Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 86-93

  Jensen, Kristian K ^a   Geoghagen, Neil S ^a   Jin, Lan ^a   Holt, Tom G ^a   Luo, Qi ^a   Malkowitz, Lorraine ^a   Ni, Weihua ^a   Quan, Shuo ^a   Waters, M Gerard ^a   Zhang, Aiwu ^a   Zhou, Heather H ^a   Cheng, Kang ^a   Luo, Ming Juan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cystathionine synthase; Homocysteine; Hydrogen sulfide

Indexed keywords

ADENOVIRUS VECTOR; CYSTATHIONINE BETA SYNTHASE; HOMOCYSTEINE; HYDROGEN SULFIDE; RECOMBINANT ENZYME; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME REGULATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENETIC MANIPULATION; IN VITRO STUDY; IN VIVO STUDY; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; CYSTATHIONINE BETA-SYNTHASE; ENZYME ACTIVATION; GENETIC ENGINEERING; HOMOCYSTEINE; HUMANS; HYDROGEN SULFIDE; MALE; MICE; MICE, INBRED C57BL; MUTATION; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE;

EID: 78649760355     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.080     Document Type: Article

References (36)

1. A. Araki, and Y. Sako Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection J. Chromatogr. 422 1987 43 52
2. R. Banerjee, R. Evande, O. Kabil, S. Ojha, and S. Taoka Reaction mechanism and regulation of cystathionine beta-synthase Biochim. Biophys. Acta 1647 2003 30 35
3. X. Chen, K.H. Jhee, and W.D. Kruger Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine J. Biol. Chem. 279 2004 52082 52086
4. L. Chen, S. Ingrid, Y.G. Ding, Y. Liu, J.G. Qi, C.S. Tang, and J.B. Du Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children Chin. Med. J. (Engl.) 120 2007 389 393
5. J.D. Finkelstein, W.E. Kyle, J.L. Martin, and A.M. Pick Activation of cystathionine synthase by adenosylmethionine and adenosylethionine Biochem. Biophys. Res. Commun. 66 1975 81 87
6. J.K. Fogo, and M. Popowsky Spectrophotometric Determination of Hydrogen Sulfide Anal. Chem. 21 1949 732 734 10.1021/ac60030a028
7. N. Frank, J.O. Kent, M. Meier, and J.P. Kraus Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli Arch. Biochem. Biophys. 470 2008 64 72
8. T.G. Holt, B.K. Choi, N.S. Geoghagen, K.K. Jensen, Q. Luo, W.A. LaMarr, G.M. Makara, L. Malkowitz, C.C. Ozbal, Y. Xiong, C. Dufresne, and M.J. Luo Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications Assay Drug Dev. Technol. 7 2009 495 506
9. R. Hosoki, N. Matsuki, and H. Kimura The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide Biochem. Biophys. Res. Commun. 237 1997 527 531
10. M. Janosik, V. Kery, M. Gaustadnes, K.N. Maclean, and J.P. Kraus Regulation of human cystathionine beta-synthase by S-adenosyl-l-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region Biochemistry (Mosc.) 40 2001 10625 10633
11. H.L. Jiang, H.C. Wu, Z.L. Li, B. Geng, and C.S. Tang Changes of the new gaseous transmitter H2S in patients with coronary heart disease Di Yi Jun Yi Da Xue Xue Bao 25 2005 951 954
12. P. Kamoun Endogenous production of hydrogen sulfide in mammals Amino Acids 26 2004 243 254
13. V. Kery, L. Poneleit, and J.P. Kraus Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences Arch. Biochem. Biophys. 355 1998 222 232
14. H. Kimura Hydrogen sulfide as a neuromodulator Mol. Neurobiol. 26 2002 13 19
15. L. Li, and P.K. Moore Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol. Sci. 29 2008 84 90
16. L. Li, M. Bhatia, and P.K. Moore Hydrogen sulphide-a novel mediator of inflammation? Curr. Opin. Pharmacol. 6 2006 125 129
17. L. Li, M. Whiteman, Y.Y. Guan, K.L. Neo, Y. Cheng, S.W. Lee, Y. Zhao, R. Baskar, C.H. Tan, and P.K. Moore Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide Circulation 117 2008 2351 2360
18. J. Loscalzo Homocysteine trials-clear outcomes for complex reasons N. Engl. J. Med. 354 2006 1629 1632
19. P.K. Moore, M. Bhatia, and S. Moochhala Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol. Sci. 24 2003 609 611
20. T.T. Pan, Z.N. Feng, S.W. Lee, P.K. Moore, and J.S. Bian Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes J. Mol. Cell. Cardiol. 40 2006 119 130
21. R.J. Pearson, T. Wilson, and R. Wang Endogenous hydrogen sulfide and the cardiovascular system-what's the smell all about? Clin. Invest. Med. 29 2006 146 150
22. R.N. Rodionov, and S.R. Lentz The homocysteine paradox Arterioscler. Thromb. Vasc. Biol. 28 2008 1031 1033
23. X. Shan, and W.D. Kruger Correction of disease-causing CBS mutations in yeast Nat. Genet. 19 1998 91 93
24. Y.X. Shi, Y. Chen, Y.Z. Zhu, G.Y. Huang, P.K. Moore, S.H. Huang, T. Yao, and Y.C. Zhu Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats Am. J. Physiol. Heart Circ. Physiol. 293 2007 H2093 H2100
25. M.H. Stipanuk, and P.W. Beck Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat Biochem. J. 206 1982 267 277
26. N.L. Sun, Y. Xi, S.N. Yang, Z. Ma, and C.S. Tang Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications Zhonghua Xin Xue Guan Bing Za Zhi 35 2007 1145 1148
27. C. Szabo Hydrogen sulphide and its therapeutic potential Nat. Rev. Drug Discov. 6 2007 917 935
28. S. Taoka, S. Ohja, X. Shan, W.D. Kruger, and R. Banerjee Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity J. Biol. Chem. 273 1998 25179 25184
29. J.L. Wallace Hydrogen sulfide-releasing anti-inflammatory drugs Trends Pharmacol. Sci. 28 2007 501 505
30. L. Wang, K.H. Jhee, X. Hua, P.M. DiBello, D.W. Jacobsen, and W.D. Kruger Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice Circ. Res. 94 2004 1318 1324
31. Y. Wang, X. Zhao, H. Jin, H. Wei, W. Li, D. Bu, X. Tang, Y. Ren, C. Tang, and J. Du Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice Arterioscler. Thromb. Vasc. Biol. 29 2009 173 179
32. M. Watanabe, J. Osada, Y. Aratani, K. Kluckman, R. Reddick, M.R. Malinow, and N. Maeda Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia Proc. Natl. Acad. Sci. U. S. A. 92 1995 1585 1589
33. H. Yan, J. Du, and C. Tang The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats Biochem. Biophys. Res. Commun. 313 2004 22 27 (Pubitemid 37524019)
34. G. Yang, L. Wu, B. Jiang, W. Yang, J. Qi, K. Cao, Q. Meng, A.K. Mustafa, W. Mu, S. Zhang, S.H. Snyder, and R. Wang H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase Science 322 2008 587 590
35. W. Zhao, J. Zhang, Y. Lu, and R. Wang The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener EMBO J. 20 2001 6008 6016
36. Y.Z. Zhu, Z.J. Wang, P. Ho, Y.Y. Loke, Y.C. Zhu, S.H. Huang, C.S. Tan, M. Whiteman, J. Lu, and P.K. Moore Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats J. Appl. Physiol. 102 2007 261 268