Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO)

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7705-7712

  Linton, Angelica ^a   Kang, Ping ^a   Ornelas, Martha ^a   Kephart, Susan ^a   Hu, Qiyue ^a   Pairish, Mason ^a   Jiang, Ying ^a   Guo, Chuangxing ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE OXIDASE; ANDROGEN RECEPTOR; IMIDAZO[1,2 A]PYRIMIDINE DERIVATIVE; N [3 [(5 CYANO 6 METHYLPYRIDIN 2 YL)OXY] 2,2,4,4 TETRAMETHYLCYCLOBUTYL]IMIDAZO[1,2 A]PYRIMIDINE 3 CARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG METABOLISM; DRUG OXIDATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; LIVER MICROSOME;

ALDEHYDE OXIDASE; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYTIC DOMAIN; CYCLOBUTANES; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN BINDING; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80455173672     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2010942     Document Type: Article

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