High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Bravo, Elena ^a   Palleschi, Simonetta ^a   Aspichueta, Patricia ^b   Buqué, Xabier ^b   Rossi, Barbara ^a   Cano, Ainara ^b   Napolitano, Mariarosaria ^a   Ochoa, Begõa ^b   Botham, Kathleen M ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Homocysteine; hyperhomocysteinemia; non alcoholic fatty liver disease; transsulphuration pathway

Indexed keywords

CHOLESTEROL; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; MESSENGER RNA; TRIACYLGLYCEROL; HOMOCYSTEINE; INSULIN; METHYLTRANSFERASE;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR RISK; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVITY; HYPERHOMOCYSTEINEMIA; LIPID DIET; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; TRANSSULPHURATION; ANIMAL; BLOOD; FAT INTAKE; FATTY LIVER; GENETIC TRANSCRIPTION; GENETICS; LIVER; METABOLISM; WISTAR RAT;

ANIMALIA; RATTUS;

ANIMALS; CYSTATHIONINE BETA-SYNTHASE; CYSTATHIONINE GAMMA-LYASE; DIETARY FATS; DOWN-REGULATION; FATTY LIVER; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; INSULIN; LIVER; MALE; METABOLIC NETWORKS AND PATHWAYS; METHYLTRANSFERASES; RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 79955105079     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-60     Document Type: Article

References (31)

