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Volumn 16, Issue 10, 2013, Pages 2245-2257

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice

Author keywords

Antihypertensive; BACE; BDNF; insulin degrading enzyme; JNK1

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; PROPRANOLOL; PROTEIN KINASE B; SYNAPTOPHYSIN; TAU PROTEIN;

EID: 84885649255     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145713000631     Document Type: Conference Paper
Times cited : (65)

References (59)
  • 1
    • 33947155494 scopus 로고    scopus 로고
    • Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
    • Aisa B, Tordera R, Lasheras B, Del Río J, Ramírez MJ (2007) Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32:256-266
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 256-266
    • Aisa, B.1    Tordera, R.2    Lasheras, B.3    Del Río, J.4    Ramírez, M.J.5
  • 2
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe KH, Zahs KR (2010) Probing the biology of Alzheimer's disease in mice. Neuron 66:631-645
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 3
    • 0034589076 scopus 로고    scopus 로고
    • Locus coeruleus and regulation of behavioral flexibility and attention
    • Aston-Jones G, Rajkowski J, Cohen J (2000) Locus coeruleus and regulation of behavioral flexibility and attention. Prog Brain Res 126:165-182
    • (2000) Prog Brain Res , vol.126 , pp. 165-182
    • Aston-Jones, G.1    Rajkowski, J.2    Cohen, J.3
  • 4
    • 0028704537 scopus 로고
    • Neurotrophins: A family of proteins supporting the survival of neurons
    • Barde YA (1994) Neurotrophins: A family of proteins supporting the survival of neurons. Prog Clin Biol Res 390:45-56
    • (1994) Prog Clin Biol Res , vol.390 , pp. 45-56
    • Barde, Y.A.1
  • 8
    • 36148946034 scopus 로고    scopus 로고
    • Increased task difficulty results in greater impact of noradrenergic modulation of cognitive flexibility
    • Campbell HL, Tivarus ME, Hillier A, Beversdorf DQ (2008) Increased task difficulty results in greater impact of noradrenergic modulation of cognitive flexibility. Pharmacol Biochem Behav 88:222-229
    • (2008) Pharmacol Biochem Behav , vol.88 , pp. 222-229
    • Campbell, H.L.1    Tivarus, M.E.2    Hillier, A.3    Beversdorf, D.Q.4
  • 11
    • 79955964916 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus
    • Dang M, Dubbin K, D'Aiello A, Hartmann M, Lodish H, Herrlich A (2011) Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus. J Biol Chem 286:17704-17713
    • (2011) J Biol Chem , vol.286 , pp. 17704-17713
    • Dang, M.1    Dubbin, K.2    D'Aiello, A.3    Hartmann, M.4    Lodish, H.5    Herrlich, A.6
  • 12
    • 0023691166 scopus 로고
    • A new one trial-test for neurobiological studies of memory in rats. 1
    • Ennaceur A, Delacour J (1988) A new one trial-test for neurobiological studies of memory in rats. 1: behavioral data. Behav Brain Res 31:47-59
    • (1988) Behavioral data. Behav Brain Res , vol.31 , pp. 47-59
    • Ennaceur, A.1    Delacour, J.2
  • 13
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    • Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribé E, Dalfó E, Avila J (2005) Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res 2:3-18
    • (2005) Curr Alzheimer Res , vol.2 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribé, E.5    Dalfó, E.6    Avila, J.7
  • 15
    • 84864920729 scopus 로고    scopus 로고
    • Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice
    • Gil-Bea FJ, Gerenu G, Aisa B, Kirazov LP, Schliebs R, Ramírez MJ (2012) Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. Neurobiol Dis 48:439-346
    • (2012) Neurobiol Dis , vol.48 , pp. 439-346
    • Gil-Bea, F.J.1    Gerenu, G.2    Aisa, B.3    Kirazov, L.P.4    Schliebs, R.5    Ramírez, M.J.6
  • 16
