B lymphocyte antigen receptor signaling: Initiation, amplification, and regulation

F1000Prime Reports

Volumn 5, Issue , 2013, Pages

  Packard, Thomas A ^a   Cambier, John C ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; GLUCOSE 6 PHOSPHATE ISOMERASE; HETERODIMER; OVALBUMIN;

ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CELL MEMBRANE; CLONE; CONFORMATIONAL TRANSITION; LIGAND BINDING; MOLECULAR MIMICRY; NONHUMAN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE;

EID: 84885671024     PISSN: None     EISSN: 20517599     Source Type: Journal    
DOI: 10.12703/P5-40     Document Type: Article

References (60)

1. Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M: Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 1990, 343:760-762.
2. Campbell KS, Cambier JC: B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J 1990, 9:441-448.
3. Gold MR, Matsuuchi L, Kelly RB, DeFranco AL: Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc Natl Acad Sci USA 1991, 88:3436-3440. (Pubitemid 21916636)
4. Cambier JC, Pleiman CM, Clark MR: Signal transduction by the B cell antigen receptor and its coreceptors. Annu Rev Immunol 1994, 12:457-486. (Pubitemid 24140422)
5. Reth M: Antigen receptor tail clue. Nature 1989, 338:383-384.
6. Yao XR, Flaswinkel H, Reth M, Scott DW: Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells. J Immunol 1995, 155:652-661.
7. Johnson SA, Pleiman CM, Pao L, Schneringer J, Hippen K, Cambier JC: Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol 1995, 155:4596-4603.
8. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A: Essential role of Srcfamily protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 2003, 4:274-279. (Pubitemid 36322138)
9. Kurosaki T, Johnson SA, Pao L, Sada K, Yamamura H, Cambier JC: Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med 1995, 182:1815-1823.
10. Rowley RB, Burkhardt AL, Chao HG, Matsueda GR, Bolen JB: Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem 1995, 270: 11590-11594.
11. Shiue L, Zoller MJ, Brugge JS: Syk is activated by phosphotyrosinecontaining peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem 1995, 270:10498-10502.
12. Fruman DA, Satterthwaite AB, Witte ON: Xid-like phenotypes: a B cell signalosome takes shape. Immunity 2000, 13:1-3.
13. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR: The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol 2002, 22:2524-2535. (Pubitemid 34262975)
14. Fu C, Turck CW, Kurosaki T, Chan AC: BLNK: a central linker protein in B cell activation. Immunity 1998, 9:93-103. (Pubitemid 28361298)
15. Coggeshall KM, Cambier JC: B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol 1984, 133:3382-3386. (Pubitemid 15216522)
16. Ransom JT, Harris LK, Cambier JC: Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol 1986, 137:708-714. (Pubitemid 16045106)
17. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD: The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature 2008, 456:116-120.
18. Hogan PG, Lewis RS, Rao A: Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol 2010, 28:491-533.
19. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A: Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 2007, 27:2732-2745. (Pubitemid 46581361)
20. Stone JC: Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells. Genes Cancer 2011, 2:320-334.
21. Guo B, Su TT, Rawlings DJ: Protein kinase C family functions in B-cell activation. Curr Opin Immunol 2004, 16:367-373. (Pubitemid 38595376)
22. Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T: Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 2003, 197:657-667. (Pubitemid 36314660)
23. Maxwell MJ, Duan M, Armes JE, Anderson GP, Tarlinton DM, Hibbs ML: Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice. J Immunol 2011, 186:7164-7175.
24. O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC: Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatasemediated inhibitory signaling cascade required for B cell anergy. Immunity 2011, 35:746-756.
25. Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, ThomasML,Neel BG, Rajewsky K:B cell-specific deletion of proteintyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 2007, 27:35-48. (Pubitemid 47089020)
26. Metzger H: Transmembrane signaling: the joy of aggregation. J Immunol 1992, 149:1477-1487.
27. Minguet S, Dopfer EP, Schamel WW: Low-valency, but not monovalent, antigens trigger the B-cell antigen receptor (BCR). Int Immunol 2010, 22:205-212.
28. Tolar P, Hanna J, Krueger PD, Pierce SK: The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity 2009, 30:44-55.
29. Schamel WW, Reth M: Monomeric and oligomeric complexes of the B cell antigen receptor. Immunity 2000, 13:5-14.
30. Reth M, Wienands J, Schamel WW: An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor. Immunol Rev 2000, 176:10-18.
