메뉴 건너뛰기




Volumn 91, Issue 11, 2013, Pages 913-919

High-fat diet stimulates hepatic cystathionine β-synthase and cystathionine γ-lyase expression

Author keywords

High fat diet; Homocysteine; Hydrogen sulfide; Trans sulfuration pathway

Indexed keywords

CHOLESTEROL; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; GLUTATHIONE; HOMOCYSTEINE; HYDROGEN SULFIDE; LIPID PEROXIDE; MESSENGER RNA; TRIACYLGLYCEROL;

EID: 84885467821     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2013-0106     Document Type: Article
Times cited : (50)

References (49)
  • 1
    • 0022272493 scopus 로고
    • Determination of glutathione and glutathione disulfide in biological samples
    • doi:10.1016/S0076-6879(85)13073-9. PMID:4088074
    • Anderson, M.E. 1985. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113: 548-555. doi:10.1016/S0076-6879(85)13073-9. PMID:4088074.
    • (1985) Methods Enzymol. , vol.113 , pp. 548-555
    • Anderson, M.E.1
  • 2
    • 79955105079 scopus 로고    scopus 로고
    • High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway
    • doi:10.1186/1476-511X-10-60. PMID: 21504583
    • Bravo, E., Palleschi, S., Aspichueta, P., Buque, X., Rossi, B., Cano, A., et al. 2011. High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway. Lipids Health Dis. 10: 60. doi:10.1186/1476-511X-10-60. PMID: 21504583.
    • (2011) Lipids Health Dis. , vol.10 , pp. 60
    • Bravo, E.1    Palleschi, S.2    Aspichueta, P.3    Buque, X.4    Rossi, B.5    Cano, A.6
  • 3
    • 10644254287 scopus 로고    scopus 로고
    • Production of the neuromodulator H2S by cystathionine β-synthase via the condensation of cysteine and homocysteine
    • doi:10.1074/jbc.C400481200. PMID:15520012
    • Chen, X., Jhee, K.H., and Kruger, W.D. 2004. Production of the neuromodulator H2S by cystathionine β-synthase via the condensation of cysteine and homocysteine. J. Biol. Chem. 279(50): 52082-52086. doi:10.1074/jbc.C400481200. PMID:15520012.
    • (2004) J. Biol. Chem. , vol.279 , Issue.50 , pp. 52082-52086
    • Chen, X.1    Jhee, K.H.2    Kruger, W.D.3
  • 4
    • 66449109703 scopus 로고    scopus 로고
    • H2S biogenesis by human cystathionine γ-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
    • PMID: 19261609
    • Chiku, T., Padovani, D., Zhu, W., Singh, S., Vitvitsky, V., and Banerjee, R. 2009. H2S biogenesis by human cystathionine γ-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J. Biol. Chem. 284(17): 11601-11612. PMID: 19261609.
    • (2009) J. Biol. Chem. , vol.284 , Issue.17 , pp. 11601-11612
    • Chiku, T.1    Padovani, D.2    Zhu, W.3    Singh, S.4    Vitvitsky, V.5    Banerjee, R.6
  • 5
    • 2442710044 scopus 로고    scopus 로고
    • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: Physiological and molecular characteristics
    • doi:10.1016/j.physbeh.2004.02. 006. PMID:15159170
    • Collins, S., Martin, T.L., Surwit, R.S., and Robidoux, J. 2004. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol. Behav. 81(2): 243-248. doi:10.1016/j.physbeh.2004.02. 006. PMID:15159170.
    • (2004) Physiol. Behav. , vol.81 , Issue.2 , pp. 243-248
    • Collins, S.1    Martin, T.L.2    Surwit, R.S.3    Robidoux, J.4
  • 6
    • 84863293129 scopus 로고    scopus 로고
    • Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: Cross-talk between integrated stress response and thiol metabolism
    • doi:10.1074/jbc.M111.304576. PMID:22215680
    • Dickhout, J.G., Carlisle, R.E., Jerome, D.E., Mohammed-Ali, Z., Jiang, H., Yang, G., et al. 2012. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J. Biol. Chem. 287(10): 7603-7614. doi:10.1074/jbc.M111.304576. PMID:22215680.