    • 0038326624 scopus 로고    scopus 로고
    • Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
    • Guillozet AL, Weintraub S, Mash DC, Mesulam MM (2003) Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60:729-736
    • (2003) Arch Neurol , vol.60 , pp. 729-736
    • Guillozet, A.L.1    Weintraub, S.2    Mash, D.C.3    Mesulam, M.M.4
  • 17
    • 0032996904 scopus 로고    scopus 로고
    • Low blood pressure and incidence of dementia in a very old sample: Dependent on initial cognition
    • Guo Z, Viitanen M, Winblad B, Fratiglioni L (1999) Low blood pressure and incidence of dementia in a very old sample: Dependent on initial cognition. J Am Geriatr Soc 47:723-726
    • (1999) J Am Geriatr Soc , vol.47 , pp. 723-726
    • Guo, Z.1    Viitanen, M.2    Winblad, B.3    Fratiglioni, L.4
  • 18
    • 31344454633 scopus 로고    scopus 로고
    • Antihypertensive agents for aging patients who are at risk for cognitive dysfunction
    • Hajjar I, Keown M, Frost B (2005) Antihypertensive agents for aging patients who are at risk for cognitive dysfunction. Curr Hypertens Rep 7:466-473
    • (2005) Curr Hypertens Rep , vol.7 , pp. 466-473
    • Hajjar, I.1    Keown, M.2    Frost, B.3
  • 19
    • 70949100259 scopus 로고    scopus 로고
    • Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease
    • Hanger DP, Seereeram A, Noble W (2009) Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Rev Neurother 9:1647-1666
    • (2009) Expert Rev Neurother , vol.9 , pp. 1647-1666
    • Hanger, D.P.1    Seereeram, A.2    Noble, W.3
  • 20
    • 33645829653 scopus 로고    scopus 로고
    • Has the amyloid cascade hypothesis for Alzheimer's disease been proved
    • Hardy J (2006) Has the amyloid cascade hypothesis for Alzheimer's disease been proved? Curr Alzheimer Res 3:71-73
    • (2006) Curr Alzheimer Res , vol.3 , pp. 71-73
    • Hardy, J.1
  • 21
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 27
    • 11844251260 scopus 로고    scopus 로고
    • Regulation of gene expression by the amyloid precursor protein: Inhibition of the JNK/cJun pathway
    • Kögel D, Schomburg R, Copanaki E, Prehn JH (2005) Regulation of gene expression by the amyloid precursor protein: Inhibition of the JNK/cJun pathway. Cell Death Differ 12:1-9
    • (2005) Cell Death Differ , vol.12 , pp. 1-9
    • Kögel, D.1    Schomburg, R.2    Copanaki, E.3    Prehn, J.H.4
  • 28
    • 0028176821 scopus 로고
    • Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    • Kurochkin IV, Goto S (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 345:33-37
    • (1994) FEBS Lett , vol.345 , pp. 33-37
    • Kurochkin, I.V.1    Goto, S.2
  • 30
    • 3843078519 scopus 로고    scopus 로고
    • The study on cognition and prognosis in the elderly (scope); outcomes in patients not receiving add-on therapy after randomization
    • SCOPE Study Group
    • Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P, Zanchetti A, SCOPE Study Group (2004) The study on COgnition and prognosis in the elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization. J Hypertens 22:1605-1612
    • (2004) J Hypertens , vol.22 , pp. 1605-1612
    • Lithell, H.1    Hansson, L.2    Skoog, I.3    Elmfeldt, D.4    Hofman, A.5    Olofsson, B.6    Trenkwalder, P.7    Zanchetti, A.8
  • 32
    • 65649111733 scopus 로고    scopus 로고
    • Stressactivated MAP kinase cascades in cellular senescence
    • Maruyama J, Naguro I, Takeda K, Ichijo H (2009) Stressactivated MAP kinase cascades in cellular senescence. Curr Med Chem 16:1229-1235
    • (2009) Curr Med Chem , vol.16 , pp. 1229-1235
    • Maruyama, J.1    Naguro, I.2    Takeda, K.3    Ichijo, H.4
  • 33
    • 60849097262 scopus 로고    scopus 로고
    • Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβoligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
    • Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβoligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci 29:1977-1986
    • (2009) J Neurosci , vol.29 , pp. 1977-1986
    • Meilandt, W.J.1    Cisse, M.2    Ho, K.3    Wu, T.4    Esposito, L.A.5    Scearce-Levie, K.6    Cheng, I.H.7    Yu, G.Q.8    Mucke, L.9
  • 34
    • 34347399599 scopus 로고    scopus 로고
    • Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model
    • Mouri A, Noda Y, Hara H, Mizoguchi H, Tabira T, Nabeshima T (2007) Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J 163:2135-2148
    • (2007) FASEB J , vol.163 , pp. 2135-2148
    • Mouri, A.1    Noda, Y.2    Hara, H.3    Mizoguchi, H.4    Tabira, T.5    Nabeshima, T.6
  • 39
    • 0034594470 scopus 로고    scopus 로고
    • Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS Honolulu-Asia aging study
    • Petrovitch H, White LR, Izmirilian G, Ross GW, Havlik RJ, Markesbery W (2000) Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS. Honolulu-Asia aging study. Neurobiol Aging 21:57-62
    • (2000) Neurobiol Aging , vol.21 , pp. 57-62
    • Petrovitch, H.1    White, L.R.2    Izmirilian, G.3    Ross, G.W.4    Havlik, R.J.5    Markesbery, W.6
  • 40
    • 0031910898 scopus 로고    scopus 로고
    • Do antiarthritic drugs decrease the risk for cognitive decline? An analysis based on data from the MRC treatment trial of hypertension in older adults
    • Prince M, Rabe-Hesketh S, Brennan P (1998) Do antiarthritic drugs decrease the risk for cognitive decline? An analysis based on data from the MRC treatment trial of hypertension in older adults. Neurology 50:374-379
    • (1998) Neurology , vol.50 , pp. 374-379
    • Prince, M.1    Rabe-Hesketh, S.2    Brennan, P.3
  • 41
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N (2007) Dose translation from animal to human studies revisited. FASEB J 22:659-661
    • (2007) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 42
    • 77952883191 scopus 로고    scopus 로고
    • Effect size of reference memory deficits in the Morris water maze in Tg2576 mice
    • Reed MN, Liu P, Kotilinek LA, Ashe KH (2010) Effect size of reference memory deficits in the Morris water maze in Tg2576 mice. Behav Brain Res 212:115-120
    • (2010) Behav Brain Res , vol.212 , pp. 115-120
    • Reed, M.N.1    Liu, P.2    Kotilinek, L.A.3    Ashe, K.H.4
  • 43
    • 84859712559 scopus 로고    scopus 로고
    • Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease
    • Ricobaraza A, Cuadrado-Tejedor M, Marco S, Pérez-Otaño I, García-Osta A (2012) Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus 22:1040-1050
    • (2012) Hippocampus , vol.22 , pp. 1040-1050
    • Ricobaraza, A.1    Cuadrado-Tejedor, M.2    Marco, S.3    Pérez-Otaño, I.4    García-Osta, A.5
  • 44
    • 4644288235 scopus 로고    scopus 로고
    • Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala
    • Roozendaal B, Hahn EL, Nathan SV, de Quervain DJ, McGaugh JL (2004) Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. J Neurosci 24:8161-8169
    • (2004) J Neurosci , vol.24 , pp. 8161-8169
    • Roozendaal, B.1    Hahn, E.L.2    Nathan, S.V.3    De Quervain, D.J.4    McGaugh, J.L.5
  • 46
    • 0036913139 scopus 로고    scopus 로고
    • Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites
    • Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y (2002) Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Arch 441:358-367
    • (2002) Virchows Arch , vol.441 , pp. 358-367
    • Sasaki, A.1    Shoji, M.2    Harigaya, Y.3    Kawarabayashi, T.4    Ikeda, M.5    Naito, M.6    Matsubara, E.7    Abe, K.8    Nakazato, Y.9
  • 47
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298:789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 48
    • 0029589442 scopus 로고
    • Low-dose propranolol reduces aggression and agitation resembling that associated with orbitofrontal dysfunction in elderly demented patients
