메뉴 건너뛰기




Volumn , Issue , 2012, Pages 93-106

Biological, Chemical, and Physical Compatibility of Chitosan and Biopharmaceuticals

Author keywords

Biocompatibility testing; Biological, chemical, and physical compatibility of chitosan; Chitin, a natural polymer of N acetylglucosamine; Chitosan based gene delivery systems; Chitosan based peptide, protein delivery systems; Chitosan based products, and accurate study of biocompatibility; Foreign body reaction; Photo cross linkable chitosan hydrogel, and chitosan safety; Physical and chemical compatibility with biopharmaceuticals

Indexed keywords


EID: 84885545294     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119962977.ch6     Document Type: Chapter
Times cited : (9)

References (89)
  • 1
    • 78049472974 scopus 로고    scopus 로고
    • Chitosan nanoparticles: a promising system in novel drug delivery
    • Nagpal, K., Singh, S.K. and Mishra, D.N. (2010) Chitosan nanoparticles: a promising system in novel drug delivery. Chem. Pharm. Bull., 58, 1423-1430.
    • (2010) Chem. Pharm. Bull. , vol.58 , pp. 1423-1430
    • Nagpal, K.1    Singh, S.K.2    Mishra, D.N.3
  • 2
    • 0037413407 scopus 로고    scopus 로고
    • Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles
    • Xu, Y.M. and Du, Y.M. (2003) Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int. J. Pharm., 250, 215-226.
    • (2003) Int. J. Pharm. , vol.250 , pp. 215-226
    • Xu, Y.M.1    Du, Y.M.2
  • 3
    • 31144452290 scopus 로고    scopus 로고
    • The bioartificial pancreas: progress and challenges
    • Kizilel, S. and Garfinkel, M. and Opara, E. (2005) The bioartificial pancreas: progress and challenges. Diabetes Technol. Ther., 7, 968-985.
    • (2005) Diabetes Technol. Ther. , vol.7 , pp. 968-985
    • Kizilel, S.1    Garfinkel, M.2    Opara, E.3
  • 4
    • 37349062385 scopus 로고    scopus 로고
    • Cardiovascular device infections in dogs: report of 8 cases and review of the literature
    • Fine, D.M. and Tobias, A.H. (2007) Cardiovascular device infections in dogs: report of 8 cases and review of the literature. J. Vet. Intern. Med., 21, 1265-1271.
    • (2007) J. Vet. Intern. Med. , vol.21 , pp. 1265-1271
    • Fine, D.M.1    Tobias, A.H.2
  • 5
    • 78651403408 scopus 로고    scopus 로고
    • Hemostasis for severe hemorrhage with photocrosslinkable chitosan hydrogel and calcium alginate
    • Hattori, H., Amano,Y., Nogami,Y. et al. (2010) Hemostasis for severe hemorrhage with photocrosslinkable chitosan hydrogel and calcium alginate. Ann. Biomed. Eng., 38, 3724-3732.
    • (2010) Ann. Biomed. Eng. , vol.38 , pp. 3724-3732
    • Hattori, H.1    Amano, Y.2    Nogami, Y.3
  • 6
    • 77950874954 scopus 로고    scopus 로고
    • Hemostatic effects of photocrosslinkable chitosan hydrogel-mixed photocrosslinked chitosan sponges (PCM-S) on hepatic bleeding in rats
    • Horio, T., Ishihara, M., Fujita, M. et al. (2010) Hemostatic effects of photocrosslinkable chitosan hydrogel-mixed photocrosslinked chitosan sponges (PCM-S) on hepatic bleeding in rats. Artif. Organs, 34, 342-347.
    • (2010) Artif. Organs , vol.34 , pp. 342-347
    • Horio, T.1    Ishihara, M.2    Fujita, M.3
  • 7
    • 0026756276 scopus 로고
    • Progress toward the development of an implantable sensor for glucose
    • Wilson, G.S., Zhang, Y., Reach, G. et al. (1992) Progress toward the development of an implantable sensor for glucose. Clin. Chem., 38, 1613-1617.
    • (1992) Clin. Chem. , vol.38 , pp. 1613-1617
    • Wilson, G.S.1    Zhang, Y.2    Reach, G.3
  • 8
    • 34249800911 scopus 로고    scopus 로고
    • In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations
    • Koschwanez, H.E. and Reichert, W.M. (2007) In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations. Biomaterials, 28, 3687-3703.
    • (2007) Biomaterials , vol.28 , pp. 3687-3703
    • Koschwanez, H.E.1    Reichert, W.M.2
  • 9
    • 0036027616 scopus 로고    scopus 로고
    • In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant
    • Mi, F.-L., Tan, Y.-C., Liang, H.-F. and Sung, H.-W. (2002) In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials, 23, 181-191.
