Myocardial angiogenesis after plasmid or adenoviral VEGF-A165 gene transfer in rat myocardial infarction model

Cardiovascular Research

Volumn 73, Issue 3, 2007, Pages 481-487

  Hao, Xiaojin ^a   Månsson Broberg, Agneta ^a   Grinnemo, Karl Henrik ^a   Siddiqui, Anwar J ^a   Dellgren, Göran ^a   Brodin, Lars Å ^a   Sylvén, Christer ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Angiogenesis; Apoptosis; Gene therapy; Growth factors; Infarction

Indexed keywords

ADENOVIRUS VECTOR; PLASMID VECTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN A 165;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIOLE; ARTICLE; BLOOD VESSEL PARAMETERS; CAPILLARY DENSITY; COLOR ULTRASOUND FLOWMETRY; COMPARATIVE STUDY; CONTROLLED STUDY; DENSITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE LOCATION; GENE TRANSFER; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; LOW DRUG DOSE; MALE; NICK END LABELING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; ARTERIOLES; CORONARY VESSELS; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; INJECTIONS; LAC OPERON; LASER-DOPPLER FLOWMETRY; MALE; MODELS, ANIMAL; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS; RATS; RATS, INBRED F344; RECOMBINANT FUSION PROTEINS; REGIONAL BLOOD FLOW; TRANSDUCTION, GENETIC; TRANSFECTION; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33846081305     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.10.011     Document Type: Article

References (24)

1. Yla-Herttuala S., and Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 9 (2003) 694-701
2. Hedman M., Hartikainen J., Syvanne M., Stjernvall J., Hedman A., Kivela A., et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase ii results of the Kuopio Angiogenesis Trial (KAT). Circulation 107 (2003) 2677-2683
3. Kastrup J., Jorgensen E., Ruck A., Tagil K., Glogar D., Ruzyllo W., et al. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial. J Am Coll Cardiol 45 (2005) 982-988
4. Gyongyosi M., Khorsand A., Zamini S., Sperker W., Strehblow C., Kastrup J., et al. NOGA-guided analysis of regional myocardial perfusion abnormalities treated with intramyocardial injections of plasmid encoding vascular endothelial growth factor A-165 in patients with chronic myocardial ischemia: subanalysis of the EUROINJECT-ONE multicenter double-blind randomized study. Circulation 112 (2005) I-157-I-165
5. Laitinen M., Pakkanen T., Donetti E., Baetta R., Luoma J., Lehtolainen P., et al. Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum Gene Ther 8 (1997) 1645-1650
6. Rissanen T.T., Rutanen J., and Yla-Herttuala S. Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia. Adv Genet (2004) 117-164
7. Lee R.J., Springer M.L., Blanco-Bose W.E., Shaw R., Ursell P.C., and Blau H.M. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 102 (2000) 898-901
8. Hay S., and Kannourakis G. A time to kill: viral manipulation of the cell death program. J Gen Virol 83 (2002) 1547-1564
9. Thomson B.J. Viruses and apoptosis. Int J Exp Pathol 82 (2001) 65-76
10. Kovesdi I., Brough D.E., Bruder J.T., and Wickham T.J. Adenoviral vectors for gene transfer. Curr Opin Biotechnol 8 (1997) 583-589
11. Danthinne X., and Imperiale M.J. Production of first generation adenovirus vectors: a review. Gene Ther 7 (2000) 1707-1714
12. Laitinen M., Makinen K., Manninen H., Matsi P., Kossila M., Agrawal R.S., et al. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Hum Gene Ther 9 (1998) 1481-1486
13. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77 (1999) 527-543
14. Sylven C., Sarkar N., Wardell E., Jamsa A., Drvota V., Blomberg P., et al. Protein and angiogenic dose-response expression of phVEGF-A(165) gene in rat myocardium. J Thromb Thrombolysis 12 (2001) 151-156
15. Rutanen J., Rissanen T.T., Markkanen J.E., Gruchala M., Silvennoinen P., Kivela A., et al. Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart. Circulation 109 (2004) 1029-1035
16. Leor J., Quinones M.J., Patterson M., Kedes L., and Kloner R.A. Adenovirus-mediated gene transfer into infarcted myocardium: feasibility, timing, and location of expression. J Mol Cell Cardiol 28 (1996) 2057-2067
17. Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
18. Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
19. Liu Q., and Muruve D.A. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther 10 (2003) 935-940
20. Siddiqui A.J., Blomberg P., Wardell E., Hellgren I., Eskandarpour M., Islam K.B., et al. Combination of angiopoietin-1 and vascular endothelial growth factor gene therapy enhances arteriogenesis in the ischemic myocardium. Biochem Biophys Res Commun 310 (2003) 1002-1009
21. Strotmann J.M., Richter A., Kukulski T., Voigt J.U., Fransson S.G., Wranne B., et al. Doppler myocardial imaging in the assessment of regional myocardial function in longitudinal direction pre- and post-PTCA. Eur J Echocardiogr 2 (2001) 178-186
22. Derumeaux G., Ovize M., Loufoua J., Andre-Fouet X., Minaire Y., Cribier A., et al. Doppler tissue imaging quantitates regional wall motion during myocardial ischemia and reperfusion. Circulation 97 (1998) 1970-1977
23. Meeson A.P., Argilla M., Ko K., Witte L., and Lang R.A. VEGF deprivation-induced apoptosis is a component of programmed capillary regression. Development 126 (1999) 1407-1415
24. Mor F., Quintana F.J., and Cohen I.R. Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J Immunol 172 (2004) 4618-4623