    • (2012) J. Biol. Chem. , vol.287 , Issue.10 , pp. 7603-7614
    • Dickhout, J.G.1    Carlisle, R.E.2    Jerome, D.E.3    Mohammed-Ali, Z.4    Jiang, H.5    Yang, G.6
  • 7
    • 39549102202 scopus 로고    scopus 로고
    • The methionine connection: Homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats
    • doi:10.1002/hep.22037. PMID:18098324
    • Distrutti, E., Mencarelli, A., Santucci, L., Renga, B., Orlandi, S., Donini, A., et al. 2008. The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats. Hepatology, 47(2): 659-667. doi:10.1002/hep.22037. PMID:18098324.
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 659-667
    • Distrutti, E.1    Mencarelli, A.2    Santucci, L.3    Renga, B.4    Orlandi, S.5    Donini, A.6
  • 8
    • 4644266615 scopus 로고    scopus 로고
    • New roles for cysteine and transsulfuration enzymes: Production of H2S, a neuromodulator and smooth muscle relaxant
    • doi:10.1111/j.1753-4887.2004.tb00060.x. PMID:15497768
    • Dominy, J.E., and Stipanuk, M.H. 2004. New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr. Rev. 62(9): 348-353. doi:10.1111/j.1753-4887.2004.tb00060.x. PMID:15497768.
    • (2004) Nutr. Rev. , vol.62 , Issue.9 , pp. 348-353
    • Dominy, J.E.1    Stipanuk, M.H.2
  • 9
    • 38949198356 scopus 로고    scopus 로고
    • Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats
    • O, K. doi:10.1139/Y07-112. PMID:18066125
    • Edirimanne, V.E., Woo, C.W., Siow, Y.L., Pierce, G.N., Xie, J.Y., and O, K. 2007. Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats. Can. J. Physiol. Pharmacol. 85(12): 1236-1247. doi:10.1139/Y07-112. PMID:18066125.
    • (2007) Can. J. Physiol. Pharmacol. , vol.85 , Issue.12 , pp. 1236-1247
    • Edirimanne, V.E.1    Woo, C.W.2    Siow, Y.L.3    Pierce, G.N.4    Xie, J.Y.5
  • 10
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: Pathways and regulation
    • doi:10.1007/PL00014300. PMID: 9587024
    • Finkelstein, J.D. 1998. The metabolism of homocysteine: pathways and regulation. Eur. J. Pediatr. 157(Suppl. 2): S40-S44. doi:10.1007/PL00014300. PMID: 9587024.
    • (1998) Eur. J. Pediatr. , vol.157 , Issue.SUPPL. 2
    • Finkelstein, J.D.1
  • 11
    • 33745920516 scopus 로고    scopus 로고
    • The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver
    • doi:10.1053/j.gastro.2006.02.033. PMID:16831608
    • Fiorucci, S., Distrutti, E., Cirino, G., and Wallace, J.L. 2006. The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology, 131(1): 259-271. doi:10.1053/j.gastro.2006.02.033. PMID:16831608.
    • (2006) Gastroenterology , vol.131 , Issue.1 , pp. 259-271
    • Fiorucci, S.1    Distrutti, E.2    Cirino, G.3    Wallace, J.L.4
  • 12
    • 79151469687 scopus 로고    scopus 로고
    • Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease
    • doi:10.1016/j.bbadis.2011.01.003. PMID:21216282
    • Gaemers, I.C., Stallen, J.M., Kunne, C., Wallner, C., van Werven, J., Nederveen, A., et al. 2011. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim. Biophys. Acta, 1812(4): 447-458. doi:10.1016/j.bbadis.2011.01.003. PMID:21216282.