    • (2002) Biomaterials , vol.23 , pp. 181-191
    • Mi, F.L.1    Tan, Y.C.2    Liang, H.F.3    Sung, H.W.4
  • 10
    • 33646886609 scopus 로고    scopus 로고
    • Therapeutic potential of chitosan and its derivatives in regenerative medicine
    • Shi, C., Zhu, Y., Ran, X. et al. (2006) Therapeutic potential of chitosan and its derivatives in regenerative medicine. J. Surg. Res., 133, 185-192.
    • (2006) J. Surg. Res. , vol.133 , pp. 185-192
    • Shi, C.1    Zhu, Y.2    Ran, X.3
  • 11
    • 78649274147 scopus 로고    scopus 로고
    • A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response
    • Onuki, Y., Bhardwaj, U., Papadimitrakopoulos, F. and Burgess, D.J. (2008) A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J. Diabetes Sci. Tech., 2, 1003-1015.
    • (2008) J. Diabetes Sci. Tech. , vol.2 , pp. 1003-1015
    • Onuki, Y.1    Bhardwaj, U.2    Papadimitrakopoulos, F.3    Burgess, D.J.4
  • 12
    • 0037409924 scopus 로고    scopus 로고
    • Implantable applications of chitin and chitosan
    • Khor, E. and Lim, L.Y. (2003) Implantable applications of chitin and chitosan. Biomaterials, 24, 2339-2349.
    • (2003) Biomaterials , vol.24 , pp. 2339-2349
    • Khor, E.1    Lim, L.Y.2
  • 13
    • 0037022697 scopus 로고    scopus 로고
    • Evaluation of the biocompatibility of a chitosan scaffold in mice
    • VandeVord, P.J., Matthew, H.W.T., DeSilva, S.P. et al. (2001) Evaluation of the biocompatibility of a chitosan scaffold in mice. J. Biomed. Mater. Res., 59, 585-590.
    • (2001) J. Biomed. Mater. Res. , vol.59 , pp. 585-590
    • VandeVord, P.J.1    Matthew, H.W.T.2    DeSilva, S.P.3
  • 14
    • 79952709587 scopus 로고    scopus 로고
    • Advances in chitosan material and its hybrid derivatives: a review
    • Lee, D.W., Lim, H., Chong, H.N. and Shim,W.B. (2009) Advances in chitosan material and its hybrid derivatives: a review. Open Biomat. J., 1, 10-20.
    • (2009) Open Biomat. J. , vol.1 , pp. 10-20
    • Lee, D.W.1    Lim, H.2    Chong, H.N.3    Shim, W.B.4
  • 15
    • 51649096831 scopus 로고    scopus 로고
    • Physicochemical characterization of chitin and chitosan from crab shells
    • Yen, M.-T., Yang, J.-H. and Mau, J.-L. (2009) Physicochemical characterization of chitin and chitosan from crab shells. Carbohydr. Polym., 75, 15-21.
    • (2009) Carbohydr. Polym. , vol.75 , pp. 15-21
    • Yen, M.T.1    Yang, J.H.2    Mau, J.L.3
  • 16
    • 1642578765 scopus 로고    scopus 로고
    • Chitin and chitosan: chemistry, properties and applications
    • Dutta, P.K., Dutta, J. and Tripathi, V.S. (2004) Chitin and chitosan: chemistry, properties and applications. J. Sci. Ind. Res., 63, 20-31.
    • (2004) J. Sci. Ind. Res. , vol.63 , pp. 20-31
    • Dutta, P.K.1    Dutta, J.2    Tripathi, V.S.3
  • 17
    • 70350045005 scopus 로고    scopus 로고
    • Whey protein isolate-chitosan interactions: a calorimetric and spectroscopic study
    • de Souza, H.K.S., Bai, G., Gonçalves, M.P. and Bastos, M. (2009) Whey protein isolate-chitosan interactions: a calorimetric and spectroscopic study. Thermochim. Acta, 495, 108-114.
    • (2009) Thermochim. Acta , vol.495 , pp. 108-114
    • de Souza, H.K.S.1    Bai, G.2    Gonçalves, M.P.3    Bastos, M.4
  • 18
    • 66249117349 scopus 로고    scopus 로고
    • Polyelectrolyte nanoparticles based on water-soluble chitosan-poly (L-aspartic acid)-polyethylene glycol for controlled protein release
    • Shu, S., Zhang, S.X., Teng, D. et al. (2009) Polyelectrolyte nanoparticles based on water-soluble chitosan-poly (L-aspartic acid)-polyethylene glycol for controlled protein release. Carbohydr. Res., 344, 1197-1204.
