메뉴 건너뛰기




Volumn 29, Issue , 2013, Pages 571-592

How microbiomes influence metazoan development: Insights from history and drosophila modeling of gut-microbe interactions

Author keywords

genetic model system; gut commensal microbiota; Metchnikoff; microbiome modulated metazoan physiology

Indexed keywords

COMMENSAL; DEVELOPMENT; DROSOPHILA; GENETIC MODEL; HISTORY; HOST PATHOGEN INTERACTION; INTESTINE FLORA; MICROBIOME; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; ANIMAL; ANIMAL MODEL; GASTROINTESTINAL TRACT; HUMAN; MICROBIOLOGY; MICROFLORA;

EID: 84885747168     PISSN: 10810706     EISSN: 15308995     Source Type: Book Series    
DOI: 10.1146/annurev-cellbio-101512-122333     Document Type: Review
Times cited : (116)

References (135)
  • 2
    • 58049218983 scopus 로고    scopus 로고
    • Tissue damage-induced intestinal stem cell division in Drosophila
    • Amcheslavsky A, Jiang J, Ip YT. 2009. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4:49-61
    • (2009) Cell Stem Cell , vol.4 , pp. 49-61
    • Amcheslavsky, A.1    Jiang, J.2    Ip, Y.T.3
  • 3
    • 78650893176 scopus 로고    scopus 로고
    • Drosophila melanogaster as a model for human intestinal infection and pathology
    • Apidianakis Y, Rahme LG. 2011. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis. Model. Mech. 4:21-30
    • (2011) Dis. Model. Mech , vol.4 , pp. 21-30
    • Apidianakis, Y.1    Rahme, L.G.2
  • 4
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • Artis D. 2008. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat. Rev. Immunol. 8:411-20
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 411-420
    • Artis, D.1
  • 6
    • 84555187036 scopus 로고    scopus 로고
    • Where simplicity meets complexity: Hydra, a model for host-microbe interactions
    • Augustin R, Fraune S, Franzenburg S, Bosch TC. 2012. Where simplicity meets complexity: Hydra, a model for host-microbe interactions. Adv. Exp. Med. Biol. 710:71-81
    • (2012) Adv. Exp. Med. Biol , vol.710 , pp. 71-81
    • Augustin, R.1    Fraune, S.2    Franzenburg, S.3    Bosch, T.C.4
  • 7
    • 77954623743 scopus 로고    scopus 로고
    • Dual oxidase in mucosal immunity and host-microbe homeostasis
    • Bae YS, Choi MK, Lee WJ. 2010. Dual oxidase in mucosal immunity and host-microbe homeostasis. Trends Immunol. 31:278-87
    • (2010) Trends Immunol , vol.31 , pp. 278-287
    • Bae, Y.S.1    Choi, M.K.2    Lee, W.J.3
  • 8
    • 36749024487 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota
    • Bates JM, Akerlund J, Mittge E, Guillemin K. 2007. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell HostMicrobe 2:371-82
    • (2007) Cell Host Microbe , vol.2 , pp. 371-382
    • Bates, J.M.1    Akerlund, J.2    Mittge, E.3    Guillemin, K.4
  • 9
    • 77953270606 scopus 로고    scopus 로고
    • The role of Cdx genes in the gut and in axial development
    • Beck F, Stringer EJ. 2010. The role of Cdx genes in the gut and in axial development. Biochem. Soc. Trans. 38:353-57
    • (2010) Biochem. Soc. Trans , vol.38 , pp. 353-357
    • Beck, F.1    Stringer, E.J.2
  • 10
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler B, Rietschel ET. 2003. Innate immune sensing and its roots: The story of endotoxin. Nat. Rev. Immunol. 3:169-76
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 11
    • 33645770760 scopus 로고    scopus 로고
    • Downregulation of the Drosophila immune response by peptidoglycan- recognition proteins SC1 and SC2
    • Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, Royet J. 2006. Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog. 2:e14
    • (2006) PLoS Pathog , vol.2
    • Bischoff, V.1    Vignal, C.2    Duvic, B.3    Boneca, I.G.4    Hoffmann, J.A.5    Royet, J.6
  • 12
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • Biteau B, Hochmuth CE, Jasper H. 2008. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3:442-55
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 13
    • 84863860686 scopus 로고    scopus 로고
    • Understanding complex host-microbe interactions in hydra
    • Bosch TCG. 2012. Understanding complex host-microbe interactions in hydra. Gut Microbes 3:345-51
    • (2012) Gut Microbes , vol.3 , pp. 345-351
    • Tcg, B.1
  • 14
    • 84863870218 scopus 로고    scopus 로고
    • Gut-associated microbes of Drosophila melanogaster
    • Broderick NA, Lemaitre B. 2012. Gut-associated microbes of Drosophila melanogaster. Gut Microbes 3:307-21
    • (2012) Gut Microbes , vol.3 , pp. 307-321
    • Broderick, N.A.1    Lemaitre, B.2
  • 15
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. 2009a. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 23:2333-44
    • (2009) Genes Dev , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 16
    • 78650397479 scopus 로고    scopus 로고
    • Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
