Locus coeruleus and regulation of behavioral flexibility and attention

Progress in Brain Research

Volumn 126, Issue , 2000, Pages 165-182

  Aston Jones, Gary ^a   Rajkowski, Janusz ^a   Cohen, Jonathan ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ATTENTION; ATTENTION DEFICIT DISORDER; BEHAVIOR; CONFERENCE PAPER; EMOTIONAL DISORDER; EVOKED SOMATOSENSORY RESPONSE; GLUCOSE INTAKE; GROOMING; LOCUS CERULEUS; MONKEY; MOOD DISORDER; NERVE CONDUCTION; NEUROPHYSIOLOGY; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SLEEP WAKING CYCLE; TASK PERFORMANCE;

EID: 0034589076     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(00)26013-5     Document Type: Conference Paper

References (91)

1. Abercrombie, E.D. and Jacobs, B.L. (1987a) Single unit response of noradrenergic neurons in locus coeruleus of freely moving cats II. Adaptation to chronically presented stessful stimuli. J. Neurosci., 7: 2844-2848.
2. Abercrombie, E.D. and Jacobs, B.L. (1987b) Single unit response of noradrenergic neurons in locus coeruleus of freely moving cats I. Acutely presented stressful and nonstressful stimuli. J. Neurosci., 7: 2837-2843.
3. Aghajanian, G.K., Cedarbaum, J.M. and Wang, R.Y. (1977) Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Res., 136: 570-577.
4. Arnsten, A.F. and Goldman, R.P. (1984) Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Res., 306: 9-18.
5. Aston-Jones, G. (1985) Behavioral functions of the locus coeruleus derived from cellular attributes. Physiol. Psych., 13: 118-126.
6. Aston-Jones, G., Alexinsky, T. and Grant, S. (1988) Activity of locus coeruleus neurons in behaving primates: Relationship with vigilance. Soc. Neurosci. Abstr., 14: 407.
7. Aston-Jones, G. and Bloom, F.E. (1981a) Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci., 1: 876-86.
8. Aston-Jones, G. and Bloom, F.E. (1981b) Norepinephrinecontaining locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J. Neurosci., 1: 887-900.
9. Aston-Jones, G., Chiang, C. and Alexinsky, T. (1991) Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog. Brain Res., 88: 501-520.
10. Aston-Jones, G., Ennis, M., Pieribone, V.A., Nickell, W.T. and Shipley, M.T. (1986) The brain nucleus locus coeruleus: Restricted afferent control of a broad efferent network. Science, 234: 734-737.
11. Aston-Jones, G., Foote, S.L. and Bloom, F.E. (1984) Anatomy and physiology of locus coeruleus neurons: Functional implications. In: M. Ziegler and C.R. Lake (Eds), Norepinephrine, Frontiers of Clinical Neuroscience, Vol. 2, Williams and Wilkins, Baltimore, pp. 92-116.
12. Aston-Jones, G., Rajkowski, J. and Cohen, J. (1999) Role of locus coeruleus in attention and behavioral flexibility. Biol. Psychiatry., 46: 1309-1320.
13. Aston-Jones, G., Rajkowsky, J. and Kubiak, P. (1997) Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task. Neuroscience, 80: 697-715.
14. Aston-Jones, G., Rajkowski, J., Kubiak, P. and Alexinsky, T. (1994a) Locus coeruleus neurons in the monkey are selectively activated by attended stimuli in a vigilance task. J. Neurosci., 14: 4467-4480.
15. Aston-Jones, G., Rajkowski, J., Kubiak, P., Valentino, R. and Shipley, M. (1996) Role of the locus coeruleus in emotional activation. Prog. Brain Res., 107: 379-402.
16. Aston-Jones, G., Shipley, M.T. and Grzanna, R. (1995) The locus coeruleus, A5 and A7 noradrenergic cell groups. In: G. Paxinos (Ed.), The Rat Nervous System, Academic Press, New York, pp. 183-214.
17. Aston-Jones, G., Valentino, R.J., Van Bockstaele, E. and Meyerson, A. (1994b) Locus coeruleus, stress, and PTSD: Neurobiological and clinical parallels. In: M. Murbug (Ed.), Catecholamine Function in Post-Traumatic Stress Disorder, Am. Psychiatric. Press, Washington, DC, pp. 17-62.
18. Bernander, O., Koch, C. and Usher, M. (1994) The effect of synchronized inputs at the single neuron level. Neur. Computat., 6: 622-641.
19. Berridge, C.W. and Foote, S.L. (1991) Effects of locus coeruleus activation on electroencephalographic activity in the neocortex and hippocampus. J. Neurosci., 11: 3135-3145.