    • (2009) Carbohydr. Res. , vol.344 , pp. 1197-1204
    • Shu, S.1    Zhang, S.X.2    Teng, D.3
  • 19
    • 34948841373 scopus 로고    scopus 로고
    • Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles
    • Sarmento, B., Ferreira, D.C., Jorgensen, L. and van deWeert, M. (2007) Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles. Eur. J. Pharm. Biopharm., 65, 10-17.
    • (2007) Eur. J. Pharm. Biopharm. , vol.65 , pp. 10-17
    • Sarmento, B.1    Ferreira, D.C.2    Jorgensen, L.3    van deWeert, M.4
  • 20
    • 77951566678 scopus 로고    scopus 로고
    • Polysaccharide-basedvaccine delivery systems:macromolecularassembly, interactions with antigen presenting cells, and in vitro immunomonitoring
    • Weber, C., Drogoz,A.,David, L. et al. (2010)Polysaccharide-basedvaccine delivery systems:macromolecularassembly, interactions with antigen presenting cells, and in vitro immunomonitoring. Biomed. Mater. Res., 93, 1322-1344.
    • (2010) Biomed. Mater. Res. , vol.93 , pp. 1322-1344
    • Weber, C.1    Drogoz, A.2    David, L.3
  • 21
    • 0035936972 scopus 로고    scopus 로고
    • Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency
    • Mao, H.-Q., Roy, K., Trong-Le, V.L. et al. (2001) Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Control. Release, 70, 399-421.
    • (2001) J. Control. Release , vol.70 , pp. 399-421
    • Mao, H.Q.1    Roy, K.2    Trong-Le, V.L.3
  • 22
    • 0035168305 scopus 로고    scopus 로고
    • Biological responses to material
    • Anderson, J.M. (2001) Biological responses to material. Annu. Rev. Mater. Res., 31, 81-110.
    • (2001) Annu. Rev. Mater. Res. , vol.31 , pp. 81-110
    • Anderson, J.M.1
  • 23
    • 0024000488 scopus 로고
    • Inflammatory response to implants
    • Anderson, J.M. (1988) Inflammatory response to implants. ASAIO Trans., 34, 101-107.
    • (1988) ASAIO Trans. , vol.34 , pp. 101-107
    • Anderson, J.M.1
  • 24
    • 0025165359 scopus 로고
    • The role of endothelial cells in inflammation
    • Pober, J.S. and Cotran, R.S. (1990) The role of endothelial cells in inflammation. Transplantation, 50, 537-544.
    • (1990) Transplantation , vol.50 , pp. 537-544
    • Pober, J.S.1    Cotran, R.S.2
  • 25
    • 0025490094 scopus 로고
    • Cytokine-endothelial interactions in inflammation, immunity, and vascular injury
    • Cotran, R.S. and Pober, J.S. (1990) Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. J. Am. Soc. Nephrol., 1, 225-235.
    • (1990) J. Am. Soc. Nephrol. , vol.1 , pp. 225-235
    • Cotran, R.S.1    Pober, J.S.2
  • 27
    • 0023729558 scopus 로고
    • Site-directed neovessel formation in vivo
    • Thompson, J.A., Anderson, K.D., DiPietro, J.M. et al. (1988) Site-directed neovessel formation in vivo. Science, 241, 2349-1352.
    • (1988) Science , vol.241 , pp. 2349-1352
    • Thompson, J.A.1    Anderson, K.D.2    DiPietro, J.M.3
  • 28
    • 0023848647 scopus 로고    scopus 로고
    • In vitro and in vivo interactions of cells with biomaterials
    • Ziats, N.P., Miller, K.M. and Anderson, J.M. (1998) In vitro and in vivo interactions of cells with biomaterials. Biomaterials, 9, 5-13.
    • (1998) Biomaterials , vol.9 , pp. 5-13
    • Ziats, N.P.1    Miller, K.M.2    Anderson, J.M.3
  • 29
    • 33746374311 scopus 로고    scopus 로고
    • Elastic fibers and vascular structure in hypertension
    • Arribas, S.M., Hinek, A. and Gonzalez, M.C. (2006) Elastic fibers and vascular structure in hypertension. Pharmacol. Ther., 111, 771-791.
    • (2006) Pharmacol. Ther. , vol.111 , pp. 771-791
    • Arribas, S.M.1    Hinek, A.2    Gonzalez, M.C.3
  • 32
    • 0023438761 scopus 로고
    • Tissue-biomaterial interactions
    • Williams, D.F. (1987) Tissue-biomaterial interactions. J. Mater. Sci., 22, 3421-3445.
    • (1987) J. Mater. Sci. , vol.22 , pp. 3421-3445
    • Williams, D.F.1
  • 33
    • 4444330267 scopus 로고    scopus 로고
    • Biomaterials: where we have been and where we are going
    • Ratner, B.D. and Bryant, S.J. (2004) Biomaterials: where we have been and where we are going. Annu. Rev. Biomed. Eng., 6, 41-75.
