-
1
-
-
0035154850
-
The potentialpharmacological and toxicological impactof P450 screening.
-
Riley, R.J. (2001) The potentialpharmacological and toxicological impactof P450 screening. Curr. Opin. DrugDiscov. Dev., 4 (1), 45-54.
-
(2001)
Curr. Opin. DrugDiscov. Dev.
, vol.4
, Issue.1
, pp. 45-54
-
-
Riley, R.J.1
-
2
-
-
78650379608
-
Aldehyde oxidase: an enzyme of emergingimportance in drug discovery.
-
Pryde, D.C., Dalvie, D., Hu, Q., Jones, P.,Obach, R.S., and Tran, T.D. (2010)Aldehyde oxidase: an enzyme of emergingimportance in drug discovery. J. Med.Chem., 53 (24), 8441-8460.
-
(2010)
J. Med.Chem.
, vol.53
, Issue.24
, pp. 8441-8460
-
-
Pryde, D.C.1
Dalvie, D.2
Hu, Q.3
Jones, P.4
Obach, R.S.5
Tran, T.D.6
-
3
-
-
0034814085
-
Interactionsof nitrogen-containing xenobiotics withmonoamine oxidase (MAO) isozymes Aand B: SAR studies on MAO substratesand inhibitors.
-
Kalgutkar, A.S., Dalvie, D.K., Castagnoli,N., Jr., and Taylor, T.J. (2001) Interactionsof nitrogen-containing xenobiotics withmonoamine oxidase (MAO) isozymes Aand B: SAR studies on MAO substratesand inhibitors. Chem. Res. Toxicol., 14 (9),1139-1162.
-
(2001)
Chem. Res. Toxicol.
, vol.14
, Issue.9
, pp. 1139-1162
-
-
Kalgutkar, A.S.1
Dalvie, D.K.2
Castagnoli Jr, N.3
Taylor, T.J.4
-
4
-
-
33645990311
-
A literature review ofenzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113drugs in human liver microsomes:structure-kinetics relationshipassessment.
-
Bu, H.Z. (2006) A literature review ofenzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113drugs in human liver microsomes:structure-kinetics relationshipassessment. Curr. Drug Metab., 7 (3),231-249.
-
(2006)
Curr. Drug Metab.
, vol.7
, Issue.3
, pp. 231-249
-
-
Bu, H.Z.1
-
5
-
-
81555223843
-
Metabolism-directeddesign of oxetane-containingarylsulfonamide derivatives as c-secretaseinhibitors.
-
Stepan, A.F., Karki, K., McDonald,W.S.,Dorff, P.H., Dutra, J.K., Dirico, K.J., Won,A., Subramanyam, C., Efremov, I.V.,O'Donnell, C.J., Nolan, C.E., Becker, S.L.,Pustilnik, L.R., Sneed, B., Sun, H., Lu, Y.,Robshaw, A.E., Riddell, D., O'Sullivan,T.J., Sibley, E., Capetta, S., Atchison, K.,Hallgren, A.J., Miller, E., Wood, A., andObach, R.S. (2011) Metabolism-directeddesign of oxetane-containingarylsulfonamide derivatives as c-secretaseinhibitors. J. Med. Chem., 54 (22),7772-7783.
-
(2011)
J. Med. Chem.
, vol.54
, Issue.22
, pp. 7772-7783
-
-
Stepan, A.F.1
Karki, K.2
McDonald, W.S.3
Dorff, P.H.4
Dutra, J.K.5
Dirico, K.J.6
Won, A.7
Subramanyam, C.8
Efremov, I.V.9
O'Donnell, C.J.10
Nolan, C.E.11
Becker, S.L.12
Pustilnik, L.R.13
Sneed, B.14
Sun, H.15
Lu, Y.16
Robshaw, A.E.17
Riddell, D.18
O'Sullivan, T.J.19
Sibley, E.20
Capetta, S.21
Atchison, K.22
Hallgren, A.J.23
Miller, E.24
Wood, A.25
Obach, R.S.26
more..
-
6
-
-
0037009288
-
Indinavir analogues withblocked metabolism sites as HIV proteaseinhibitors with improved pharmacologicalprofiles and high potency against PIresistantviral strains.
-
Cheng, Y., Zhang, F., Rano, T.A., Lu, Z.,Scheif, W.A., Gabryelski, L., Olsen, D.B., Stahlhut, M., Rutkowski, C.A., Lin, J.H.,Jin, L., Emini, E.A., Chapman, K.T., andTata, J.R. (2002) Indinavir analogues withblocked metabolism sites as HIV proteaseinhibitors with improved pharmacologicalprofiles and high potency against PIresistantviral strains. Bioorg. Med. Chem.Lett., 12 (17), 2419-2422.
-
(2002)
Bioorg. Med. Chem.Lett.
, vol.12
, Issue.17
, pp. 2419-2422
-
-
Cheng, Y.1
Zhang, F.2
Rano, T.A.3
Lu, Z.4
Scheif, W.A.5
Gabryelski, L.6
Olsen, D.B.7
Stahlhut, M.8
Rutkowski, C.A.9
Lin, J.H.10
Jin, L.11
Emini, E.A.12
Chapman, K.T.13
Tata, J.R.14
-
7
-
-
0026521187
-
Benzazepinonecalcium channel blockers. 2. Structure-activity and drug metabolism studiesleading to potent antihypertensive agents.Comparison with benzothiazepinones.
-
Floyd, D.M., Kimball, S.D., Krapcho, J.,Das, J., Turk, C.F., Moquin, R.V., Lago, M.W., Duff, K.J., Lee, V.G., White, R.E.,Ridgewell, R.E., Moreland, S., Brittain,R.J., Normandin, D.E., Hedberg, S.A., andCucinotta, G.C. (1992) Benzazepinonecalcium channel blockers. 2. Structure-activity and drug metabolism studiesleading to potent antihypertensive agents.Comparison with benzothiazepinones. J.Med. Chem., 35 (4), 756-772.
-
(1992)
J.Med. Chem.
, vol.35
, Issue.4
, pp. 756-772
-
-
Floyd, D.M.1
Kimball, S.D.2
Krapcho, J.3
Das, J.4
Turk, C.F.5
Moquin, R.V.6
Lago, M.W.7
Duff, K.J.8
Lee, V.G.9
White, R.E.10
Ridgewell, R.E.11
Moreland, S.12
Brittain, R.J.13
Normandin, D.E.14
Hedberg, S.A.15
Cucinotta, G.C.16
-
8
-
-
0035038661
-
Metabolism offluorine-containing drugs.
-
Park, B.K., Kitteringham, N.R., andO'Neill, P.M. (2001) Metabolism offluorine-containing drugs. Annu. Rev.Pharmacol. Toxicol., 41, 443-470.
-
(2001)
Annu. Rev.Pharmacol. Toxicol.
, vol.41
, pp. 443-470
-
-
Park, B.K.1
Kitteringham, N.R.2
O'Neill, P.M.3
-
9
-
-
30744467708
-
The complexities inherent inattempts to decrease drug clearance byblocking sites of CYP-mediatedmetabolism.
-
Fisher, M.B., Henne, K.R., and Boer, J.(2006) The complexities inherent inattempts to decrease drug clearance byblocking sites of CYP-mediatedmetabolism. Curr. Opin. Drug Discov. Dev.,9 (1), 101-109.
-
(2006)
Curr. Opin. Drug Discov. Dev.
, vol.9
, Issue.1
, pp. 101-109
-
-
Fisher, M.B.1
Henne, K.R.2
Boer, J.3
-
10
-
-
53549094121
-
2,6-Diaryl-4-acylaminopyrimidines as potent andselective adenosine A2A antagonists withimproved solubility and metabolic stability.
-
Moorjani, M., Luo, Z., Lin, E., Vong, B.G.,Chen, Y., Zhang, X., Rueter, J.K., Gross,R.S., Lanier, M.C., Tellew, J.E., Williams,J.P., Lechner, S.M., Malany, S., Santos, M.,Crespo, M.I., Doaz, J.-L., Saunders, J., andSlee, D.H. (2008) 2,6-Diaryl-4-acylaminopyrimidines as potent andselective adenosine A2A antagonists withimproved solubility and metabolic stability. Bioorg. Med. Chem. Lett., 18 (20),5402-5405.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.20
, pp. 5402-5405
-
-
Moorjani, M.1
Luo, Z.2
Lin, E.3
Vong, B.G.4
Chen, Y.5
Zhang, X.6
Rueter, J.K.7
Gross, R.S.8
Lanier, M.C.9
Tellew, J.E.10
Williams, J.P.11
Lechner, S.M.12
Malany, S.13
Santos, M.14
Crespo, M.I.15
Doaz, J.-L.16
Saunders, J.17
Slee, D.H.18
-
11
-
-
70349645986
-
Structure-basedoptimization of arylamides as inhibitors ofsoluble epoxide hydrolase.
-
Eldrup, A.B., Soleymanzadeh, F., Taylor,S.J., Muegge, I., Farrow, N.A., Joseph, D.,McKellop, K., Man, C.C., Kukulka, A., andDe Lombaert, S. (2009) Structure-basedoptimization of arylamides as inhibitors ofsoluble epoxide hydrolase. J. Med. Chem.,52 (19), 5880-5895.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.19
, pp. 5880-5895
-
-
Eldrup, A.B.1
Soleymanzadeh, F.2
Taylor, S.J.3
Muegge, I.4
Joseph, D.5
McKellop, K.6
Man, C.C.7
Kukulka, A.8
De Lombaert, S.9
-
12
-
-
0037434510
-
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombininhibitors. Development of an orallybioavailable series containing P1 and P3pyridines.