31. Heizmann B, Reth M, Infantino S: Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor. Proc Natl Acad Sci USA 2010, 107:18563-18568.
32. Infantino S, Benz B, Waldmann T, Jung M, Schneider R, Reth M: Arginine methylation of the B cell antigen receptor promotes differentiation. J Exp Med 2010, 207:711-719.
33. Yang J, Reth M: The dissociation activation model of B cell antigen receptor triggering. FEBS Lett 2010, 584:4872-4877.
34. Leptin M: Monoclonal antibodies specific for murine IgM. II. Activation of B lymphocytes by monoclonal antibodies specific for the four constant domains of IgM. Eur J Immunol 1985, 15:131-13.
35. Tolar P, Sohn HW, Pierce SK: The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer. Nat Immunol 2005, 6:1168-1176. (Pubitemid 41541795)
36. Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ: A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 2000, 288:2351-2354. (Pubitemid 30448156)
37. Reichlin A, Hu Y, Meffre E, Nagaoka H, Gong S, Kraus M, Rajewsky K, NussenzweigMC:Bcell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. J Exp Med 2001, 193:13-23. (Pubitemid 32060694)
38. Rolli V, Gallwitz M, Wossning T, Flemming A, Schamel WW, Zürn C, Reth M: Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell 2002, 10:1057-1069. (Pubitemid 36001972)
39. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM: Molecular mechanism of the Syk activation switch. J Biol Chem 2008, 283:32650-32659.
40. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A: Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal 2013, 6:ra1.
41. Takata M, Sabe H, Hata A, Inazu T, Homma Y, Nukada T, Yamamura H, Kurosaki T: Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J 1994, 13:1341-1349.
42. Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL: Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proc Natl Acad Sci USA 2006, 103:3327-3332. (Pubitemid 43346469)
43. Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD: CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 2008, 9:63-72. (Pubitemid 350286205)
44. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF: CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 2000, 13:47-57.
45. Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD: The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity 2013, 38:461-474.
46. Harwood NE, Batista FD: The cytoskeleton coordinates the early events of B-cell activation. Cold Spring Harb Perspect Biol 2011, 3.
47. Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T: BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000, 13:817-827. (Pubitemid 32041804)
48. Aiba Y, Kameyama M, Yamazaki T, Tedder TF, Kurosaki T: Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 2008, 111:1497-1503. (Pubitemid 351213438)
49. Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T: A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med 1998, 187:1343-1348. (Pubitemid 28189123)
50. Pao LI, Famiglietti SJ, Cambier JC: Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J Immunol 1998, 160:3305-3314. (Pubitemid 28164721)
51. Khalil AM, Cambier JC, Shlomchik MJ: B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science 2012, 336:1178-1181.
52. Leung WH, Tarasenko T, Bolland S: Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes. Immunol Res 2009, 43:243-251.
53. Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF: A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J Immunol 2001, 167:2469-2478. (Pubitemid 32768872)
54. Hibbs ML, Harder KW, Armes J, Kountouri N, Quilici C, Casagranda F, Dunn AR, Tarlinton DM: Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med 2002, 196:1593-1604. (Pubitemid 36026471)
55. Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, Yamamoto T: Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling. Int Immunol 1999, 11:1441-1449. (Pubitemid 29425735)
56. Castillejo-Lopez C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sanchez E, Pollmann D, Lopez-Egido JR, Fineschi S, Domínguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegård J, Pons-Estel BA, D'Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcón-Riquelme ME: Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis 2012, 71:136-142.
57. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC: Predominant autoantibody production by early human B cell precursors. Science 2003, 301:1374-1377. (Pubitemid 37075812)
58. Zikherman J, Parameswaran R, Weiss A: Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature 2012, 489:160-164.
59. Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, Cambier JC: Identification of anergic B cells within a wild-type repertoire. Immunity 2006, 25:953-962. (Pubitemid 44894955)
60. Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, Zhang N, Katzman SD, Jenkins MK, Mueller DL: Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 2012, 209:2065-2077.