20. Biegon, A. and Fieldust, S. (1992) Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse, 10: 79-82.
21. Botvinick, M.M., Nystrom, L., Fissell, K., Carter, C.S. and Cohen, J.D. (1999) Conflict monitoring vs. selection-foraction in anterior cingulate cortex. Nature, 402: 179-181.
22. Carter, C.S., Braver, T.S., Barch, D.M., Botvinick, M.M., Noll, D. and Cohen, J.D. (1998) Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280: 747-749.
23. Chan-Palay, V. (1991) Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Progr. Brain Res., 88: 625-30.
24. Chan-Palay, V. (1993) Depression and dementia in Parkinson's disease. Catecholamine changes in the locus ceruleus, a basis for therapy. Adv. Neurol., 60: 438-46.
25. Chiang, C. and Aston-Jones, G. (1993) Response of locus coeruleus neurons to footshock stimulation is mediated by neurons in the ventrolateral medulla. Neuroscience, 53: 705-715.
26. Christie, M.J. and Jelinek, H.F. (1993) Dye-coupling among neurons of the rat locus coeruleus during postnatal development. Neuroscience, 56: 129-137.
27. Christie, M.J., Williams, J.T. and North, R.A. (1989) Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats. J. Neurosci., 9: 3584-3589.
28. Dahlstrom, A. and Fuxe, K. (1964) Evidence for the existence of monoamine-containing neurons in the central nervous system. I. demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand., 62 (Suppl. 232): 5-55.
29. Easterbrook, J.A. (1959) The effect of emotion on cue utilization and the organization of behavior. Psych. Rev., 66: 183-201.
30. Ennis, M. and Aston-Jones, G. (1986) Evidence for self- and neighbor-mediated postactivation inhibition of locus coeruleus neurons. Brain Res., 374: 299-305.
31. Ennis, M. and Aston-Jones, G. (1988) Activation of locus coeruleus from nucleus paragigantocellularis: A new excitatory amino acid pathway in brain. J. Neurosci., 8: 3644-3657.
32. Foote, S.L., Aston-Jones, G. and Bloom, F.E. (1980) Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc. Natl. Acad. Sci. USA, 77: 3033-3037.
33. Foote, S.L., Bloom, F.E. and Aston-Jones, G. (1983) Nucleus locus ceruelus: New evidence of anatomical and physiological specificity. Physiol. Rev., 63: 844-914.
34. Foote, S.L., Freedman, R. and Oliver, A.P. (1975) Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex. Brain Res., 86: 229-242.
35. Freedman, R., Foote, S.L. and Bloom, F.E. (1975) Histochemical characterization of a neocortical projection of the nucleus locus coeruleus in the squirrel monkey. J. Comp. Neurol., 164: 209-231.
36. German, D.C., Manaye, K.F., White, C.L.d., Woodward, D.J., McIntire, D.D., Smith, W.K., Kalaria, R.N. and Mann, D.M. (1992) Disease-specific patterns of locus coeruleus cell loss. Ann. Neurol., 32: 667-676.
37. Grace, A.A. and Bunney, B.S. (1983) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-3. Evidence for electrotonic coupling. Neuroscience, 10: 333-348.
38. Grant, S.J., Aston-Jones, G. and Redmond, D.E.J. (1988) Responses of primate locus coeruleus neurons to simple and complex sensory stimuli. Brain Res. Bull., 21: 401-410.
39. Hobson, J.A., McCarley, R.W. and Wyzinski, P.W. (1975) Sleep cycle oscillation: Reciprocal discharge by two brainstem neuronal groups. Science, 189: 55-58.
40. Holler, B.J., Siggins, G.R., Oliver, A.P. and Bloom, F.E. (1973) Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: Pharmacological evidence of noradrenergic central inhibition. J. Pharmac. Exp. Ther., 184: 553-569.
41. Hoogendijk, W.J., Pool, C.W., Troost, D., van Zwieten, E. and Swaab, D.F. (1995) Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain, 118: 131-43.
42. Ishimatsu, M. and Williams, J.T. (1996) Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J. Neurosci., 16: 5196-5204.
43. Ivanov, A.Y. and Aston-Jones, G. (1995) Intrinsic mechanisms regulating spontaneous discharge and subthreshold oscillations in locus coeruleus (LC) neurons in vitro. Soc. Neurosci. Abstr,. 21: 633.
44. Ivanova, S., Rajkowski, J., Silakov, V., Watanabe, T. and AstonJones, G. (1997) Local chemomanipulations of locus coeruleus (LC) activity in monkeys alter cortical event-related potentials (ERPs) and task performance. Soc. Neurosci. Abstr., 23: 1587.