-
Burgey, C.S., Robinson, K.A., Lyle, T.A.,Sanderson, P.E.J., Lewis, S.D., Lucas, B.J.,Krueger, J.A., Singh, R., Miller-Stein, C.,White, R.A., Wong, B., Lyle, E.A.,Williams, P.D., Coburn, C.A., Dorsey, B.D., Barrow, J.C., Stranieri, M.T., Holahan,M.A., Sitko, G.R., Cook, J.J., McMasters,D.R., McDonough, C.M., Sanders,W.M.,Wallace, A.A., Clayton, F.C., Bohn, D.,Leonard, Y.M., Detwiler, T.J., Jr., Lynch,J.J., Jr., Yan, Y., Chen, Z., Kuo, L., Gardell,S.J., Shafer, J.A., and Vacca, J.P. (2003)Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombininhibitors. Development of an orallybioavailable series containing P1 and P3pyridines. J. Med. Chem., 46 (4), 461-473.
-
(2003)
J. Med. Chem.
, vol.46
, Issue.4
, pp. 461-473
-
-
Burgey, C.S.1
Robinson, K.A.2
Lyle, T.A.3
Sanderson, P.E.J.4
Lewis, S.D.5
Lucas, B.J.6
Krueger, J.A.7
Singh, R.8
Miller-Stein, C.9
White, R.A.10
Wong, B.11
Lyle, E.A.12
Williams, P.D.13
Coburn, C.A.14
Dorsey, B.D.15
Barrow, J.C.16
Stranieri, M.T.17
Holahan, M.A.18
Sitko, G.R.19
Cook, J.J.20
McMasters, D.R.21
McDonough, C.M.22
Sanders, W.M.23
Wallace, A.A.24
Clayton, F.C.25
Bohn, D.26
Leonard, Y.M.27
Detwiler Jr, T.J.28
Lynch Jr, J.J.29
Yan, Y.30
Chen, Z.31
Kuo, L.32
Gardell, S.J.33
Shafer, J.A.34
Vacca, J.P.35
more..
-
13
-
-
0029975253
-
Metabolism and structure activity databased drug design: discovery of(-)-SCH53079, an analog of the potentcholesterol absorption inhibitor(-)-SCH48461.
-
Dugar, S., Yumibe, N., Clader, J.W.,Vizziano, M., Huie, K., Van Heek, M.,Compton, D.S., and Davis, H.R., Jr. (1996)Metabolism and structure activity databased drug design: discovery of(-)-SCH53079, an analog of the potentcholesterol absorption inhibitor(-)-SCH48461. Bioorg. Med. Chem. Lett., 6(11), 1271-1274.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, Issue.11
, pp. 1271-1274
-
-
Dugar, S.1
Yumibe, N.2
Clader, J.W.3
Vizziano, M.4
Huie, K.5
Van Heek, M.6
Compton, D.S.7
Davis Jr, H.R.8
-
14
-
-
0030567853
-
(-)-SCH 57939:synthesis and pharmacological propertiesof a potent, metabolically stablecholesterol absorption inhibitor.
-
Kirkup, M.P., Rizvi, R., Shanker, B.B.,Dugar, S., Clader, J.W., McCombie, S.W.,Lin, S.-I., Yumibe, N., Huie, K., Van Heek,M., Compton, D.S., Davis, H.R., Jr., andMcPhail, A.T. (1996) (-)-SCH 57939:synthesis and pharmacological propertiesof a potent, metabolically stablecholesterol absorption inhibitor. Bioorg.Med. Chem. Lett., 6 (17), 2069-2072.
-
(1996)
Bioorg.Med. Chem. Lett.
, vol.6
, Issue.17
, pp. 2069-2072
-
-
Kirkup, M.P.1
Rizvi, R.2
Shanker, B.B.3
Dugar, S.4
Clader, J.W.5
McCombie, S.W.6
Lin, S.-I.7
Yumibe, N.8
Huie, K.9
Van Heek, M.10
Compton, D.S.11
Davis Jr, H.R.12
McPhail, A.T.13
-
15
-
-
0032510318
-
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH58235): a designed, potent, orally activeinhibitor of cholesterol absorption.
-
Rosenblum, S.B., Huynh, T., Afonso, A.,Davis, H.R., Jr., Yumibe, N., Clader, J.W.,and Burnett, D.A. (1998) Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH58235): a designed, potent, orally activeinhibitor of cholesterol absorption. J. Med.Chem., 41 (6), 973-980.
-
(1998)
J. Med.Chem.
, vol.41
, Issue.6
, pp. 973-980
-
-
Rosenblum, S.B.1
Huynh, T.2
Afonso, A.3
Davis Jr, H.R.4
Yumibe, N.5
Clader, J.W.6
Burnett, D.A.7
-
16
-
-
13444266910
-
Synthesis and biological evaluation of the1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib).
-
Penning, T.D., Talley, J.J., Bertenshaw,S.R., Carter, J.S., Collins, P.W., Docter, S.,Graneto, M.J., Lee, L.F., Malecha, J.W.,Rogers, R.S., Rogier, D.J., Yu, S.S.,Anderson, G.D., Burton, E.G., Cogburn,J.N., Gregory, S.A., Koboldt, C.M.,Perkins, W.E., Seibert, K., Veenhuizen, A.W., Zhang, Y.Y., and Isakson, P.C. (1997)Synthesis and biological evaluation of the1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib). J. Med. Chem., 40 (9),1347-1365.
-
(1997)
J. Med. Chem.
, vol.40
, Issue.9
, pp. 1347-1365
-
-
Penning, T.D.1
Talley, J.J.2
Bertenshaw, S.R.3
Carter, J.S.4
Collins, P.W.5
Docter, S.6
Graneto, M.J.7
Lee, L.F.8
Malecha, J.W.9
Rogers, R.S.10
Rogier, D.J.11
Yu, S.S.12
Anderson, G.D.13
Burton, E.G.14
Cogburn, J.N.15
Gregory, S.A.16
Koboldt, C.M.17
Perkins, W.E.18
Seibert, K.19
Veenhuizen, A.W.20
Zhang, Y.Y.21
Isakson, P.C.22
more..
-
17
-
-
77956165653
-
Metabolism-guided design of short-actingcalcium-sensing receptor antagonists.
-
Southers, J.A., Bauman, J.N., Price, D.A.,Humphries, P.S., Balan, G., Sagal, J.F.,Maurer, T.S., Zhang, Y., Oliver, R., Herr,M., Healy, D.R., Li, M., Kapinos, B., Fate,G.D., Riccardi, K.A., Paralkar, V.M.,Brown, T.A., and Kalgutkar, A.S. (2010)Metabolism-guided design of short-actingcalcium-sensing receptor antagonists.ACS Med. Chem. Lett., 1, 219-223.
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 219-223
-
-
Southers, J.A.1
Bauman, J.N.2
Price, D.A.3
Humphries, P.S.4
Balan, G.5
Sagal, J.F.6
Maurer, T.S.7
Zhang, Y.8
Olive, R.9
Herr, M.10
Healy, D.R.11
Li, M.12
Kapinos, B.13
Fate, G.D.14
Riccardi, K.A.15
Paralkar, V.M.16
Brown, T.A.17
Kalgutkar, A.S.18
-
18
-
-
52249122619
-
Designing rapid onset selectiveserotonin re-uptake inhibitors. Part 3.Site-directed metabolism as a strategy toavoid active circulating metabolites:structure-activity relationships of(thioalkyl)phenoxy benzylamines.
-
Middleton, D.S., Andrews, M., Glossop,P., Gymer, G., Hepworth, D., Jessiman,A., Johnson, P.S., MacKenny, M., Stobie,A., Tang, K., Morgan, P., and Jones, B.(2008) Designing rapid onset selectiveserotonin re-uptake inhibitors. Part 3.Site-directed metabolism as a strategy toavoid active circulating metabolites:structure-activity relationships of(thioalkyl)phenoxy benzylamines. Bioorg.Med. Chem. Lett., 18 (19), 5303-5306.
-
(2008)
Bioorg.Med. Chem. Lett.
, vol.18
, Issue.19
, pp. 5303-5306
-
-
Middleton, D.S.1
Andrews, M.2
Glossop, P.3
Gymer, G.4
Hepworth, D.5
Jessiman, A.6
Johnson, P.S.7
MacKenny, M.8
Stobie, A.9
Tang, K.10
Morgan, P.11
Jones, B.12
-
19
-
-
72249086358
-
Discovery of azetidinyl ketolides forthe treatment of susceptible andmultidrug resistant community-acquiredrespiratory tract infections.