1. Recent concepts in non-alcoholic fatty liver disease. LA Adams P Angulo, Diabetic Med 2005 22 1129 1133 10.1111/j.1464-5491.2005.01748.x 16108837 (Pubitemid 41224168)
2. A model of insulin resistance and nonalcoholic steatohepatitis in rats. G Svegliati-Baroni C Candelaresi S Saccomanno G Ferretti T Bachetti M Marzioni S De Minicis L Nobili R Salzano A Omenetti D Pacetti S Sigmund A Benedetti AA Casini, Am J Pathol 2006 169 846 860 10.2353/ajpath.2006.050953 16936261
3. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. LA Videla R Rodrigo J Araya J Ponichik, Trends Mol Med 2006 12 555 558 10.1016/j.molmed.2006.10.001 17049925 (Pubitemid 44780196)
4. Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis. I Grattagliano VO Palmieri P Portincasa A Moschetta G Palasciano, J Nutr Biochem 2008 19 491 504 10.1016/j.jnutbio.2007. 06.011 17855068 (Pubitemid 351952322)
5. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. LA Videla R Rodrigo J Araya J Poniachik, Free Radic Biol Med 2004 37 1499 1507 10.1016/j.freeradbiomed.2004.06.033 15454290 (Pubitemid 39349251)
6. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. LA Videla RN Rodrigo M Orellana V Fernandez G Tapia L Quĩones N Varela J Contreras R Lazarte A Csendes J Rojas F Maluenda P Burdiles JC Diaz G Smok L Thielemann J Poniachik, Clin Sci 2004 106 261 268 10.1042/CS20030285 14556645 (Pubitemid 38365832)
7. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. J Araya RN Rodrigo LA Videla L Thielemann M Orellana P Pettinelli J Poniachik, Clin Sci 2004 106 635 643 10.1042/CS20030326 14720121 (Pubitemid 38797577)
8. Hepatic lipid metabolism and non-alcoholic fatty liver disease. P Tessari A Coracina A Cosma A Tiengo, Nutr Metab Cardiovasc Dis 2009 19 291 302 10.1016/j.numecd.2008.12.015 19359149
9. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. X Buque MJ Martinez A Cano ME Miquilena C Garcia-Monzon P Aspichueta B Ochoa, J Lipid Res 2009 51 500 513 10.1194/jlr.M001966 19783528
10. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. G Targher G Arcaro, Atherosclerosis 2007 191 235 240 10.1016/j.atherosclerosis.2006.08.021 16970951 (Pubitemid 46400718)
11. Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms. J Zhou RC Austin, BioFactors 2009 35 120 129 10.1002/biof.17 19449439
12. Homocysteine metabolism in diabetes. EP Wijekoon ME Brosnan JT Brosnan, Biochem Soc Trans 2007 35 1175 1179 10.1042/BST0351175 17956306 (Pubitemid 350206455)
13. The Role of Cystathionine beta-synthase in homocysteine metabolism. KH Jhee WD Kruger, Antioxid Redox Signal 2005 7 813 822 10.1089/ars.2005.7.813 15890029 (Pubitemid 40563223)
14. Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies. G Gaull JA Starman N Schaffner, J Pediatr 1974 84 381 390 10.1016/S0022-3476(74)80721-3 4811988
15. Abnormal lipid metabolism in cystathionine -synthase-deficient mice, an animal model for hyperhomocysteinemia. K Namekata Y Enokido I Ishii Y Nagai T Harada H Kimura, J Biol Chem 2004 279 52961 52969 10.1074/jbc.M406820200 15466479 (Pubitemid 40051794)
16. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease. M Gulsen Z Yesilova S Bagci A Uygun A Ozcan CN Ercin A Erdil SY Sanisoglu E Cakir Y Ates MK Erbil N Karaeren K Dagalp, J Gastroenterol Hepatol 2005 20 1448 1455 10.1111/j.1440-1746.2005.03891.x 16105135 (Pubitemid 43960846)
17. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect? GM Safwat S Pisan E D'Amore G Borioni M Napolitano AA Kamal P Ballanti KM Botham E Bravo, Nutrition 2009 25 1157 1168 10.1016/j.nut.2009.02. 009 19592219
18. Hepatic very low density lipoprotein assembly is disturbed in a rat model of non alcoholic fatty liver disease: Is there a role for dietary Coenzyme Q? A Cano F Ciaffoni GM Safwa P Aspichueta B Ochoa E Bravo KM Botham, J Applied Physiol 2009 107 707 717 10.1152/japplphysiol.00297.2009
19. A simple method for the isolation and purification of total lipids from animal tissues. J Folch N Lees GH Sloane-Stanley, J Biol Chem 1957 226 497 509 13428781
20. Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway. S Mudd HDJ Finkelstein F Irreverre L Laster, J Biol Chem 1965 240 4382 4392 4954368
21. Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo. K Heinonen, Biochem J 1973 136 1011 1015 4786524
22. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. J Vandesompele KD Preter F Pattyn B Poppe N Van Roy A De Paepe F Speleman, Genome Biol 2002 http://genomebiology. com/2002/3/7/research/0034 18 12184808
23. A sensitive method for quantitation of microgram quantities of protein utilizing the principle of dye-binding. M Bradford, Anal Biochem 1976 72 248 254 10.1016/0003-2697(76)90527-3 942051
24. Rapid and Accurate HPLC Assay for Plasma Total Homocysteine and Cysteine in a Clinical Laboratory Setting. CM Pfeiffer DL Huff EW Gunter, Clin Chem 1999 45 290 292 9931056 (Pubitemid 29079132)
25. Reactive oxygen species have a causal role in multiple forms of insulin resistance. N Houstis ED Rosen ES Lander, Nature 2006 440 944 948 10.1038/nature04634 16612386
26. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. M Cravo L Gloria J Selhub M Nadeau M Camilo M Resende J Cardoso C Leitao F Mira, Am J Clin Nutr 1996 63 220 224 8561063 (Pubitemid 26036243)
27. Mice deficient in cystathionine -synthase: animal models for mild and severe homocyst(e)inemia. M Watanabe J Osada Y Aratani K Kluckman R Reddick MR Malinow N Maeda, Proc Natl Acad Sci USA 1995 92 1585 1589 10.1073/pnas.92.5.1585 7878023
28. Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver. S Hirsch J Poniachick M Avendão A Csendes P Burdiles G Smok JC Diaz MP de la Maza, Nutrition 2005 21 137 141 10.1016/j.nut.2004.03.022 15723740 (Pubitemid 40255721)
29. Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development. B Gil M Casado MA Pajares, Hepatology 1996 24 876 881 8855191 (Pubitemid 26334288)
30. Impaired Sulfur-Amino Acid Metabolism and Oxidative Stress in Nonalcoholic Fatty Liver Are Alleviated by Betaine Supplementation in Rats. DY Kwon YS Jung SJ Kim HK Park JH Park YC Kim, J Nutr 2009 139 63 68 19056644
31. Glutathione. A Meister ME Anderson, Annu Rev Biochem 1983 52 711 760 10.1146/annurev.bi.52.070183.003431 6137189 (Pubitemid 13030692)