    • (2011) Biochim. Biophys. Acta , vol.1812 , Issue.4 , pp. 447-458
    • Gaemers, I.C.1    Stallen, J.M.2    Kunne, C.3    Wallner, C.4    van Werven, J.5    Nederveen, A.6
  • 13
    • 0030914304 scopus 로고    scopus 로고
    • The role of dietary fat in obesity
    • PMID:9225171
    • Golay, A., and Bobbioni, E. 1997. The role of dietary fat in obesity. Int. J. Obes. Relat. Metab. Disord. 21(Suppl. 3): S2-S11. PMID:9225171.
    • (1997) Int. J. Obes. Relat. Metab. Disord. , vol.21 , Issue.SUPPL. 3
    • Golay, A.1    Bobbioni, E.2
  • 14
    • 33644649625 scopus 로고    scopus 로고
    • Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease
    • doi:10.1111/j.1440-1746.2005.03891.x. PMID:16105135
    • Gulsen, M., Yesilova, Z., Bagci, S., Uygun, A., Ozcan, A., Ercin, C.N., et al. 2005. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 20(9): 1448-1455. doi:10.1111/j.1440-1746.2005.03891.x. PMID:16105135.
    • (2005) J. Gastroenterol. Hepatol. , vol.20 , Issue.9 , pp. 1448-1455
    • Gulsen, M.1    Yesilova, Z.2    Bagci, S.3    Uygun, A.4    Ozcan, A.5    Ercin, C.N.6
  • 15
    • 77957672249 scopus 로고    scopus 로고
    • A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content
    • doi:10.1016/j.nutres.2010.09.003. PMID:20934605
    • Hariri, N., Gougeon, R., and Thibault, L. 2010. A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content. Nutr. Res. 30(9): 632-643. doi:10.1016/j.nutres.2010.09.003. PMID:20934605.
    • (2010) Nutr. Res. , vol.30 , Issue.9 , pp. 632-643
    • Hariri, N.1    Gougeon, R.2    Thibault, L.3
  • 16
    • 13844267785 scopus 로고    scopus 로고
    • Serum folate and homocysteine levels in obese females with nonalcoholic fatty liver
    • doi:10.1016/j.nut.2004.03.022. PMID:15723740
    • Hirsch, S., Poniachick, J., Avendano, M., Csendes, A., Burdiles, P., Smok, G., et al. 2005. Serum folate and homocysteine levels in obese females with nonalcoholic fatty liver. Nutrition, 21(2): 137-141. doi:10.1016/j.nut.2004.03.022. PMID:15723740.
    • (2005) Nutrition , vol.21 , Issue.2 , pp. 137-141
    • Hirsch, S.1    Poniachick, J.2    Avendano, M.3    Csendes, A.4    Burdiles, P.5    Smok, G.6
  • 17
    • 0003633755 scopus 로고    scopus 로고
    • ILAR (Institute of Laboratory Animal Resources). NIH Publication No. 85-23 (revised 1996). National Academy Press, Washington, D.C. Available from
    • ILAR (Institute of Laboratory Animal Resources). 1996. Guide for the Care and Use of Laboratory Animals. NIH Publication No. 85-23 (revised 1996). National Academy Press, Washington, D.C. Available from www.nap.edu/openbook.php?record_id=5140.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 18
    • 33947137852 scopus 로고    scopus 로고
    • Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet
    • doi:10.1111/j.1872-034X. 2007.00008.x. PMID:17300698
    • Ito, M., Suzuki, J., Tsujioka, S., Sasaki, M., Gomori, A., Shirakura, T., et al. 2007. Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet. Hepatol. Res. 37(1): 50-57. doi:10.1111/j.1872-034X. 2007.00008.x. PMID:17300698.