    • Shankle WR, Nielson KA, Cotman CW (1995) Low-dose propranolol reduces aggression and agitation resembling that associated with orbitofrontal dysfunction in elderly demented patients. Alzheimer Dis Assoc Disord 9:233-237
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , pp. 233-237
    • Shankle, W.R.1    Nielson, K.A.2    Cotman, C.W.3
  • 49
    • 0033813571 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's and Parkinson's disease brain
    • Siegel GJ, Chauhan NB (2000) Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Rev 33:199-227
    • (2000) Brain Res Rev , vol.33 , pp. 199-227
    • Siegel, G.J.1    Chauhan, N.B.2
  • 50
    • 33749015483 scopus 로고    scopus 로고
    • Update on hypertension and Alzheimer's disease
    • Skoog I, Gustafson D (2006) Update on hypertension and Alzheimer's disease. Neurol Res 28:605-611
    • (2006) Neurol Res , vol.28 , pp. 605-611
    • Skoog, I.1    Gustafson, D.2
  • 51
    • 0030002516 scopus 로고    scopus 로고
    • Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: Comparison to confirmed Alzheimer's disease patients
    • Sparks DL, Scheff SW, Liu H, Landers T, Danner F, Coyne CN, Hunsaker JC III (1996) Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: Comparison to confirmed Alzheimer's disease patients. J Neurol Sci 138:97-104
    • (1996) J Neurol Sci , vol.138 , pp. 97-104
    • Sparks, D.L.1    Scheff, S.W.2    Liu, H.3    Landers, T.4    Danner, F.5    Coyne, C.N.6    Hunsaker III, J.C.7
  • 52
    • 62649147319 scopus 로고    scopus 로고
    • Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
    • Taglialatela G, Hogan D, Zhang WR, Dineley KT (2009) Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res 200:95-99
    • (2009) Behav Brain Res , vol.200 , pp. 95-99
    • Taglialatela, G.1    Hogan, D.2    Zhang, W.R.3    Dineley, K.T.4
  • 53
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Abeta peptide: The many roads to perdition
    • Tanzi RE, Moir RD, Wagner SL (2004) Clearance of Alzheimer's Abeta peptide: The many roads to perdition. Neuron 43:605-608
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 54
    • 0035813199 scopus 로고    scopus 로고
    • Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor
    • Tartaglia N, Du J, Tyler WJ, Neale E, Pozzo-Miller L, Lu B (2001) Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor. J Biol Chem 276:37585-37593
    • (2001) J Biol Chem , vol.276 , pp. 37585-37593
    • Tartaglia, N.1    Du, J.2    Tyler, W.J.3    Neale, E.4    Pozzo-Miller, L.5    Lu, B.6
  • 56
    • 1842714295 scopus 로고    scopus 로고
    • Synaptophysin: Leading actor or walk-on role in synaptic vesicle exocytosis
    • Valtorta F, Pennuto M, Bonanomi D, Benfenati F (2004) Synaptophysin: Leading actor or walk-on role in synaptic vesicle exocytosis? Bioessays 26:445-453
    • (2004) Bioessays , vol.26 , pp. 445-453
    • Valtorta, F.1    Pennuto, M.2    Bonanomi, D.3    Benfenati, F.4
  • 57
    • 33748295795 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system: Learning to survive
    • van der Heide LP, Ramakers GM, Smidt MP (2006) Insulin signaling in the central nervous system: Learning to survive. Prog Neurobiol 79:205-221
    • (2006) Prog Neurobiol , vol.79 , pp. 205-221
    • Van Der Heide, L.P.1    Ramakers, G.M.2    Smidt, M.P.3
  • 59
    • 58849148507 scopus 로고    scopus 로고
    • Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization
    • Zhao W, Wang J, Ho L, Ono K, Teplow DB, Pasinetti GM (2009) Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. J Alzheimers Dis 16:49-57
    • (2009) J Alzheimers Dis , vol.16 , pp. 49-57
    • Zhao, W.1    Wang, J.2    Ho, L.3    Ono, K.4    Teplow, D.B.5    Pasinetti, G.M.6


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