Burns, bacterial translocation, gut barrier function, and failure

Journal of Burn Care and Rehabilitation

Volumn 26, Issue 5, 2005, Pages 383-391

  Magnotti, Louis J ^a   Deitch, Edwin A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TRANSLOCATION; BURN; HUMAN; INFLAMMATION; INTESTINE; INTESTINE FUNCTION; MULTIPLE ORGAN FAILURE; NUTRITION; ORGAN INJURY; REVIEW;

BACTERIAL TRANSLOCATION; BURNS; ENTERAL NUTRITION; GASTROINTESTINAL TRACT; HUMANS; INFLAMMATION; ISCHEMIA; MULTIPLE ORGAN FAILURE; NUTRITIONAL STATUS; SEPSIS;

EID: 26444515925     PISSN: 02738481     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.bcr.0000176878.79267.e8     Document Type: Review

References (54)

1. Deitch EA. Multiple organ failure: pathophysiology and potential future therapies. Ann Surg 1992;216:117-34.
2. Deitch EA, Xu DZ, Franko L, et al. Evidence favoring the role of the gut as a cytokine generating organ in rats subjected to hemorrhagic shock. Shock 1994;1:141-6.
3. Deitch EA. Role of the gut lymphatic system in multiple organ failure. Current Opin Crit Care 2001;7:92-8.
4. Woodruff PW, O'Carroll DE, Koizumi S, et al. Role of the intestinal flora in major trauma. J Inf Dis 1973;128(S):S290-4.
5. Deitch EA, Berg RD. Bacterial translocation from the gut: a mechanism of infection. J Burn Care Rehab 1987;8:475-82.
6. Deitch EA. Bacterial translocation of the gut flora. J Trauma 1990;30:S184-9.
7. van Der Waaij D, Berghuis-de Vries JM, Lekkerkerk-van der Wees JEC. Colonization resistance of the digestive tract and the spread of bacteria to the lymphatic organs in mice. J Hyg Camb 1972;70:335-42.
8. Berg RD, Garlington AW. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979;23:403-11.
9. Deitch EA, Maejima K, Berg RD. Effect of oral antibiotics and bacterial overgrowth on the translocation of the GI-tract microflora in burned rats. J Trauma 1985;25:385-92.
10. Deitch EA, Berg RD. Endotoxin but not malnutrition promotes bacterial translocation of the gut flora in burned mice. J Trauma 1987;27:161-6.
11. Li M, Specian RD, Berg RD, Deitch EA. Effects of protein malnutrition and endotoxin on the intestinal mucosal barrier to the translocation of indigenous flora in mice. J Parenter Enteral Nutr 1989;13:572-8.
12. Maddaus MA, Wells CL, Platt JL, et al. Effect of T cell modulation on the translocation of bacteria from the gut and mesenteric lymph node. Ann Surg 1988;207:387-98.
13. Maejima K, Deitch EA, Berg RD. Bacterial translocation from the gastrointestinal tracts of rats receiving thermal injury. Infect Immun 1984;43:6-10.
14. Maejima K, Deitch EA, Berg RD. Promotion by burn stress of the translocation of bacteria from the gastrointestinal tracts of mice. Arch Surg 1984;119:166-72.
15. Baker JW, Deitch EA, Li M, Berg RD, Specian RD. Hemorrhagic shock induces bacterial translocation from the gut. J Trauma 1988;28:896-906.
16. Deitch EA, Taylor M, Grisham M, Ma L, Bridges W, Berg R. Endotoxin induces bacterial translocation and increases xanthine oxidase activity. J Trauma 1989;29:1679-83.
17. Sorrells DL, Friend C, Koltuksuz U, et al. Inhibition of nitric oxide with aminoguanidine reduces bacterial translocation after endotoxin challenge in vivo. Arch Surg 1996;131:1155-63.
18. Mishima S, Xu DZ, Lu Q, et al. Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth. Arch Surg 1997;132:1190-5.
19. Salzman AL. Nitric oxide in the gut. New Horiz 1995;3:33-45.
20. McDonald WS, Sharp Jr., CW Deitch EA. Immediate enteral feeding in burn patients is safe and effective. Ann Surg 1991;213:177-83.
21. Coffey Jr., JA, Milhoan RA, Abdula A, et al. Bombesin inhibits bacterial translocation from the gut in burned rats. Surg Forum 1988;39:109-10.
22. Deitch EA. Nutrition and the gut mucosal barrier. Curr Opin Gen Surg 1993;85-91.
23. Saito H, Trocki O, Alexander JW, et al. The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion and gut mucosal integrity after burn injury. JPEN 1987;11:1-7.
24. Kudsk KA, Stone JM, Carpenter G, et al. Enteral and parenteral feeding influences mortality after hemoglobin E coli peritonitis. J Trauma 1983;23:605-9.
25. Alexander JW, MacMillan BG, Stinnett JD, et al. Beneficial effects of aggressive protein feeding in severely burned children. Ann Surg 1980;192:505-17.
26. Kudsk KA, Croce MA, Fabian TC, et al. Enteral versus parenteral feeding: effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 1992;215:503-13.