    • (2007) Hepatol. Res. , vol.37 , Issue.1 , pp. 50-57
    • Ito, M.1    Suzuki, J.2    Tsujioka, S.3    Sasaki, M.4    Gomori, A.5    Shirakura, T.6
  • 19
    • 78649760355 scopus 로고    scopus 로고
    • Pharmacological activation and genetic manipulation of cystathionine β-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice
    • doi:10.1016/j.ejphar.2010.09.080. PMID: 20955694
    • Jensen, K.K., Geoghagen, N.S., Jin, L., Holt, T.G., Luo, Q., Malkowitz, L., et al. 2011. Pharmacological activation and genetic manipulation of cystathionine β-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice. Eur. J. Pharmacol. 650(1): 86-93. doi:10.1016/j.ejphar.2010.09.080. PMID: 20955694.
    • (2011) Eur. J. Pharmacol. , vol.650 , Issue.1 , pp. 86-93
    • Jensen, K.K.1    Geoghagen, N.S.2    Jin, L.3    Holt, T.G.4    Luo, Q.5    Malkowitz, L.6
  • 20
    • 52449104880 scopus 로고    scopus 로고
    • Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: Role of an-tioxidant and antiapoptotic signaling
    • doi:10.1152/ajpheart.00377.2008. PMID:18567706
    • Jha, S., Calvert, J.W., Duranski, M.R., Ramachandran, A., and Lefer, D.J. 2008. Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of an-tioxidant and antiapoptotic signaling. Am. J. Physiol. Heart Circ. Physiol. 295(2): H801-H806. doi:10.1152/ajpheart.00377.2008. PMID:18567706.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295 , Issue.2
    • Jha, S.1    Calvert, J.W.2    Duranski, M.R.3    Ramachandran, A.4    Lefer, D.J.5
  • 21
    • 70350553616 scopus 로고    scopus 로고
    • Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats
    • doi:10.1002/lt.21810. PMID:19790158
    • Kang, K., Zhao, M., Jiang, H., Tan, G., Pan, S., and Sun, X. 2009. Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats. Liver Transpl. 15(10): 1306-1314. doi:10.1002/lt.21810. PMID:19790158.
    • (2009) Liver Transpl. , vol.15 , Issue.10 , pp. 1306-1314
    • Kang, K.1    Zhao, M.2    Jiang, H.3    Tan, G.4    Pan, S.5    Sun, X.6
  • 22
    • 58649089148 scopus 로고    scopus 로고
    • Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats
    • doi:10.3945/jn.108.094771. PMID:19056644
    • Kwon, D.Y., Jung, Y.S., Kim, S.J., Park, H.K., Park, J.H., and Kim, Y.C. 2009. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J. Nutr. 139(1): 63-68. doi:10.3945/jn.108.094771. PMID:19056644.
    • (2009) J. Nutr. , vol.139 , Issue.1 , pp. 63-68
    • Kwon, D.Y.1    Jung, Y.S.2    Kim, S.J.3    Park, H.K.4    Park, J.H.5    Kim, Y.C.6
  • 23
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • doi:10.1111/j.1440-1746.2008.05543.x. PMID:18752564
    • Larter, C.Z., and Yeh, M.M. 2008. Animal models of NASH: getting both pathology and metabolic context right. J. Gastroenterol. Hepatol. 23(11): 1635-1648. doi:10.1111/j.1440-1746.2008.05543.x. PMID:18752564.
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , Issue.11 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 24
    • 28344446460 scopus 로고    scopus 로고
    • Mechanisms of homocysteine-induced atherothrombosis
    • doi:10.1111/j.1538-7836.2005.01364.x. PMID:16102030
    • Lentz, S.R. 2005. Mechanisms of homocysteine-induced atherothrombosis. J. Thromb. Haemost. 3(8): 1646-1654. doi:10.1111/j.1538-7836.2005.01364.x. PMID:16102030.