    • Buchon N, Broderick NA, Kuraishi T, Lemaitre B. 2010. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 8:152
    • (2010) BMC Biol , vol.8 , pp. 152
    • Buchon, N.1    Broderick, N.A.2    Kuraishi, T.3    Lemaitre, B.4
  • 17
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
    • Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. 2009b. Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation. Cell Host Microbe 5:200-11
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 18
    • 84855174006 scopus 로고    scopus 로고
    • Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
    • Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, et al. 2011. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol. 9:e1001212
    • (2011) PLoS Biol , vol.9
    • Caricilli, A.M.1    Picardi, P.K.2    De Abreu, L.L.3    Ueno, M.4    Prada, P.O.5
  • 19
    • 58949101489 scopus 로고    scopus 로고
    • Intestinal stem cells in mammals and Drosophila
    • Casali A, Batlle E. 2009. Intestinal stem cells in mammals and Drosophila. Cell Stem Cell 4:124-27
    • (2009) Cell Stem Cell , vol.4 , pp. 124-127
    • Casali, A.1    Batlle, E.2
  • 20
    • 80053435147 scopus 로고    scopus 로고
    • Bacterial communities of diverse Drosophila species: Ecological context of a host-microbe model system
    • Chandler JA, Lang JM, Bhatnagar S, Eisen JA, Kopp A. 2011. Bacterial communities of diverse Drosophila species: Ecological context of a host-microbe model system. PLoS Genet. 7:e1002272
    • (2011) PLoS Genet , vol.7
    • Chandler, J.A.1    Lang, J.M.2    Bhatnagar, S.3    Eisen, J.A.4    Kopp, A.5
  • 21
    • 84857063242 scopus 로고    scopus 로고
    • Gut-microbiota interactions in non-mammals: What can we learn from Drosophila?
    • Charroux B, Royet J. 2012. Gut-microbiota interactions in non-mammals:What can we learn from Drosophila? Semin. Immunol. 24:17-24
    • (2012) Semin. Immunol , vol.24 , pp. 17-24
    • Charroux, B.1    Royet, J.2
  • 22
    • 67650388208 scopus 로고    scopus 로고
    • Pathogenic stimulation of intestinal stem cell response in Drosophila
    • Chatterjee M, Ip YT. 2009. Pathogenic stimulation of intestinal stem cell response in Drosophila. J. Cell. Physiol. 220:664-71
    • (2009) J. Cell. Physiol , vol.220 , pp. 664-671
    • Chatterjee, M.1    Ip, Y.T.2
  • 23
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: An integrative view
    • Clemente JC, Ursell LK, Parfrey LW, Knight R. 2012. The impact of the gut microbiota on human health: An integrative view. Cell 148:1258-70
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 25
    • 78650538188 scopus 로고    scopus 로고
    • The role of CDX2 in intestinal homeostasis and inflammation
    • Coskun M, Troelsen JT, Nielsen OH. 2011. The role of CDX2 in intestinal homeostasis and inflammation. Biochim. Biophys. Acta 1812:283-89
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 283-289
    • Coskun, M.1    Troelsen, J.T.2    Nielsen, O.H.3
  • 26
    • 34147172817 scopus 로고    scopus 로고
    • Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis
    • Cox CR, Gilmore MS. 2007. Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infect. Immun. 75:1565-76
    • (2007) Infect. Immun , vol.75 , pp. 1565-1576
    • Cox, C.R.1    Gilmore, M.S.2
  • 27
    • 67650831470 scopus 로고    scopus 로고
    • Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection
    • Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, et al. 2009. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325:340-43
    • (2009) Science , vol.325 , pp. 340-343
    • Cronin, S.J.1    Nehme, N.T.2    Limmer, S.3    Liegeois, S.4    Pospisilik, J.A.5
  • 28
    • 84866423583 scopus 로고    scopus 로고
    • The human gut microbiome: Current knowledge, challenges, and future directions
    • Dave M, Higgins PD, Middha S, Rioux KP. 2012. The human gut microbiome: Current knowledge, challenges, and future directions. Transl. Res. 160:246-57
    • (2012) Transl. Res , vol.160 , pp. 246-257
    • Dave, M.1    Higgins, P.D.2    Middha, S.3    Rioux, K.P.4
  • 29
    • 0034725643 scopus 로고    scopus 로고
    • Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family
    • De Deken X, Wang D, Many M-C, Costagliola S, Libert F, et al. 2000. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J. Biol. Chem. 275:23227-33
    • (2000) J. Biol. Chem , vol.275 , pp. 23227-23233
    • De Deken, X.1    Wang, D.2    Many, M.-C.3    Costagliola, S.4    Libert, F.5
  • 30
    • 34447530305 scopus 로고    scopus 로고
    • A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    • Dietzl G, Chen D, Schnorrer F, Su K-C, Barinova Y, et al. 2007. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448:151-56
    • (2007) Nature , vol.448 , pp. 151-156
    • Dietzl, G.1    Chen, D.2    Schnorrer, F.3    Su, K.-C.4    Barinova, Y.5
  • 31
    • 83655165305 scopus 로고    scopus 로고
    • Is the regulation of insulin signaling multi-organismal?
