Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno- associated virus vectors

Circulation

Volumn 99, Issue 2, 1999, Pages 201-205

  Svensson, Eric C ^a   Marshall, Deborah J ^a   Woodard, Karen ^a   Lin, Hua ^a   Jiang, Fang ^a   Chu, Lein ^a   Leiden, Jeffrey M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Genes; Molecular biology; Myocardium

Indexed keywords

PLASMID DNA; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CORONARY ARTERY BLOOD FLOW; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC RECOMBINATION; HEART MUSCLE CELL; HEART PERFUSION; PRIORITY JOURNAL; RECOMBINANT ADENO ASSOCIATED VIRUS VECTOR;

EID: 0032902054     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.2.201     Document Type: Article

References (14)

1. Nabel EG. Gene therapy for cardiovascular disease. Circulation. 1995; 91:541-548.
2. Lin H, Parmacek MS, Morle G, Bolling S, Leiden JM. Expression of recombinant genes in myocardium in vivo after direct injection of DNA. Circulation. 1990;82:2217-2221.
3. Kass EA, Falck PE, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A. 1993;90:11498-11502.
4. Guzman RJ, Lemarchand P, Crystal RG, Epstein SE, Finkel T. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res. 1993;73:1202-1207.
5. French BA, Mazur W, Geske RS, Bolli R. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation. 1994;90:2414-2424.
6. Barr E, Carroll J, Kalynych AM, Tripathy SK, Kozarsky K, Wilson JM, Leiden JM. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther. 1994;1:51-58.
7. Fisher KJ, Jooss K, Alston J, Yang Y, Haecker SE, High K, Pathak R, Raper SE, Wilson JM. Recombinant adeno-associated virus for muscle directed gene therapy. Nat Med. 1997;3:306-312.
8. Kessler PD, Podsakoff GM, Chen X, McQuiston SA, Colosi PC, Matelis LA, Kurtzman GJ, Byrne BJ. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc Natl Acad Sci U S A. 1996;93:14082-14087.
9. Snyder RO, Miao CH, Patijn GA, Spratt SK, Danos O, Nagy D, Gown AM, Winther B, Meuse L, Cohen LK, Thompson AR, Kay MA. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet. 1997;16: 270-276.
10. Kaplitt MG, Xiao X, Samulski RJ, Li J, Ojamaa K, Klein IL, Makimura H, Kaplitt MJ, Strumpf RK, Diethrich EB. Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector. Ann Thorac Surg. 1996;62:1669-1676.
11. Rolling F, Samulski RJ. AAV as a viral vector for human gene therapy: generation of recombinant virus. Mol Biotechnol. 1995;3:9-15.
12. Parmacek MS, Vora AJ, Shen T, Barr E, Jung F, Leiden JM. Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene. Mol Cell Biol. 1992;12: 1967-1976.
13. Lin H, Iammattoni MD, Modblum JR, Bolling SF. Experimental heterotopic heart transplantation without ischemia or reperfusion. J Heart Transplant. 1990;9:720-723.
14. Ferrari FK, Samulski T, Shenk T, Samulski RJ. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol. 1996;70:3227-3234.