    • (2005) J. Thromb. Haemost. , vol.3 , Issue.8 , pp. 1646-1654
    • Lentz, S.R.1
  • 25
    • 0034711007 scopus 로고    scopus 로고
    • The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes
    • doi:10.1021/bi001088w. PMID:11041866
    • Mosharov, E., Cranford, M.R., and Banerjee, R. 2000. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry, 39(42): 13005-13011. doi:10.1021/bi001088w. PMID:11041866.
    • (2000) Biochemistry , vol.39 , Issue.42 , pp. 13005-13011
    • Mosharov, E.1    Cranford, M.R.2    Banerjee, R.3
  • 26
    • 0013817677 scopus 로고
    • Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway
    • PMID:4954368
    • Mudd, S.H., Finkelstein, J.D., Irreverre, F., and Laster, L. 1965. Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway. J. Biol. Chem. 240(11): 4382-4392. PMID:4954368.
    • (1965) J. Biol. Chem. , vol.240 , Issue.11 , pp. 4382-4392
    • Mudd, S.H.1    Finkelstein, J.D.2    Irreverre, F.3    Laster, L.4
  • 27
    • 79954575059 scopus 로고    scopus 로고
    • Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes
    • doi:10.1016/j.bbadis.2011.03.011. PMID:21447386
    • Noll, C., Lacraz, G., Ehses, J., Coulaud, J., Bailbe, D., Paul, J.L., et al. 2011. Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes. Biochim. Biophys. Acta, 1812(6): 699-702. doi:10.1016/j.bbadis.2011.03.011. PMID:21447386.
    • (2011) Biochim. Biophys. Acta , vol.1812 , Issue.6 , pp. 699-702
    • Noll, C.1    Lacraz, G.2    Ehses, J.3    Coulaud, J.4    Bailbe, D.5    Paul, J.L.6
  • 28
    • 80052031168 scopus 로고    scopus 로고
    • The liver as a central regulator of hydrogen sulfide
    • doi:10.1097/SHK.0b013e3182252ee7. PMID:21617578
    • Norris, E.J., Culberson, C.R., Narasimhan, S., and Clemens, M.G. 2011. The liver as a central regulator of hydrogen sulfide. Shock, 36(3): 242-250. doi:10.1097/SHK.0b013e3182252ee7. PMID:21617578.
    • (2011) Shock , vol.36 , Issue.3 , pp. 242-250
    • Norris, E.J.1    Culberson, C.R.2    Narasimhan, S.3    Clemens, M.G.4
  • 29
    • 83055197038 scopus 로고    scopus 로고
    • Serum homocysteine levels in patients with nonalcoholic fatty liver disease
    • PMID:22166563
    • Polyzos, S.A., Kountouras, J., Patsiaoura, K., Katsiki, E., Zafeiriadou, E., Deretzi, G., et al. 2012. Serum homocysteine levels in patients with nonalcoholic fatty liver disease. Ann. Hepatol. 11(1): 68-76. PMID:22166563.
    • (2012) Ann. Hepatol. , vol.11 , Issue.1 , pp. 68-76
    • Polyzos, S.A.1    Kountouras, J.2    Patsiaoura, K.3    Katsiki, E.4    Zafeiriadou, E.5    Deretzi, G.6
  • 30
    • 34248215290 scopus 로고    scopus 로고
    • Detrimental role of homocysteine in renal ischemia-reperfusion injury
    • O, K. doi:10.1152/ajprenal.00301.2006. PMID:17264313
    • Prathapasinghe, G.A., Siow, Y.L., and O, K. 2007. Detrimental role of homocysteine in renal ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 292(5): F1354-F1363. doi:10.1152/ajprenal.00301.2006. PMID:17264313.