-
Magee, T.V., Ripp, S.L., Li, B., Buzon,R.A., Chupak, L., Dougherty, T.J., Finegan,S.M., Girard, D., Hagen, A.E., Falcone,M.J., Farley, K.A., Granskog, K., Hardink,J.R., Huband, M.D., Kamicker, B.J.,Kaneko, T., Knickerbocker, M.J., Liras,J.L., Marra, A., Medina, I., Nguyen, T.T.,Noe, M.C., Obach, R.S., O'Donnell, J.P.,Penzien, J.B., Reilly, U.D., Schafer, J.R.,Shen, Y., Stone, G.G., Strelevitz, T.J., Sun,J., Tait-Kamradt, A., Vaz, A.D., Whipple,D.A., Widlicka, D.W., Wishka, D.G.,Wolkowski, J.P., and Flanagan, M.E.(2009) Discovery of azetidinyl ketolides forthe treatment of susceptible andmultidrug resistant community-acquiredrespiratory tract infections. J. Med. Chem.,52 (23), 7446-7457.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.23
, pp. 7446-7457
-
-
Magee, T.V.1
Ripp, S.L.2
Li, B.3
Buzon, R.A.4
Chupak, L.5
Dougherty, T.J.6
Finegan, S.M.7
Girard, D.8
Hagen, A.E.9
Falcone, M.J.10
Farley, K.A.11
Granskog, K.12
Hardink, J.R.13
Huband, M.D.14
Kamicker, B.J.15
Kaneko, T.16
Knickerbocker, M.J.17
Liras, J.L.18
Marra, A.19
Medina, I.20
Nguyen, T.T.21
Noe, M.C.22
Obach, R.S.23
O'Donnell, J.P.24
Penzien, J.B.25
Reilly, U.D.26
Schafer, J.R.27
Shen, Y.28
Stone, G.G.29
Strelevitz, T.J.30
Sun, J.31
Tait-Kamradt, A.32
Vaz, A.D.33
Whipple, D.A.34
Widlicka, D.W.35
Wishka, D.G.36
Wolkowski, J.P.37
Flanagan, M.E.38
more..
-
20
-
-
80455173672
-
Systematic structuremodifications of imidazo[1,2-a]pyrimidineto reduce metabolism mediated byaldehyde oxidase (AO).
-
Linton, A., Kang, P., Ornelas, M., Kephart,S., Hu, Q., Pairish, M., Jiang, Y., and Guo,C. (2011) Systematic structuremodifications of imidazo[1,2-a]pyrimidineto reduce metabolism mediated byaldehyde oxidase (AO). J. Med. Chem., 54(21), 7705-7712.
-
(2011)
J. Med. Chem.
, vol.54
, Issue.21
, pp. 7705-7712
-
-
Linton, A.1
Kang, P.2
Ornelas, M.3
Kephart, S.4
Hu, Q.5
Pairish, M.6
Jiang, Y.7
Guo, C.8
-
21
-
-
0028353855
-
Characterization of the enzymeresponsible for the metabolism ofsumatriptan in human liver.
-
Dixon, C.M., Park, G.R., and Tarbit, M.H.(1994) Characterization of the enzymeresponsible for the metabolism ofsumatriptan in human liver. Biochem.Pharmacol., 47 (7), 1253-1257.
-
(1994)
Biochem.Pharmacol.
, vol.47
, Issue.7
, pp. 1253-1257
-
-
Dixon, C.M.1
Park, G.R.2
Tarbit, M.H.3
-
22
-
-
16444386701
-
Clinical pharmacokinetics of almotriptan,a serotonin 5-HT(1B/1D) receptor agonistfor the treatment of migraine.
-
McEnroe, J.D., and Fleishaker, J.C. (2005)Clinical pharmacokinetics of almotriptan,a serotonin 5-HT(1B/1D) receptor agonistfor the treatment of migraine. Clin.Pharmacokinet., 44 (3), 237-246.
-
(2005)
Clin.Pharmacokinet.
, vol.44
, Issue.3
, pp. 237-246
-
-
McEnroe, J.D.1
Fleishaker, J.C.2
-
23
-
-
18544394111
-
Dispositionand pharmacokinetics of the antimigrainedrug, rizatriptan, in humans.
-
Vyas, K.P., Halpin, R.A., Geer, L.A., Ellis,J.D., Liu, L., Cheng, H., Chavez-Eng, C.,Matuszewski, B.K., Varga, S.L., Guiblin,A.R., and Rogers, J.D. (2000) Dispositionand pharmacokinetics of the antimigrainedrug, rizatriptan, in humans. Drug Metab.Dispos., 28 (1), 89-95.
-
(2000)
Drug Metab.Dispos.
, vol.28
, Issue.1
, pp. 89-95
-
-
Vyas, K.P.1
Halpin, R.A.2
Geer, L.A.3
Ellis, J.D.4
Liu, L.5
Cheng, H.6
Chavez-Eng, C.7
Matuszewski, B.K.8
Varga, S.L.9
Guiblin, A.R.10
Rogers, J.D.11
-
24
-
-
0032878034
-
Determination of the humancytochrome P450 isoforms involved in themetabolism of zolmitriptan.
-
Wild, M.J., McKillop, D., and Butters, C.J.(1999) Determination of the humancytochrome P450 isoforms involved in themetabolism of zolmitriptan. Xenobiotica,29 (8), 847-857.
-
(1999)
Xenobiotica
, vol.29
, Issue.8
, pp. 847-857
-
-
Wild, M.J.1
McKillop, D.2
Butters, C.J.3
-
25
-
-
0037974639
-
Eletriptan metabolism by humanhepatic CYP450 enzymes and transport byhuman P-glycoprotein.
-
Evans, D.C., O'Conner, D., Lake, B.G.,Evers, R., Allen, C., and Hargreaves, R.(2003) Eletriptan metabolism by humanhepatic CYP450 enzymes and transport byhuman P-glycoprotein. Drug Metab.Dispos., 31 (7), 861-869.
-
(2003)
Drug Metab.Dispos.
, vol.31
, Issue.7
, pp. 861-869
-
-
Evans, D.C.1
O'Conner, D.2
Lake, B.G.3
Evers, R.4
Allen, C.5
Hargreaves, R.6
-
26
-
-
0036273441
-
Clinical pharmacokineticsof frovatriptan.
-
Buchan, P., Keywood, C., Wade, A., andWard, C. (2002) Clinical pharmacokineticsof frovatriptan. Headache, 42 (Suppl. 2),S54-S62.
-
(2002)
Headache
, vol.42
, Issue.2 SUPPL
-
-
Buchan, P.1
Keywood, C.2
Wade, A.3
Ward, C.4
-
27
-
-
0034524151
-
Triptans in migraine: acomparative review of pharmacology,pharmacokinetics and efficacy.
-
Tfelt-Hansen, P., De Vries, P., and Saxena,P.R. (2000) Triptans in migraine: acomparative review of pharmacology,pharmacokinetics and efficacy. Drugs, 60(6), 1259-1287.
-
(2000)
Drugs
, vol.60
, Issue.6
, pp. 1259-1287
-
-
Tfelt-Hansen, P.1
De Vries, P.2
Saxena, P.R.3
-
28
-
-
0035209568
-
The role ofhepatic and extrahepatic UDPglucuronosyltransferasesin human drugmetabolism.
-
Fisher, M.B., Paine, M.F., Strelevitz, T.J.,and Wrighton, S.A. (2001) The role ofhepatic and extrahepatic UDPglucuronosyltransferasesin human drugmetabolism. Drug Metab. Rev., 33 (3-4),273-297.
-
(2001)
Drug Metab. Rev.
, vol.33
, Issue.3-4
, pp. 273-297
-
-
Fisher, M.B.1
Paine, M.F.2
Strelevitz, T.J.3
Wrighton, S.A.4
-
29
-
-
41549125368
-
Structure, function andpolymorphism of human cytosolic sulfotransferases.
-
Lindsay, J., Wang, L.L., Li, Y., and Zhou,S.F. (2008) Structure, function andpolymorphism of human cytosolic sulfotransferases. Curr. Drug Metab., 9 (2),99-105.
-
(2008)
Curr. Drug Metab.
, vol.9
, Issue.2
, pp. 99-105
-
-
Lindsay, J.1
Wang, L.L.2
Li, Y.3
Zhou, S.F.4
-
30
-
-
0036320382
-
Phenolsulfotransferase, ST1A3, as the mainenzyme catalyzing sulfation oftroglitazone in human liver.
-
Honma,W., Shimada, M., Sasano, H.,Ozawa, S., Miyata, M., Nagata, K., Ikeda,T., and Yamazoe, Y. (2002) Phenolsulfotransferase, ST1A3, as the mainenzyme catalyzing sulfation oftroglitazone in human liver. Drug Metab.Dispos., 30 (8), 944-949.
-
(2002)
Drug Metab.Dispos.
, vol.30
, Issue.8
, pp. 944-949
-
-
Honma, W.1
Shimada, M.2
Sasano, H.3
Ozawa, S.4
Miyata, M.5
Nagata, K.6
Ikeda, T.7
Yamazoe, Y.8
-
31
-
-
13944258781
-
Synthesis andSAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f ][1,2,4]triazine based VEGFR-2kinase inhibitors.
-
Borzilleri, R.M., Cai, Z.W., Ellis, C.,Fargnoli, J., Fura, A., Gerhardt, T., Goyal,B., Hunt, J.T., Mortillo, S., Qian, L.,Tokarski, J., Vyas, V., Wautlet, B., Zheng,X., and Bhide, R.S. (2005) Synthesis andSAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f ][1,2,4]triazine based VEGFR-2kinase inhibitors. Bioorg. Med. Chem. Lett.,15 (5), 1429-1433.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, Issue.5
, pp. 1429-1433
-
-
Borzilleri, R.M.1
Cai, Z.W.2
Ellis, C.3
Fargnoli, J.4
Fura, A.5
Gerhardt, T.6
Goyal, B.7
Hunt, J.T.8
Mortillo, S.9
Qian, L.10
Tokarski, J.11
Vyas, V.12
Wautlet, B.13
Zheng, X.14
Bhide, R.S.15
-
32
-
-
15144342082
-
Structure-activity relationships ofN-hydroxyurea 5-lipoxygenase inhibitors.