45. Jodo, E. and Aston-Jones, G. (1997) Activation of locus coeruleus by prefrontal cortex is mediated by excitatory amino acid inputs. Brain Res., 768: 327-332.
46. Jodo, E., Chiang, C. and Aston-Jones, G. (1998) Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons. Neuroscience, 83: 63-80.
47. Knight, B. (1972) Dynamics of encoding in a population of neurons. J. Gen. Physiol., 59: 734-766.
48. Koda, L.Y., Schulman, J.A. and Bloom, F.E. (1978) Ultrastructural identification of noradrenergic terminals in the rat hippocampus: Unilateral destruction of the locus coeruleus with 6-hydroxydopamine. Brain Res., 145: 190-195.
49. Kubiak, P., Rajkowski, J. and Aston-Jones, G. (1992) Behavioral performance and sensory responsiveness of LC neurons in a vigilance task varies with tonic LC discharge rate. Soc. Neurosci. Abstr., 18: 538.
50. McMahon, D. and Brown, D. (1994) Modulation of gapjunction channel gating at zebrafish retinal electrical synapses. J. Neurophysiol., 72: 2257-2268.
51. McMahon, D.G. and Mattson, M. P. (1996) Horizontal cell electrical coupling in the giant danio: Synaptic modulation by dopamine and synaptic maintenance by calcium. Brain Res,. 718: 89-96.
52. Morilak, D.A., Fornal, C.A. and Jacobs, B.L. (1987a) Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. I. Thermoregulatory challenge. Brain Res., 422: 17-23.
53. Morilak, D.A., Fornal, C.A. and Jacobs, B.L. (1987b) Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. II. Cardiovascular challenge. Brain Res., 422: 24-31.
54. Morilak, D.A., Fornal, C.A. and Jacobs, B.L. (1987c) Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. III. Glucoregulatory challenge. Brain Res., 422: 32-39.
55. Morrison, J. and Foote, S. (1986) Noradrenergic and serotonergic innervation of cortical, thalamic and tectal visual structures in old and new world monkeys. J. Comp. Neurol., 243: 117-128.
56. Morrison, J.H., Foote, S.L., O'Connor, D. and Bloom, F.E. (1982) Laminar, tangential and regional organization of the noradrenergic innervation of the monkey cortex: Dopamine-beta-hydroxylase immunohistochemistry. Brain Res. Bull., 9: 309-319.
57. O'Donnell, P. and Grace, A.A. (1997) Cortical afferents modulate striatal gap junction permeability via nitric oxide. Neuroscience, 76: 1-5.
58. Olschowka, J.A., Molliver, M.E., Grzanna, R., Rice, F.L. and Coyle, J.T. (1981) Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. J. Histochem. Cytochem., 29: 271-280.
59. Ordway, G.A., Smith, K.S. and Haycock, J.W. (1994a) Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J. Neurochem., 62: 680-685.
60. Ordway, G.A., Widdowson, P.S., Smith, K.S. and Halaris, A. (1994b) Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. J. Neurochem., 63: 617-624.
61. Papadopoulos, G.C., Parnavelas, J.G. and Buijs, R. (1987) Monoaminergic fibers form conventional synapses in the cerebral cortex. Neurosci. Lett., 76: 275-279.
62. Papadopoulos, G.C., Parnavelas, J.G. and Buijs, R.M. (1989) Light and electron microscopic immunocytochemical analysis of the noradrenaline innervation of the rat visual cortex. J. Neurocytol., 18: 1-10.
63. Parasuraman, R. (1984) The psychobiology of sustained attention. In: J.S. Warm (Ed.), Sustained Attention in Human Performance, John Wiley & Sons, New York, pp. 61-101.
64. Pitman, R.K., Orr, S.P., Shalev, A.Y., Metzger, L.J. and Mellman, T.A. (1999) Psychophysiological alterations in post-traumatic stress disorder. Semin. Clin. Neuropsychiatry., 4: 234-241.
65. Rajkowski, J., Kubiak, P. and Aston-Jones, G. (1992) Activity of locus coeruleus neurons in behaving monkeys varies with focused attention: Short- and long-term changes. Soc. Neurosci. Abstr., 18: 538.
66. Rajkowski, J., Kubiak, P. and Aston-Jones, G. (1993) Correlations between locus coeruleus (LC) neural activity, pupil diameter and behavior in monkey support a role of LC in attention. Soc. Neurosci. Abstr., 19: 974.
67. Rajkowski, J., Kubiak, P. and Aston-Jones, G. (1994) Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance. Brain Res. Bull., 35: 607-616.