    • (2007) Am. J. Physiol. Renal Physiol. , vol.292 , Issue.5
    • Prathapasinghe, G.A.1    Siow, Y.L.2
  • 31
    • 19044385595 scopus 로고    scopus 로고
    • Cystathionine β synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver
    • doi:10.1053/j.gastro.2005.02.034. PMID:15887121
    • Robert, K., Nehme, J., Bourdon, E., Pivert, G., Friguet, B., Delcayre, C., et al. 2005. Cystathionine β synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology, 128(5): 1405-1415. doi:10.1053/j.gastro.2005.02.034. PMID:15887121.
    • (2005) Gastroenterology , vol.128 , Issue.5 , pp. 1405-1415
    • Robert, K.1    Nehme, J.2    Bourdon, E.3    Pivert, G.4    Friguet, B.5    Delcayre, C.6
  • 32
    • 84863133957 scopus 로고    scopus 로고
    • Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase
    • O, K. doi:10.1139/y11-124. PMID:22309437
    • Sarna, L.K., Wu, N., Wang, P., Hwang, S.Y., Siow, Y.L., and O, K. 2012. Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase. Can. J. Physiol. Pharmacol. 90(2): 155-165. doi:10.1139/y11-124. PMID:22309437.
    • (2012) Can. J. Physiol. Pharmacol. , vol.90 , Issue.2 , pp. 155-165
    • Sarna, L.K.1    Wu, N.2    Wang, P.3    Hwang, S.Y.4    Siow, Y.L.5
  • 33
    • 27744527545 scopus 로고    scopus 로고
    • -) are determined both by cellular GSH level and HO activity in macrophages
    • doi:10.1016/S0076-6879(05)96035-7. PMID:16291250
    • -) are determined both by cellular GSH level and HO activity in macrophages. Methods Enzymol. 396: 414-424. doi:10.1016/S0076-6879(05)96035-7. PMID:16291250.
    • (2005) Methods Enzymol. , vol.396 , pp. 414-424
    • Srisook, K.1    Kim, C.2    Cha, Y.N.3
  • 34
    • 0034664982 scopus 로고    scopus 로고
    • Characterization of homocysteine metabolism in the rat liver
    • doi:10.1042/0264-6021:3500685. PMID:10970780
    • Stead, L.M., Brosnan, M.E., and Brosnan, J.T. 2000. Characterization of homocysteine metabolism in the rat liver. Biochem. J. 350(3): 685-692. doi:10.1042/0264-6021:3500685. PMID:10970780.
    • (2000) Biochem. J. , vol.350 , Issue.3 , pp. 685-692
    • Stead, L.M.1    Brosnan, M.E.2    Brosnan, J.T.3
  • 35
    • 0018570990 scopus 로고
    • Effect of excess dietary methionine on the catabolism of cysteine in rats
    • PMID:512701
    • Stipanuk, M.H. 1979. Effect of excess dietary methionine on the catabolism of cysteine in rats. J. Nutr. 109(12): 2126-2139. PMID:512701.
    • (1979) J. Nutr. , vol.109 , Issue.12 , pp. 2126-2139
    • Stipanuk, M.H.1
  • 36
    • 0020483746 scopus 로고
    • Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
    • PMID:7150244
    • Stipanuk, M.H., and Beck, P.W. 1982. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem. J. 206(2): 267-277. PMID:7150244.
    • (1982) Biochem. J. , vol.206 , Issue.2 , pp. 267-277
    • Stipanuk, M.H.1    Beck, P.W.2
  • 37
    • 79953715220 scopus 로고    scopus 로고
    • Dealing with methionine/homocysteine sulfur: Cysteine metabolism to taurine and inorganic sulfur
    • doi:10.1007/s10545-009-9006-9. PMID:20162368
    • Stipanuk, M.H., and Ueki, I. 2011. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J. Inherit. Metab. Dis. 34(1): 17-32. doi:10.1007/s10545-009-9006-9. PMID:20162368.
