kurmasheva, R.T.1
Houghton, P.J.2
-
6
-
-
61449097712
-
The role of IGF-1R in pediatric malignancies
-
Kim SY, Toretsky JA, Scher D, et al. The role of IGF-1R in pediatric malignancies. Oncologist 2009; 14: 83-91.
-
(2009)
Oncologist
, vol.14
, pp. 83-91
-
-
Kim, S.Y.1
Toretsky, J.A.2
Scher, D.3
-
7
-
-
65549161522
-
Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma
-
Avnet S, Sciacca L, Salerno M, et al. Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. Cancer Res 2009; 69: 2443-2452.
-
(2009)
Cancer Res
, vol.69
, pp. 2443-2452
-
-
Avnet, S.1
Sciacca, L.2
Salerno, M.3
-
8
-
-
33846458639
-
Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
-
Zhang H, Pelzer AM, Kiang DT, et al. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res 2007; 67: 391-397.
-
(2007)
Cancer Res
, vol.67
, pp. 391-397
-
-
Zhang, H.1
Pelzer, A.M.2
Kiang, D.T.3
-
9
-
-
73149120253
-
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
-
Carboni JM, Wittman M, Yang Z, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 2009; 8: 3341-3349.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 3341-3349
-
-
Carboni, J.M.1
Wittman, M.2
Yang, Z.3
-
10
-
-
72249089981
-
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development
-
Wittman MD, Carboni JM, Yang Z, et al. Discovery of a 2, 4-disubstituted pyrrolo[1, 2-f][1, 2, 4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 2009; 52: 7360-7363.
-
(2009)
J Med Chem
, vol.52
, pp. 7360-7363
-
-
Wittman, M.D.1
Carboni, J.M.2
Yang, Z.3
-
11
-
-
34147135644
-
A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations
-
Frgala T, Kalous O, Proffitt RT, et al. A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. Mol Cancer Ther 2007; 6: 886-897.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 886-897
-
-
Frgala, T.1
Kalous, O.2
Proffitt, R.T.3
-
12
-
-
36849020943
-
Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
-
Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 37-45.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 37-45
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
-
13
-
-
0038380346
-
Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells
-
Hailey J, Maxwell E, Koukouras K, et al. Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells. Mol Cancer Ther 2002; 1: 1349-1353.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 1349-1353
-
-
Hailey, J.1
Maxwell, E.2
Koukouras, K.3
-
14
-
-
0023731771
-
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents
-
Friedman HS, Colvin OM, Skapek SX, et al. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res 1988; 48: 4189-4195.
-
(1988)
Cancer Res
, vol.48
, pp. 4189-4195
-
-
Friedman, H.S.1
Colvin, O.M.2
Skapek, S.X.3
-
15
-
-
2342531648
-
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
-
Liem NL, Papa RA, Milross CG, et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood 2004; 103: 3905-3914.
-
(2004)
Blood
, vol.103
, pp. 3905-3914
-
-
Liem, N.L.1
Papa, R.A.2
Milross, C.G.3
-
16
-
-
34447249881
-
The pediatric preclinical testing program: Description of models and early testing results
-
Houghton PJ, Morton CL, Tucker C, et al. The pediatric preclinical testing program: Description of models and early testing results. Pediatr Blood Cancer 2007; 49: 928-940.
-
(2007)
Pediatr Blood Cancer
, vol.49
, pp. 928-940
-
-
Houghton, P.J.1
Morton, C.L.2
Tucker, C.3
-
17
-
-
77957218340
-
Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells
-
Pollak M, Richard M. Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. J Natl Cancer Inst 1990; 82: 1349-1352.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1349-1352
-
-
Pollak, M.1
Richard, M.2
-
18
-
-
0035842534
-
Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells
-
Bostedt KT, Schmid C, Ghirlanda-Keller C, et al. Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells. Exp Cell Res 2001; 271: 368-377.
-
(2001)
Exp Cell Res
, vol.271
, pp. 368-377
-
-
Bostedt, K.T.1
Schmid, C.2
Ghirlanda-Keller, C.3
-
19
-
-
5444242379
-
IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma
-
MacEwen EG, Pastor J, Kutzke J, et al. IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 2004; 92: 77-91.