-
Stewart, A.O., Bhatia, P.A., Martin, J.G.,Summers, J.B., Rodriques, K.E., Martin,M.B., Holms, J.H., Moore, J.L., Craig, R.A., Kolasa, T., Ratajczyk, J.D., Mazdiyasni,H., Kerdesky, F.A., DeNinno, S.L., Maki,R.G., Bouska, J.B., Young, P.R., Lanni, C.,Bell, R.L., Carter, G.W., and Brooks, C.D.(1997) Structure-activity relationships ofN-hydroxyurea 5-lipoxygenase inhibitors.J. Med. Chem., 40 (13), 1955-1968.
-
(1997)
J. Med. Chem.
, vol.40
, Issue.13
, pp. 1955-1968
-
-
Stewart, A.O.1
Bhatia, P.A.2
Martin, J.G.3
Summers, J.B.4
Rodriques, K.E.5
Martin, M.B.6
Holms, J.H.7
Moore, J.L.8
Craig, R.A.9
Kolasa, T.10
Ratajczyk, J.D.11
Mazdiyasni, H.12
Kerdesky, F.A.13
DeNinno, S.L.14
Maki, R.G.15
Bouska, J.B.16
Young, P.R.17
Lanni, C.18
Bell, R.L.19
Carter, G.W.20
Brooks, C.D.21
more..
-
33
-
-
0028807678
-
Pharmacokinetics andpharmacodynamics of zileuton after oraladministration of single and multipledose regimens of zileuton 600 mg inhealthy volunteers.
-
Awni, W.M., Braeckman, R.A.,Granneman, G.R., Witt, G., and Dube,L.M. (1995) Pharmacokinetics andpharmacodynamics of zileuton after oraladministration of single and multipledose regimens of zileuton 600 mg inhealthy volunteers. Clin. Pharmacokinet.,29 (Suppl. 2), 22-33.
-
(1995)
Clin. Pharmacokinet.
, vol.29
, Issue.2 SUPPL.
, pp. 22-33
-
-
Awni, W.M.1
Braeckman, R.A.2
Granneman, G.R.3
Witt, G.4
Dube, L.M.5
-
34
-
-
62249105894
-
A strategy for therisk assessment of human genotoxicmetabolites.
-
Dobo, K.L., Obach, R.S., Luffer-Atlas, D.,and Bercu, J.P. (2009) A strategy for therisk assessment of human genotoxicmetabolites. Chem. Res. Toxicol., 22 (2),348-356.
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 348-356
-
-
Dobo, K.L.1
Obach, R.S.2
Luffer-Atlas, D.3
Bercu, J.P.4
-
35
-
-
34548805504
-
Mechanism-based inactivationof cytochrome P450 enzymes: chemicalmechanisms, structure-activityrelationships and relationship to clinicaldrug-drug interactions and idiosyncraticadverse drug reactions.
-
Kalgutkar, A.S., Obach, R.S., and Maurer,T.S. (2007) Mechanism-based inactivationof cytochrome P450 enzymes: chemicalmechanisms, structure-activityrelationships and relationship to clinicaldrug-drug interactions and idiosyncraticadverse drug reactions. Curr. Drug Metab.,8 (5), 407-447.
-
(2007)
Curr. Drug Metab.
, vol.8
, Issue.5
, pp. 407-447
-
-
Kalgutkar, A.S.1
Obach, R.S.2
Maurer, T.S.3
-
36
-
-
80053004364
-
Structuralalert/reactive metabolite concept as applied in medicinal chemistry to mitigatethe risk of idiosyncratic drug toxicity: aperspective based on the criticalexamination of trends in the top 200 drugsmarketed in the United States.
-
Stepan, A.F.,Walker, D.P., Bauman, J.,Price, D.A., Baillie, T.A., Kalgutkar, A.S.,and Aleo, M.D. (2011) Structuralalert/reactive metabolite concept as applied in medicinal chemistry to mitigatethe risk of idiosyncratic drug toxicity: aperspective based on the criticalexamination of trends in the top 200 drugsmarketed in the United States. Chem. Res.Toxicol., 24 (9), 1345-1410.
-
(2011)
Chem. Res.Toxicol.
, vol.24
, Issue.9
, pp. 1345-1410
-
-
Stepan, A.F.1
Walker, D.P.2
Bauman, J.3
Price, D.A.4
Baillie, T.A.5
Kalgutkar, A.S.6
Aleo, M.D.7
-
37
-
-
79953314978
-
Managing thechallenge of chemical reactive metabolitesin drug development.
-
Park, B.K., Boobis, A., Clarke, S.,Goldring, C.E., Jones, D., Kenna, J.G.,Lambert, C., Laverty, H.G., Naisbitt, D.J.,Nelson, S., Nicoll-Griffith, D.A., Obach, R.S., Routledge, P., Smith, D.A., Tweedie, D.J., Vermeulen, N., Williams, D.P., Wilson,I.D., and Baillie, T.A. (2011) Managing thechallenge of chemical reactive metabolitesin drug development. Nat. Rev. DrugDiscov., 10 (4), 292-306.
-
(2011)
Nat. Rev. DrugDiscov.
, vol.10
, Issue.4
, pp. 292-306
-
-
Park, B.K.1
Boobis, A.2
Clarke, S.3
Goldring, C.E.4
Jones, D.5
Kenna, J.G.6
Lambert, C.7
Laverty, H.G.8
Naisbitt, D.J.9
Nelson, S.10
Nicoll-Griffith, D.A.11
Obach, R.S.12
Routledge, P.13
Smith, D.A.14
Tweedie, D.J.15
Vermeulen, N.16
Williams, D.P.17
Wilson, I.D.18
Baillie, T.A.19
-
38
-
-
37849042912
-
Minimizing metabolic activation duringpharmaceutical lead optimization:progress, knowledge gaps and futuredirections.
-
Kumar, S., Kassahun, K., Tschirret-Guth,R.A., Mitra, K., and Baillie, T.A. (2008)Minimizing metabolic activation duringpharmaceutical lead optimization:progress, knowledge gaps and futuredirections. Curr. Opin. Drug Discov. Dev.,11 (1), 43-52.
-
(2008)
Curr. Opin. Drug Discov. Dev.
, vol.11
, Issue.1
, pp. 43-52
-
-
Kumar, S.1
Kassahun, K.2
Tschirret-Guth, R.A.3
Mitra, K.4
Baillie, T.A.5
-
39
-
-
34047266790
-
Applying mechanisms of chemicaltoxicity to predict drug safety.
-
Guengerich, F.P. and MacDonald, J.S.(2007) Applying mechanisms of chemicaltoxicity to predict drug safety. Chem. Res.Toxicol., 20 (3), 344-369.
-
(2007)
Chem. Res.Toxicol.
, vol.20
, Issue.3
, pp. 344-369
-
-
Guengerich, F.P.1
MacDonald, J.S.2
-
40
-
-
34249103662
-
Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine,a novel 5-hydroxytryptamine 2C receptoragonist for the treatment of obesity: role ofmetabolic activation.
-
Kalgutkar, A.S., Dalvie, D.K., Aubrecht, J.,Smith, E.B., Coffing, S.L., Cheung, J.R.,Vage, C., Lame, M.E., Chiang, P.,McClure, K.F., Maurer, T.S., Coelho, R.V.,Jr., Soliman, V.F., and Schildknegt, K.(2007) Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine,a novel 5-hydroxytryptamine 2C receptoragonist for the treatment of obesity: role ofmetabolic activation. Drug Metab. Dispos.,35 (6), 848-858.
-
(2007)
Drug Metab. Dispos.
, vol.35
, Issue.6
, pp. 848-858
-
-
Kalgutkar, A.S.1
Dalvie, D.K.2
Aubrecht, J.3
Smith, E.B.4
Coffing, S.L.5
Cheung, J.R.6
Vage, C.7
Lame, M.E.8
Chiang, P.9
McClure, K.F.10
Maurer, T.S.11
Coelho Jr, R.V.12
Soliman, V.F.13
Schildknegt, K.14
-
41
-
-
61349145768
-
Biochemical basis fordifferences in metabolism-dependentgenotoxicity by two diazinylpiperazinebased5-HT2C receptor agonists.
-
Kalgutkar, A.S., Bauman, J.N., McClure,K.F., Aubrecht, J., Cortina, S.R., andParalkar, J. (2009) Biochemical basis fordifferences in metabolism-dependentgenotoxicity by two diazinylpiperazinebased5-HT2C receptor agonists. Bioorg.Med. Chem. Lett., 19 (6), 1559-1563.
-
(2009)
Bioorg.Med. Chem. Lett.
, vol.19
, Issue.6
, pp. 1559-1563
-
-
Kalgutkar, A.S.1
Bauman, J.N.2
McClure, K.F.3
Aubrecht, J.4
Cortina, S.R.5
Paralkar, J.6
-
42
-
-
79960504825
-
Overcoming the genotoxicityof a pyrrolidine substitutedarylindenopyrimidine as a potent dualadenosine A2A/A1 antagonist by minimizing bioactivation to an iminiumion reactive intermediate.
-
Lim, H.-K., Chen, J., Sensenhauser, C.,Cook, K., Preston, R., Thomas, T., Shook,B., Jackson, P.F., Rassnick, S., Rhodes, K.,Gopaul, V., Salter, R., Silva, J., and Evans,D.C. (2011) Overcoming the genotoxicityof a pyrrolidine substitutedarylindenopyrimidine as a potent dualadenosine A2A/A1 antagonist by minimizing bioactivation to an iminiumion reactive intermediate. Chem. Res.Toxicol., 24 (7), 1012-1030.