    • Douglas AE. 2011. Is the regulation of insulin signaling multi-organismal? Sci. Signal. 4:pe46
    • (2011) Sci. Signal , vol.4
    • Douglas, A.E.1
  • 33
    • 49649116149 scopus 로고    scopus 로고
    • FlyBase: A database for the Drosophila research community
    • Drysdale R. 2008. FlyBase: A database for the Drosophila research community. Methods Mol. Biol. 420:45-59
    • (2008) Methods Mol. Biol , vol.420 , pp. 45-59
    • Drysdale, R.1
  • 34
    • 56549122798 scopus 로고    scopus 로고
    • Human colonic microbiota associated with diet, obesity and weight loss
    • Duncan SH, Lobley GE,Holtrop G, Ince J, Johnstone AM, et al. 2008. Human colonic microbiota associated with diet, obesity and weight loss. Int. J. Obes. 32:1720-24
    • (2008) Int. J. Obes , vol.32 , pp. 1720-1724
    • Duncan, S.H.1    Lobley, G.E.2    Holtrop, G.3    Ince, J.4    Johnstone, A.M.5
  • 35
    • 0033601327 scopus 로고    scopus 로고
    • Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs
    • Dupuy C, Ohayon R, Valent A, Noel-Hudson M-S,DémeD, Virion A. 1999. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs. J. Biol. Chem. 274:37265-69
    • (1999) J. Biol. Chem , vol.274 , pp. 37265-37269
    • Dupuy, C.1    Ohayon, R.2    Valent, A.3    M-Sdémed, N.4    Virion, A.5
  • 37
    • 84870322666 scopus 로고    scopus 로고
    • Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease
    • Erickson AR, Cantarel BL, Lamendella R, Darzi Y, Mongodin EF, et al. 2012. Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease. PLoS ONE 7:e49138
    • (2012) PLoS ONE , vol.7
    • Erickson, A.R.1    Cantarel, B.L.2    Lamendella, R.3    Darzi, Y.4    Mongodin, E.F.5
  • 38
    • 44949101395 scopus 로고    scopus 로고
    • Cytokines: From gut inflammation to colorectal cancer
    • Fantini MC, Pallone F. 2008. Cytokines: from gut inflammation to colorectal cancer. Curr. Drug Targets 9:375-80
    • (2008) Curr. Drug Targets , vol.9 , pp. 375-380
    • Fantini, M.C.1    Pallone, F.2
  • 39
    • 35549006674 scopus 로고    scopus 로고
    • The Drosophila systemic immune response: Sensing and signalling during bacterial and fungal infections
    • Ferrandon D, Imler JL,Hetru C, Hoffmann JA. 2007. The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nat. Rev. Immunol. 7:862-74
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 862-874
    • Ferrandon, D.1    Imler Jlhetru, C.2    Hoffmann, J.A.3
  • 40
    • 69949103673 scopus 로고    scopus 로고
    • Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota
    • Fraune S, Abe Y, Bosch TCG. 2009. Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ. Microbiol. 11:2361-69
    • (2009) Environ. Microbiol , vol.11 , pp. 2361-2369
    • Fraune, S.1    Abe, Y.2    Tcg, B.3
  • 41
    • 34548779029 scopus 로고    scopus 로고
    • Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra
    • Fraune S, Bosch TC. 2007. Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc. Natl. Acad. Sci. USA 104:13146-51
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 13146-13151
    • Fraune, S.1    Bosch, T.C.2
  • 44
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • Garrett WS, Gallini CA, Yatsunenko T, MichaudM, DuBois A, et al. 2010. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 8:292-300
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1    Gallini, C.A.2    Yatsunenko, T.3    Michaudm Dubois, A.4
  • 45
    • 0042203535 scopus 로고    scopus 로고
    • Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense
    • Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. 2003. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 17:1502-4
    • (2003) FASEB J , vol.17 , pp. 1502-1504
    • Geiszt, M.1    Witta, J.2    Baffi, J.3    Lekstrom, K.4    Leto, T.L.5
  • 48
    • 33846055395 scopus 로고    scopus 로고
    • Metabolomics of a superorganism
    • Goodacre R. 2007. Metabolomics of a superorganism. J. Nutr. 137:259S-66S.