    • (2004) Annu. Rev. Biomed. Eng. , vol.6 , pp. 41-75
    • Ratner, B.D.1    Bryant, S.J.2
  • 34
    • 0034751530 scopus 로고    scopus 로고
    • Experimental evaluation of photocrosslinkable chitosan as a biological adhesive with surgical application
    • Ono, K., Ishihara, M., Ozeki, Y. et al. (2001) Experimental evaluation of photocrosslinkable chitosan as a biological adhesive with surgical application. Surgery, 130, 844-850.
    • (2001) Surgery , vol.130 , pp. 844-850
    • Ono, K.1    Ishihara, M.2    Ozeki, Y.3
  • 35
    • 63449142315 scopus 로고    scopus 로고
    • In vitro in biocompatibility assessment for biomedical-grade chitosan derivatives in wound management
    • Keong, L.C. and Halim, A.S. (2009) In vitro in biocompatibility assessment for biomedical-grade chitosan derivatives in wound management. Int. J. Mol. Sci., 10, 1300-1313.
    • (2009) Int. J. Mol. Sci. , vol.10 , pp. 1300-1313
    • Keong, L.C.1    Halim, A.S.2
  • 36
    • 0028335894 scopus 로고
    • Discrimination of irritancy potential of surfactants in vitro by two cytotoxicity assays using normal human keratinocytes, HacaT cells and 3T3 mouse fibroblasts: correlation with in vivo data from a soap chamber assay
    • Korting, H.C., Herzinger, T., Hartinger, A. et al. (1994) Discrimination of irritancy potential of surfactants in vitro by two cytotoxicity assays using normal human keratinocytes, HacaT cells and 3T3 mouse fibroblasts: correlation with in vivo data from a soap chamber assay. J. Dermatol. Sci., 7, 119-129.
    • (1994) J. Dermatol. Sci. , vol.7 , pp. 119-129
    • Korting, H.C.1    Herzinger, T.2    Hartinger, A.3
  • 37
    • 77649189751 scopus 로고    scopus 로고
    • In vitro biocompatibility of chitosan porous regenerating templates (PSRTs) using primary human skin keratinocytes
    • Lim, C.K., Yaacob, N.S., Ismail, Z. and Halim, A.S. (2010) In vitro biocompatibility of chitosan porous regenerating templates (PSRTs) using primary human skin keratinocytes. Toxicol. In Vitro, 24, 721-727.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 721-727
    • Lim, C.K.1    Yaacob, N.S.2    Ismail, Z.3    Halim, A.S.4
  • 38
    • 0021193203 scopus 로고
    • Microelectrotrophoretic study of radiation-induced DNA damages in individual mammalian cells
    • Ostling, O. and Johanson, K.J. (1984) Microelectrotrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Comm., 123, 291-298.
    • (1984) Biochem. Biophys. Res. Comm. , vol.123 , pp. 291-298
    • Ostling, O.1    Johanson, K.J.2
  • 39
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage individual cells
    • Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, C.P. (1988) A simple technique for quantitation of low levels of DNA damage individual cells. Exp. Cell Res., 175, 184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, C.P.4
  • 40
    • 0032549460 scopus 로고    scopus 로고
    • DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring
    • Mitchelmore, C.L. and Chipman, J.K. (1998) DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring. Mutation Res., 399, 135-147.
    • (1998) Mutation Res. , vol.399 , pp. 135-147
    • Mitchelmore, C.L.1    Chipman, J.K.2
  • 41
    • 0030581771 scopus 로고    scopus 로고
    • Genetic toxicity of cytokine
    • Lazutka, J.R. (1996) Genetic toxicity of cytokine. Mutation Res., 361, 95-105.
    • (1996) Mutation Res. , vol.361 , pp. 95-105
    • Lazutka, J.R.1
  • 45
    • 0029863338 scopus 로고    scopus 로고
    • Evaluation of a human patch test for the identification and classification of skin irritation potential
    • York, M., Griffiths, H.A., Whittle, E. and Basketter, D.A. (1996) Evaluation of a human patch test for the identification and classification of skin irritation potential. Contact Dermatitis, 34, 204-212.
    • (1996) Contact Dermatitis , vol.34 , pp. 204-212
    • York, M.1    Griffiths, H.A.2    Whittle, E.3    Basketter, D.A.4
  • 46
    • 0002116440 scopus 로고    scopus 로고
    • The keratinocyte in cutaneous irritation and sensitization
    • (eds A.F. Kydonieus and J.J. Wille), CRC Press, Boca Raton, FL.
    • Coquette, A., Poumay, Y. and Pittelkow, M.R. (2000) The keratinocyte in cutaneous irritation and sensitization, in Biochemical Modulation of Skin Reactions (eds A.F. Kydonieus and J.J. Wille), CRC Press, Boca Raton, FL.