-
(2011)
Chem. Res.Toxicol.
, vol.24
, Issue.7
, pp. 1012-1030
-
-
Lim, H.-K.1
Chen, J.2
Sensenhauser, C.3
Cook, K.4
Preston, R.5
Thomas, T.6
Shook, B.7
Jackson, P.F.8
Rassnick, S.9
Rhodes, K.10
Gopaul, V.11
Salter, R.12
Silva, J.13
Evans, D.C.14
-
43
-
-
0037369622
-
Apparent mechanism-basedinhibition of human CYP2D6 in vitro byparoxetine: comparison with fluoxetineand quinidine.
-
Bertelsen, K.M., Venkatakrishnan, K., VonMoltke, L.L., Obach, R.S., and Greenblatt,D.J. (2003) Apparent mechanism-basedinhibition of human CYP2D6 in vitro byparoxetine: comparison with fluoxetineand quinidine. Drug Metab. Dispos., 31 (3),289-293.
-
(2003)
Drug Metab. Dispos.
, vol.31
, Issue.3
, pp. 289-293
-
-
Bertelsen, K.M.1
Venkatakrishnan, K.2
VonMoltke, L.L.3
Obach, R.S.4
Greenblatt, D.J.5
-
44
-
-
0034232506
-
Mechanisms ofinhibitory and regulatory effects ofmethylenedioxyphenyl compounds oncytochrome P450-dependent drugoxidation.
-
Murray, M. (2000) Mechanisms ofinhibitory and regulatory effects ofmethylenedioxyphenyl compounds oncytochrome P450-dependent drugoxidation. Curr. Drug Metab., 1 (1), 67-84.
-
(2000)
Curr. Drug Metab.
, vol.1
, Issue.1
, pp. 67-84
-
-
Murray, M.1
-
45
-
-
0024435503
-
Metabolicpathways of paroxetine in animals andman and the comparative pharmacologicalproperties of its metabolites.
-
Haddock, R.E., Johnson, A.M., Langley, P.F., Nelson, D.R., Pope, J.A., Thomas, D.R., and Woods, F.R. (1989) Metabolicpathways of paroxetine in animals andman and the comparative pharmacologicalproperties of its metabolites. ActaPsychiatr. Scand. Suppl., 350, 24-26.
-
(1989)
ActaPsychiatr. Scand. Suppl.
, vol.350
, pp. 24-26
-
-
Haddock, R.E.1
Johnson, A.M.2
Langley, P.F.3
Nelson, D.R.4
Pope, J.A.5
Thomas, D.R.6
Woods, F.R.7
-
46
-
-
37249018714
-
NADPH-dependent covalent binding of[3H]paroxetine to human livermicrosomes and S-9 fractions:identification of an electrophilic quinonemetabolite of paroxetine.
-
Zhao, S.X., Dalvie, D.K., Kelly, J.M.,Soglia, J.R., Frederick, K.S., Smith, E.B.,Obach, R.S., and Kalgutkar, A.S. (2007)NADPH-dependent covalent binding of[3H]paroxetine to human livermicrosomes and S-9 fractions:identification of an electrophilic quinonemetabolite of paroxetine. Chem. Res.Toxicol., 20 (11), 1649-1657.
-
(2007)
Chem. Res.Toxicol.
, vol.20
, Issue.11
, pp. 1649-1657
-
-
Zhao, S.X.1
Dalvie, D.K.2
Kelly, J.M.3
Soglia, J.R.4
Frederick, K.S.5
Smith, E.B.6
Obach, R.S.7
Kalgutkar, A.S.8
-
47
-
-
0024434806
-
A review of themetabolism and pharmacokinetics ofparoxetine in man.
-
Kaye, C.M., Haddock, R.E., Langley, P.F.,Mellows, G., Tasker, T.C., Zussman, B.D.,and Greb, W.H. (1989) A review of themetabolism and pharmacokinetics ofparoxetine in man. Acta Psychiatr. Scand.Suppl., 350, 60-75.
-
(1989)
Acta Psychiatr. Scand.Suppl.
, vol.350
, pp. 60-75
-
-
Kaye, C.M.1
Haddock, R.E.2
Langley, P.F.3
Mellows, G.4
Tasker, T.C.5
Zussman, B.D.6
Greb, W.H.7
-
48
-
-
0008803827
-
Paroxetineaffects metoprolol pharmacokinetics andpharmacodynamics in healthy volunteers.
-
Hemeryck, A., Lefebyre, R.A., De Vriendt,C., and Belpaire, F.M. (2000) Paroxetineaffects metoprolol pharmacokinetics andpharmacodynamics in healthy volunteers.Clin. Pharmacol. Ther., 67 (3), 283-291.
-
(2000)
Clin. Pharmacol. Ther.
, vol.67
, Issue.3
, pp. 283-291
-
-
Hemeryck, A.1
Lefebyre, R.A.2
De Vriendt, C.3
Belpaire, F.M.4
-
49
-
-
0035012610
-
Plasma concentrations ofrisperidone and 9-hydroxyrisperidoneduring combined treatment withparoxetine.
-
Spina, E., Avenoso, A., Facciola, G.,Scordo, M.G., Ancione, M., and Madia, A.(2001) Plasma concentrations ofrisperidone and 9-hydroxyrisperidoneduring combined treatment withparoxetine. Ther. Drug Monit., 23 (3),223-227.
-
(2001)
Ther. Drug Monit.
, vol.23
, Issue.3
, pp. 223-227
-
-
Spina, E.1
Avenoso, A.2
Facciola, G.3
Scordo, M.G.4
Ancione, M.5
Madia, A.6
-
50
-
-
0036838952
-
Effect of potentCYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics.
-
Belle, D.J., Ernest, C.S., Sauer, J.M.,Smith, B.P., Thomasson, H.R., andWitcher, J.W. (2002) Effect of potentCYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics. J. Clin.Pharmacol., 42 (11), 1219-1227.
-
(2002)
J. Clin.Pharmacol.
, vol.42
, Issue.11
, pp. 1219-1227
-
-
Belle, D.J.1
Ernest, C.S.2
Sauer, J.M.3
Smith, B.P.4
Thomasson, H.R.5
Witcher, J.W.6
-
51
-
-
76149083688
-
Heavy-hydrogen drugsturn heads again.
-
Yarnell, A.T. (2009) Heavy-hydrogen drugsturn heads, again. Chem. Eng. News, 87(25), 36-39.
-
(2009)
Chem. Eng. News
, vol.87
, Issue.25
, pp. 36-39
-
-
Yarnell, A.T.1
-
52
-
-
71749100944
-
Therapeutic targeting of the focaladhesion complex prevents oncogenicTGF-beta signaling and metastasis.
-
Wendt, M.K., and Schiemann, W.P. (2009)Therapeutic targeting of the focaladhesion complex prevents oncogenicTGF-beta signaling and metastasis. BreastCancer Res., 11 (5), R68.
-
(2009)
BreastCancer Res.
, vol.11
, Issue.5
-
-
Wendt, M.K.1
Schiemann, W.P.2
-
53
-
-
55549143963
-
Trifluoromethylpyrimidine-basedinhibitors of proline-rich tyrosinekinase 2 (PYK2): structure-activityrelationships and strategies for theelimination of reactive metaboliteformation.
-
Walker, D.P., Bi, F.C., Kalgutkar, A.S.,Bauman, J.N., Zhao, S.X., Soglia, J.R.,Aspnes, G.E., Kung, D.W., Klug-McLeod, J., Zawistoski, M.P., McGlynn,M.A., Oliver, R., Dunn, M., Li, J.C.,Richter, D.T., Cooper, B.A., Kath, J.C.,Hulford, C.A., Autry, C.L., Luzzio, M.J.,Ung, E.J., Roberts, W.G., Bonnette,P.C., Buckbinder, L., Mistry, A., Griffor,M.C., Han, S., and Guzman-Perez, A.(2008) Trifluoromethylpyrimidine-basedinhibitors of proline-rich tyrosinekinase 2 (PYK2): structure-activityrelationships and strategies for theelimination of reactive metaboliteformation. Bioorg. Med. Chem. Lett., 18(23), 6071-6077.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.23
, pp. 6071-6077
-
-
Walker, D.P.1
Bi, F.C.2
Kalgutkar, A.S.3
Bauman, J.N.4
Zhao, S.X.5
Soglia, J.R.6
Aspnes, G.E.7
Kung, D.W.8
Klug-McLeod, J.9
Zawistoski, M.P.10
McGlynn, M.A.11
Oliver, R.12
Dunn, M.13
Li, J.C.14
Richter, D.T.15
Cooper, B.A.16
Kath, J.C.17
Hulford, C.A.18
Autry, C.L.19
Luzzio, M.J.20
Ung, E.J.21
Roberts, W.G.22
Bonnette, P.C.23
Buckbinder, L.24
Mistry, A.25
Griffor, M.C.26
Han, S.27
Guzman-Perez, A.28
more..
-
54
-
-
20644455122
-
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic:application in the synthesis of potenthuman melanocortin-4 receptor selectiveagonists.