-
(2004)
J Cell Biochem
, vol.92
, pp. 77-91
-
-
MacEwen, E.G.1
Pastor, J.2
Kutzke, J.3
-
20
-
-
0026101018
-
Insulin-like growth factor II-mediated proliferation of human neuroblastoma
-
El-Badry OM, Helman LJ, Chatten J, et al. Insulin-like growth factor II-mediated proliferation of human neuroblastoma. J Clin Invest 1991; 87: 648-657.
-
(1991)
J Clin Invest
, vol.87
, pp. 648-657
-
-
El-Badry, O.M.1
Helman, L.J.2
Chatten, J.3
-
21
-
-
0345491971
-
Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
-
Weber A, Huesken C, Bergmann E, et al. Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. Clin Cancer Res 2003; 9: 5683-5692.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5683-5692
-
-
Weber, A.1
Huesken, C.2
Bergmann, E.3
-
22
-
-
0023768544
-
The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma
-
Sandberg AC, Engberg C, Lake M, et al. The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma. Neurosci Lett 1988; 93: 114-119.
-
(1988)
Neurosci Lett
, vol.93
, pp. 114-119
-
-
Sandberg, A.C.1
Engberg, C.2
Lake, M.3
-
23
-
-
0030029754
-
Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA
-
Resnicoff M, Li W, Basak S, et al. Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA. Cancer Immunol Immunother 1996; 42: 64-68.
-
(1996)
Cancer Immunol Immunother
, vol.42
, pp. 64-68
-
-
Resnicoff, M.1
Li, W.2
Basak, S.3
-
24
-
-
0026575130
-
Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry
-
Antoniades HN, Galanopoulos T, Neville-Golden J, et al. Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry. Int J Cancer 1992; 50: 215-222.
-
(1992)
Int J Cancer
, vol.50
, pp. 215-222
-
-
Antoniades, H.N.1
Galanopoulos, T.2
Neville-Golden, J.3
-
25
-
-
0036278440
-
Insulin-like growth factor I receptor activity in human medulloblastomas
-
Del Valle L, Enam S, Lassak A, et al. Insulin-like growth factor I receptor activity in human medulloblastomas. Clin Cancer Res 2002; 8: 1822-1830.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1822-1830
-
-
Del Valle, L.1
Enam, S.2
Lassak, A.3
-
26
-
-
0028363159
-
Diverse roles of insulin-like growth factors in pediatric solid tumors
-
Hirschfeld S, Helman L. Diverse roles of insulin-like growth factors in pediatric solid tumors. In Vivo 1994; 8: 81-90.
-
(1994)
In Vivo
, vol.8
, pp. 81-90
-
-
Hirschfeld, S.1
Helman, L.2
-
27
-
-
0346725866
-
The role of the IGF axis in hepatocarcinogenesis
-
Scharf JG, Braulke T. The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 2003; 35: 685-693.
-
(2003)
Horm Metab Res
, vol.35
, pp. 685-693
-
-
Scharf, J.G.1
Braulke, T.2
-
28
-
-
0033951995
-
The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models
-
Gidding CE, Germain GS, Dilling MB, et al. The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models. Cancer Chemother Pharmacol 2000; 45: 21-30.
-
(2000)
Cancer Chemother Pharmacol
, vol.45
, pp. 21-30
-
-
Gidding, C.E.1
Germain, G.S.2
Dilling, M.B.3
-
29
-
-
0037439835
-
Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways
-
Thimmaiah KN, Easton J, Huang S, et al. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. Cancer Res 2003; 63: 364-374.
-
(2003)
Cancer Res
, vol.63
, pp. 364-374
-
-
Thimmaiah, K.N.1
Easton, J.2
Huang, S.3
-
30
-
-
0032865667
-
High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma
-
Fukuzawa R, Umezawa A, Ochi K, et al. High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma. Int J Cancer 1999; 82: 490-497.
-
(1999)
Int J Cancer
, vol.82
, pp. 490-497
-
-
Fukuzawa, R.1
Umezawa, A.2
Ochi, K.3
-
31
-
-
17744417798
-
Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice
-
Scotlandi K, Benini S, Nanni P, et al. Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice. Cancer Res 1998; 58: 4127-4131.