    • (2007) J. Nutr , vol.137
    • Goodacre, R.1
  • 49
    • 84861982483 scopus 로고    scopus 로고
    • Honor thy gut symbionts redux
    • Gordon JI. 2012. Honor thy gut symbionts redux. Science 336:1251-53
    • (2012) Science , vol.336 , pp. 1251-1253
    • Gordon, J.I.1
  • 50
    • 16244388032 scopus 로고    scopus 로고
    • The role of Cdx proteins in intestinal development and cancer
    • Guo RJ, Suh ER, Lynch JP. 2004. The role of Cdx proteins in intestinal development and cancer. Cancer Biol. Ther. 3:593-601
    • (2004) Cancer Biol. Ther , vol.3 , pp. 593-601
    • Guo, R.J.1    Suh, E.R.2    Lynch, J.P.3
  • 51
    • 61749104447 scopus 로고    scopus 로고
    • Regulation ofDUOXby theGaq-phospholipase C?-Ca2+ pathway in Drosophila gut immunity
    • HaE-M, LeeK-A,Park SH,KimS-H,NamH-J, et al. 2009a.Regulation ofDUOXby theGaq-phospholipase C?-Ca2+ pathway in Drosophila gut immunity. Dev. Cell 16:386-97
    • (2009) Dev. Cell , vol.16 , pp. 386-397
    • Ha, E.-M.1    Lee, K.-A.2    Park, S.H.3    Kim, S.-H.4    Nam, H.-J.5
  • 52
    • 69049088645 scopus 로고    scopus 로고
    • Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in Drosophila gut
    • Ha E-M, Lee K-A, Seo YY, Kim S-H, Lim JH, et al. 2009b. Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in Drosophila gut. Nat. Immunol. 10:949-57
    • (2009) Nat. Immunol , vol.10 , pp. 949-957
    • Ha, E.-M.1    Lee, K.-A.2    Seo, Y.Y.3    Kim, S.-H.4    Lim, J.H.5
  • 53
    • 27644498442 scopus 로고    scopus 로고
    • A direct role for dual oxidase in Drosophila gut immunity
    • Ha EM, Oh CT, Bae YS, Lee WJ. 2005. A direct role for dual oxidase in Drosophila gut immunity. Science 310:847-50
    • (2005) Science , vol.310 , pp. 847-850
    • Ha, E.M.1    Oh, C.T.2    Bae, Y.S.3    Lee, W.J.4
  • 54
    • 84871588520 scopus 로고    scopus 로고
    • Systems-level characterization of a host-microbe metabolic symbiosis in the mammalian gut
    • Heinken A, Sahoo S, Fleming RM, Thiele I. 2013. Systems-level characterization of a host-microbe metabolic symbiosis in the mammalian gut. Gut Microbes 4:28-40
    • (2013) Gut Microbes , vol.4 , pp. 28-40
    • Heinken, A.1    Sahoo, S.2    Fleming, R.M.3    Thiele, I.4
  • 55
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C, Hao L, MehalWZ, et al. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482:179-85
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3    Hao, L.4    Mehal, W.Z.5
  • 56
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation byKeap1 andNrf2 controls intestinal stem cell proliferation in Drosophila
    • Hochmuth CE, Biteau B, Bohmann D, Jasper H. 2011. Redox regulation byKeap1 andNrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 8:188-99
    • (2011) Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 57
    • 0032054355 scopus 로고    scopus 로고
    • Host-microbial symbiosis in the mammalian intestine: Exploring an internal ecosystem
    • HooperLV, BryL, Falk PG,Gordon JI. 1998. Host-microbial symbiosis in the mammalian intestine: Exploring an internal ecosystem. BioEssays 20:336-43
    • (1998) BioEssays , vol.20 , pp. 336-343
    • Hooper, L.V.1    Bry, L.2    Falk, P.G.3    Gordon, J.I.4
  • 58
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between themicrobiota and the immune system
    • Hooper LV, Littman DR,Macpherson AJ. 2012. Interactions between themicrobiota and the immune system. Science 336:1268-73
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 60
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    • Jiang H, Edgar BA. 2009. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136:483-93
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 61
    • 84865584204 scopus 로고    scopus 로고
    • Intestinal stem cell function in Drosophila andmice
    • JiangH, EdgarBA. 2012. Intestinal stem cell function in Drosophila andmice. Curr. Opin.Genet.Dev. 22:354-60
    • (2012) Curr. Opin.Genet.Dev , vol.22 , pp. 354-360
    • Jiang, H.1    Edgar, B.A.2
  • 62
    • 78650977190 scopus 로고    scopus 로고
    • EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
    • Jiang H, Grenley MO, Bravo M-J, Blumhagen RZ, Edgar BA. 2011. EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8:84-95
    • (2011) Cell Stem Cell , vol.8 , pp. 84-95
    • Jiang, H.1    Grenley, M.O.2    Bravo, M.-J.3    Blumhagen, R.Z.4    Edgar, B.A.5
  • 63
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. 2009. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137:1343-55
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5    Edgar, B.A.6
  • 64
    • 77249101479 scopus 로고    scopus 로고