-
Bakshi, R.K., Hong, Q., Olson, J.T., Ye, Z.,Sebhat, I.K.,Weinberg, D.H., MacNeil, T.,Kalyani, R.N., Tang, R., Martin, W.J.,Strack, A., McGowan, E., Tamvakopoulos,C., Miller, R.R., Stearns, R.A., Tang, W.,MacIntyre, D.E., van der Ploeg, L.H.T.,Patchett, A.A., and Nargund, R.P. (2005)1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic:application in the synthesis of potenthuman melanocortin-4 receptor selectiveagonists. Bioorg. Med. Chem. Lett., 15 (14),3430-3433.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, Issue.14
, pp. 3430-3433
-
-
Bakshi, R.K.1
Hong, Q.2
Olson, J.T.3
Ye, Z.4
Sebhat, I.K.5
Weinberg, D.H.6
MacNeil, T.7
Kalyani, R.N.8
Tang, R.9
Martin, W.J.10
Strack, A.11
McGowan, E.12
Tamvakopoulos, C.13
Miller, R.R.14
Stearns, R.A.15
Tang, W.16
MacIntyre, D.E.17
van der Ploeg, L.H.T.18
Patchett, A.A.19
Nargund, R.P.20
more..
-
55
-
-
55549119262
-
Assessing and minimizingtime-dependent inhibition of cytochromeP450 3A in drug discovery: a case studywith melanocortin-4 receptor agonists.
-
Tang, W., Stearns, R.A., Wang, R.W.,Miller, R.R., Chen, Q., Ngui, J., Bakshi, R.K., Nargund, R.P., Dean, D.C., and Baillie,T.A. (2008) Assessing and minimizingtime-dependent inhibition of cytochromeP450 3A in drug discovery: a case studywith melanocortin-4 receptor agonists.Xenobiotica, 38 (11), 1437-1451.
-
(2008)
Xenobiotica
, vol.38
, Issue.11
, pp. 1437-1451
-
-
Tang, W.1
Stearns, R.A.2
Wang, R.W.3
Miller, R.R.4
Chen, Q.5
Ngui, J.6
Bakshi, R.K.7
Nargund, R.P.8
Dean, D.C.9
Baillie, T.A.10
-
56
-
-
57449099296
-
Chemicalreactivity of methoxy 4-o-aryl quinolines:identification of glutathione displacement products in vitro and in vivo.
-
Teffera, Y., Colletti, A.E., Harmange, J.C.,Hollis, L.S., Albrecht, B.K., Boezio, A.A.,Liu, J., and Zhao, Z. (2008) Chemicalreactivity of methoxy 4-o-aryl quinolines:identification of glutathione displacement products in vitro and in vivo. Chem. Res.Toxicol., 21 (11), 2216-2222.
-
(2008)
Chem. Res.Toxicol.
, vol.21
, Issue.11
, pp. 2216-2222
-
-
Teffera, Y.1
Colletti, A.E.2
Harmange, J.C.3
Hollis, L.S.4
Albrecht, B.K.5
Boezio, A.A.6
Liu, J.7
Zhao, Z.8
-
57
-
-
65749097886
-
Pyridones asglucokinase activators: identification of aunique metabolic liability of the4-sulfonyl-2-pyridone heterocycle.
-
Pfefferkorn, J.A., Lou, J., Minich, M.L.,Filipski, K.J., He, M., Zhou, R., Ahmed,S., Benbow, J., Perez, A.G., Tu, M.,Litchfield, J., Sharma, R., Metzler, K.,Bourbonais, F., Huang, C., Beebe, D.A.,and Oates, P.J. (2009) Pyridones asglucokinase activators: identification of aunique metabolic liability of the4-sulfonyl-2-pyridone heterocycle. Bioorg.Med. Chem. Lett., 19 (12), 3247-3252.
-
(2009)
Bioorg.Med. Chem. Lett.
, vol.19
, Issue.12
, pp. 3247-3252
-
-
Pfefferkorn, J.A.1
Lou, J.2
Minich, M.L.3
Filipski, K.J.4
He, M.5
Zhou, R.6
Ahmed, S.7
Benbow, J.8
Perez, A.G.9
Tu, M.10
Litchfield, J.11
Sharma, R.12
Metzler, K.13
Bourbonais, F.14
Huang, C.15
Beebe, D.A.16
Oates, P.J.17
-
58
-
-
77957879376
-
Intrinsicelectrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinaseactivators: role of glutathione-Stransferasesand in vivo quantitation of aglutathione conjugate in rats.
-
Litchfield, J., Sharma, R., Atkinson, K.,Filipski, K.J., Wright, S.W., Pfefferkorn, J.A., Tan, B., Kosa, R.E., Stevens, B., Tu, M.,and Kalgutkar, A.S. (2010) Intrinsicelectrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinaseactivators: role of glutathione-Stransferasesand in vivo quantitation of aglutathione conjugate in rats. Bioorg. Med.Chem. Lett., 20 (21), 6262-6267.
-
(2010)
Bioorg. Med.Chem. Lett.
, vol.20
, Issue.21
, pp. 6262-6267
-
-
Litchfield, J.1
Sharma, R.2
Atkinson, K.3
Filipski, K.J.4
Wright, S.W.5
Pfefferkorn, J.A.6
Tan, B.7
Kosa, R.E.8
Stevens, B.9
Tu, M.10
Kalgutkar, A.S.11
-
59
-
-
80052381675
-
Designingglucokinase activators with reducedhypoglycemia risk: discovery of N,Ndimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinicalcandidate for the treatment of type 2diabetes mellitus.
-
Pfefferkorn, J.A., Guzman-Perez, A.,Oates, P.J., Litchfield, J., Aspnes, G.,Basak, A., Benbow, J., Berliner, M.A.,Bian, J., Choi, C., Freeman-Cook, K.,Corbett, J.W., Didiuk, M., Dunetz, J.R.,Filipski, K.J., Hungerford,W.M., Jones,C.S., Karki, K., Ling, A., Li, J.-C., Patel, L.,Perreault, C., Risley, H., Saenz, J., Song,W., Tu, M., Aiello, R., Atkinson, K.,Barucci, N., Beebe, D., Bourassa, P.,Bourbounais, F., Brodeur, A.M., Burbey,R., Chen, J., D'Aquila, T., Derksen, D.R.,Haddish-Berhane, N., Huang, C., Landro,J., Lapworth, A.L., MacDougall, M.,Perregaux, D., Pettersen, J., Robertson, A.,Tan, B., Treadway, J.L., Liu, S., Qiu, X.,Knafels, J., Ammirati, M., Song, X.,DaSilva-Jardine, P., Liras, S., Sweet, L.,and Rolph, T.P. (2011) Designingglucokinase activators with reducedhypoglycemia risk: discovery of N,Ndimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinicalcandidate for the treatment of type 2diabetes mellitus. Med. Chem. Commun.,2, 828-839.
-
(2011)
Med. Chem. Commun.
, vol.2
, pp. 828-839
-
-
Pfefferkorn, J.A.1
Guzman-Perez, A.2
Oates, P.J.3
Litchfield, J.4
Aspnes, G.5
Basak, A.6
Benbow, J.7
Berliner, M.A.8
Bian, J.9
Choi, C.10
Freeman-Cook, K.11
Corbett, J.W.12
Didiuk, M.13
Dunetz, J.R.14
Filipski, K.J.15
Hungerford, W.M.16
Jones, C.S.17
Karki, K.18
Ling, A.19
Li, J.-C.20
Patel, L.21
Perreault, C.22
Risley, H.23
Saenz, J.24
Song, W.25
Tu, M.26
Aiello, R.27
Atkinson, K.28
Barucci, N.29
Beebe, D.30
Bourassa, P.31
Bourbounais, F.32
Brodeur, A.M.33
Burbey, R.34
Chen, J.35
D'Aquila, T.36
Derksen, D.R.37
Haddish-Berhane, N.38
Huang, C.39
Landro, J.40
Lapworth, A.L.41
MacDougall, M.42
Perregaux, D.43
Pettersen, J.44
Robertson, A.45
Tan, B.46
Treadway, J.L.47
Liu, S.48
Qiu, X.49
Knafels, J.50
Ammirati, M.51
Song, X.52
DaSilva-Jardine, P.53
Liras, S.54
Sweet, L.55
Rolph, T.P.56
more..
-
60
-
-
33747834655
-
Role ofinnate immunity in acetaminopheninducedhepatotoxicity.
-
Liu, Z.X., and Kaplowitz, N. (2006) Role ofinnate immunity in acetaminopheninducedhepatotoxicity. Expert Opin. DrugMetab. Toxicol., 2 (4), 493-503.
-
(2006)
Expert Opin. DrugMetab. Toxicol.
, vol.2
, Issue.4
, pp. 493-503
-
-
Liu, Z.X.1
Kaplowitz, N.2
-
61
-
-
0021345926
-
N-Acetyl-pbenzoquinoneimine: a cytochrome P-450-mediated oxidation product ofacetaminophen.
-
Dahlin, D.C., Miwa, G.T., Lu, A.Y., andNelson, S.D. (1984) N-Acetyl-pbenzoquinoneimine: a cytochrome P-450-mediated oxidation product ofacetaminophen. Proc. Natl. Acad. Sci.USA, 81 (5), 1327-1331.
-
(1984)
Proc. Natl. Acad. Sci.USA
, vol.81
, Issue.5
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
62
-
-
70350273017
-
Structural alerts, reactive metabolites, andprotein covalent binding: how reliable arethese attributes as predictors of drugtoxicity.
