Valproic Acid Treatment Inhibits Hypoxia-Inducible Factor 1α Accumulation and Protects against Burn-Induced Gut Barrier Dysfunction in a Rodent Model

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Luo, Hong Min ^a   Du, Ming Hua ^a   Lin, Zhi Long ^a   Zhang, Lin ^a   Ma, Li ^a   Wang, Huan ^a   Yu, Wen ^a   Lv, Yi ^a   Lu, Jiang Yang ^a   Pi, Yu Li ^a   Hu, Sen ^a   Sheng, Zhi Yong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; HISTONE; HYPOXIA INDUCIBLE FACTOR 1; MYOSIN LIGHT CHAIN KINASE; PROTEIN ZO1; SMALL INTERFERING RNA; VALPROIC ACID; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE SILENCING; HIF 1ALPHA GENE; HISTONE ACETYLATION; HISTOPATHOLOGY; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; INTESTINE PROTECTION; MALE; MLCK GENE; NONHUMAN; PROPHYLAXIS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; TRANSCRIPTION TERMINATION; VEGF GENE;

ACETYLATION; ANIMALS; BURNS; CACO-2 CELLS; DISEASE MODELS, ANIMAL; GASTROENTERITIS; HISTONES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTESTINAL MUCOSA; MALE; MYOSIN-LIGHT-CHAIN KINASE; PERMEABILITY; PROTECTIVE AGENTS; RATS; VALPROIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84885713154     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077523     Document Type: Article

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