    • Host-microbe interactions in the developing zebrafish
    • Kanther M, Rawls JF. 2010. Host-microbe interactions in the developing zebrafish. Curr. Opin. Immunol. 22:10-19
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 10-19
    • Kanther, M.1    Rawls, J.F.2
  • 65
    • 84870700189 scopus 로고    scopus 로고
    • Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage
    • Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H. 2012. Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet. 8:e1003045
    • (2012) PLoS Genet , vol.8
    • Kapuria, S.1    Karpac, J.2    Biteau, B.3    Hwangbo, D.4    Jasper, H.5
  • 67
    • 70349617474 scopus 로고    scopus 로고
    • Bacterial-modulated host immunity and stem cell activation for gut homeostasis
    • Lee WJ. 2009. Bacterial-modulated host immunity and stem cell activation for gut homeostasis. Genes Dev. 23:2260-65
    • (2009) Genes Dev , vol.23 , pp. 2260-2265
    • Lee, W.J.1
  • 68
    • 84877723813 scopus 로고    scopus 로고
    • Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila
    • Lee KA, Kim SH, Kim EK, Ha EM, You H, et al. 2013. Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila. Cell 153:797-811
    • (2013) Cell , vol.153 , pp. 797-811
    • Lee, K.A.1    Kim, S.H.2    Kim, E.K.3    Ha, E.M.4    You, H.5
  • 69
    • 3142691844 scopus 로고    scopus 로고
    • The road to Toll
    • Lemaitre B. 2004. The road to Toll. Nat. Rev. Immunol. 4:521-27
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 521-527
    • Lemaitre, B.1
  • 70
    • 34047268684 scopus 로고    scopus 로고
    • The host defense of Drosophila melanogaster
    • Lemaitre B, Hoffmann J. 2007. The host defense of Drosophila melanogaster. Annu. Rev. Immunol. 25:697-743
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 697-743
    • Lemaitre, B.1    Hoffmann, J.2
  • 71
    • 0038664357 scopus 로고    scopus 로고
    • The Drosophila immune system detects bacteria through specific peptidoglycan recognition
    • Leulier F, Parquet C, Pili-Floury S, Ryu JH, Caroff M, et al. 2003. The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat. Immunol. 4:478-84
    • (2003) Nat. Immunol. , vol.4 , pp. 478-484
    • Leulier, F.1    Parquet, C.2    Pili-Floury, S.3    Ryu, J.H.4    Caroff, M.5
  • 72
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. 2006. Microbial ecology: Human gut microbes associated with obesity. Nature 444:1022-23
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 73
    • 54549104587 scopus 로고    scopus 로고
    • Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
    • Lin G, Xu N, Xi R. 2008. Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455:1119-23
    • (2008) Nature , vol.455 , pp. 1119-1123
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 74
    • 43049157518 scopus 로고    scopus 로고
    • The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation
    • Maillet F, Bischoff V, Vignal C,Hoffmann J, Royet J. 2008. The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. Cell Host Microbe 3:293-303
    • (2008) Cell Host Microbe , vol.3 , pp. 293-303
    • Maillet, F.1    Bischoff, V.2    Vignal, C.3    Hoffmann, J.4    Royet, J.5
  • 75
    • 84872535919 scopus 로고    scopus 로고
    • Xenobiotics shape the physiology and gene expression of the active human gut microbiome
    • Maurice CF, Haiser HJ, Turnbaugh PJ. 2013. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152:39-50
    • (2013) Cell , vol.152 , pp. 39-50
    • Maurice, C.F.1    Haiser, H.J.2    Turnbaugh, P.J.3
  • 76
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • Maynard CL, Elson CO, Hatton RD, Weaver CT. 2012. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489:231-41
    • (2012) Nature , vol.489 , pp. 231-241
    • Maynard, C.L.1    Elson, C.O.2    Hatton, R.D.3    Weaver, C.T.4
  • 77
    • 58149168627 scopus 로고    scopus 로고
    • Host-microbe symbiosis: The squid-Vibrio association- A naturally occurring, experimental model of animal/bacterial partnerships
    • McFall-Ngai M. 2008. Host-microbe symbiosis: The squid-Vibrio association-a naturally occurring, experimental model of animal/bacterial partnerships. Adv. Exp. Med. Biol. 635:102-12
    • (2008) Adv. Exp. Med. Biol , vol.635 , pp. 102-112
    • McFall-Ngai, M.1
  • 78
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov R, Janeway CA Jr. 1997. Innate immunity: The virtues of a nonclonal system of recognition. Cell 91:295-98
    • (1997) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 80
    • 79952733029 scopus 로고
    • Les microbes intestinaux
    • 265-82
    • Metchnikoff E. 1903. Les microbes intestinaux. Bull. Inst. Pasteur 1:217-28; 265-82