    • (2000) in Biochemical Modulation of Skin Reactions
    • Coquette, A.1    Poumay, Y.2    Pittelkow, M.R.3
  • 47
    • 0001976094 scopus 로고    scopus 로고
    • Immunity at body surface
    • 6th edn(ed. I.R. Tizard), Saunders, Philadelphia P.A.
    • Tizard, I.R. (2000) Immunity at body surface, in Veterinary Immunology. An Introduction, 6th edn(ed. I.R. Tizard), Saunders, Philadelphia, PA.
    • (2000) in Veterinary Immunology. An Introduction
    • Tizard, I.R.1
  • 48
    • 0037031754 scopus 로고    scopus 로고
    • Keratinocytes and cytokines
    • Grone, A. (2002) Keratinocytes and cytokines. Vet. Immunol. Immunopathol., 88, 1-12.
    • (2002) Vet. Immunol. Immunopathol. , vol.88 , pp. 1-12
    • Grone, A.1
  • 49
    • 0034142515 scopus 로고    scopus 로고
    • Photocrosslinkable chitosan as a biological adhesive
    • Ono, K., Saito,Y.,Yura, H. et al. (2000) Photocrosslinkable chitosan as a biological adhesive. J. Biomed. Mater. Res., 49, 289-295.
    • (2000) J. Biomed. Mater. Res. , vol.49 , pp. 289-295
    • Ono, K.1    Saito, Y.2    Yura, H.3
  • 50
    • 0030176094 scopus 로고    scopus 로고
    • A new biological glue from gelatin and poly (L-glutamic acid)
    • Otani, Y., Tabata, Y. and Ikada, Y. (1996) A new biological glue from gelatin and poly (L-glutamic acid). J. Biomed. Mater. Res., 31, 157-166.
    • (1996) J. Biomed. Mater. Res. , vol.31 , pp. 157-166
    • Otani, Y.1    Tabata, Y.2    Ikada, Y.3
  • 51
    • 0025341818 scopus 로고
    • Modification of synthesis and investigation of properties for 2- cyanoacrylates
    • Tseng, Y.C., Hyon, S.H. and Ikada, Y. (1990) Modification of synthesis and investigation of properties for 2- cyanoacrylates. Biomaterials, 11, 73-79.
    • (1990) Biomaterials , vol.11 , pp. 73-79
    • Tseng, Y.C.1    Hyon, S.H.2    Ikada, Y.3
  • 52
    • 0027642424 scopus 로고
    • Cyanoacrylate tissue adhesive for closing skin wounds: a double blind randomized comparison with suture
    • Vanholder, R., Misotten, A., Roels, H. and Matton, G. (1993) Cyanoacrylate tissue adhesive for closing skin wounds: a double blind randomized comparison with suture. Biomaterials, 14, 737-743.
    • (1993) Biomaterials , vol.14 , pp. 737-743
    • Vanholder, R.1    Misotten, A.2    Roels, H.3    Matton, G.4
  • 53
    • 0021199340 scopus 로고
    • An effective hemostatic agent for nonsuturable intraoperative bleeding
    • John, A., Rousou, M.D., Richard, M. et al. (1984) An effective hemostatic agent for nonsuturable intraoperative bleeding. Ann. Thorac. Surg., 38, 409-410.
    • (1984) Ann. Thorac. Surg. , vol.38 , pp. 409-410
    • John, A.1    Rousou, M.D.2    Richard, M.3
  • 54
    • 0023906150 scopus 로고
    • Fibrin seal adhesive versus nonadsorbable microsuture in peripheral nerve repair
    • Moy, O.J., Peimer, C.A., Koniuchi, M.P. et al. (1988) Fibrin seal adhesive versus nonadsorbable microsuture in peripheral nerve repair. J. Hand Surg., 13, 273-278.
    • (1988) J. Hand Surg. , vol.13 , pp. 273-278
    • Moy, O.J.1    Peimer, C.A.2    Koniuchi, M.P.3
  • 55
    • 0028822746 scopus 로고
    • Chitinase activity in human serum and leukocytes
    • Escott, G.M. and Adams, D.J. (1995) Chitinase activity in human serum and leukocytes. Infect. Immun., 63, 4770-4773.
    • (1995) Infect. Immun. , vol.63 , pp. 4770-4773
    • Escott, G.M.1    Adams, D.J.2
  • 56
    • 0037022697 scopus 로고    scopus 로고
    • Evaluation of the biocompatibility of a chitosan scaffold in mice
    • Van deVord, P.J., Matthew, H.W., DeSilva, S.P. et al. (2002) Evaluation of the biocompatibility of a chitosan scaffold in mice. J. Biomed. Mater. Res., 59, 585-590.