27. Sugiura T, Tashiro T, Yamamori H, Takagi K, Hayashi N, Itahashi T, et al. Effects of total parenteral nutrition on endotoxin translocation and extent of the stress response in burned rats. Nutrition 1999;15:570-575
28. Herndon DN, Barrow RE, Stein M, et al. Increased mortality with intravenous supplemental feeding in severely burned patients. J Burn Care Rehabil 1989;10:309-13.
29. Gottschlich MM, Jenkins ME, Mayes T, Khoury J, Kagan RJ, Warden GD. The 2002 Clinical Research Award. An evaluation of the safety of early vs delayed enteral support and effects on clinical, nutritional and endocrine outcomes after burns. J Burn Care Rehabil 2002;23:401-15.
30. Andel H, Rab M, Andel D, et al. Impact of early high caloric duodenal feeding on the oxygen balance of the splanchnic region after severe burn injury. Burns 2001;27:389-93.
31. Morris SE, Navaratnam N, Herndon DN. A comparison of effects of thermal injury and smoke inhalation on bacterial translocation. J Trauma 1990;30:639-45.
32. Tokyay R, Loick HM, Traber DL, et al. Effects of thromboxane synthetase inhibition on post-burn mesenteric vascular resistance in the rate of bacterial translocation in a chronic porcine model. Surg Gynecol Obstet 1992;174:125-32.
33. Deitch EA. Intestinal permeability is increased in burn patients shortly after injury. Surgery 1990;107:411-6.
34. Ziegler TR, Smith RJ, Mitchell CJ, et al. Increased intestinal permeability associated with infection in burn patients. Arch Surg 1988;123:1313-9.
35. Ryan CM, Yarmush ML, Burke JF, et al. Increased gut permeability early after burns correlates with the extent of burn injury. Crit Care Med 1992;20:1508-12.
36. LeVoyer T, Cioffi WG, Pratt L, et al. Alterations in intestinal permeability after severe thermal injury. Arch Surg 1992;127:26-9.
37. Deitch EA. Simple intestinal obstruction causes bacterial translocation in man. Arch Surg 1989;124:699-701.
38. Ambrose NS, Johnson M, Burdon DW, et al. Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. Br J Surg 1984;71:624-5.
39. MacFie J, O'Boyle C, Mitchell CJ, et al. Gut origin sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora and septic morbidity. Gut 1999;45:223-8.
40. Desai MH, Herndon DN, Rutan RL, Abston S, Linares HA. Ischemic intestinal complications in patients with burns. Surg Gynecol Obstet 1991;172:257-61.
41. Moore FA, Moore EE, Poggetti R, et al. Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma 1991;31:629-38.
42. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 1990;125:403-4.
43. Deitch EA, Forsythe R, Anjaria D, et al. The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock. Shock 2004;22:221-8.
44. Magnotti LJ, Upperman JS, Xu DZ, et al. Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 1998;228:518-27.
45. Magnotti LJ, Xu DZ, Lu Q, et al. Gut-derived mesenteric lymph: a link between burn and lung injury. Arch Surg 1999;143:1333-11.
46. Anjaria DJ, Rameshwar P, Deitch EA, et al. Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph. Crit Care Med 2001;29:1780-5.
47. Sambol JT, White J, Horton JW, Deitch EA. Burn-induced impairment of cardiac contractile function is due to gut-derived factors transported in mesenteric lymph. Shock 2002;18:272-6.
48. Deitch EA, Shi HP, Lu Q, Feketeova E, Skurnick J, Xu da Z. Mesenteric lymph from burned rats induces endothelial cell injury and activates neutrophils. Crit Care Med 2004;32:533-8.
49. Adams JM, Hauser CJ, Adams CA, Xu Dz, Livingston DH, Deitch EA. Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. Crit Care Med 2001;29:2194-8.
50. Zaets SB, Berezina TL, Caruso J, Xu da Z, Deitch EA, Machiedo GW. Mesenteric lymph duct ligation prevents shock-induced RBC deformability and shape changes. J Surg Res 2003;109:51-6.
51. Xu DZ, Lu Q, Adams CA, Issekutz AC, Deitch EA. Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation. Crit Care Med 2004;32:760-5.
52. Shi HP, Deitch EA, Da Xu Z, Lu Q, Hauser CJ. Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock. Shock 2002;17:496-501.
53. Osband AJ, Deitch EA, Hauser CJ, et al. Albumin protects against gut-induced lung injury in vitro and in vivo. Ann Surg 2004;240:331-9.
54. Deitch EA, Shi HP, Feketeova E, Xu DZ. Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury. Shock 2003;19:452-6.