    • (1903) Bull. Inst. Pasteur , vol.1 , pp. 217-228
    • Metchnikoff, E.1
  • 81
    • 0001522914 scopus 로고
    • Etudes sur la flore intestinale. 1er mémoire: Putréfaction intestinale
    • Metchnikoff E. 1908a. Etudes sur la flore intestinale. 1er mémoire: Putréfaction intestinale. Ann. Inst. Pasteur 22:929-55
    • (1908) Ann. Inst. Pasteur , vol.22 , pp. 929-955
    • Metchnikoff, E.1
  • 82
    • 84885767089 scopus 로고
    • Sur les microbes de la putréfaction intestinale
    • Metchnikoff E. 1908b. Sur les microbes de la putréfaction intestinale. C. R. Acad. Sci. Paris 147:579-81
    • (1908) C. R. Acad. Sci. Paris , vol.147 , pp. 579-581
    • Metchnikoff, E.1
  • 84
    • 0006566494 scopus 로고
    • Etudes sur la flore intestinale. 2e mémoire: Poisons intestinaux et scléroses
    • Metchnikoff E. 1910. Etudes sur la flore intestinale. 2e mémoire: Poisons intestinaux et scléroses. Ann. Inst. Pasteur 24:755-70
    • (1910) Ann. Inst. Pasteur , vol.24 , pp. 755-770
    • Metchnikoff, E.1
  • 85
    • 84885736505 scopus 로고
    • Les microbes lactiques et leur utilité pour la santé
    • Metchnikoff E. 1911. Les microbes lactiques et leur utilité pour la santé. La Revue 1911:145-60
    • (1911) La Revue , vol.1911 , pp. 145-160
    • Metchnikoff, E.1
  • 87
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli CA, Perrimon N. 2006. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439:475-79
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 88
    • 0019484394 scopus 로고
    • Co-evolution of luminous bacteria and their eukaryotic hosts
    • Nealson K, Cohn D, LeismanG, Tebo B. 1981. Co-evolution of luminous bacteria and their eukaryotic hosts. Ann. N.Y. Acad. Sci. 361:76-91
    • (1981) Ann. N.Y. Acad. Sci , vol.361 , pp. 76-91
    • Nealson, K.1    Cohn, D.2    Leismang Tebo, B.3
  • 91
    • 4344568725 scopus 로고    scopus 로고
    • The winnowing: Establishing the squid-Vibrio symbiosis
    • Nyholm SV, McFall-Ngai MJ. 2004. The winnowing: Establishing the squid-Vibrio symbiosis. Nat. Rev. Microbiol. 2:632-42
    • (2004) Nat. Rev. Microbiol , vol.2 , pp. 632-642
    • Nyholm, S.V.1    McFall-Ngai, M.J.2
  • 92
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein B, Spradling A. 2006. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439:470-74
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 93
    • 33847168133 scopus 로고    scopus 로고
    • Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    • Ohlstein B, Spradling A. 2007. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 315:988-92
    • (2007) Science , vol.315 , pp. 988-992
    • Ohlstein, B.1    Spradling, A.2
  • 94
    • 82055177179 scopus 로고    scopus 로고
    • Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection
    • Paredes JC, Welchman DP, Poidevin M, Lemaitre B. 2011. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Immunity 35:770-79
    • (2011) Immunity , vol.35 , pp. 770-779
    • Paredes, J.C.1    Welchman, D.P.2    Poidevin, M.3    Lemaitre, B.4
  • 96
    • 0142051132 scopus 로고
    • Note Logothetis D.E. Pasteur-La théorie des germes et ses applications ̀a la médecine et ̀a la chirurgie (en commun avec MM. Joubert et Chamberland)
    • Pasteur L. 1878. Note Logothetis D.E. Pasteur-La théorie des germes et ses applications ̀a la médecine et ̀a la chirurgie (en commun avec MM. Joubert et Chamberland). C. R. Acad. Sci. Paris 86:1037-1043
    • (1878) C. R. Acad. Sci. Paris , vol.86 , pp. 1037-1043
    • Pasteur, L.1
  • 97
    • 0344657241 scopus 로고
    • Observations relatives ̀a la note précédente de M
    • Pasteur L. 1885. Observations relatives ̀a la note précédente de M. Duclaux. C. R. Acad. Sci. Paris 100:68
    • (1885) Duclaux. C. R. Acad. Sci. Paris , vol.100 , pp. 68
    • Pasteur, L.1
  • 98
    • 44649129135 scopus 로고    scopus 로고
    • Commensals, bacterial pathogens and intestinal inflammation: An intriguing ménage ̀a trois
    • Pedron T, Sansonetti P. 2008. Commensals, bacterial pathogens and intestinal inflammation: An intriguing ménage ̀a trois. Cell Host Microbe 3:344-47
    • (2008) Cell Host Microbe , vol.3 , pp. 344-347
    • Pedron, T.1    Sansonetti, P.2
  • 99
    • 0032544098 scopus 로고    scopus 로고
    • New advances in Drosophila provide opportunities to study gene functions
    • PerrimonN. 1998. New advances in Drosophila provide opportunities to study gene functions. Proc. Natl. Acad. Sci. USA 95:9716-17
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9716-9717
    • Perrimon, N.1
  • 101
    • 84863463129 scopus 로고    scopus 로고
    • Modulation of symbiont lipid A signaling by host alkaline phosphatases in the squid-vibrio symbiosis