    • (2002) J. Biomed. Mater. Res. , vol.59 , pp. 585-590
    • Van DeVord, P.J.1    Matthew, H.W.2    DeSilva, S.P.3
  • 57
    • 0029045246 scopus 로고
    • Regulation of vascular endothelial growth factor expression in cultured keratinocytes: implications for normal and impaired wound healing
    • Frank, S., Hubner, G., Breier, G. et al. (1995) Regulation of vascular endothelial growth factor expression in cultured keratinocytes: implications for normal and impaired wound healing. J. Biol. Chem., 270, 12607-12613.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12607-12613
    • Frank, S.1    Hubner, G.2    Breier, G.3
  • 58
    • 9444265293 scopus 로고    scopus 로고
    • Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis
    • Chavakis, T., Cines, D.B., Liang, O.D. et al. (2004) Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. FASEB. J., 18, 1306-1308.
    • (2004) FASEB. J. , vol.18 , pp. 1306-1308
    • Chavakis, T.1    Cines, D.B.2    Liang, O.D.3
  • 59
    • 0142089544 scopus 로고    scopus 로고
    • Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization
    • Ishihara, M., Obara, K., Ishizuka, T. et al. (2003) Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization. J. Biomed. Mater. Res., 64, 551-559.
    • (2003) J. Biomed. Mater. Res. , vol.64 , pp. 551-559
    • Ishihara, M.1    Obara, K.2    Ishizuka, T.3
  • 60
    • 33749163529 scopus 로고    scopus 로고
    • Medium (DMEM/F12)-containing chitosan hydrogel as adhesive and dressing in autologous skin grafts and accelerator in the healing process
    • Kiyozumi, T., Kanatani, Y., Ishihara, M. et al. (2006) Medium (DMEM/F12)-containing chitosan hydrogel as adhesive and dressing in autologous skin grafts and accelerator in the healing process. J. Biomed. Mater. Res. B, 798, 129-136.
    • (2006) J. Biomed. Mater. Res. B , vol.798 , pp. 129-136
    • Kiyozumi, T.1    Kanatani, Y.2    Ishihara, M.3
  • 61
    • 0033178547 scopus 로고    scopus 로고
    • Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs
    • Ueno, H., Yamada, H., Tanaka, I. et al. (1999) Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials, 20, 1407-1414.
    • (1999) Biomaterials , vol.20 , pp. 1407-1414
    • Ueno, H.1    Yamada, H.2    Tanaka, I.3
  • 62
    • 0036132348 scopus 로고    scopus 로고
    • Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process
    • Ishihara, M., Nakanishi, K., Ono, K. et al. (2002) Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process. Biomaterials, 23, 833-840.
    • (2002) Biomaterials , vol.23 , pp. 833-840
    • Ishihara, M.1    Nakanishi, K.2    Ono, K.3
  • 63
    • 12444272727 scopus 로고    scopus 로고
    • Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice
    • Obara, K., Ishihara, M., Ishizuka, T. et al. (2003) Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials, 24, 3437-3444.
    • (2003) Biomaterials , vol.24 , pp. 3437-3444
    • Obara, K.1    Ishihara, M.2    Ishizuka, T.3
  • 64
    • 0342289468 scopus 로고
    • Promotion of wound repair in old mice by local injection of macrophages
    • Danon, D., Kowatch, M.A. and Roth, G.S. (1989) Promotion of wound repair in old mice by local injection of macrophages. Proc. Natl. Acad. Sci. USA, 86, 2018-2020.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2018-2020
    • Danon, D.1    Kowatch, M.A.2    Roth, G.S.3
  • 65
    • 0037634195 scopus 로고    scopus 로고
    • Controlled delivery of drugs from alginate matrix
    • Shilpa, A., Agawal, S.S. and Ray, A.R. (2003) Controlled delivery of drugs from alginate matrix. JMS. Polym. Rev., C43, 187-196.
    • (2003) J.MS. Polym. Rev. , vol.43 , pp. 187-196
    • Shilpa, A.1    Agawal, S.S.2    Ray, A.R.3
  • 66
    • 0030129683 scopus 로고    scopus 로고
    • Swelling behavior of pectin/chitosan complex films
    • Yao, K.D., Liu, J., Cheng, G.X. et al. (1996) Swelling behavior of pectin/chitosan complex films. J. Appl. Polym. Sci., 60, 279-788.
    • (1996) J. Appl. Polym. Sci. , vol.60 , pp. 279-788
    • Yao, K.D.1    Liu, J.2    Cheng, G.X.3
  • 67
    • 0037768709 scopus 로고    scopus 로고
    • Release phenomena of insulin from an implantable device composed of polyion complex of chitosan and sodium hyaluronan
    • Surrini, S., Akiyama, H., Morishita, M. et al. (2003) Release phenomena of insulin from an implantable device composed of polyion complex of chitosan and sodium hyaluronan. J. Control. Release, 90, 291-301.