-
Kalgutkar, A.S., and Didiuk, M.T. (2009)Structural alerts, reactive metabolites, andprotein covalent binding: how reliable arethese attributes as predictors of drugtoxicity. Chem. Biodivers., 6 (11),2115-2137.
-
(2009)
Chem. Biodivers.
, vol.6
, Issue.11
, pp. 2115-2137
-
-
Kalgutkar, A.S.1
Didiuk, M.T.2
-
63
-
-
0013677025
-
Metabolism ofclozapine by neutrophils. Possibleimplications for clozapine-inducedagranulocytosis.
-
Uetrecht, J.P. (1992) Metabolism ofclozapine by neutrophils. Possibleimplications for clozapine-inducedagranulocytosis. Drug Saf., 7 (Suppl. 1),51-56.
-
(1992)
Drug Saf.
, vol.7
, Issue.1 SUPPL
, pp. 51-56
-
-
Uetrecht, J.P.1
-
64
-
-
0031814439
-
Acomparison of the covalent binding ofclozapine and olanzapine to humanneutrophils in vitro and in vivo.
-
Gardner, I., Leeder, J.S., Chin, T., Zahid,N., and Uetrecht, J.P. (1998) Acomparison of the covalent binding ofclozapine and olanzapine to humanneutrophils in vitro and in vivo. Mol.Pharmacol., 53 (6), 999-1008.
-
(1998)
Mol.Pharmacol.
, vol.53
, Issue.6
, pp. 999-1008
-
-
Gardner, I.1
Leeder, J.S.2
Chin, T.3
Zahid, N.4
Uetrecht, J.P.5
-
65
-
-
0030913557
-
Structural featuresassociated with reactive metaboliteformation with clozapine analogues.
-
Uetrecht, J., Zahid, N., Tehim, A., Fu, J.M.,and Rakhit, S. (1997) Structural featuresassociated with reactive metaboliteformation with clozapine analogues. Chem.Biol. Interact., 104 (2-3), 117-129.
-
(1997)
Chem.Biol. Interact.
, vol.104
, Issue.2-3
, pp. 117-129
-
-
Uetrecht, J.1
Zahid, N.2
Tehim, A.3
Fu, J.M.4
Rakhit, S.5
-
66
-
-
53549107196
-
In vitrometabolism and covalent binding of enolcarboxamidederivatives and antiinflammatoryagents sudoxicam andmeloxicam: insights into thehepatotoxicity of sudoxicam.
-
Obach, R.S., Kalgutkar, A.S., Ryder, T.F.,and Walker, G.S. (2008) In vitrometabolism and covalent binding of enolcarboxamidederivatives and antiinflammatoryagents sudoxicam andmeloxicam: insights into thehepatotoxicity of sudoxicam. Chem. Res.Toxicol., 21 (9), 1890-1899.
-
(2008)
Chem. Res.Toxicol.
, vol.21
, Issue.9
, pp. 1890-1899
-
-
Obach, R.S.1
Kalgutkar, A.S.2
Ryder, T.F.3
Walker, G.S.4
-
67
-
-
72249097682
-
Astrategy to minimize reactive metaboliteformation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent orally bioavailablecorticotropin-releasing factor-1 receptorantagonist.
-
Hartz, R.A., Ahuja, V.T., Zhuo, X.,Mattson, R.J., Denhart, D.J., Deskus, J.A.,Vrudhula, V.M., Pan, S., Ditta, J.L., Shu, Y.Z., Grace, J.E., Lentz, K.A., Lelas, S., Li, Y.W., Molski, T.F., Krishnananthan, S.,Wong, H., Qian-Cutrone, J., Schartman,R., Denton, R., Lodge, N.J., Zaczek, R.,Macor, J.E., and Bronson, J.J. (2009) Astrategy to minimize reactive metaboliteformation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailablecorticotropin-releasing factor-1 receptorantagonist. J. Med. Chem., 52 (23),7653-7668.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.23
, pp. 7653-7668
-
-
Hartz, R.A.1
Ahuja, V.T.2
Zhuo, X.3
Mattson, R.J.4
Denhart, D.J.5
Deskus, J.A.6
Vrudhula, V.M.7
Pan, S.8
Ditta, J.L.9
Shu, Y.Z.10
Grace, J.E.11
Lentz, K.A.12
Lelas, S.13
Li, Y.W.14
Molski, T.F.15
Krishnananthan, S.16
Wong, H.17
Qian-Cutrone, J.18
Schartman, R.19
Denton, R.20
Lodge, N.J.21
Zaczek, R.22
Macor, J.E.23
Bronson, J.J.24
more..
-
68
-
-
73149095594
-
Comparativebiotransformation of pyrazinonecontainingcorticotropin-releasing factorreceptor-1 antagonists: minimizing thereactive metabolite formation.
-
Zhuo, X., Hartz, R.A., Bronson, J.J.,Wong, H., Ahuja, V.T., Vrudhula, V.M.,Leet, J.E., Huang, S., Macor, J.E., and Shu,Y.Z. (2010) Comparativebiotransformation of pyrazinonecontainingcorticotropin-releasing factorreceptor-1 antagonists: minimizing thereactive metabolite formation. DrugMetab. Dispos., 38 (1), 5-15.
-
(2010)
DrugMetab. Dispos.
, vol.38
, Issue.1
, pp. 5-15
-
-
Zhuo, X.1
Hartz, R.A.2
Bronson, J.J.3
Wong, H.4
Ahuja, V.T.5
Vrudhula, V.M.6
Leet, J.E.7
Huang, S.8
Macor, J.E.9
Shu, Y.Z.10
-
69
-
-
38149063929
-
A rational chemicalintervention strategy to circumventbioactivation liabilities associated with anonpeptidyl thrombopoietin receptoragonist containing a 2-amino-4-arylthiazole motif.
-
Kalgutkar, A.S., Driscoll, J., Zhao, S.X.,Walker, G.S., Shepard, R.M., Soglia, J.R.,Atherton, J., Yu, Li., Mutlib, A.E.,Munchhof, M.J., Reiter, L.A., Jones, C.S.,Doty, J.L., Trevena, K.A., Shaffer, C.L., andRipp, S.L. (2007) A rational chemicalintervention strategy to circumventbioactivation liabilities associated with anonpeptidyl thrombopoietin receptoragonist containing a 2-amino-4-arylthiazole motif. Chem. Res. Toxicol., 20(12), 1954-1965.
-
(2007)
Chem. Res. Toxicol.
, vol.20
, Issue.12
, pp. 1954-1965
-
-
Kalgutkar, A.S.1
Driscoll, J.2
Zhao, S.X.3
Walker, G.S.4
Shepard, R.M.5
Soglia, J.R.6
Atherton, J.7
Yu, L.8
Mutlib, A.E.9
Munchhof, M.J.10
Reiter, L.A.11
Jones, C.S.12
Doty, J.L.13
Trevena, K.A.14
Shaffer, C.L.15
Ripp, S.L.16
-
70
-
-
77953872914
-
Structure-activity relationships and hepatic safetyrisks of thiazole agonists of thethrombopoietin receptor.
-
Antipas, A.S., Blumberg, L.C., Brissette,W.H., Brown, M.F., Casavant, J.M., Doty,J.L., Driscoll, J., Harris, T.M., Jones, C.S.,McCurdy, S.P., McElroy, E., Mitton-Fry,M., Munchhof, M.J., Reim, D.A., Reiter, L.A., Ripp, S.L., Shavnya, A., Smeets, M.I.,and Trevena, K.A. (2010) Structure-activity relationships and hepatic safetyrisks of thiazole agonists of thethrombopoietin receptor. Bioorg. Med.Chem. Lett., 20 (14), 4069-4072.
-
(2010)
Bioorg. Med.Chem. Lett.
, vol.20
, Issue.14
, pp. 4069-4072
-
-
Antipas, A.S.1
Blumberg, L.C.2
Brissette, W.H.3
Brown, M.F.4
Casavant, J.M.5
Doty, J.L.6
Driscoll, J.7
Harris, T.M.8
Jones, C.S.9
McCurdy, S.P.10
McElroy, E.11
Mitton-Fry, M.12
Munchhof, M.J.13
Reim, D.A.14
Reiter, L.A.15
Ripp, S.L.16
Shavnya, A.17
Smeets, M.I.18
Trevena, K.A.19
-
71
-
-
0028802468
-
Thebioactivation of amodiaquine by humanpolymorphonuclear leucocytes in vitro:chemical mechanisms and the effects offluorine substitution.
-
Tingle, M.D., Jewell, H., Maggs, J.L.,O'Neill, P.M., and Park, B.K. (1995) Thebioactivation of amodiaquine by humanpolymorphonuclear leucocytes in vitro:chemical mechanisms and the effects offluorine substitution. Biochem.Pharmacol., 50 (7), 1113-1119.
-
(1995)
Biochem.Pharmacol.
, vol.50
, Issue.7
, pp. 1113-1119
-
-
Tingle, M.D.1
Jewell, H.2
Maggs, J.L.3
O'Neill, P.M.4
Park, B.K.5
-
72
-
-
0023855476
-
Drug-proteinconjugates. 14. Mechanisms of formationof protein-arylating intermediates fromamodiaquine a myelotoxin andhepatotoxin in man.
-
Maggs, J.L., Tingle, M.D., Kitteringham,N.R., and Park, B.K. (1988) Drug-proteinconjugates. 14. Mechanisms of formationof protein-arylating intermediates fromamodiaquine, a myelotoxin andhepatotoxin in man. Biochem. Pharmacol.,37 (2), 303-311.