68. Rajkowski, J., Kubiak, P., Ivanova, S. and Aston-Jones, G. (1996) LC Neurons in monkey are selectively activated by the earliest predictors of reward. Soc. Neurosci. Abstr., 22: 2063.
69. Rajkowski, J., Kubiak, P., Ivanova, S. and Aston-Jones, G. (1998) State related activity and reactivity of locus coeruleus neurons in behaving monkeys. In: D. Goldstein, G. Eisenhofer and R. McCarty (Eds), Catecholamines: Bridging Basic Science with Clinical Medicine, Vol. 42, Academic Press, New York, pp. 740-744.
70. Rajkowski, J., Silakov, V., Ivanova, S. and Aston-Jones, G. (1997) Locus coeruleus neurons in monkey are quiescent in paradoxical sleep. Soc. Neurosci. Abst., 23: 2130.
71. Rasmussen, K., Morilak, D.A. and Jacobs, B.L. (1986) Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behaviors and in response to simple and complex stimuli. Brain Res., 371: 324-334.
72. Segal, M. and Bloom, F.E. (1974) The action of norepinephrine in the rat hippocampus.I. Iontophoretic studies. Brain Res., 72: 79-97.
73. Segal, M. and Bloom, F.E. (1976) The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal unit activity. Brain Res., 107: 513-525.
74. Servan-Schreiber, D., Printz, H. and Cohen, J.D. (1990) A network model of catecholamine effects gain signal to noise ratio and behavior. Science, 249: 892-895.
75. Shipley, M.T., Fu, L., Ennis, M., Liu, W. and Aston-Jones, G. (1996) Dendrites of locus coeruleus neurons extend preferentially into two pericoerulear zones. J. Comp. Neurol., 365: 56-68.
76. Siever, L.J. and Davis, K.L. (1985) Overview: Toward a dysregulation hypothesis of depression. Am. J. Psychiatry, 142: 1017-1031.
77. Solanto, M.V. (1998) Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration, Behav. Brain Res., 94: 127-152.
78. Southwick, S.M., Paige, S., Morgan, C.A., 3rd, Bremner, J.D., Krystal, J.H. and Charney, D.S. (1999) Neurotransmitter alterations in PTSD: Catecholamines and serotonin. Semin. Clin. Neuropsychiatry, 4: 242-248.
79. Traub, R., Whittington, M., Colling, S., Buzsaki, G. and Jefferys, J. (1996) Analysis of gamma rhythms in the rat hippocampus in vitro and in vivo. J. Physiol. (Lond.), 493: 471-484.
80. Travagli, R.A., Wessendorf, M., Dunwiddie, T.V. and Williams, J.T. (1994) The opioid-induced current in rat locus coeruleus: Electrotonic considerations. Soc. Neurosci. Abstr., 20: 1734.
81. Travalgi, R.A., Dunwiddie, T.V. and Williams, J.T. (1995) Opioid inhibition in locus coeruleus. J. Neurophysiol., 74: 519-528.
82. Ungerstedt, U. (1971) Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand. Suppl., 367: 1-48.
83. Usher, M., Cohen, J.D., Rajkowski, J., Kubiak, P. and Aston-Jones, G. (1999) The role of locus coeruleus in the regulation of cognitive performance. Science, 283: 549-554.
84. Valentino, R., Page, M. and Curtis, A. (1991) Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor. Brain Res., 555: 25-34.
85. Valentino, R.J., Foote, S.L. and Aston-Jones, G. (1983) Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus. Brain Res., 270: 363-7.
86. Waterhouse, B.D., Moises, H.C. and Woodward, D.J. (1980) Noradrenergic modulation of somatosensory cortical neuronal responses to iontophoretically applied putative neurotransmitters. Exp. Neurol., 69: 30-49.
87. Waterhouse, B.D., Moises, H.C., Yeh, H.H., Geller, H.M. and Woodward, D.J. (1984) Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA). J. Pharmacol. Exp. Ther., 228: 257-67.
88. Waterhouse, B.D. and Woodward, D.J. (1980) Interaction of norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in the rat. Exp. Neurol., 67: 11-34.
89. Widdowson, P.S., Ordway, G.A. and Halaris, A.E. (1992) Reduced neuropeptide Y concentrations in suicide brain. J. Neurochem., 59: 73-80.
90. Zhu, Y. and Aston-Jones, G. (1996) The medial prefrontal cortex prominently innervates a peri-locus coeruleus dendritic zone in rat. Soc. Neurosci. Abstr., 22: 601.
91. Zweig, R.M., Cardillo, J.E., Cohen, M., Giere, S. and Hedreen, J.C. (1993) The locus ceruleus and dementia in Parkinson's disease. Neurology, 43: 986-991.