    • (2003) J. Control. Release , vol.90 , pp. 291-301
    • Surrini, S.1    Akiyama, H.2    Morishita, M.3
  • 68
    • 79953270285 scopus 로고    scopus 로고
    • Characterization of chitosan-chondroitin sulfate blended membranes and effects on the growth of corneal cells
    • Yao, Z.-A. andWu, H.-G. (2010) Characterization of chitosan-chondroitin sulfate blended membranes and effects on the growth of corneal cells. Adv. Mater. Lett., 1, 67-74.
    • (2010) Adv. Mater. Lett. , vol.1 , pp. 67-74
    • Yao, Z.A.1    Wu, H.G.2
  • 69
    • 0038078504 scopus 로고    scopus 로고
    • Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions
    • Cheng, M., Deng, J., Yang, F. et al. (2003). Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions. Biomaterials, 24, 2871-2880.
    • (2003) Biomaterials , vol.24 , pp. 2871-2880
    • Cheng, M.1    Deng, J.2    Yang, F.3
  • 71
    • 10044287286 scopus 로고    scopus 로고
    • An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes
    • Liu, W., Sun, S., Cao, Z. et al. (2005) An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes. Biomaterials, 26, 2705-2711.
    • (2005) Biomaterials , vol.26 , pp. 2705-2711
    • Liu, W.1    Sun, S.2    Cao, Z.3
  • 72
    • 0035158241 scopus 로고    scopus 로고
    • Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy
    • Nielsen, L., Frokjaer, S., Carpenter, J. and Brange, J. (2001) Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy. J. Pharm. Sci., 90, 29-37.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 29-37
    • Nielsen, L.1    Frokjaer, S.2    Carpenter, J.3    Brange, J.4
  • 74
    • 3242791810 scopus 로고    scopus 로고
    • In vitro cytocompatibility of MG63 cells on chitosanorganosiloxane hybrid membranes
    • Shirosaki, Y., Tsuru, K., Hayakawa, S. et al. (2005) In vitro cytocompatibility of MG63 cells on chitosanorganosiloxane hybrid membranes. Biomaterials, 26, 485-493.
    • (2005) Biomaterials , vol.26 , pp. 485-493
    • Shirosaki, Y.1    Tsuru, K.2    Hayakawa, S.3
  • 75
    • 51549118860 scopus 로고    scopus 로고
    • Synthesis of chitosan derivatives with anionic groups and its biocompatibility in vitro
    • Jung, B.-O., Na, J. and Kim, C.H. (2007) Synthesis of chitosan derivatives with anionic groups and its biocompatibility in vitro. J. Ind. Eng. Chem., 13, 772-776.
    • (2007) J. Ind. Eng. Chem. , vol.13 , pp. 772-776
    • Jung, B.O.1    Na, J.2    Kim, C.H.3
  • 76
    • 67049086155 scopus 로고    scopus 로고
    • New insights into chitosan-DNA interactions using isothermal titration microcalorimetry
    • Ma, P.L., Lavertu, M., Winnik, F.M. and Buschmann, M.D. (2009) New insights into chitosan-DNA interactions using isothermal titration microcalorimetry. Biomacromolecules, 10, 1490-1499.
    • (2009) Biomacromolecules , vol.10 , pp. 1490-1499
    • Ma, P.L.1    Lavertu, M.2    Winnik, F.M.3    Buschmann, M.D.4
  • 77
    • 0142090707 scopus 로고    scopus 로고
    • Sustained expression in mammalian cells with DNA complexed with chitosan nanoparticles
    • Li, X.W., Lee, D.K.L., Chan, A.S.C. and Alpar, H.O. (2003) Sustained expression in mammalian cells with DNA complexed with chitosan nanoparticles. Biochim. Biophys. Acta, 1630, 7-18.
    • (2003) Biochim. Biophys. Acta , vol.1630 , pp. 7-18
    • Li, X.W.1    Lee, D.K.L.2    Chan, A.S.C.3    Alpar, H.O.4
  • 78
    • 33646555163 scopus 로고    scopus 로고
    • Aself-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin
    • Kissei, T., Mao, S. and Jintapattanakit, U. (2006)Aself-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J. Pharm. Sci., 95, 1035-1048.
    • (2006) J. Pharm. Sci. , vol.95 , pp. 1035-1048
    • Kissei, T.1    Mao, S.2    Jintapattanakit, U.3
  • 79
    • 33645520636 scopus 로고    scopus 로고
    • Stable and pH-sensitive nanogels prepared by self-assembly of chitosan and ovalbumin
    • Yu, S.Y., Hu, J.H., Pan, X.Y. et al. (2006) Stable and pH-sensitive nanogels prepared by self-assembly of chitosan and ovalbumin. Langmuir, 22, 2754-2759.