-
(1988)
Biochem. Pharmacol.
, vol.37
, Issue.2
, pp. 303-311
-
-
Maggs, J.L.1
Tingle, M.D.2
Kitteringham, N.R.3
Park, B.K.4
-
73
-
-
0028802468
-
Thebioactivation of amodiaquine by humanpolymorphonuclear leucocytes in vitro:chemical mechanisms and the effects offluorine substitution.
-
Tingle, M.D., Jewell, H., Maggs, J.L.,O'Neill, P.M., and Park, B.K. (1995) Thebioactivation of amodiaquine by humanpolymorphonuclear leucocytes in vitro:chemical mechanisms and the effects offluorine substitution. Biochem.Pharmacol., 50 (7), 1113-1119.
-
(1995)
Biochem.Pharmacol.
, vol.50
, Issue.7
, pp. 1113-1119
-
-
Tingle, M.D.1
Jewell, H.2
Maggs, J.L.3
O'Neill, P.M.4
Park, B.K.5
-
74
-
-
0028307644
-
The effect of fluorine substitutionon the metabolism and antimalarialactivity of amodiaquine.
-
O'Neill, P.M., Harrison, A.C., Storr, R.C.,Hawley, S.R., Ward, S.A., and Park, B.K.(1994) The effect of fluorine substitutionon the metabolism and antimalarialactivity of amodiaquine. J. Med. Chem., 37(9), 1362-1370.
-
(1994)
J. Med. Chem.
, vol.37
, Issue.9
, pp. 1362-1370
-
-
O'Neill, P.M.1
Harrison, A.C.2
Storr, R.C.3
Hawley, S.R.4
Ward, S.A.5
Park, B.K.6
-
75
-
-
64549138445
-
Synthesis, antimalarial activity, andpreclinical pharmacology of a novel seriesof 40-fluoro and 40-chloro analogues ofamodiaquine. Identification of a suitable"back-up" compound for N-tert-butylisoquine.
-
O'Neill, P.M., Shone, A.E., Stanford, D.,Nixon, G., Asadollahy, E., Park, B.K.,Maggs, J.L., Roberts, P., Stocks, P.A.,Biagini, G., Bray, P.G., Davies, J., Berry,N., Hall, C., Rimmer, K., Winstanley, P.A.,Hindley, S., Bambal, R.B., Davis, C.B.,Bates, M., Gresham, S.L., Brigandi, R.A.,Gomez-de-Las-Heras, F.M., Gargallo, D.V., Parapini, S., Vivas, L., Lander, H.,Taramelli, D., and Ward, S.A. (2009)Synthesis, antimalarial activity, andpreclinical pharmacology of a novel seriesof 40-fluoro and 40-chloro analogues ofamodiaquine. Identification of a suitable"back-up" compound for N-tert-butylisoquine. J. Med. Chem., 52 (7), 1828-1844.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.7
, pp. 1828-1844
-
-
O'Neill, P.M.1
Shone, A.E.2
Stanford, D.3
Nixon, G.4
Asadollahy, E.5
Park, B.K.6
Maggs, J.L.7
Roberts, P.8
Stocks, P.A.9
Biagini, G.10
Bray, P.G.11
Davies, J.12
Berry, N.13
Hall, C.14
Rimmer, K.15
Winstanley, P.A.16
Hindley, S.17
Bambal, R.B.18
Davis, C.B.19
Bates, M.20
Gresham, S.L.21
Brigandi, R.A.22
Gomez-de-Las-Heras, F.M.23
Gargallo, D.V.24
Parapini, S.25
Vivas, L.26
Lander, H.27
Taramelli, D.28
Ward, S.A.29
more..
-
76
-
-
64349092617
-
Candidateselection and preclinical evaluation ofN-tert-butyl isoquine (GSK369796)anaffordable and effective 4-aminoquinolineantimalarial for the 21st century.
-
O'Neill, P.M., Park, B.K., Shone, A.E.,Maggs, J.L., Roberts, P., Stocks, P.A.,Biagini, G.A., Bray, P.G., Gibbons, P.,Berry, N., Winstanley, P.A., Mukhtar, A.,Bonar-Law, R., Hindley, S., Bambal, R.B.,Davis, C.B., Bates, M., Hart, T.K.,Gresham, S.L., Lawrence, R.M., Brigandi,R.A., Gomez-delas-Heras, F.M., Gargallo,D.V., and Ward, S.A. (2009) Candidateselection and preclinical evaluation ofN-tert-butyl isoquine (GSK369796), anaffordable and effective 4-aminoquinolineantimalarial for the 21st century. J. Med.Chem., 52 (5), 1408-1415.
-
(2009)
J. Med.Chem.
, vol.52
, Issue.5
, pp. 1408-1415
-
-
O'Neill, P.M.1
Park, B.K.2
Shone, A.E.3
Maggs, J.L.4
Roberts, P.5
Stocks, P.A.6
Biagini, G.A.7
Bray, P.G.8
Gibbons, P.9
Berry, N.10
Winstanley, P.A.11
Mukhtar, A.12
Bonar-Law, R.13
Hindley, S.14
Bambal, R.B.15
Davis, C.B.16
Bates, M.17
Hart, T.K.18
Gresham, S.L.19
Lawrence, R.M.20
Brigandi, R.A.21
Gomez-delas-Heras, F.M.22
Gargallo, D.V.23
Ward, S.A.24
more..
-
77
-
-
52449108446
-
The discovery oftaranabant a selective cannabinoid-1receptor inverse agonist for the treatmentof obesity.
-
Hagmann,W.K. (2008) The discovery oftaranabant, a selective cannabinoid-1receptor inverse agonist for the treatmentof obesity. Arch. Pharm., 341, 405-411.
-
(2008)
Arch. Pharm.
, vol.341
, pp. 405-411
-
-
Hagmann, W.K.1
-
78
-
-
0028059354
-
Recommendationto immediately withdraw patients fromtreatment with felbamate.
-
Nightingale, S.L. (1994) Recommendationto immediately withdraw patients fromtreatment with felbamate. J. Am. Med.Assoc., 272 (13), 995.
-
(1994)
J. Am. Med.Assoc.
, vol.272
, Issue.13
, pp. 995
-
-
Nightingale, S.L.1
-
79
-
-
0029849184
-
Synthesis and invitro reactivity of 3-carbamoyl-2-phenylpropionaldeyde and 2-phenylpropenal: putative reactivemetabolites of felbamate.
-
Thompson, C.D., Kinter, M.T., andMacdonald, T.L. (1996) Synthesis and invitro reactivity of 3-carbamoyl-2-phenylpropionaldeyde and 2-phenylpropenal: putative reactivemetabolites of felbamate. Chem. Res.Toxicol., 9 (8), 1225-1229.
-
(1996)
Chem. Res.Toxicol.
, vol.9
, Issue.8
, pp. 1225-1229
-
-
Thompson, C.D.1
Kinter, M.T.2
Macdonald, T.L.3
-
80
-
-
0037058251
-
Mechanisms of idiosyncratic drugreactions: the case of felbamate.
-
Diekhaus, C.M., Thompson, C.D., Roller,S.G., and MacDonald, T.L. (2002)Mechanisms of idiosyncratic drugreactions: the case of felbamate. Chem.Biol. Interact., 142 (1-2), 99-117.
-
(2002)
Chem.Biol. Interact.
, vol.142
, Issue.1-2
, pp. 99-117
-
-
Diekhaus, C.M.1
Thompson, C.D.2
Roller, S.G.3
MacDonald, T.L.4
-
81
-
-
0033012622
-
Quantitation in patient urine samples offelbamate and three metabolites: acidcarbamate and two mercapturic acids.
-
Thompson, C.D., Barthen, M.T., Hopper,D.W., Miller, T.A., Quigg, M., Hudspeth,C., Montouris, G., Marsh, L., Perhach, J.L., Sofia, R.D., and Macdonald, T.L. (1999)Quantitation in patient urine samples offelbamate and three metabolites: acidcarbamate and two mercapturic acids.Epilepsia, 40 (6), 769-776.
-
(1999)
Epilepsia
, vol.40
, Issue.6
, pp. 769-776
-
-
Thompson, C.D.1
Barthen, M.T.2
Hopper, D.W.3
Miller, T.A.4
Quigg, M.5
Hudspeth, C.6
Montouris, G.7
Marsh, L.8
Perhach, J.L.9
Sofia, R.D.10
Macdonald, T.L.11
-
82
-
-
33846222410
-
-
Roecklein, B.A., Sacks, H.J., Mortko, H.,and Stables, J. (2007) Fluorofelbamate.Neurotherapeutics, 4 (1), 97-101.
-
(2007)
Fluorofelbamate.Neurotherapeutics
, vol.4
, Issue.1
, pp. 97-101
-
-
Roecklein, B.A.1
Sacks, H.J.2
Mortko, H.3
Stables, J.4
-
83
-
-
85009673315
-
-
3rd edn, Wiley-VCH VerlagGmbH,Weinheim.
-
Smith, D.A., Allerton, C., Kalgutkar, A.,van deWaterbeemd, H., and Walker, D.K.(2012) Pharmacokinetics and Metabolism inDrug Design, 3rd edn, Wiley-VCH VerlagGmbH,Weinheim.
-
(2012)
Pharmacokinetics and Metabolism inDrug Design
-
-
Smith, D.A.1
Allerton, C.2
Kalgutkar, A.3
van deWaterbeemd, H.4
Walker, D.K.5
|