    • Rader BA, Kremer N, Apicella MA, Goldman WE, McFall-Ngai MJ. 2012. Modulation of symbiont lipid A signaling by host alkaline phosphatases in the squid-vibrio symbiosis. mBio 3:e00093-12
    • (2012) MBio , vol.3
    • Rader, B.A.1    Kremer, N.2    Apicella, M.A.3    Goldman, W.E.4    McFall-Ngai, M.J.5
  • 102
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. 2004. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118:229-41
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 103
    • 34547440528 scopus 로고    scopus 로고
    • Increased internal and external bacterial load during Drosophila aging without life-span trade-off
    • Ren C,Webster P, Finkel SE, Tower J. 2007. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 6:144-52
    • (2007) Cell Metab , vol.6 , pp. 144-152
    • Ren, C.1    Webster, P.2    Finkel, S.E.3    Tower, J.4
  • 107
    • 85027958029 scopus 로고    scopus 로고
    • Peptidoglycan recognition proteins: Modulators of the microbiome and inflammation
    • Royet J, Gupta D, Dziarski R. 2011. Peptidoglycan recognition proteins: Modulators of the microbiome and inflammation. Nat. Rev. Immunol. 11:837-51
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 837-851
    • Royet, J.1    Gupta, D.2    Dziarski, R.3
  • 108
    • 74849098506 scopus 로고    scopus 로고
    • Innate immunity and gut-microbe mutualism in Drosophila
    • Ryu JH, Ha EM, Lee WJ. 2010. Innate immunity and gut-microbe mutualism in Drosophila. Dev. Comp. Immunol. 34:369-76
    • (2010) Dev. Comp. Immunol , vol.34 , pp. 369-376
    • Ryu, J.H.1    Ha, E.M.2    Lee, W.J.3
  • 109
    • 38949153861 scopus 로고    scopus 로고
    • Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    • Ryu JH, Kim SH, Lee HY, Bai JY, Nam YD, et al. 2008. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science 319:777-82
    • (2008) Science , vol.319 , pp. 777-782
    • Ryu, J.H.1    Kim, S.H.2    Lee, H.Y.3    Bai, J.Y.4    Nam, Y.D.5
  • 110
    • 55949091259 scopus 로고    scopus 로고
    • Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
    • Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, et al. 2008. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc. Natl. Acad. Sci. USA 105:16767-72
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16767-16772
    • Samuel, B.S.1    Shaito, A.2    Motoike, T.3    Rey, F.E.4    Backhed, F.5
  • 111
    • 10244226689 scopus 로고    scopus 로고
    • War and peace at mucosal surfaces
    • Sansonetti PJ. 2004. War and peace at mucosal surfaces. Nat. Rev. Immunol. 4:953-64
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 953-964
    • Sansonetti, P.J.1
  • 112
    • 73949137604 scopus 로고    scopus 로고
    • Microbiota and SCFA in lean and overweight healthy subjects
    • Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, et al. 2010. Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18:190-95
    • (2010) Obesity , vol.18 , pp. 190-195
    • Schwiertz, A.1    Taras, D.2    Schafer, K.3    Beijer, S.4    Bos, N.A.5
  • 113
    • 84860290552 scopus 로고    scopus 로고
    • Intestinal microbiOMICS to define health and disease in human and mice
    • Serino M, Chabo C, Burcelin R. 2012. Intestinal microbiOMICS to define health and disease in human and mice. Curr. Pharm. Biotechnol. 13:746-58
    • (2012) Curr. Pharm. Biotechnol , vol.13 , pp. 746-758
    • Serino, M.1    Chabo, C.2    Burcelin, R.3
  • 115
    • 80051750115 scopus 로고    scopus 로고
    • Symbiotic bacteria are responsible for dietinduced mating preference in Drosophila melanogaster, providing support for the hologenome concept of evolution
    • Sharon G, Segal D, Zilber-Rosenberg I, Rosenberg E. 2011. Symbiotic bacteria are responsible for dietinduced mating preference in Drosophila melanogaster, providing support for the hologenome concept of evolution. Gut Microbes 2:190-92
    • (2011) Gut Microbes , vol.2 , pp. 190-192
    • Sharon, G.1    Segal, D.2    Zilber-Rosenberg, I.3    Rosenberg, E.4
  • 116
    • 80555143077 scopus 로고    scopus 로고
    • Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling
    • Shin SC, Kim SH, You H, Kim B, Kim AC, et al. 2011. Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. Science 334:670-74
    • (2011) Science , vol.334 , pp. 670-674
    • Shin, S.C.1    Kim, S.H.2    You, H.3    Kim, B.4    Kim, A.C.5
  • 117
    • 0029144417 scopus 로고
    • Intestinal epithelial cell differentiation: New insights from mice, flies and nematodes
    • Simon TC, Gordon JI. 1995. Intestinal epithelial cell differentiation: New insights from mice, flies and nematodes. Curr. Opin. Genet. Dev. 5:577-86