    • (2011) J. Inherit. Metab. Dis. , vol.34 , Issue.1 , pp. 17-32
    • Stipanuk, M.H.1    Ueki, I.2
  • 38
    • 80054709263 scopus 로고    scopus 로고
    • Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats
    • doi:10.1371/journal.pone. 0025943. PMID:22022478
    • Tan, G., Pan, S., Li, J., Dong, X., Kang, K., Zhao, M., et al. 2011. Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. PLoS One, 6(10): e25943. doi:10.1371/journal.pone. 0025943. PMID:22022478.
    • (2011) PLoS One , vol.6 , Issue.10
    • Tan, G.1    Pan, S.2    Li, J.3    Dong, X.4    Kang, K.5    Zhao, M.6
  • 39
    • 0032566713 scopus 로고    scopus 로고
    • Evidence for heme-mediated redox regulation of human cystathionine β-synthase activity
    • doi:10.1074/jbc.273.39.25179. PMID: 9737978
    • Taoka, S., Ohja, S., Shan, X., Kruger, W.D., and Banerjee, R. 1998. Evidence for heme-mediated redox regulation of human cystathionine β-synthase activity. J. Biol. Chem. 273(39): 25179-25184. doi:10.1074/jbc.273.39.25179. PMID: 9737978.
    • (1998) J. Biol. Chem. , vol.273 , Issue.39 , pp. 25179-25184
    • Taoka, S.1    Ohja, S.2    Shan, X.3    Kruger, W.D.4    Banerjee, R.5
  • 40
    • 0037276590 scopus 로고    scopus 로고
    • Redox regulation of homocysteine-dependent glutathione synthesis
    • doi:10.1179/135100003125001260. PMID:12631446
    • Vitvitsky, V., Mosharov, E., Tritt, M., Ataullakhanov, F., and Banerjee, R. 2003. Redox regulation of homocysteine-dependent glutathione synthesis. Redox Rep. 8(1): 57-63. doi:10.1179/135100003125001260. PMID:12631446.
    • (2003) Redox Rep. , vol.8 , Issue.1 , pp. 57-63
    • Vitvitsky, V.1    Mosharov, E.2    Tritt, M.3    Ataullakhanov, F.4    Banerjee, R.5
  • 41
    • 84860117196 scopus 로고    scopus 로고
    • Physiological implications of hydrogen sulfide: A whiff exploration that blossomed
    • doi:10.1152/physrev.00017. 2011. PMID:22535897
    • Wang, R. 2012. Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol. Rev. 92(2): 791-896. doi:10.1152/physrev.00017. 2011. PMID:22535897.
    • (2012) Physiol. Rev. , vol.92 , Issue.2 , pp. 791-896
    • Wang, R.1
  • 42
    • 78650485623 scopus 로고    scopus 로고
    • Hydrogen sulfide and inflammation: The good, the bad, the ugly and the promising
    • doi:10.1586/ecp.10.134. PMID:22115346
    • Whiteman, M., and Winyard, P.G. 2011. Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Rev. Clin. Pharmacol. 4(1): 13-32. doi:10.1586/ecp.10.134. PMID:22115346.
    • (2011) Expert Rev. Clin. Pharmacol. , vol.4 , Issue.1 , pp. 13-32
    • Whiteman, M.1    Winyard, P.G.2
  • 43
    • 30744462183 scopus 로고    scopus 로고
    • Homocysteine metabolism in ZDF (type 2) diabetic rats
    • doi:10.2337/diabetes.54.11.3245. PMID:16249451
    • Wijekoon, E.P., Hall, B., Ratnam, S., Brosnan, M.E., Zeisel, S.H., and Brosnan, J.T. 2005. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes, 54(11): 3245-3251. doi:10.2337/diabetes.54.11.3245. PMID:16249451.