-
(1998)
Cancer Res
, vol.58
, pp. 4127-4131
-
-
Scotlandi, K.1
Benini, S.2
Nanni, P.3
-
32
-
-
0029838475
-
Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
-
Scotlandi K, Benini S, Sarti M, et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target. Cancer Res 1996; 56: 4570-4574.
-
(1996)
Cancer Res
, vol.56
, pp. 4570-4574
-
-
Scotlandi, K.1
Benini, S.2
Sarti, M.3
-
33
-
-
0033870294
-
Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma
-
de Alava E, Panizo A, Antonescu CR, et al. Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma. Am J Pathol 2000; 156: 849-855.
-
(2000)
Am J Pathol
, vol.156
, pp. 849-855
-
-
de Alava, E.1
Panizo, A.2
Antonescu, C.R.3
-
34
-
-
3543026281
-
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
-
Prieur A, Tirode F, Cohen P, et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004; 24: 7275-7283.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7275-7283
-
-
Prieur, A.1
Tirode, F.2
Cohen, P.3
-
35
-
-
0031704545
-
Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma
-
Burrow S, Andrulis IL, Pollak M, et al. Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. J Surg Oncol 1998; 69: 21-27.
-
(1998)
J Surg Oncol
, vol.69
, pp. 21-27
-
-
Burrow, S.1
Andrulis, I.L.2
Pollak, M.3
-
36
-
-
0026721016
-
Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy
-
Pollak M, Sem AW, Richard M, et al. Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy. J Natl Cancer Inst 1992; 84: 966-971.
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 966-971
-
-
Pollak, M.1
Sem, A.W.2
Richard, M.3
-
37
-
-
42349083307
-
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
-
Kolb EA, Gorlick R, Houghton PJ, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 1190-1197.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 1190-1197
-
-
Kolb, E.A.1
Gorlick, R.2
Houghton, P.J.3
-
38
-
-
0036164295
-
Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
-
Vorwerk P, Wex H, Hohmann B, et al. Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia. Mol Pathol 2002; 55: 40-45.
-
(2002)
Mol Pathol
, vol.55
, pp. 40-45
-
-
Vorwerk, P.1
Wex, H.2
Hohmann, B.3
-
39
-
-
67649400543
-
Pediatric Preclinical Testing Program (PPTP) evaluation of the fully human anti-IGF-1R antibody IMC-A12
-
176 (Abstr #558)
-
Kolb EA, Morton C, Houghton PJ, et al. Pediatric Preclinical Testing Program (PPTP) evaluation of the fully human anti-IGF-1R antibody IMC-A12. Eur J Cancer Suppl 2008; 6: 176 (Abstr #558).
-
(2008)
Eur J Cancer Suppl
, vol.6
-
-
Kolb, E.A.1
Morton, C.2
Houghton, P.J.3
-
40
-
-
42349083307
-
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
-
Kolb EA, Gorlick R, Houghton PJ, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 1190-1197.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 1190-1197
-
-
Kolb, E.A.1
Gorlick, R.2
Houghton, P.J.3
-
41
-
-
77951747892
-
Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
-
Houghton PJ, Morton CL, Gorlick R, et al. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2010; 54: 921-926.
-
(2010)
Pediatr Blood Cancer
, vol.54
, pp. 921-926
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
-
42
-
-
68849085354
-
Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor
-
Carden CP, Molife LR, de Bono JS. Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor. Mol Cancer Ther 2009; 8: 2077-2078.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2077-2078
-
-
Carden, C.P.1
Molife, L.R.2
de Bono, J.S.3
-
43
-
-
58249101005
-
The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
-
Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 2009; 69: 161-170.
-
(2009)
Cancer Res
, vol.69
, pp. 161-170
-
-
Huang, F.1
Greer, A.2
Hurlburt, W.3
-
44
-
-
69949106121
-
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
-
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res 2009; 15: 5445-5456.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5445-5456
-
-
Desbois-Mouthon, C.1
Baron, A.2
Blivet-Van Eggelpoel, M.J.3
-
45
-
-
40449120461
-
Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer
-
Chakraborty AK, Liang K, DiGiovanna MP. Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer. Cancer Res 2008; 68: 1538-1545.
-
(2008)
Cancer Res
, vol.68
, pp. 1538-1545
-
-
Chakraborty, A.K.1
Liang, K.2
DiGiovanna, M.P.3
|