    • (2006) Langmuir , vol.22 , pp. 2754-2759
    • Yu, S.Y.1    Hu, J.H.2    Pan, X.Y.3
  • 80
    • 15044341172 scopus 로고    scopus 로고
    • Chitosan-dextran sulfate nanoparticles for delivery of an antiangiogenesis peptide
    • Chen, Y., Mohanraj, V.J. and Parkin, J.E. (2003) Chitosan-dextran sulfate nanoparticles for delivery of an antiangiogenesis peptide. Lett. Pept. Sci., 10, 621-629.
    • (2003) Lett. Pept. Sci. , vol.10 , pp. 621-629
    • Chen, Y.1    Mohanraj, V.J.2    Parkin, J.E.3
  • 81
    • 0034623660 scopus 로고    scopus 로고
    • Immune stimulating activity of two new chitosan containing adjuvant formulations
    • Seferian, P.G. and Martinez, M.I. (2000) Immune stimulating activity of two new chitosan containing adjuvant formulations. Vaccine, 19, 661-668.
    • (2000) Vaccine , vol.19 , pp. 661-668
    • Seferian, P.G.1    Martinez, M.I.2
  • 82
    • 39749108700 scopus 로고    scopus 로고
    • Towards biocompatible vaccine delivery systems: interactions of colloidal PECs based on polysaccharides with HIV-1 p24 antigen
    • Drogoz, A., Munier, S., Verrier, B. et al. (2008) Towards biocompatible vaccine delivery systems: interactions of colloidal PECs based on polysaccharides with HIV-1 p24 antigen. Biomacromolecules, 9, 583-591.
    • (2008) Biomacromolecules , vol.9 , pp. 583-591
    • Drogoz, A.1    Munier, S.2    Verrier, B.3
  • 84
    • 1942470953 scopus 로고    scopus 로고
    • The effect of the degree of chitosan deacetylation on the efficiency of gene transfection
    • Kiang, T.,Wen, J., Lim, H.W. et al. (2004) The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials, 25, 5293-5301.
    • (2004) Biomaterials , vol.25 , pp. 5293-5301
    • Kiang, T.1    Wen, J.2    Lim, H.W.3
  • 85
    • 33745077164 scopus 로고    scopus 로고
    • High efficiency gene transfer using chitosan/ DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation
    • Lavertu, M., Methot, S., Tran-Khanh, N. and Buschmann, M.D. (2006) High efficiency gene transfer using chitosan/ DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. Biomaterials, 27, 4815-4825.
    • (2006) Biomaterials , vol.27 , pp. 4815-4825
    • Lavertu, M.1    Methot, S.2    Tran-Khanh, N.3    Buschmann, M.D.4
  • 86
    • 38949151545 scopus 로고    scopus 로고
    • Design of novel polysaccharidic nanostructures for gene delivery
    • de la Fuente, M., Seijo, B. and Alonso, M.J. (2008) Design of novel polysaccharidic nanostructures for gene delivery. Nanotechnology, 19, 075105.
    • (2008) Nanotechnology , vol.19 , pp. 075105
    • De La Fuente, M.1    Seijo, B.2    Alonso, M.J.3
  • 87
    • 84914798734 scopus 로고
    • IR spectroscopic determination of CONH content in highly deacylated chitosan
    • Miya, M., Iwamoto, R. and Yoshikawa, S. (1980) IR spectroscopic determination of CONH content in highly deacylated chitosan. Int. J. Biol. Macromol., 2, 323-324.
    • (1980) Int. J. Biol. Macromol. , vol.2 , pp. 323-324
    • Miya, M.1    Iwamoto, R.2    Yoshikawa, S.3
  • 88
    • 77956619084 scopus 로고    scopus 로고
    • Biological activities of chitosan and chitooligosaccharides
    • Xia, W., Liu, P., Zhang, J. and Chen, J. (2011) Biological activities of chitosan and chitooligosaccharides. Food Hydrocolloids, 25, 170-179.
    • (2011) Food Hydrocolloids , vol.25 , pp. 170-179
    • Xia, W.1    Liu, P.2    Zhang, J.3    Chen, J.4
  • 89
    • 9644287958 scopus 로고    scopus 로고
    • Structure analysis and degree of substitution of chitin, chitosan and dibutyrylchitin by FTIR spectroscopy and solid state 13C-NMR
    • DeValde, K.V. and Kiekens, P. (2004) Structure analysis and degree of substitution of chitin, chitosan and dibutyrylchitin by FTIR spectroscopy and solid state 13C-NMR. Carbohydr. Polym., 58, 409-416.
    • (2004) Carbohydr. Polym. , vol.58 , pp. 409-416
    • DeValde, K.V.1    Kiekens, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.