    • (1995) Curr. Opin. Genet. Dev , vol.5 , pp. 577-586
    • Simon, T.C.1    Gordon, J.I.2
  • 118
    • 78649303577 scopus 로고    scopus 로고
    • Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia
    • Stairs DB, Kong J, Lynch JP. 2010. Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia. Prog. Mol. Biol. Transl. Sci. 96:231-70
    • (2010) Prog. Mol. Biol. Transl. Sci , vol.96 , pp. 231-270
    • Stairs, D.B.1    Kong, J.2    Lynch, J.P.3
  • 119
    • 80052774197 scopus 로고    scopus 로고
    • Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing
    • Storelli G, Defaye A, Erkosar B, Hols P, Royet J, Leulier F. 2011. Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. Cell Metab. 14:403-14
    • (2011) Cell Metab , vol.14 , pp. 403-414
    • Storelli, G.1    Defaye, A.2    Erkosar, B.3    Hols, P.4    Royet, J.5    Leulier, F.6
  • 120
    • 37549007255 scopus 로고    scopus 로고
    • Microbiology. Detoxifying enzyme helps animals stomach bacteria
    • Strauss E. 2007. Microbiology. Detoxifying enzyme helps animals stomach bacteria. Science 318:1853-54
    • (2007) Science , vol.318 , pp. 1853-1854
    • Strauss, E.1
  • 121
    • 80052700951 scopus 로고    scopus 로고
    • Lactobacillus plantarum gives Drosophila the grow signal
    • Tower J. 2011. Lactobacillus plantarum gives Drosophila the grow signal. Cell Metab. 14:283-84
    • (2011) Cell Metab , vol.14 , pp. 283-284
    • Tower, J.1
  • 122
    • 0029919065 scopus 로고    scopus 로고
    • Intestine-specific gene transcription
    • Traber PG, Silberg DG. 1996. Intestine-specific gene transcription. Annu. Rev. Physiol. 58:275-97
    • (1996) Annu. Rev. Physiol , vol.58 , pp. 275-297
    • Traber, P.G.1    Silberg, D.G.2
  • 123
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Backhed F. 2012. Functional interactions between the gut microbiota and host metabolism. Nature 489:242-49
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 124
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked tomarked but reversible alterations in the mouse distal gut microbiome
    • Turnbaugh PJ, Backhed F, Fulton L,Gordon JI. 2008. Diet-induced obesity is linked tomarked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3:213-23
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 127
    • 0033638404 scopus 로고    scopus 로고
    • Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
    • Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, et al. 2000. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13:737-48
    • (2000) Immunity , vol.13 , pp. 737-748
    • Tzou, P.1    Ohresser, S.2    Ferrandon, D.3    Capovilla, M.4    Reichhart, J.M.5
  • 130
    • 79953733693 scopus 로고    scopus 로고
    • Gut florametabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z, Klipfell E, Bennett BJ,Koeth R, Levison BS, et al. 2011. Gut florametabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472:57-63
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3    Koeth, R.4    Levison, B.S.5
  • 131
    • 79959841282 scopus 로고    scopus 로고
    • Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster
    • Wong CN, Ng P, Douglas AE. 2011. Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster. Environ. Microbiol. 13:1889-900
    • (2011) Environ. Microbiol , vol.13 , pp. 1889-1900
    • Wong, C.N.1    Ng, P.2    Douglas, A.E.3
  • 132
    • 79955521176 scopus 로고    scopus 로고
    • EGFR,Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
    • Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R. 2011. EGFR,Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol. 354:31-43
    • (2011) Dev. Biol , vol.354 , pp. 31-43
    • Xu, N.1    Wang, S.Q.2    Tan, D.3    Gao, Y.4    Lin, G.5    Xi, R.6
  • 133
    • 77952890162 scopus 로고    scopus 로고
    • Alcohol dehydrogenase of acetic acid bacteria: Structure, mode of action, and applications in biotechnology
    • Yakushi T,Matsushita K. 2010. Alcohol dehydrogenase of acetic acid bacteria: structure, mode of action, and applications in biotechnology. Appl. Microbiol. Biotechnol. 86:1257-65
    • (2010) Appl. Microbiol. Biotechnol , vol.86 , pp. 1257-1265
    • Yakushi, T.1    Matsushita, K.2
  • 135
    • 49649111434 scopus 로고    scopus 로고
    • Role of microorganisms in the evolution of animals and plants: The hologenome theory of evolution
    • Zilber-Rosenberg I, Rosenberg E. 2008. Role of microorganisms in the evolution of animals and plants: The hologenome theory of evolution. FEMS Microbiol. Rev. 32:723-35
    • (2008) FEMS Microbiol. Rev , vol.32 , pp. 723-735
    • Zilber-Rosenberg, I.1    Rosenberg, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.