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3245-3251
    • Wijekoon, E.P.1    Hall, B.2    Ratnam, S.3    Brosnan, M.E.4    Zeisel, S.H.5    Brosnan, J.T.6
  • 44
    • 33746854283 scopus 로고    scopus 로고
    • Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation
    • O, K. doi:10.1016/j.bbadis.2006. 05.012. PMID:16837172
    • Woo, C.W., Prathapasinghe, G.A., Siow, Y.L., and O, K. 2006. Hyperhomocysteinemia induces liver injury in rat: protective effect of folic acid supplementation. Biochim. Biophys. Acta, 1762(7): 656-665. doi:10.1016/j.bbadis.2006. 05.012. PMID:16837172.
    • (2006) Biochim. Biophys. Acta , vol.1762 , Issue.7 , pp. 656-665
    • Woo, C.W.1    Prathapasinghe, G.A.2    Siow, Y.L.3
  • 45
    • 38549177421 scopus 로고    scopus 로고
    • Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation
    • O, K. doi:10.1074/jbc. M707886200. PMID:18024959
    • Woo, C.W., Siow, Y.L., and O, K. 2008. Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation. J. Biol. Chem. 283(3): 1282-1292. doi:10.1074/jbc. M707886200. PMID:18024959.
    • (2008) J. Biol. Chem. , vol.283 , Issue.3 , pp. 1282-1292
    • Woo, C.W.1    Siow, Y.L.2
  • 46
    • 67650733075 scopus 로고    scopus 로고
    • Ischemia-reperfusion reduces cystathionine-β-synthase-mediated hydrogen sulfide generation in the kidney
    • O, K. doi:10.1152/ajprenal.00096.2009. PMID:19439522
    • Xu, Z., Prathapasinghe, G., Wu, N., Hwang, S.Y., Siow, Y.L., and O, K. 2009. Ischemia-reperfusion reduces cystathionine-β-synthase-mediated hydrogen sulfide generation in the kidney. Am. J. Physiol. Renal Physiol. 297(1): F27-F35. doi:10.1152/ajprenal.00096.2009. PMID:19439522.
    • (2009) Am. J. Physiol. Renal Physiol. , vol.297 , Issue.1
    • Xu, Z.1    Prathapasinghe, G.2    Wu, N.3    Hwang, S.Y.4    Siow, Y.L.5
  • 47
    • 54949084607 scopus 로고    scopus 로고
    • 2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine β-lyase
    • doi:10.1126/science.1162667. PMID:18948540
    • 2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine β-lyase. Science, 322(5901): 587-590. doi:10.1126/science.1162667. PMID:18948540.
    • (2008) Science , vol.322 , Issue.5901 , pp. 587-590
    • Yang, G.1    Wu, L.2    Jiang, B.3    Yang, W.4    Qi, J.5    Cao, K.6
  • 48
    • 84872688278 scopus 로고    scopus 로고
    • Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet
    • doi:10.1007/s00394-011-0294-0. PMID: 22209966
    • Yun, K.U., Ryu, C.S., Oh, J.M., Kim, C.H., Lee, K.S., Lee, C.H., et al. 2013. Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet. Eur. J. Nutr. 52(1): 127-134. doi:10.1007/s00394-011-0294-0. PMID: 22209966.
    • (2013) Eur. J. Nutr. , vol.52 , Issue.1 , pp. 127-134
    • Yun, K.U.1    Ryu, C.S.2    Oh, J.M.3    Kim, C.H.4    Lee, K.S.5    Lee, C.H.6
  • 49
    • 80052024330 scopus 로고    scopus 로고
    • Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    • doi:10.1016/j.tips.2011.05.003. PMID:21684021
    • Zhuo, J.M., Wang, H., and Pratico, D. 2011. Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol. Sci. 32(9): 562-571. doi:10.1016/j.tips.2011.05.003. PMID:21684021.
    • (2011) Trends Pharmacol. Sci. , vol.32 , Issue.9 , pp. 562-571
    • Zhuo, J.M.1    Wang, H.2    Pratico, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.